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Details

Stereochemistry ACHIRAL
Molecular Formula C25H23N5O3
Molecular Weight 441.4818
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BILR-355

SMILES

CCN1C2=NC=CC=C2N(C)C(=O)C3=C1N=CC(CCOC4=CC=[N+]([O-])C5=CC=CC=C45)=C3

InChI

InChIKey=BEMBRAMZGVDPMH-UHFFFAOYSA-N
InChI=1S/C25H23N5O3/c1-3-29-23-19(25(31)28(2)21-9-6-12-26-24(21)29)15-17(16-27-23)11-14-33-22-10-13-30(32)20-8-5-4-7-18(20)22/h4-10,12-13,15-16H,3,11,14H2,1-2H3

HIDE SMILES / InChI
Molecular Formula C25H23N5O3
Molecular Weight 441.4818
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Unknown
139594
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:56:40 UTC 2023
Edited
by admin
on Fri Dec 15 15:56:40 UTC 2023
Record UNII
V7T28EEE1C
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BILR-355
Common Name English
6H-DIPYRIDO(3,2-B:2',3'-E)(1,4)DIAZEPIN-6-ONE, 11-ETHYL-5,11-DIHYDRO-5-METHYL-8-(2-((1-OXIDO-4-QUINOLINYL)OXY)ETHYL)-
Systematic Name English
Code System Code Type Description
CAS
380378-81-4
Created by admin on Fri Dec 15 15:56:40 UTC 2023 , Edited by admin on Fri Dec 15 15:56:40 UTC 2023
PRIMARY
FDA UNII
V7T28EEE1C
Created by admin on Fri Dec 15 15:56:40 UTC 2023 , Edited by admin on Fri Dec 15 15:56:40 UTC 2023
PRIMARY
PUBCHEM
3010663
Created by admin on Fri Dec 15 15:56:40 UTC 2023 , Edited by admin on Fri Dec 15 15:56:40 UTC 2023
PRIMARY
EPA CompTox
DTXSID30191455
Created by admin on Fri Dec 15 15:56:40 UTC 2023 , Edited by admin on Fri Dec 15 15:56:40 UTC 2023
PRIMARY
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The in vitro results showed that the EC50 of BILR 355 was 0.26 ng/ml (0.59 nM) against wild-type HIV-1 and ranged from 1.5 to 13 ng/ml (3.4 –29 nM) against clinically common single and double NNRTI mutations .
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Scientific Literature
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ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Biological Half-life PHARMACOKINETIC ORAL ADMINISTRATION

Tmax PHARMACOKINETIC ORAL ADMINISTRATION

SINGLE DOSE

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