Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C20H24N2O3 |
| Molecular Weight | 340.4162 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)C1=C(N(CC2CC2)C(=O)NC1=O)C(=O)C3=CC(C)=CC(C)=C3
InChI
InChIKey=UCOAKFIVSAVHLC-UHFFFAOYSA-N
InChI=1S/C20H24N2O3/c1-11(2)16-17(18(23)15-8-12(3)7-13(4)9-15)22(10-14-5-6-14)20(25)21-19(16)24/h7-9,11,14H,5-6,10H2,1-4H3,(H,21,24,25)
| Molecular Formula | C20H24N2O3 |
| Molecular Weight | 340.4162 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
IQP-0528 is an antiretroviral pyrimidinedione derivative with activity against human immunodeficiency virus (HIV) in the nanomolar range. It is a non-nucleoside reverse transcriptase inhibitor that also inhibits HIV entry through an unknown mechanism thought to target a conformational epitope formed prior to the fusion of the viral envelope with the host cellular membrane. IQP-0528 is under clinical development for HIV prevention.
Originator
Approval Year
Sample Use Guides
IQP-0528 (SJ-3366) exhibited a Ki value of 3.2 nM, with a mixed mechanism of inhibition against human immunodeficiency virus type 1 (HIV-1) reverse transcriptase, but it did not inhibit HIV-2 reverse transcriptase. SJ-3366 also inhibited the entry of both HIV-1 and HIV-2 into target cells.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:02:45 UTC 2023
by
admin
on
Sat Dec 16 08:02:45 UTC 2023
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| Record UNII |
1Y42TZL33O
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| Record Status |
Validated (UNII)
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| Record Version |
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1367755-87-0
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1Y42TZL33O
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483499
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DB14888
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301297-45-0
Created by
admin on Sat Dec 16 08:02:45 UTC 2023 , Edited by admin on Sat Dec 16 08:02:45 UTC 2023
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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TARGET ORGANISM->INHIBITOR |
EC50
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TARGET -> INHIBITOR |
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| Related Record | Type | Details | ||
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ACTIVE MOIETY |
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