U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

1972
178
Substance Class Structurally Diverse
Created
by admin
on Fri Dec 15 16:40:06 UTC 2023
Edited
by admin
on Fri Dec 15 16:40:06 UTC 2023
Source Materials Class ORGANISM
Source Materials Type PLANT
Source Materials Parent
NICOTIANA TABACUM WHOLE
Part LEAF
Record UNII
6YR2608RSU
Record Status Validated (UNII)
Record Version
  • Download
Related Record Type
Name Type Language
TOBACCO LEAF
Common Name English
TABACUM LEAF
Common Name English
TOBACCO [MART.]
Common Name English
TABACUM [HPUS]
Common Name English
TOBACCO
MART.   VANDF  
Common Name English
CULTIVATED TOBACCO LEAF
Common Name English
TOBACCO OIL
Common Name English
NICOTIANA TABACUM LEAF
Common Name English
TOBACCO [VANDF]
Common Name English
TABACUM
HPUS  
Common Name English
COMMON TOBACCO LEAF
Common Name English
YAN CAO LEAF
Common Name English
Classification Tree Code System Code
NDF-RT N0000185375
Created by admin on Fri Dec 15 16:40:07 UTC 2023 , Edited by admin on Fri Dec 15 16:40:07 UTC 2023
Code System Code Type Description
NCI_THESAURUS
C891
Created by admin on Fri Dec 15 16:40:07 UTC 2023 , Edited by admin on Fri Dec 15 16:40:07 UTC 2023
PRIMARY
NDF-RT
N0000008246
Created by admin on Fri Dec 15 16:40:07 UTC 2023 , Edited by admin on Fri Dec 15 16:40:07 UTC 2023
PRIMARY Plant Proteins [Chemical/Ingredient]
DAILYMED
6YR2608RSU
Created by admin on Fri Dec 15 16:40:07 UTC 2023 , Edited by admin on Fri Dec 15 16:40:07 UTC 2023
PRIMARY
NDF-RT
N0000175629
Created by admin on Fri Dec 15 16:40:07 UTC 2023 , Edited by admin on Fri Dec 15 16:40:07 UTC 2023
PRIMARY Increased Histamine Release [PE]
NDF-RT
N0000184306
Created by admin on Fri Dec 15 16:40:07 UTC 2023 , Edited by admin on Fri Dec 15 16:40:07 UTC 2023
PRIMARY Cell-mediated Immunity [PE]
NDF-RT
N0000185001
Created by admin on Fri Dec 15 16:40:07 UTC 2023 , Edited by admin on Fri Dec 15 16:40:07 UTC 2023
PRIMARY Increased IgG Production [PE]
EVMPD
SUB33503
Created by admin on Fri Dec 15 16:40:07 UTC 2023 , Edited by admin on Fri Dec 15 16:40:07 UTC 2023
PRIMARY
NDF-RT
N0000171131
Created by admin on Fri Dec 15 16:40:07 UTC 2023 , Edited by admin on Fri Dec 15 16:40:07 UTC 2023
PRIMARY Allergens [Chemical/Ingredient]
DRUG BANK
DB10710
Created by admin on Fri Dec 15 16:40:07 UTC 2023 , Edited by admin on Fri Dec 15 16:40:07 UTC 2023
PRIMARY
CAS
8037-19-2
Created by admin on Fri Dec 15 16:40:07 UTC 2023 , Edited by admin on Fri Dec 15 16:40:07 UTC 2023
PRIMARY
EPA CompTox
DTXSID50897326
Created by admin on Fri Dec 15 16:40:07 UTC 2023 , Edited by admin on Fri Dec 15 16:40:07 UTC 2023
PRIMARY
FDA UNII
6YR2608RSU
Created by admin on Fri Dec 15 16:40:07 UTC 2023 , Edited by admin on Fri Dec 15 16:40:07 UTC 2023
PRIMARY
RXCUI
852062
Created by admin on Fri Dec 15 16:40:07 UTC 2023 , Edited by admin on Fri Dec 15 16:40:07 UTC 2023
PRIMARY RxNorm
Related Record Type Details
Structure of CLUSIPARALICOLINE C
CONSTITUENT ALWAYS PRESENT -> PARENT
TMV infection inhibition activity of compound 26.8 ? 2.1%. Powdered leaves and stems of N. tabacum were extracted with 70% aqueous acetone.
Structure of LEAD
CONSTITUENT ALWAYS PRESENT -> PARENT
LEAD (ng/cigarette) Canadian = 257.7 SD(77.7) Imported = 257.0 SD(66.5)
Structure of ANABASINE
CONSTITUENT ALWAYS PRESENT -> PARENT
ANABASINE (ug/cigarette) Canadian = 67.1 SD(9.4) Imported = 63.3 SD(6.5)
Structure of SOLANACOL
CONSTITUENT ALWAYS PRESENT -> PARENT
Structure of 2,3'-BIPYRIDINE
CONSTITUENT ALWAYS PRESENT -> PARENT
Structure of 3-METHYL-4-PENTANOLIDE, (3R,4S)-
CONSTITUENT ALWAYS PRESENT -> PARENT
Oriental tobacco is a sun-cured, highly aromatic, small-leafed variety (Nicotiana tabacum) that is grown in Turkey, Greece, Bulgaria, Lebanon, and the Republic of Macedonia. https://en.wikipedia.org/wiki/Types_of_tobacco
Structure of DOITUNGBIPHENYL B
CONSTITUENT ALWAYS PRESENT -> PARENT
TMV infection inhibition activity of compound 24.8 ? 2.6%. Powdered leaves and stems of N. tabacum were extracted with 70% aqueous acetone.
Structure of TABABIPHENYL D
CONSTITUENT ALWAYS PRESENT -> PARENT
TMV infection inhibition activity of compound 28.7 ? 2.6%. Powdered leaves and stems of N. tabacum were extracted with 70% aqueous acetone.
ALLERGENIC EXTRACT- TOBACCO NICOTIANA SPP
SUB_CONCEPT->SUBSTANCE
Structure of CHROMIUM
CONSTITUENT ALWAYS PRESENT -> PARENT
CHROMIUM (ng/cigarette) Canadian = 353.3 SD(115.3) Imported = 581.4 SD(103.0)
Structure of 6-NONEN-4-OLIDE, (Z)-
CONSTITUENT ALWAYS PRESENT -> PARENT
Oriental tobacco is a sun-cured, highly aromatic, small-leafed variety (Nicotiana tabacum) that is grown in Turkey, Greece, Bulgaria, Lebanon, and the Republic of Macedonia. https://en.wikipedia.org/wiki/Types_of_tobacco
Structure of ANATABINE
CONSTITUENT ALWAYS PRESENT -> PARENT
ANATABINE (ug/cigarette) Canadian = 477.1 SD(64.1) Imported = 398.0 SD(93.4)
Structure of N-CAFFEOYLTYRAMINE
CONSTITUENT ALWAYS PRESENT -> PARENT
A 70% aq. acetone extract prepared from the leaves of N. tabacum was partitioned between EtOAc and H2O. TMV infection inhibition activity of compound 15.3 ? 2.0%.
Structure of 3-HYDROXYSOLAVETIVONE
CONSTITUENT ALWAYS PRESENT -> PARENT
Structure of NICKEL
CONSTITUENT ALWAYS PRESENT -> PARENT
NICKEL (ng/cigarette) Canadian = 250.4 SD(100.2) Imported = 823.3 SD(121.9)
AMERICAN TOBACCO LEAF
SUB_CONCEPT->SUBSTANCE
Structure of 3-METHOXYLUTEOLIN
CONSTITUENT ALWAYS PRESENT -> PARENT
The highest 3-MQ yield was obtained using ethanol in the extraction with a plant:solvent ratio of 1:15 (w/v) and 30-min extraction time. Isolating 3-MQ from the ethanol extract was successfully performed from the corresponding dry residue by normal phase column chromatography (CC). The younger leaves of the Dark variety, cultivated in vase and collected at night, showed the highest 3-MQ yield.
NICOTIANA TABACUM (TOBACCO) LEAF EXTRACT
SUB_CONCEPT->SUBSTANCE
Structure of NICOTYRINE
CONSTITUENT ALWAYS PRESENT -> PARENT
Structure of GLYCERIN
CONSTITUENT ALWAYS PRESENT -> PARENT
Glycerol (mg/cigarette) Canadian = 13.2 SD(1.3) Imported = 13.5 SD(0.0)
Structure of TABABIPHENYL E
CONSTITUENT ALWAYS PRESENT -> PARENT
TMV infection inhibition activity of compound 32.1 ? 2.9%. Powdered leaves and stems of N. tabacum were extracted with 70% aqueous acetone.
Structure of TABABIPHENYL B
CONSTITUENT ALWAYS PRESENT -> PARENT
TMV infection inhibition activity of compound 25.6 ? 3.0%.
Structure of TABABIPHENYL A
CONSTITUENT ALWAYS PRESENT -> PARENT
Anti TMV infection inhibition activity of compound 22.5 ? 2.8%.
Structure of 2'-HYDROXYAUCUPARIN
CONSTITUENT ALWAYS PRESENT -> PARENT
TMV infection inhibition activity of compound 20.8 ? 2.4%. Powdered leaves and stems of N. tabacum were extracted with 70% aqueous acetone.
Structure of NORNICOTINE
CONSTITUENT ALWAYS PRESENT -> PARENT
Nornicotine (ug/cigarette) Canadian = 289.3 SD(67.1) Imported = 422.5 SD(98.4)
Structure of 5-METHYL-4-HEXANOLIDE
CONSTITUENT ALWAYS PRESENT -> PARENT
Oriental tobacco is a sun-cured, highly aromatic, small-leafed variety (Nicotiana tabacum) that is grown in Turkey, Greece, Bulgaria, Lebanon, and the Republic of Macedonia. https://en.wikipedia.org/wiki/Types_of_tobacco
Structure of N'-NITROSOANATABINE
CONSTITUENT ALWAYS PRESENT -> PARENT
NAT (ng/cigarette) Canadian = 378.8 SD(169.3) Imported = 992.1 SD(332.4)
ALLERGENIC EXTRACT- TOBACCO, LEAF
SUB_CONCEPT->SUBSTANCE
Structure of SELENIUM
CONSTITUENT ALWAYS PRESENT -> PARENT
SELENIUM (ng/cigarette) Imported = 110.5 SD(?)
Structure of OXO-.ALPHA.-IONOL GLUCOSIDE, (6R,9S)-3-
CONSTITUENT ALWAYS PRESENT -> PARENT
Compound was extracted from the dried leaves of N. tabacum (3.5 kg) with 90% EtOH at room temperature and partitioned between EtOAc and H2O.
Structure of AMMONIA
CONSTITUENT ALWAYS PRESENT -> PARENT
AMMONIA (ug/cigarette) Canadian = 261.1 SD(90.3) Imported = 1136.9 SD(613.8)
Structure of N-NITROSOANABASINE
CONSTITUENT ALWAYS PRESENT -> PARENT
NAB (ng/cigarette) Canadian = 82.0 SD(5.3) Imported = 240.0 SD(?)
Structure of NICOTABACOSIDE F
CONSTITUENT ALWAYS PRESENT -> PARENT
Compound was extracted from the dried leaves of N. tabacum (3.5 kg) with 90% EtOH at room temperature and partitioned between EtOAc and H2O.
Structure of NICOTINE
CONSTITUENT ALWAYS PRESENT -> PARENT
Nicotine (mg/cigarette) Domestic = 12.6 SD(1.6) Imported = 11.1 SD(2.2)
Structure of MYOSMINE
CONSTITUENT ALWAYS PRESENT -> PARENT
The other minor alkaloids (myosmine, anabasine, and anatabine) have the same (leaf) distribution pattern as nicotine (figures not presented).
Structure of 3-(4-METHYL-L-PENTYL)-2-BUTEN-4-OLIDE
CONSTITUENT ALWAYS PRESENT -> PARENT
Oriental tobacco is a sun-cured, highly aromatic, small-leafed variety (Nicotiana tabacum) that is grown in Turkey, Greece, Bulgaria, Lebanon, and the Republic of Macedonia. https://en.wikipedia.org/wiki/Types_of_tobacco
Structure of 2H-FURO(3,2-B)PYRAN-2-ONE, HEXAHYDRO-7A-METHYL-5-(1-METHYLETHENYL)-, (3AR,5R,7AR)-
CONSTITUENT ALWAYS PRESENT -> PARENT
Oriental tobacco is a sun-cured, highly aromatic, small-leafed variety (Nicotiana tabacum) that is grown in Turkey, Greece, Bulgaria, Lebanon, and the Republic of Macedonia. https://en.wikipedia.org/wiki/Types_of_tobacco
Structure of Triacetin
CONSTITUENT ALWAYS PRESENT -> PARENT
Triacetine (ug/cigarette) Canadian = 23.1 SD(15.6) Imported = 36.3 SD(9.3)
Structure of TABAMIDE C
CONSTITUENT ALWAYS PRESENT -> PARENT
A 70% aq. acetone extract prepared from the leaves of N. tabacum was partitioned between EtOAc and H2O. TMV infection inhibition activity of compound 22.4 ? 2.8%.
ALLERGENIC EXTRACT- TOBACCO, PIPE
SUB_CONCEPT->SUBSTANCE
Structure of NICOTABACOSIDE B
CONSTITUENT ALWAYS PRESENT -> PARENT
Compound was extracted from the dried leaves of N. tabacum (3.5 kg) with 90% EtOH at room temperature and partitioned between EtOAc and H2O.
Structure of CADMIUM
CONSTITUENT ALWAYS PRESENT -> PARENT
CADMIUM (ng/cigarette) Canadian = 929.7 SD(201.8) Imported = 765.8 SD(69.8)
Structure of 2,4-DIMETHOXY-3,7-DIBENZOFURANDIOL
CONSTITUENT ALWAYS PRESENT -> PARENT
TMV infection inhibition activity of compound 18.6 ? 2.3%. Powdered leaves and stems of N. tabacum were extracted with 70% aqueous acetone.
Structure of ARSENIC
CONSTITUENT ALWAYS PRESENT -> PARENT
ARSENIC (ng/cigarette) Canadian = 151.4 SD(64.4) Imported = 169.2 (26.2)
Structure of 3,5,5-TRIMETHYL-4-(3-(((2R,3R,4S,5S,6R)-3,4,5-TRIHYDROXY-6-(HYDROXYMETHYL)OXAN-2-YL)OXY)BUTYLIDENE)CYCLOHEX-2-EN-1-ONE, (4Z)-
CONSTITUENT ALWAYS PRESENT -> PARENT
Compound was extracted from the dried leaves of N. tabacum (3.5 kg) with 90% EtOH at room temperature and partitioned between EtOAc and H2O.
Structure of NICOTABACOSIDE E
CONSTITUENT ALWAYS PRESENT -> PARENT
Compound was extracted from the dried leaves of N. tabacum (3.5 kg) with 90% EtOH at room temperature and partitioned between EtOAc and H2O.
Structure of PROPYLENE GLYCOL
CONSTITUENT ALWAYS PRESENT -> PARENT
Propylene Glycol(mg/cigarette) Canadian = 1.7 SD(0.2) Imported = 4.7 SD(0.0)
Structure of NICOTABACOSIDE A
CONSTITUENT ALWAYS PRESENT -> PARENT
Compound was extracted from the dried leaves of N. tabacum (3.5 kg) with 90% EtOH at room temperature and partitioned between EtOAc and H2O.
Structure of ACTINIDIOIONOSIDE
CONSTITUENT ALWAYS PRESENT -> PARENT
Compound was extracted from the dried leaves of N. tabacum (3.5 kg) with 90% EtOH at room temperature and partitioned between EtOAc and H2O.
Structure of BYZANTIONOSIDE B
CONSTITUENT ALWAYS PRESENT -> PARENT
Compound was extracted from the dried leaves of N. tabacum (3.5 kg) with 90% EtOH at room temperature and partitioned between EtOAc and H2O.
Structure of NICOTABACOSIDE C
CONSTITUENT ALWAYS PRESENT -> PARENT
Compound was extracted from the dried leaves of N. tabacum (3.5 kg) with 90% EtOH at room temperature and partitioned between EtOAc and H2O.
Structure of 4-OXA-7,11,11-TRIMETHYLBICYCLO-(5.4.0)UNDECAN-3-ONE
CONSTITUENT ALWAYS PRESENT -> PARENT
Oriental tobacco is a sun-cured, highly aromatic, small-leafed variety (Nicotiana tabacum) that is grown in Turkey, Greece, Bulgaria, Lebanon, and the Republic of Macedonia. https://en.wikipedia.org/wiki/Types_of_tobacco
Structure of DOITUNGBIPHENYL A
CONSTITUENT ALWAYS PRESENT -> PARENT
TMV infection inhibition activity of compound 18.8 ? 2.5%. Powdered leaves and stems of N. tabacum were extracted with 70% aqueous acetone.
Structure of NICOTABACOSIDE D
CONSTITUENT ALWAYS PRESENT -> PARENT
Compound was extracted from the dried leaves of N. tabacum (3.5 kg) with 90% EtOH at room temperature and partitioned between EtOAc and H2O.
Structure of 4-(N-NITROSOMETHYLAMINO)-1-(3-PYRIDYL)-1-BUTANONE
CONSTITUENT ALWAYS PRESENT -> PARENT
Highly effective lung carcinogen in rats and induces lung tumors in mice and hamsters as well (1) . It also causes tumors of the pancreas, liver, and nasal mucosa in rats. NNK (ng/cigarette)Canadian = 448.5 SD(237.4)Imported = 437.2 SD(376.1)
Structure of OXO-.ALPHA.-IONOL GLUCOSIDE, (6R,9R)-3-
CONSTITUENT ALWAYS PRESENT -> PARENT
Compound was extracted from the dried leaves of N. tabacum (3.5 kg) with 90% EtOH at room temperature and partitioned between EtOAc and H2O.
Structure of 3-ISOPROPYL-2,4-PENTADIEN-5-OLIDE
CONSTITUENT ALWAYS PRESENT -> PARENT
Oriental tobacco is a sun-cured, highly aromatic, small-leafed variety (Nicotiana tabacum) that is grown in Turkey, Greece, Bulgaria, Lebanon, and the Republic of Macedonia. https://en.wikipedia.org/wiki/Types_of_tobacco
Structure of BENZO(A)PYRENE
CONSTITUENT ALWAYS PRESENT -> PARENT
BENZO(A)PYRENE (ng/cigarette) Canadian = 6.1 SD(8.6) Imported = 5.7 SD(7.8)
ALLERGENIC EXTRACT- TOBACCO, CIGAR
SUB_CONCEPT->SUBSTANCE
Structure of 3-ETHYL-4-METHYL-2-PENTEN-4-OLIDE
CONSTITUENT ALWAYS PRESENT -> PARENT
Oriental tobacco is a sun-cured, highly aromatic, small-leafed variety (Nicotiana tabacum) that is grown in Turkey, Greece, Bulgaria, Lebanon, and the Republic of Macedonia. https://en.wikipedia.org/wiki/Types_of_tobacco
Structure of 4-METHYL-3-(3-OXO-L-BUTYL)-2-PENTEN-4-OLIDE
CONSTITUENT ALWAYS PRESENT -> PARENT
Oriental tobacco is a sun-cured, highly aromatic, small-leafed variety (Nicotiana tabacum) that is grown in Turkey, Greece, Bulgaria, Lebanon, and the Republic of Macedonia. https://en.wikipedia.org/wiki/Types_of_tobacco
Structure of DIHYDRO-N-CAFFEOYLTYRAMINE
CONSTITUENT ALWAYS PRESENT -> PARENT
A 70% aq. acetone extract prepared from the leaves of N. tabacum was partitioned between EtOAc and H2O. TMV infection inhibition activity of compound 20.1 ? 2.2%.
Structure of N-NITROSONORNICOTINE
CONSTITUENT ALWAYS PRESENT -> PARENT
NNN (ng/cigarette) Canadian = 286.9 SD(118.3) Imported = 1776.2 SD(817.2)
Structure of TABAMIDE A
CONSTITUENT ALWAYS PRESENT -> PARENT
A 70% aq. acetone extract prepared from the leaves of N. tabacum was partitioned between EtOAc and H2O. TMV infection inhibition activity of compound 38.6 ? 3.8%.
Structure of NITRATE ION
CONSTITUENT ALWAYS PRESENT -> PARENT
Nitrate (mg/cigarette) Canadian = 1.2 SD(0.6) Imported = 5.9 SD(2.0)
Structure of TABABIPHENYL C
CONSTITUENT ALWAYS PRESENT -> PARENT
TMV infection inhibition activity of compound 48.4 ? 3.4%. Powdered leaves and stems of N. tabacum were extracted with 70% aqueous acetone.
Structure of TABAMIDE B
CONSTITUENT ALWAYS PRESENT -> PARENT
A 70% aq. acetone extract prepared from the leaves of N. tabacum was partitioned between EtOAc and H2O. TMV infection inhibition activity of compound 26.5 ? 2.6%.
Structure of N-TRANS-FERULOYLTRAMINE
CONSTITUENT ALWAYS PRESENT -> PARENT
A 70% aq. acetone extract prepared from the leaves of N. tabacum was partitioned between EtOAc and H2O. TMV infection inhibition activity of compound 18.2 ? 2.5%.
Structure of 3-ISOPROPYL-2-PENTEN-4-OLIDE
CONSTITUENT ALWAYS PRESENT -> PARENT
Oriental tobacco is a sun-cured, highly aromatic, small-leafed variety (Nicotiana tabacum) that is grown in Turkey, Greece, Bulgaria, Lebanon, and the Republic of Macedonia. https://en.wikipedia.org/wiki/Types_of_tobacco
Structure of 3-METHYL-4-PENTANOLIDE, (3R,4R)-
CONSTITUENT ALWAYS PRESENT -> PARENT
Oriental tobacco is a sun-cured, highly aromatic, small-leafed variety (Nicotiana tabacum) that is grown in Turkey, Greece, Bulgaria, Lebanon, and the Republic of Macedonia. https://en.wikipedia.org/wiki/Types_of_tobacco
Structure of MERCURY
CONSTITUENT ALWAYS PRESENT -> PARENT
MERCURY (ng/cigarette) Canadian = 26.8 SD(4.6)
ALLERGENIC EXTRACT- TOBACCO, CIGARETTE
SUB_CONCEPT->SUBSTANCE
Related Record Type Details
TOBACCO LEAF
ACTIVE MOIETY
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
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National Center for Advancing Translational Sciences (NCATS),
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