GLYCERIN

US Approved OTC

First marketed in 1921

Details

Stereochemistry	ACHIRAL
Molecular Formula	C3H8O3
Molecular Weight	92.0939
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C(C(CO)O)O

InChI

InChIKey=PEDCQBHIVMGVHV-UHFFFAOYSA-N

InChI=1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2

HIDE SMILES / InChI

Molecular Formula	C3H8O3
Molecular Weight	92.0939
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.drugs.com/inactive/glycerin-448.html |https://www.ncbi.nlm.nih.gov/pubmed/9802172 |https://www.drugs.com/ppa/glycerin.html

Glycerin (glycerol) is 3-carbon alcohol naturally occurring in the human body. It is the structural backbone triacylglycerol molecules, and can also be converted to a glycolytic substrate for subsequent metabolism. Glycerin is a colorless, odorless, viscous, sweet-tasting liquid. The FDA classifies glycerol as "generally recognized as safe". Glycerin is used in the pharmaceutical industry as a sweetener in syrups, lozenges, and as an excipient in eyewash solutions. As an individual prescription product, glycerin has uses as a hyperosmotic, osmotic diuretic, and ophthalmic agent. It may be used as an eye drop in the treatment of glaucoma to reduce intraocular pressure, as a solution or suppository for short-term treatment of constipation, to evacuate the bowel prior to a colonoscopy, and in some ocular surgeries. It may be given intravenously to reduce pressure inside the brain and used externally on the skin as a moisturizer. Glycerin has many other uses in the agricultural, food and pharmaceutical industry.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Dry skin or hair 1 Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=66143c1d-17d3-4895-bfd4-f5a085b617f3	Palliative		Approved 7997	DERM-APPLY Approved Use Restore moisture balance in dry skin or hair. Launch Date 599529600000

C_max

Value	Dose	Co-administered	Analyte	Population
1770 mg/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/8369006/	1.2 g/kg single, oral dose: 1.2 g/kg route of administration: Oral experiment type: SINGLE co-administered:		GLYCERIN serum	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED

T_1/2

Value	Dose	Co-administered	Analyte	Population
0.895 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/8369006/	1.2 g/kg single, oral dose: 1.2 g/kg route of administration: Oral experiment type: SINGLE co-administered:		GLYCERIN serum	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
39.3 min EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/4300572/	120 mmol/m² single, intravenous dose: 120 mmol/m² route of administration: Intravenous experiment type: SINGLE co-administered:		GLYCERIN serum	Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN

Doses

Dose	Population	Adverse events
310 g single, oral Overdose Dose: 310 g Route: oral Route: single Dose: 310 g Sources: https://pubmed.ncbi.nlm.nih.gov/19514878	unhealthy, 72 years Health Status: unhealthy Age Group: 72 years Sex: M Sources: https://pubmed.ncbi.nlm.nih.gov/19514878	Other AEs: Agitation, Groaning... Other AEs: Agitation (1 patient) Groaning (1 patient) Speech loss (1 patient) Sources: https://pubmed.ncbi.nlm.nih.gov/19514878

AEs

AE	Significance	Dose	Population
Agitation	1 patient	310 g single, oral Overdose Dose: 310 g Route: oral Route: single Dose: 310 g Sources: https://pubmed.ncbi.nlm.nih.gov/19514878	unhealthy, 72 years Health Status: unhealthy Age Group: 72 years Sex: M Sources: https://pubmed.ncbi.nlm.nih.gov/19514878
Groaning	1 patient	310 g single, oral Overdose Dose: 310 g Route: oral Route: single Dose: 310 g Sources: https://pubmed.ncbi.nlm.nih.gov/19514878	unhealthy, 72 years Health Status: unhealthy Age Group: 72 years Sex: M Sources: https://pubmed.ncbi.nlm.nih.gov/19514878
Speech loss	1 patient	310 g single, oral Overdose Dose: 310 g Route: oral Route: single Dose: 310 g Sources: https://pubmed.ncbi.nlm.nih.gov/19514878	unhealthy, 72 years Health Status: unhealthy Age Group: 72 years Sex: M Sources: https://pubmed.ncbi.nlm.nih.gov/19514878

Overview

CYP3A4	CYP2C9	CYP2D6	hERG

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
		CYP2E1 116

Drug as perpetrator

Target	Modality	Activity	Metabolite	Clinical evidence
CYP2E1 841	inducer 1333 Sources: https://pubmed.ncbi.nlm.nih.gov/9113273/	yes

Sourcing

Vendor/Aggregator	ID	URL
1PlusChem LLC	1P0035FJ
A2B Chem	AB46207
AA Blocks	AA0034W3
AK Scientific	C740
AK Scientific	O752
AKOS	AKOS028109951
AKOS	AKOS028109988
AbovChem LLC	HY-B1659
Acros Organics	15892
Acros Organics	18469
Acros Organics	27736
Acros Organics	29560
Acros Organics	32725
Acros Organics	33203
Acros Organics	41098
Alfa Chemistry	32450
Alfa Chemistry	36646
Alfa Chemistry	38988
Alfa Chemistry	A16205
Alfa Chemistry	ACM56815
Alfa Chemistry	ACM816411
Alfa Chemistry	ACM84074442
Alfa Chemistry	ACM84713188
Alfa Chemistry	J61059
Alfa Chemistry	J62399
Alfa Chemistry	J64719
Angene	AGN-PC-0WADEB
Angene	AGN-PC-0WH407
Apollo Scientific	BIA3092
AstaTech	C13300
BOC Sciences	39951-36-5
BOC Sciences	56-81-5
BOC Sciences	8043-29-6
BOC Sciences	85187-41-3
BioSynth	Q-201167
BlocksMatrix Scientific	134296
Capot Chemical	16092
Chem Scene	CS-6964
Chem Scene	CS-B1784
Chem-Impex International	30144
Chem-Impex International	599
Combi-Blocks	QE-8640
Compound Cloud	753
Enamine	BBV-46883679
Enamine	EN300-19328
Fluorochem	399429
Fluorochem	94580
Hairui	HR101833
Hangzhou Yuhao Chemical Technology	LT6375
Hangzhou Yuhao Chemical Technology	RT14397
Hangzhou Yuhao Chemical Technology	XJ4849
Lab Network	LN00196493
Lab Network	LN04530866
Lab Seeker	SC-13789
Life Chemicals	F0001-1470
MolPort	MolPort-001-785-853
MolPort	MolPort-023-220-454
MolPort	MolPort-046-860-193
MuseChem	R031031
MuseChem	R041274
NCI Plated 2007	9230
Nanjing Pope Bio-tech	NSTH-MA06508
Norris Pharm	NSTH-MA06508
Oakwood	102072
Oakwood	94580
Otava	2825442
PI Chemicals	PI-12961
Sigma Aldrich	12-1120
Sigma Aldrich	12-1120\|SAJ
Sigma Aldrich	12-1130
Sigma Aldrich	12-1130\|SAJ
Sigma Aldrich	12146
Sigma Aldrich	12146\|SIAL
Sigma Aldrich	1295607
Sigma Aldrich	1295607\|USP
Sigma Aldrich	134872
Sigma Aldrich	134872\|ALDRICH
Sigma Aldrich	15523
Sigma Aldrich	15523-M
Sigma Aldrich	15523\|SIGALD
Sigma Aldrich	15524
Sigma Aldrich	15524\|SIGALD
Sigma Aldrich	191612
Sigma Aldrich	191612\|SIAL
Sigma Aldrich	320005
Sigma Aldrich	320005\|ALDRICH
Sigma Aldrich	373869
Sigma Aldrich	373869\|ALDRICH
Sigma Aldrich	373877
Sigma Aldrich	373877\|ALDRICH
Sigma Aldrich	373885
Sigma Aldrich	373885\|ALDRICH
Sigma Aldrich	409189
Sigma Aldrich	409189\|ALDRICH
Sigma Aldrich	44892-U
Sigma Aldrich	44892-U\|SUPELCO
Sigma Aldrich	49767
Sigma Aldrich	49767\|SIGMA
Sigma Aldrich	49770
Sigma Aldrich	49770\|SIGALD
Sigma Aldrich	49779
Sigma Aldrich	49779\|SIAL
Sigma Aldrich	49781
Sigma Aldrich	49781\|SIGMA
Sigma Aldrich	49782
Sigma Aldrich	49782\|SIGALD
Sigma Aldrich	49927
Sigma Aldrich	49927\|SIGMA
Sigma Aldrich	77067
Sigma Aldrich	77067\|SIAL
Sigma Aldrich	CRM44892
Sigma Aldrich	CRM44892\|SUPELCO
Sigma Aldrich	G2025
Sigma Aldrich	G2025\|SIGMA
Sigma Aldrich	G2289
Sigma Aldrich	G2289\|SIAL
Sigma Aldrich	G5150
Sigma Aldrich	G5150\|SIAL
Sigma Aldrich	G5516
Sigma Aldrich	G5516\|SIGMA
Sigma Aldrich	G6279
Sigma Aldrich	G6279\|SIAL
Sigma Aldrich	G7757
Sigma Aldrich	G7757-M
Sigma Aldrich	G7757\|SIGALD
Sigma Aldrich	G7893
Sigma Aldrich	G7893\|SIGALD
Sigma Aldrich	G9012
Sigma Aldrich	G9012\|SIAL
Sigma Aldrich	PHR1020
Sigma Aldrich	PHR1020\|SIAL
Sigma Aldrich	V001569
Sigma Aldrich	V001569\|VETEC
Sigma Aldrich	V800196
Sigma Aldrich	V800196\|VETEC
Sigma Aldrich	V800197
Sigma Aldrich	V800197\|VETEC
Sigma Aldrich	V900122
Sigma Aldrich	V900122\|VETEC
Sigma Aldrich	V900860
Sigma Aldrich	V900860\|VETEC
Sigma Aldrich	W252506
Sigma Aldrich	W252506\|ALDRICH
StruChem	SC-13789
TargetMol	56-81-5
TargetMol	BBP03456
TargetMol	HMDB0000131
TargetMol	T4776
Tetrahedron	TS03653
Tetrahedron	TS64624
Tetrahedron	TS93602
Tocris	5220
Toronto Research Chemicals	G598407
Vitas-M Laboratory	STL199174
W&J PharmaChem	50A262536
Wonderchem	WD0568Q
Wonderchem	WD056E6
Wonderchem	WD06D55
Wonderchem	WD09HN7
ZINC	ZINC000000895048	http://zinc15.docking.org/substances/ZINC000000895048
eMolecules	109712596
eMolecules	193736912
eMolecules	276005067
eMolecules	283122700
eMolecules	36905463
eMolecules	44678302
eMolecules	476493
eMolecules	50419038
mcule	MCULE-6349111826

PubMed

Title	Date	PubMed
Inhibition of carcinogen induced c-Ha-ras and c-fos proto-oncogenes expression by dietary curcumin.	2001	11231886
Capillary electrophoresis with glycerol as an additive.	2001	11217337
Protein microarrays for highly parallel detection and quantitation of specific proteins and antibodies in complex solutions.	2001	11182887
Isolation and characterization of rheumatoid arthritis synovial fibroblasts from primary culture--primary culture cells markedly differ from fourth-passage cells.	2001	11178129
Induced cytoskeletal changes in bovine pulmonary artery endothelial cells by resveratrol and the accompanying modified responses to arterial shear stress.	2001	11178103
A comparison of F-actin labeling methods for light microscopy in different plant specimens: multiple techniques supplement each other.	2001 Aug	11166577
RNA-dependent RNA polymerase activity associated with endogenous double-stranded RNA in rice.	2001 Feb	11230574
Potential of freezing in wastewater treatment: soluble pollutant applications.	2001 Feb	11229009
Characterization of northern pintail (Anas acuta) ejaculate and the effect of sperm preservation on fertility.	2001 Feb	11226051
Effects of the perfusion of beta-, beta2-, or beta3-adrenergic agonists or epinephrine on in situ adipose tissue lipolysis measured by microdialysis in underfed ewes.	2001 Feb	11219455
Increase in hydration and protective function of horny layer by glycerol and a W/O emulsion: are these effects maintained during long-term use?	2001 Feb	11205397
Intracellular contents and assembly states of all 12 subunits of the RNA polymerase II in the fission yeast Schizosaccharomyces pombe.	2001 Feb	11168400
Ultracentrifugal studies of the effect of molecular crowding by trimethylamine N-oxide on the self-association of muscle glycogen phosphorylase b.	2001 Feb	11168388
How water molecules pass through aquaporins.	2001 Feb	11166555
Upregulation of uncoupling protein homologues in skeletal muscle but not adipose tissue in posttraumatic insulin resistance.	2001 Feb 23	11181051
Rapid screening of H(2)O(2) production by Mycoplasma mycoides and differentiation of European subsp. mycoides SC (small colony) isolates.	2001 Feb 26	11182500
Evidence against a major role of plasmalogens in the resistance of astrocytes in lactic acid-induced oxidative stress in vitro.	2001 Jan	11218046
Biochemical characterization of Mycoplasma bovirhinis, Mycoplasma dispar and recent bovine isolates of Mycoplasma canis.	2001 Jan	11214667
A technique for preserving pigmentation in some capsalid monogeneans for taxonomic purposes.	2001 Jan	11213200
Azospirillum doebereinerae sp. nov., a nitrogen-fixing bacterium associated with the C4-grass Miscanthus.	2001 Jan	11211255
Avoid unnecessary drug-related carbohydrates for patients consuming the ketogenic diet.	2001 Jan	11209590
Distinct long-term regulation of glycerol and non-esterified fatty acid release by insulin and TNF-alpha in 3T3-L1 adipocytes.	2001 Jan	11206412
Lipid-dependent control of hepatic glycogen stores in healthy humans.	2001 Jan	11206411
Effects of L-carnitine on nitrogen retention and blood metabolites of growing steers and performance of finishing steers.	2001 Jan	11204708
L-glutamate efflux with Corynebacterium glutamicum: why is penicillin treatment or Tween addition doing the same?	2001 Jan	11200230
Determination of Cremophor EL in plasma after sample preparation with solid phase extraction and plasma protein precipitation.	2001 Jan	11199229
Modeling the growth boundary of Staphylococcus aureus for risk assessment purposes.	2001 Jan	11198441
[Life style-related disease].	2001 Jan	11197854
Spontaneous otoacoustic emissions in humans with endolymphatic hydrops.	2001 Jan	11192908
Distortion-product otoacoustic emissions and glycerol testing in endolymphatic hydrops.	2001 Jan	11192876
The innervation of the triangular fibrocartilage complex: nitric acid maceration rediscovered.	2001 Jan	11176611
The thermic effect is greater for structured medium- and long-chain triacylglycerols versus long-chain triacylglycerols in healthy young women.	2001 Jan	11172486
Nod factor-induced phosphatidic acid and diacylglycerol pyrophosphate formation: a role for phospholipase C and D in root hair deformation.	2001 Jan	11169182
Leavening ability of baker's yeast exposed to hyperosmotic media.	2001 Jan 15	11164301
Characterization of lyso-galactolipids, C-2 and C-3 O-acyl trigalactosylglycerol isomers, obtained from the lichenized fungus Dictyonema glabratum.	2001 Jan 15	11164300
Inhibition of a model protease--pyroglutamate aminopeptidase by a natural oligosaccharide gum from Hakea gibbosa.	2001 Jan 16	11165074
Aquaporin 3, a glycerol and water transporter, is regulated by p73 of the p53 family.	2001 Jan 26	11231003
Cerebroprotective action of a Na+/Ca2+ channel blocker NS-7. I. Effect on the cerebral infarction and edema at the acute stage of permanent middle cerebral artery occlusion in rats.	2001 Jan 26	11164779
Modification of the lyotropic liquid crystalline microstructure of amphiphilic block copolymers in the presence of cosolvents.	2001 Jan 29	11215804
Postexercise ketosis in night-migrating passerine birds.	2001 Jan-Feb	11226017
Comparative hemolytic activity of undiluted organic water-miscible solvents for intravenous and intra-arterial injection.	2001 Jan-Feb	11212416
In-vitro growth of murine pre-antral follicles after isolation from cryopreserved ovarian tissue.	2001 Mar	11228206
Crystallization and preliminary X-ray analysis of the glycerol-3-phosphate 1-acyltransferase from squash (Cucurbita moschata).	2001 Mar	11223529
Purification and crystallization of the human RXRalpha ligand-binding domain-9-cisRA complex.	2001 Mar	11223524
Production of ethanol and xylitol from corn cobs by yeasts.	2001 Mar	11211076
Effects of food texture change on metabolic parameters: short- and long-term feeding patterns and body weight.	2001 Mar	11171658
Signposts in the assembly of chylomicrons.	2001 Mar 1	11229873
Preparation of anhydrothrombin and characterization of its interaction with natural thrombin substrates.	2001 Mar 1	11171108
Optimization of the high-level production of Rhizopus oryzae lipase in Pichia pastoris.	2001 Mar 9	11223145
Dialysis addition of trehalose/glycerol cryoprotectant allows recovery of cryopreserved mouse spermatozoa with satisfactory fertilizing ability as assessed by yield of live young.	2001 Mar-Apr	11229808

Substance Class	Chemical Created by `admin` on `Fri Jun 25 21:13:28 UTC 2021` Edited by `admin` on `Fri Jun 25 21:13:28 UTC 2021`
Record UNII	PDC6A3C0OX
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

GLYCERIN

Official Name

English

PZN 7474853

Code

English

GLYCERIN,ANHYDROUS

Common Name

English

GLYCEROL [INN]

Common Name

English

GLYCEROL [EP]

Common Name

English

GLYCERIN [ORANGE BOOK]

Common Name

English

GLYCEROL 85% [WHO-DD]

Common Name

English

1,2,3-PROPANETRIOL

Systematic Name

English

GLYCEROL

Official Name

English

GLYCERIN [II]

Common Name

English

GLYCERIN [USP]

Common Name

English

GLYCERINUM

Common Name

English

2-PROPANOL, 1,3-DIHYDROXY-

Systematic Name

English

E-422

Code

English

1,2,3-TRIHYDROXYPROPANE

Systematic Name

English

GLYCERINE

Systematic Name

English

GLYCEROLUM [WHO-IP LATIN]

Common Name

English

TRYHYDROXYPROPANE

Common Name

English

GLYCERIN,ANHYDROUS [VANDF]

Common Name

English

GLYCEROL [EP MONOGRAPH]

Common Name

English

INS-422

Code

English

GLYCERIN [USP-RS]

Common Name

English

GLYCEROL [WHO-DD]

Common Name

English

NSC-9230

Code

English

MONOCTANOIN COMPONENT D

Common Name

English

GLYCERIN [HSDB]

Common Name

English

GLYCEROL [FHFI]

Common Name

English

M 314429

Code

English

GLYCERIN [INCI]

Common Name

English

GLYCERINUM [HPUS]

Common Name

English

FEMA NO. 2525

Code

English

GLYCEROL [WHO-IP]

Common Name

English

GLYCEROL [MART.]

Common Name

English

INS NO.422

Code

English

GLYCEROL [MI]

Common Name

English

GLYCERIN [VANDF]

Common Name

English

Classification Tree Code System Code

LOINC

54283-7