U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C3H8O3
Molecular Weight 92.0938
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of GLYCERIN

SMILES

OCC(O)CO

InChI

InChIKey=PEDCQBHIVMGVHV-UHFFFAOYSA-N
InChI=1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2

HIDE SMILES / InChI

Molecular Formula C3H8O3
Molecular Weight 92.0938
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Glycerin (glycerol) is 3-carbon alcohol naturally occurring in the human body. It is the structural backbone triacylglycerol molecules, and can also be converted to a glycolytic substrate for subsequent metabolism. Glycerin is a colorless, odorless, viscous, sweet-tasting liquid. The FDA classifies glycerol as "generally recognized as safe". Glycerin is used in the pharmaceutical industry as a sweetener in syrups, lozenges, and as an excipient in eyewash solutions. As an individual prescription product, glycerin has uses as a hyperosmotic, osmotic diuretic, and ophthalmic agent. It may be used as an eye drop in the treatment of glaucoma to reduce intraocular pressure, as a solution or suppository for short-term treatment of constipation, to evacuate the bowel prior to a colonoscopy, and in some ocular surgeries. It may be given intravenously to reduce pressure inside the brain and used externally on the skin as a moisturizer. Glycerin has many other uses in the agricultural, food and pharmaceutical industry.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
DERM-APPLY

Approved Use

Restore moisture balance in dry skin or hair.

Launch Date

1988
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
1770 mg/L
1.2 g/kg single, oral
dose: 1.2 g/kg
route of administration: Oral
experiment type: SINGLE
co-administered:
GLYCERIN serum
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
0.895 h
1.2 g/kg single, oral
dose: 1.2 g/kg
route of administration: Oral
experiment type: SINGLE
co-administered:
GLYCERIN serum
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
39.3 min
120 mmol/m² single, intravenous
dose: 120 mmol/m²
route of administration: Intravenous
experiment type: SINGLE
co-administered:
GLYCERIN serum
Homo sapiens
population: HEALTHY
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
310 g single, oral (total)
Overdose
Dose: 310 g
Route: oral
Route: single
Dose: 310 g
Sources:
unhealthy, 72 years
n = 1
Health Status: unhealthy
Age Group: 72 years
Sex: M
Population Size: 1
Sources:
Other AEs: Agitation, Groaning...
Other AEs:
Agitation (1 patient)
Groaning (1 patient)
Speech loss (1 patient)
Sources:
AEs

AEs

AESignificanceDosePopulation
Agitation 1 patient
310 g single, oral (total)
Overdose
Dose: 310 g
Route: oral
Route: single
Dose: 310 g
Sources:
unhealthy, 72 years
n = 1
Health Status: unhealthy
Age Group: 72 years
Sex: M
Population Size: 1
Sources:
Groaning 1 patient
310 g single, oral (total)
Overdose
Dose: 310 g
Route: oral
Route: single
Dose: 310 g
Sources:
unhealthy, 72 years
n = 1
Health Status: unhealthy
Age Group: 72 years
Sex: M
Population Size: 1
Sources:
Speech loss 1 patient
310 g single, oral (total)
Overdose
Dose: 310 g
Route: oral
Route: single
Dose: 310 g
Sources:
unhealthy, 72 years
n = 1
Health Status: unhealthy
Age Group: 72 years
Sex: M
Population Size: 1
Sources:
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer

Drug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
yes
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Cloning and functional expression of rAOP9L a new member of aquaporin family from rat liver.
1999 Feb
Calcitriol directly sensitizes renal tubular cells to ATP-depletion- and iron-mediated attack.
1999 Jun
Ventricular tachycardia caused by hyperkalemia after administration of hypertonic mannitol.
2000 Nov
Inhibition of carcinogen induced c-Ha-ras and c-fos proto-oncogenes expression by dietary curcumin.
2001
Isolation and characterization of rheumatoid arthritis synovial fibroblasts from primary culture--primary culture cells markedly differ from fourth-passage cells.
2001
Strategy for preventing peritoneal dialysis failure.
2001
A comparison of F-actin labeling methods for light microscopy in different plant specimens: multiple techniques supplement each other.
2001 Aug
Vascular endothelial growth factor in peritoneal dialysis: a longitudinal follow-up.
2001 Feb
Ultracentrifugal studies of the effect of molecular crowding by trimethylamine N-oxide on the self-association of muscle glycogen phosphorylase b.
2001 Feb
Individual expression of recombinant alpha- and beta-tubulin from Haemonchus contortus: polymerization and drug effects.
2001 Feb
Origin of the cytoplasmic pH changes during anaerobic stress in higher plant cells. Carbon-13 and phosphorous-31 nuclear magnetic resonance studies.
2001 Feb
Effective plasma concentration of a novel Na+/Ca2+ channel blocker NS-7 for its cerebroprotective actions in rats with a transient middle cerebral artery occlusion.
2001 Feb
Glucose kinetics and substrate oxidation during exercise in the follicular and luteal phases.
2001 Feb
Catalase has a novel protective role against electrophile killing of Xanthomonas.
2001 Feb
Chronic ingestion of ethanol stimulates lipogenic response in rat hepatocytes.
2001 Feb 2
The yeast glycerol 3-phosphatases Gpp1p and Gpp2p are required for glycerol biosynthesis and differentially involved in the cellular responses to osmotic, anaerobic, and oxidative stress.
2001 Feb 2
A technique for preserving pigmentation in some capsalid monogeneans for taxonomic purposes.
2001 Jan
Avoid unnecessary drug-related carbohydrates for patients consuming the ketogenic diet.
2001 Jan
Lipid-dependent control of hepatic glycogen stores in healthy humans.
2001 Jan
Determination of Cremophor EL in plasma after sample preparation with solid phase extraction and plasma protein precipitation.
2001 Jan
Spontaneous otoacoustic emissions in humans with endolymphatic hydrops.
2001 Jan
Distortion-product otoacoustic emissions and glycerol testing in endolymphatic hydrops.
2001 Jan
Partially carboxymethylated feather keratins. 2. Thermal and mechanical properties of films.
2001 Jan
Role of botrytized grape micro-organisms in SO2 binding phenomena.
2001 Jan
Stoichiometry and compartmentation of NADH metabolism in Saccharomyces cerevisiae.
2001 Jan
Intracellular transport of phosphatidic acid and phosphatidylcholine into lipid bodies in an oleaginous fungus, Mortierella ramanniana var. angulispora.
2001 Jan
Physical exercise and normobaric hypoxia: independent modulators of peripheral cholecystokinin metabolism in man.
2001 Jan
Molecular oxygen spin-lattice relaxation in solutions measured by proton magnetic relaxation dispersion.
2001 Jan
A single bout of exercise induces beta-adrenergic desensitization in human adipose tissue.
2001 Jan
Characterization of lyso-galactolipids, C-2 and C-3 O-acyl trigalactosylglycerol isomers, obtained from the lichenized fungus Dictyonema glabratum.
2001 Jan 15
Expression of a cytoplasmic transhydrogenase in Saccharomyces cerevisiae results in formation of 2-oxoglutarate due to depletion of the NADPH pool.
2001 Jan 15
Inhibition of a model protease--pyroglutamate aminopeptidase by a natural oligosaccharide gum from Hakea gibbosa.
2001 Jan 16
Modification of the lyotropic liquid crystalline microstructure of amphiphilic block copolymers in the presence of cosolvents.
2001 Jan 29
Probing the relative timing of hydrogen abstraction steps in the flavocytochrome b2 reaction with primary and solvent deuterium isotope effects and mutant enzymes.
2001 Jan 30
Succinic acid production with reduced by-product formation in the fermentation of Anaerobiospirillum succiniciproducens using glycerol as a carbon source.
2001 Jan 5
Rhamnolipid production by Pseudomonas aeruginosa under denitrification: effects of limiting nutrients and carbon substrates.
2001 Jan 5
A rational approach to improving productivity in recombinant Pichia pastoris fermentation.
2001 Jan 5
Nucleophile selection for the endonuclease activities of human, ovine, and avian retroviral integrases.
2001 Jan 5
Early ultrastructural findings and superoxide dismutase levels in experimental ischemic optic neuropathy: effect of hypertension and hypotension on ischemic changes.
2001 Jan-Feb
Effects of food texture change on metabolic parameters: short- and long-term feeding patterns and body weight.
2001 Mar
Conformational and temperature-sensitive stability defects of the delta F508 cystic fibrosis transmembrane conductance regulator in post-endoplasmic reticulum compartments.
2001 Mar 23
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:00:46 GMT 2023
Edited
by admin
on Fri Dec 15 15:00:46 GMT 2023
Record UNII
PDC6A3C0OX
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
GLYCERIN
FCC   HSDB   II   INCI   ORANGE BOOK   USP   USP-RS   VANDF  
INCI  
Official Name English
PZN 7474853
Code English
GLYCERIN,ANHYDROUS
VANDF  
Common Name English
glycerol [INN]
Common Name English
GLYCERIN [USP MONOGRAPH]
Common Name English
GLYCERIN [ORANGE BOOK]
Common Name English
1,2,3-PROPANETRIOL
Systematic Name English
Glycerol
EP   FHFI   INN   MART.   MI   WHO-DD   WHO-IP  
INN  
Official Name English
GLYCERIN [II]
Common Name English
GLYCERINUM
HPUS  
Common Name English
2-PROPANOL, 1,3-DIHYDROXY-
Systematic Name English
E-422
Code English
1,2,3-TRIHYDROXYPROPANE
Systematic Name English
GLYCERINE
Systematic Name English
GLYCEROLUM [WHO-IP LATIN]
Common Name English
TRYHYDROXYPROPANE
Common Name English
GLYCERIN,ANHYDROUS [VANDF]
Common Name English
GLYCEROL [EP MONOGRAPH]
Common Name English
INS-422
Code English
GLYCERIN [USP-RS]
Common Name English
NSC-9230
Code English
GLYCERIN [JAN]
Common Name English
GLYCEROL [EP IMPURITY]
Common Name English
MONOCTANOIN COMPONENT D
Common Name English
Glycerol 85% [WHO-DD]
Common Name English
GLYCERIN [HSDB]
Common Name English
GLYCEROL [FHFI]
Common Name English
M 314429
Code English
Glycerol [WHO-DD]
Common Name English
GLYCERIN [INCI]
Common Name English
GLYCERINUM [HPUS]
Common Name English
FEMA NO. 2525
Code English
GLYCEROL [WHO-IP]
Common Name English
GLYCEROL [MART.]
Common Name English
INS NO.422
Code English
GLYCEROL [MI]
Common Name English
GLYCERIN [VANDF]
Common Name English
Classification Tree Code System Code
LOINC 54283-7
Created by admin on Fri Dec 15 15:00:46 GMT 2023 , Edited by admin on Fri Dec 15 15:00:46 GMT 2023
FDA ORPHAN DRUG 28188
Created by admin on Fri Dec 15 15:00:46 GMT 2023 , Edited by admin on Fri Dec 15 15:00:46 GMT 2023
JECFA EVALUATION GLYCEROL
Created by admin on Fri Dec 15 15:00:46 GMT 2023 , Edited by admin on Fri Dec 15 15:00:46 GMT 2023
JECFA EVALUATION INS-422
Created by admin on Fri Dec 15 15:00:46 GMT 2023 , Edited by admin on Fri Dec 15 15:00:46 GMT 2023
CODEX ALIMENTARIUS (GSFA) INS-422
Created by admin on Fri Dec 15 15:00:46 GMT 2023 , Edited by admin on Fri Dec 15 15:00:46 GMT 2023
LOINC 45300-1
Created by admin on Fri Dec 15 15:00:46 GMT 2023 , Edited by admin on Fri Dec 15 15:00:46 GMT 2023
WHO-VATC QA16QA03
Created by admin on Fri Dec 15 15:00:46 GMT 2023 , Edited by admin on Fri Dec 15 15:00:46 GMT 2023
LOINC 54285-2
Created by admin on Fri Dec 15 15:00:46 GMT 2023 , Edited by admin on Fri Dec 15 15:00:46 GMT 2023
LOINC 2388-7
Created by admin on Fri Dec 15 15:00:46 GMT 2023 , Edited by admin on Fri Dec 15 15:00:46 GMT 2023
LOINC 2387-9
Created by admin on Fri Dec 15 15:00:46 GMT 2023 , Edited by admin on Fri Dec 15 15:00:46 GMT 2023
DSLD 1110 (Number of products:309)
Created by admin on Fri Dec 15 15:00:46 GMT 2023 , Edited by admin on Fri Dec 15 15:00:46 GMT 2023
WHO-ATC A06AG04
Created by admin on Fri Dec 15 15:00:46 GMT 2023 , Edited by admin on Fri Dec 15 15:00:46 GMT 2023
CFR 21 CFR 349.12
Created by admin on Fri Dec 15 15:00:46 GMT 2023 , Edited by admin on Fri Dec 15 15:00:46 GMT 2023
WHO-ATC A06AX01
Created by admin on Fri Dec 15 15:00:46 GMT 2023 , Edited by admin on Fri Dec 15 15:00:46 GMT 2023
LOINC 54284-5
Created by admin on Fri Dec 15 15:00:46 GMT 2023 , Edited by admin on Fri Dec 15 15:00:46 GMT 2023
NCI_THESAURUS C29697
Created by admin on Fri Dec 15 15:00:46 GMT 2023 , Edited by admin on Fri Dec 15 15:00:46 GMT 2023
WHO-VATC QA06AG04
Created by admin on Fri Dec 15 15:00:46 GMT 2023 , Edited by admin on Fri Dec 15 15:00:46 GMT 2023
NDF-RT N0000185370
Created by admin on Fri Dec 15 15:00:46 GMT 2023 , Edited by admin on Fri Dec 15 15:00:46 GMT 2023
EPA PESTICIDE CODE 63507
Created by admin on Fri Dec 15 15:00:46 GMT 2023 , Edited by admin on Fri Dec 15 15:00:46 GMT 2023
WHO-VATC QA06AX01
Created by admin on Fri Dec 15 15:00:46 GMT 2023 , Edited by admin on Fri Dec 15 15:00:46 GMT 2023
CFR 21 CFR 347.10
Created by admin on Fri Dec 15 15:00:46 GMT 2023 , Edited by admin on Fri Dec 15 15:00:46 GMT 2023
LOINC 47632-5
Created by admin on Fri Dec 15 15:00:46 GMT 2023 , Edited by admin on Fri Dec 15 15:00:46 GMT 2023
Code System Code Type Description
EPA CompTox
DTXSID9020663
Created by admin on Fri Dec 15 15:00:46 GMT 2023 , Edited by admin on Fri Dec 15 15:00:46 GMT 2023
PRIMARY
DRUG BANK
DB09462
Created by admin on Fri Dec 15 15:00:46 GMT 2023 , Edited by admin on Fri Dec 15 15:00:46 GMT 2023
PRIMARY
NDF-RT
N0000006566
Created by admin on Fri Dec 15 15:00:46 GMT 2023 , Edited by admin on Fri Dec 15 15:00:46 GMT 2023
PRIMARY Glycerol [Chemical/Ingredient]
WIKIPEDIA
GLYCEROL
Created by admin on Fri Dec 15 15:00:46 GMT 2023 , Edited by admin on Fri Dec 15 15:00:46 GMT 2023
PRIMARY
EVMPD
SUB07948MIG
Created by admin on Fri Dec 15 15:00:46 GMT 2023 , Edited by admin on Fri Dec 15 15:00:46 GMT 2023
PRIMARY
EVMPD
SUB13992MIG
Created by admin on Fri Dec 15 15:00:46 GMT 2023 , Edited by admin on Fri Dec 15 15:00:46 GMT 2023
PRIMARY
NDF-RT
N0000171131
Created by admin on Fri Dec 15 15:00:46 GMT 2023 , Edited by admin on Fri Dec 15 15:00:46 GMT 2023
PRIMARY Allergens [Chemical/Ingredient]
PUBCHEM
753
Created by admin on Fri Dec 15 15:00:46 GMT 2023 , Edited by admin on Fri Dec 15 15:00:46 GMT 2023
PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
GLYCERIN
Created by admin on Fri Dec 15 15:00:46 GMT 2023 , Edited by admin on Fri Dec 15 15:00:46 GMT 2023
PRIMARY Description: A clear, colourless or almost colourless, syrupy liquid; odourless. Miscibility: Miscible with water and ethanol (~750 g/l) TS; slightly miscible with acetone R; practically immiscible with ether R. Category: Solvent; humectant.Storage: Glycerol should be kept in a tightly closed container. Additional information: Glycerol is hygroscopic. Requirement: Glycerol contains not less than 95.0% and not more than the equivalent of 101.0% of C3H8O3, calculated with reference to theanhydrous substance.
FDA UNII
PDC6A3C0OX
Created by admin on Fri Dec 15 15:00:46 GMT 2023 , Edited by admin on Fri Dec 15 15:00:46 GMT 2023
PRIMARY
CAS
56-81-5
Created by admin on Fri Dec 15 15:00:46 GMT 2023 , Edited by admin on Fri Dec 15 15:00:46 GMT 2023
PRIMARY
ChEMBL
CHEMBL692
Created by admin on Fri Dec 15 15:00:46 GMT 2023 , Edited by admin on Fri Dec 15 15:00:46 GMT 2023
PRIMARY
NCI_THESAURUS
C29077
Created by admin on Fri Dec 15 15:00:46 GMT 2023 , Edited by admin on Fri Dec 15 15:00:46 GMT 2023
PRIMARY
NDF-RT
N0000184306
Created by admin on Fri Dec 15 15:00:46 GMT 2023 , Edited by admin on Fri Dec 15 15:00:46 GMT 2023
PRIMARY Cell-mediated Immunity [PE]
ECHA (EC/EINECS)
200-289-5
Created by admin on Fri Dec 15 15:00:46 GMT 2023 , Edited by admin on Fri Dec 15 15:00:46 GMT 2023
PRIMARY
DAILYMED
PDC6A3C0OX
Created by admin on Fri Dec 15 15:00:46 GMT 2023 , Edited by admin on Fri Dec 15 15:00:46 GMT 2023
PRIMARY
DRUG CENTRAL
1316
Created by admin on Fri Dec 15 15:00:46 GMT 2023 , Edited by admin on Fri Dec 15 15:00:46 GMT 2023
PRIMARY
MERCK INDEX
m5790
Created by admin on Fri Dec 15 15:00:46 GMT 2023 , Edited by admin on Fri Dec 15 15:00:46 GMT 2023
PRIMARY Merck Index
INN
444
Created by admin on Fri Dec 15 15:00:46 GMT 2023 , Edited by admin on Fri Dec 15 15:00:46 GMT 2023
PRIMARY
NDF-RT
N0000175629
Created by admin on Fri Dec 15 15:00:46 GMT 2023 , Edited by admin on Fri Dec 15 15:00:46 GMT 2023
PRIMARY Increased Histamine Release [PE]
RS_ITEM_NUM
1295607
Created by admin on Fri Dec 15 15:00:46 GMT 2023 , Edited by admin on Fri Dec 15 15:00:46 GMT 2023
PRIMARY
NSC
9230
Created by admin on Fri Dec 15 15:00:46 GMT 2023 , Edited by admin on Fri Dec 15 15:00:46 GMT 2023
PRIMARY
RXCUI
4910
Created by admin on Fri Dec 15 15:00:46 GMT 2023 , Edited by admin on Fri Dec 15 15:00:46 GMT 2023
PRIMARY RxNorm
MESH
D005990
Created by admin on Fri Dec 15 15:00:46 GMT 2023 , Edited by admin on Fri Dec 15 15:00:46 GMT 2023
PRIMARY
NDF-RT
N0000185001
Created by admin on Fri Dec 15 15:00:46 GMT 2023 , Edited by admin on Fri Dec 15 15:00:46 GMT 2023
PRIMARY Increased IgG Production [PE]
HSDB
492
Created by admin on Fri Dec 15 15:00:46 GMT 2023 , Edited by admin on Fri Dec 15 15:00:46 GMT 2023
PRIMARY
CHEBI
17754
Created by admin on Fri Dec 15 15:00:46 GMT 2023 , Edited by admin on Fri Dec 15 15:00:46 GMT 2023
PRIMARY
SMS_ID
100000092821
Created by admin on Fri Dec 15 15:00:46 GMT 2023 , Edited by admin on Fri Dec 15 15:00:46 GMT 2023
PRIMARY
Related Record Type Details
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
PARENT -> CONSTITUENT ALWAYS PRESENT
Glycerol (mg/cigarette) Canadian = 13.2 SD(1.3) Imported = 13.5 SD(0.0)
Related Record Type Details
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (GC)
USP
IMPURITY -> PARENT
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (GC)
USP
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (GC)
USP
Related Record Type Details
ACTIVE MOIETY