U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C3H8O3
Molecular Weight 92.0939
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of GLYCERIN

SMILES

C(C(CO)O)O

InChI

InChIKey=PEDCQBHIVMGVHV-UHFFFAOYSA-N
InChI=1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2

HIDE SMILES / InChI

Molecular Formula C3H8O3
Molecular Weight 92.0939
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Glycerin (glycerol) is 3-carbon alcohol naturally occurring in the human body. It is the structural backbone triacylglycerol molecules, and can also be converted to a glycolytic substrate for subsequent metabolism. Glycerin is a colorless, odorless, viscous, sweet-tasting liquid. The FDA classifies glycerol as "generally recognized as safe". Glycerin is used in the pharmaceutical industry as a sweetener in syrups, lozenges, and as an excipient in eyewash solutions. As an individual prescription product, glycerin has uses as a hyperosmotic, osmotic diuretic, and ophthalmic agent. It may be used as an eye drop in the treatment of glaucoma to reduce intraocular pressure, as a solution or suppository for short-term treatment of constipation, to evacuate the bowel prior to a colonoscopy, and in some ocular surgeries. It may be given intravenously to reduce pressure inside the brain and used externally on the skin as a moisturizer. Glycerin has many other uses in the agricultural, food and pharmaceutical industry.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
DERM-APPLY

Approved Use

Restore moisture balance in dry skin or hair.

Launch Date

599529600000
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
1770 mg/L
1.2 g/kg single, oral
dose: 1.2 g/kg
route of administration: Oral
experiment type: SINGLE
co-administered:
GLYCERIN serum
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
0.895 h
1.2 g/kg single, oral
dose: 1.2 g/kg
route of administration: Oral
experiment type: SINGLE
co-administered:
GLYCERIN serum
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
39.3 min
120 mmol/m² single, intravenous
dose: 120 mmol/m²
route of administration: Intravenous
experiment type: SINGLE
co-administered:
GLYCERIN serum
Homo sapiens
population: HEALTHY
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
310 g single, oral
Overdose
Dose: 310 g
Route: oral
Route: single
Dose: 310 g
Sources:
unhealthy, 72 years
Health Status: unhealthy
Age Group: 72 years
Sex: M
Sources:
Other AEs: Agitation, Groaning...
Other AEs:
Agitation (1 patient)
Groaning (1 patient)
Speech loss (1 patient)
Sources:
AEs

AEs

AESignificanceDosePopulation
Agitation 1 patient
310 g single, oral
Overdose
Dose: 310 g
Route: oral
Route: single
Dose: 310 g
Sources:
unhealthy, 72 years
Health Status: unhealthy
Age Group: 72 years
Sex: M
Sources:
Groaning 1 patient
310 g single, oral
Overdose
Dose: 310 g
Route: oral
Route: single
Dose: 310 g
Sources:
unhealthy, 72 years
Health Status: unhealthy
Age Group: 72 years
Sex: M
Sources:
Speech loss 1 patient
310 g single, oral
Overdose
Dose: 310 g
Route: oral
Route: single
Dose: 310 g
Sources:
unhealthy, 72 years
Health Status: unhealthy
Age Group: 72 years
Sex: M
Sources:
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer

Drug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
yes
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Inhibition of carcinogen induced c-Ha-ras and c-fos proto-oncogenes expression by dietary curcumin.
2001
Capillary electrophoresis with glycerol as an additive.
2001
Protein microarrays for highly parallel detection and quantitation of specific proteins and antibodies in complex solutions.
2001
Isolation and characterization of rheumatoid arthritis synovial fibroblasts from primary culture--primary culture cells markedly differ from fourth-passage cells.
2001
Induced cytoskeletal changes in bovine pulmonary artery endothelial cells by resveratrol and the accompanying modified responses to arterial shear stress.
2001
A comparison of F-actin labeling methods for light microscopy in different plant specimens: multiple techniques supplement each other.
2001 Aug
RNA-dependent RNA polymerase activity associated with endogenous double-stranded RNA in rice.
2001 Feb
Potential of freezing in wastewater treatment: soluble pollutant applications.
2001 Feb
Characterization of northern pintail (Anas acuta) ejaculate and the effect of sperm preservation on fertility.
2001 Feb
Effects of the perfusion of beta-, beta2-, or beta3-adrenergic agonists or epinephrine on in situ adipose tissue lipolysis measured by microdialysis in underfed ewes.
2001 Feb
Increase in hydration and protective function of horny layer by glycerol and a W/O emulsion: are these effects maintained during long-term use?
2001 Feb
Intracellular contents and assembly states of all 12 subunits of the RNA polymerase II in the fission yeast Schizosaccharomyces pombe.
2001 Feb
Ultracentrifugal studies of the effect of molecular crowding by trimethylamine N-oxide on the self-association of muscle glycogen phosphorylase b.
2001 Feb
How water molecules pass through aquaporins.
2001 Feb
Upregulation of uncoupling protein homologues in skeletal muscle but not adipose tissue in posttraumatic insulin resistance.
2001 Feb 23
Rapid screening of H(2)O(2) production by Mycoplasma mycoides and differentiation of European subsp. mycoides SC (small colony) isolates.
2001 Feb 26
Evidence against a major role of plasmalogens in the resistance of astrocytes in lactic acid-induced oxidative stress in vitro.
2001 Jan
Biochemical characterization of Mycoplasma bovirhinis, Mycoplasma dispar and recent bovine isolates of Mycoplasma canis.
2001 Jan
A technique for preserving pigmentation in some capsalid monogeneans for taxonomic purposes.
2001 Jan
Azospirillum doebereinerae sp. nov., a nitrogen-fixing bacterium associated with the C4-grass Miscanthus.
2001 Jan
Avoid unnecessary drug-related carbohydrates for patients consuming the ketogenic diet.
2001 Jan
Distinct long-term regulation of glycerol and non-esterified fatty acid release by insulin and TNF-alpha in 3T3-L1 adipocytes.
2001 Jan
Lipid-dependent control of hepatic glycogen stores in healthy humans.
2001 Jan
Effects of L-carnitine on nitrogen retention and blood metabolites of growing steers and performance of finishing steers.
2001 Jan
L-glutamate efflux with Corynebacterium glutamicum: why is penicillin treatment or Tween addition doing the same?
2001 Jan
Determination of Cremophor EL in plasma after sample preparation with solid phase extraction and plasma protein precipitation.
2001 Jan
Modeling the growth boundary of Staphylococcus aureus for risk assessment purposes.
2001 Jan
[Life style-related disease].
2001 Jan
Spontaneous otoacoustic emissions in humans with endolymphatic hydrops.
2001 Jan
Distortion-product otoacoustic emissions and glycerol testing in endolymphatic hydrops.
2001 Jan
The innervation of the triangular fibrocartilage complex: nitric acid maceration rediscovered.
2001 Jan
The thermic effect is greater for structured medium- and long-chain triacylglycerols versus long-chain triacylglycerols in healthy young women.
2001 Jan
Nod factor-induced phosphatidic acid and diacylglycerol pyrophosphate formation: a role for phospholipase C and D in root hair deformation.
2001 Jan
Leavening ability of baker's yeast exposed to hyperosmotic media.
2001 Jan 15
Characterization of lyso-galactolipids, C-2 and C-3 O-acyl trigalactosylglycerol isomers, obtained from the lichenized fungus Dictyonema glabratum.
2001 Jan 15
Inhibition of a model protease--pyroglutamate aminopeptidase by a natural oligosaccharide gum from Hakea gibbosa.
2001 Jan 16
Aquaporin 3, a glycerol and water transporter, is regulated by p73 of the p53 family.
2001 Jan 26
Cerebroprotective action of a Na+/Ca2+ channel blocker NS-7. I. Effect on the cerebral infarction and edema at the acute stage of permanent middle cerebral artery occlusion in rats.
2001 Jan 26
Modification of the lyotropic liquid crystalline microstructure of amphiphilic block copolymers in the presence of cosolvents.
2001 Jan 29
Postexercise ketosis in night-migrating passerine birds.
2001 Jan-Feb
Comparative hemolytic activity of undiluted organic water-miscible solvents for intravenous and intra-arterial injection.
2001 Jan-Feb
In-vitro growth of murine pre-antral follicles after isolation from cryopreserved ovarian tissue.
2001 Mar
Crystallization and preliminary X-ray analysis of the glycerol-3-phosphate 1-acyltransferase from squash (Cucurbita moschata).
2001 Mar
Purification and crystallization of the human RXRalpha ligand-binding domain-9-cisRA complex.
2001 Mar
Production of ethanol and xylitol from corn cobs by yeasts.
2001 Mar
Effects of food texture change on metabolic parameters: short- and long-term feeding patterns and body weight.
2001 Mar
Signposts in the assembly of chylomicrons.
2001 Mar 1
Preparation of anhydrothrombin and characterization of its interaction with natural thrombin substrates.
2001 Mar 1
Optimization of the high-level production of Rhizopus oryzae lipase in Pichia pastoris.
2001 Mar 9
Dialysis addition of trehalose/glycerol cryoprotectant allows recovery of cryopreserved mouse spermatozoa with satisfactory fertilizing ability as assessed by yield of live young.
2001 Mar-Apr
Substance Class Chemical
Created
by admin
on Fri Jun 25 21:13:28 UTC 2021
Edited
by admin
on Fri Jun 25 21:13:28 UTC 2021
Record UNII
PDC6A3C0OX
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
GLYCERIN
FCC   HSDB   II   INCI   ORANGE BOOK   USP   USP-RS   VANDF  
INCI  
Official Name English
PZN 7474853
Code English
GLYCERIN,ANHYDROUS
VANDF  
Common Name English
GLYCEROL [INN]
Common Name English
GLYCEROL [EP]
Common Name English
GLYCERIN [ORANGE BOOK]
Common Name English
GLYCEROL 85% [WHO-DD]
Common Name English
1,2,3-PROPANETRIOL
Systematic Name English
GLYCEROL
EP   FHFI   INN   MART.   MI   WHO-DD   WHO-IP  
INN  
Official Name English
GLYCERIN [II]
Common Name English
GLYCERIN [USP]
Common Name English
GLYCERINUM
HPUS  
Common Name English
2-PROPANOL, 1,3-DIHYDROXY-
Systematic Name English
E-422
Code English
1,2,3-TRIHYDROXYPROPANE
Systematic Name English
GLYCERINE
Systematic Name English
GLYCEROLUM [WHO-IP LATIN]
Common Name English
TRYHYDROXYPROPANE
Common Name English
GLYCERIN,ANHYDROUS [VANDF]
Common Name English
GLYCEROL [EP MONOGRAPH]
Common Name English
INS-422
Code English
GLYCERIN [USP-RS]
Common Name English
GLYCEROL [WHO-DD]
Common Name English
NSC-9230
Code English
MONOCTANOIN COMPONENT D
Common Name English
GLYCERIN [HSDB]
Common Name English
GLYCEROL [FHFI]
Common Name English
M 314429
Code English
GLYCERIN [INCI]
Common Name English
GLYCERINUM [HPUS]
Common Name English
FEMA NO. 2525
Code English
GLYCEROL [WHO-IP]
Common Name English
GLYCEROL [MART.]
Common Name English
INS NO.422
Code English
GLYCEROL [MI]
Common Name English
GLYCERIN [VANDF]
Common Name English
Classification Tree Code System Code
LOINC 54283-7
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
FDA ORPHAN DRUG 28188
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
JECFA EVALUATION GLYCEROL
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
JECFA EVALUATION INS-422
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
CODEX ALIMENTARIUS (GSFA) INS-422
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
LOINC 45300-1
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
WHO-VATC QA16QA03
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
LOINC 54285-2
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
LOINC 2388-7
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
LOINC 2387-9
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
DSLD 1110 (Number of products:309)
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
WHO-ATC A06AG04
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
CFR 21 CFR 349.12
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
WHO-ATC A06AX01
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
LOINC 54284-5
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
NCI_THESAURUS C29697
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
WHO-VATC QA06AG04
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
NDF-RT N0000185370
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
EPA PESTICIDE CODE 63507
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
WHO-VATC QA06AX01
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
CFR 21 CFR 347.10
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
LOINC 47632-5
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
Code System Code Type Description
EPA CompTox
56-81-5
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY
DRUG BANK
DB09462
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY
USP_CATALOG
1295607
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY USP-RS
NDF-RT
N0000006566
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY Glycerol [Chemical/Ingredient]
WIKIPEDIA
GLYCEROL
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY
EVMPD
SUB07948MIG
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY
EVMPD
SUB13992MIG
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY
NDF-RT
N0000171131
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY Allergens [Chemical/Ingredient]
PUBCHEM
753
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
GLYCERIN
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY Description: A clear, colourless or almost colourless, syrupy liquid; odourless. Miscibility: Miscible with water and ethanol (~750 g/l) TS; slightly miscible with acetone R; practically immiscible with ether R. Category: Solvent; humectant.Storage: Glycerol should be kept in a tightly closed container. Additional information: Glycerol is hygroscopic. Requirement: Glycerol contains not less than 95.0% and not more than the equivalent of 101.0% of C3H8O3, calculated with reference to theanhydrous substance.
FDA UNII
PDC6A3C0OX
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY
CAS
56-81-5
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY
ChEMBL
CHEMBL692
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY
NCI_THESAURUS
C29077
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY
NDF-RT
N0000184306
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY Cell-mediated Immunity [PE]
JECFA MONOGRAPH
INS-422
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY
ECHA (EC/EINECS)
200-289-5
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY
DRUG CENTRAL
1316
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY
MERCK INDEX
M5790
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY Merck Index
INN
444
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY
NDF-RT
N0000175629
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY Increased Histamine Release [PE]
RXCUI
4910
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY RxNorm
MESH
D005990
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY
NDF-RT
N0000185001
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY Increased IgG Production [PE]
HSDB
492
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY
Related Record Type Details
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
PARENT -> CONSTITUENT ALWAYS PRESENT
Glycerol (mg/cigarette) Canadian = 13.2 SD(1.3) Imported = 13.5 SD(0.0)
Related Record Type Details
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (GC)
USP
PARENT -> IMPURITY
IMPURITY -> PARENT
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (GC)
USP
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (GC)
USP
Related Record Type Details
ACTIVE MOIETY