Details
Stereochemistry | ACHIRAL |
Molecular Formula | C3H8O3 |
Molecular Weight | 92.0938 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OCC(O)CO
InChI
InChIKey=PEDCQBHIVMGVHV-UHFFFAOYSA-N
InChI=1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2
Molecular Formula | C3H8O3 |
Molecular Weight | 92.0938 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Glycerin (glycerol) is 3-carbon alcohol naturally occurring in the human body. It is the structural backbone triacylglycerol molecules, and can also be converted to a glycolytic substrate for subsequent metabolism. Glycerin is a colorless, odorless, viscous, sweet-tasting liquid. The FDA classifies glycerol as "generally recognized as safe". Glycerin is used in the pharmaceutical industry as a sweetener in syrups, lozenges, and as an excipient in eyewash solutions. As an individual prescription product, glycerin has uses as a hyperosmotic, osmotic diuretic, and ophthalmic agent. It may be used as an eye drop in the treatment of glaucoma to reduce intraocular pressure, as a solution or suppository for short-term treatment of constipation, to evacuate the bowel prior to a colonoscopy, and in some ocular surgeries. It may be given intravenously to reduce pressure inside the brain and used externally on the skin as a moisturizer. Glycerin has many other uses in the agricultural, food and pharmaceutical industry.
Approval Year
Cmax
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
1770 mg/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/8369006/ |
1.2 g/kg single, oral dose: 1.2 g/kg route of administration: Oral experiment type: SINGLE co-administered: |
GLYCERIN serum | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
T1/2
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
0.895 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/8369006/ |
1.2 g/kg single, oral dose: 1.2 g/kg route of administration: Oral experiment type: SINGLE co-administered: |
GLYCERIN serum | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
39.3 min EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/4300572/ |
120 mmol/m² single, intravenous dose: 120 mmol/m² route of administration: Intravenous experiment type: SINGLE co-administered: |
GLYCERIN serum | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
Doses
Dose | Population | Adverse events |
---|---|---|
310 g single, oral (total) Overdose |
unhealthy, 72 years n = 1 Health Status: unhealthy Age Group: 72 years Sex: M Population Size: 1 Sources: |
Other AEs: Agitation, Groaning... Other AEs: Agitation (1 patient) Sources: Groaning (1 patient) Speech loss (1 patient) |
AEs
AE | Significance | Dose | Population |
---|---|---|---|
Agitation | 1 patient | 310 g single, oral (total) Overdose |
unhealthy, 72 years n = 1 Health Status: unhealthy Age Group: 72 years Sex: M Population Size: 1 Sources: |
Groaning | 1 patient | 310 g single, oral (total) Overdose |
unhealthy, 72 years n = 1 Health Status: unhealthy Age Group: 72 years Sex: M Population Size: 1 Sources: |
Speech loss | 1 patient | 310 g single, oral (total) Overdose |
unhealthy, 72 years n = 1 Health Status: unhealthy Age Group: 72 years Sex: M Population Size: 1 Sources: |
Overview
CYP3A4 | CYP2C9 | CYP2D6 | hERG |
---|---|---|---|
OverviewOther
Other Inhibitor | Other Substrate | Other Inducer |
---|---|---|
Drug as perpetrator
Target | Modality | Activity | Metabolite | Clinical evidence |
---|---|---|---|---|
Sources: https://pubmed.ncbi.nlm.nih.gov/9113273/ |
yes |
PubMed
Title | Date | PubMed |
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Inhibition of carcinogen induced c-Ha-ras and c-fos proto-oncogenes expression by dietary curcumin. | 2001 |
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Capillary electrophoresis with glycerol as an additive. | 2001 |
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A comparison of F-actin labeling methods for light microscopy in different plant specimens: multiple techniques supplement each other. | 2001 Aug |
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RNA-dependent RNA polymerase activity associated with endogenous double-stranded RNA in rice. | 2001 Feb |
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Potential of freezing in wastewater treatment: soluble pollutant applications. | 2001 Feb |
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Characterization of northern pintail (Anas acuta) ejaculate and the effect of sperm preservation on fertility. | 2001 Feb |
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Effects of the perfusion of beta-, beta2-, or beta3-adrenergic agonists or epinephrine on in situ adipose tissue lipolysis measured by microdialysis in underfed ewes. | 2001 Feb |
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Isolation and characterization of mitochondrial F(1)-ATPase from crayfish (Orconectes virilis) gills. | 2001 Feb |
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Vascular endothelial growth factor in peritoneal dialysis: a longitudinal follow-up. | 2001 Feb |
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Intracellular contents and assembly states of all 12 subunits of the RNA polymerase II in the fission yeast Schizosaccharomyces pombe. | 2001 Feb |
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Ultracentrifugal studies of the effect of molecular crowding by trimethylamine N-oxide on the self-association of muscle glycogen phosphorylase b. | 2001 Feb |
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How water molecules pass through aquaporins. | 2001 Feb |
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Correlation of the electrical and intrinsic optical signals in the chicken spreading depression phenomenon. | 2001 Feb 16 |
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Chronic ingestion of ethanol stimulates lipogenic response in rat hepatocytes. | 2001 Feb 2 |
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Upregulation of uncoupling protein homologues in skeletal muscle but not adipose tissue in posttraumatic insulin resistance. | 2001 Feb 23 |
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Evidence against a major role of plasmalogens in the resistance of astrocytes in lactic acid-induced oxidative stress in vitro. | 2001 Jan |
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Biochemical characterization of Mycoplasma bovirhinis, Mycoplasma dispar and recent bovine isolates of Mycoplasma canis. | 2001 Jan |
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A technique for preserving pigmentation in some capsalid monogeneans for taxonomic purposes. | 2001 Jan |
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Azospirillum doebereinerae sp. nov., a nitrogen-fixing bacterium associated with the C4-grass Miscanthus. | 2001 Jan |
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Avoid unnecessary drug-related carbohydrates for patients consuming the ketogenic diet. | 2001 Jan |
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Lipid-dependent control of hepatic glycogen stores in healthy humans. | 2001 Jan |
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Effects of L-carnitine on nitrogen retention and blood metabolites of growing steers and performance of finishing steers. | 2001 Jan |
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L-glutamate efflux with Corynebacterium glutamicum: why is penicillin treatment or Tween addition doing the same? | 2001 Jan |
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Modeling the growth boundary of Staphylococcus aureus for risk assessment purposes. | 2001 Jan |
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[Life style-related disease]. | 2001 Jan |
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Distortion-product otoacoustic emissions and glycerol testing in endolymphatic hydrops. | 2001 Jan |
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The thermic effect is greater for structured medium- and long-chain triacylglycerols versus long-chain triacylglycerols in healthy young women. | 2001 Jan |
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Partially carboxymethylated feather keratins. 2. Thermal and mechanical properties of films. | 2001 Jan |
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Identification of amino acids in wines by one- and two-dimensional nuclear magnetic resonance spectroscopy. | 2001 Jan |
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Nod factor-induced phosphatidic acid and diacylglycerol pyrophosphate formation: a role for phospholipase C and D in root hair deformation. | 2001 Jan |
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Addition of hydrophilic and lipophilic compounds of biological relevance to the monoolein/water system. I. Phase behavior. | 2001 Jan |
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Leavening ability of baker's yeast exposed to hyperosmotic media. | 2001 Jan 15 |
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Characterization of lyso-galactolipids, C-2 and C-3 O-acyl trigalactosylglycerol isomers, obtained from the lichenized fungus Dictyonema glabratum. | 2001 Jan 15 |
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Inhibition of a model protease--pyroglutamate aminopeptidase by a natural oligosaccharide gum from Hakea gibbosa. | 2001 Jan 16 |
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Aquaporin 3, a glycerol and water transporter, is regulated by p73 of the p53 family. | 2001 Jan 26 |
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Cerebroprotective action of a Na+/Ca2+ channel blocker NS-7. I. Effect on the cerebral infarction and edema at the acute stage of permanent middle cerebral artery occlusion in rats. | 2001 Jan 26 |
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Modification of the lyotropic liquid crystalline microstructure of amphiphilic block copolymers in the presence of cosolvents. | 2001 Jan 29 |
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Probing the relative timing of hydrogen abstraction steps in the flavocytochrome b2 reaction with primary and solvent deuterium isotope effects and mutant enzymes. | 2001 Jan 30 |
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Postexercise ketosis in night-migrating passerine birds. | 2001 Jan-Feb |
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Comparative hemolytic activity of undiluted organic water-miscible solvents for intravenous and intra-arterial injection. | 2001 Jan-Feb |
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In-vitro growth of murine pre-antral follicles after isolation from cryopreserved ovarian tissue. | 2001 Mar |
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Crystallization and preliminary X-ray analysis of the glycerol-3-phosphate 1-acyltransferase from squash (Cucurbita moschata). | 2001 Mar |
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Purification and crystallization of the human RXRalpha ligand-binding domain-9-cisRA complex. | 2001 Mar |
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Production of ethanol and xylitol from corn cobs by yeasts. | 2001 Mar |
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Effects of food texture change on metabolic parameters: short- and long-term feeding patterns and body weight. | 2001 Mar |
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Effect of nicotinic acid administration on hepatic very low density lipoprotein-triglyceride production. | 2001 Mar |
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Signposts in the assembly of chylomicrons. | 2001 Mar 1 |
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Preparation of anhydrothrombin and characterization of its interaction with natural thrombin substrates. | 2001 Mar 1 |
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Optimization of the high-level production of Rhizopus oryzae lipase in Pichia pastoris. | 2001 Mar 9 |
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Dialysis addition of trehalose/glycerol cryoprotectant allows recovery of cryopreserved mouse spermatozoa with satisfactory fertilizing ability as assessed by yield of live young. | 2001 Mar-Apr |
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:00:46 GMT 2023
by
admin
on
Fri Dec 15 15:00:46 GMT 2023
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Record UNII |
PDC6A3C0OX
|
Record Status |
Validated (UNII)
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Record Version |
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-
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Classification Tree | Code System | Code | ||
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LOINC |
54283-7
Created by
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FDA ORPHAN DRUG |
28188
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JECFA EVALUATION |
GLYCEROL
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JECFA EVALUATION |
INS-422
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CODEX ALIMENTARIUS (GSFA) |
INS-422
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LOINC |
45300-1
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WHO-VATC |
QA16QA03
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LOINC |
54285-2
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LOINC |
2388-7
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LOINC |
2387-9
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DSLD |
1110 (Number of products:309)
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WHO-ATC |
A06AG04
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CFR |
21 CFR 349.12
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WHO-ATC |
A06AX01
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LOINC |
54284-5
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NCI_THESAURUS |
C29697
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WHO-VATC |
QA06AG04
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NDF-RT |
N0000185370
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EPA PESTICIDE CODE |
63507
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WHO-VATC |
QA06AX01
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CFR |
21 CFR 347.10
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LOINC |
47632-5
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Code System | Code | Type | Description | ||
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DTXSID9020663
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PRIMARY | |||
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DB09462
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PRIMARY | |||
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N0000006566
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PRIMARY | Glycerol [Chemical/Ingredient] | ||
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GLYCEROL
Created by
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PRIMARY | |||
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SUB07948MIG
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PRIMARY | |||
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SUB13992MIG
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PRIMARY | |||
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N0000171131
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PRIMARY | Allergens [Chemical/Ingredient] | ||
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753
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PRIMARY | |||
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GLYCERIN
Created by
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PRIMARY | Description: A clear, colourless or almost colourless, syrupy liquid; odourless. Miscibility: Miscible with water and ethanol (~750 g/l) TS; slightly miscible with acetone R; practically immiscible with ether R. Category: Solvent; humectant.Storage: Glycerol should be kept in a tightly closed container. Additional information: Glycerol is hygroscopic. Requirement: Glycerol contains not less than 95.0% and not more than the equivalent of 101.0% of C3H8O3, calculated with reference to theanhydrous substance. | ||
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PDC6A3C0OX
Created by
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PRIMARY | |||
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56-81-5
Created by
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PRIMARY | |||
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CHEMBL692
Created by
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PRIMARY | |||
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C29077
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PRIMARY | |||
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N0000184306
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PRIMARY | Cell-mediated Immunity [PE] | ||
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200-289-5
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PRIMARY | |||
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PDC6A3C0OX
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PRIMARY | |||
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1316
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PRIMARY | |||
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m5790
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PRIMARY | Merck Index | ||
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444
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PRIMARY | |||
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N0000175629
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PRIMARY | Increased Histamine Release [PE] | ||
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1295607
Created by
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PRIMARY | |||
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9230
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PRIMARY | |||
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4910
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PRIMARY | RxNorm | ||
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D005990
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PRIMARY | |||
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N0000185001
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PRIMARY | Increased IgG Production [PE] | ||
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492
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PRIMARY | |||
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17754
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PRIMARY | |||
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100000092821
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PRIMARY |
Related Record | Type | Details | ||
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SALT/SOLVATE -> PARENT |
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SALT/SOLVATE -> PARENT |
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PARENT -> CONSTITUENT ALWAYS PRESENT |
Glycerol (mg/cigarette)
Canadian = 13.2 SD(1.3)
Imported = 13.5 SD(0.0)
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Related Record | Type | Details | ||
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (GC)
USP
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IMPURITY -> PARENT |
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (GC)
USP
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PARENT -> IMPURITY |
CHROMATOGRAPHIC PURITY (GC)
USP
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Related Record | Type | Details | ||
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ACTIVE MOIETY |
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