Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C3H8O3 |
| Molecular Weight | 92.0938 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OCC(O)CO
InChI
InChIKey=PEDCQBHIVMGVHV-UHFFFAOYSA-N
InChI=1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2
| Molecular Formula | C3H8O3 |
| Molecular Weight | 92.0938 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Glycerin (glycerol) is 3-carbon alcohol naturally occurring in the human body. It is the structural backbone triacylglycerol molecules, and can also be converted to a glycolytic substrate for subsequent metabolism. Glycerin is a colorless, odorless, viscous, sweet-tasting liquid. The FDA classifies glycerol as "generally recognized as safe". Glycerin is used in the pharmaceutical industry as a sweetener in syrups, lozenges, and as an excipient in eyewash solutions. As an individual prescription product, glycerin has uses as a hyperosmotic, osmotic diuretic, and ophthalmic agent. It may be used as an eye drop in the treatment of glaucoma to reduce intraocular pressure, as a solution or suppository for short-term treatment of constipation, to evacuate the bowel prior to a colonoscopy, and in some ocular surgeries. It may be given intravenously to reduce pressure inside the brain and used externally on the skin as a moisturizer. Glycerin has many other uses in the agricultural, food and pharmaceutical industry.
Approval Year
Cmax
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
1770 mg/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/8369006/ |
1.2 g/kg single, oral dose: 1.2 g/kg route of administration: Oral experiment type: SINGLE co-administered: |
GLYCERIN serum | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
T1/2
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
39.3 min EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/4300572/ |
120 mmol/m² single, intravenous dose: 120 mmol/m² route of administration: Intravenous experiment type: SINGLE co-administered: |
GLYCERIN serum | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
0.895 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/8369006/ |
1.2 g/kg single, oral dose: 1.2 g/kg route of administration: Oral experiment type: SINGLE co-administered: |
GLYCERIN serum | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
Doses
| Dose | Population | Adverse events |
|---|---|---|
310 g single, oral Overdose |
unhealthy, 72 years |
Other AEs: Agitation, Groaning... Other AEs: Agitation (1 patient) Sources: Groaning (1 patient) Speech loss (1 patient) |
AEs
| AE | Significance | Dose | Population |
|---|---|---|---|
| Agitation | 1 patient | 310 g single, oral Overdose |
unhealthy, 72 years |
| Groaning | 1 patient | 310 g single, oral Overdose |
unhealthy, 72 years |
| Speech loss | 1 patient | 310 g single, oral Overdose |
unhealthy, 72 years |
Overview
| CYP3A4 | CYP2C9 | CYP2D6 | hERG |
|---|---|---|---|
OverviewOther
| Other Inhibitor | Other Substrate | Other Inducer |
|---|---|---|
Drug as perpetrator
| Target | Modality | Activity | Metabolite | Clinical evidence |
|---|---|---|---|---|
Sources: https://pubmed.ncbi.nlm.nih.gov/9113273/ |
yes |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Optimization of the high-level production of Rhizopus oryzae lipase in Pichia pastoris. | 2001-03-09 |
|
| Dialysis addition of trehalose/glycerol cryoprotectant allows recovery of cryopreserved mouse spermatozoa with satisfactory fertilizing ability as assessed by yield of live young. | 2001-03-07 |
|
| Signposts in the assembly of chylomicrons. | 2001-03-01 |
|
| Preparation of anhydrothrombin and characterization of its interaction with natural thrombin substrates. | 2001-03-01 |
|
| In-vitro growth of murine pre-antral follicles after isolation from cryopreserved ovarian tissue. | 2001-03 |
|
| Crystallization and preliminary X-ray analysis of the glycerol-3-phosphate 1-acyltransferase from squash (Cucurbita moschata). | 2001-03 |
|
| Purification and crystallization of the human RXRalpha ligand-binding domain-9-cisRA complex. | 2001-03 |
|
| Production of ethanol and xylitol from corn cobs by yeasts. | 2001-03 |
|
| Effects of food texture change on metabolic parameters: short- and long-term feeding patterns and body weight. | 2001-03 |
|
| Effect of nicotinic acid administration on hepatic very low density lipoprotein-triglyceride production. | 2001-03 |
|
| Rapid screening of H(2)O(2) production by Mycoplasma mycoides and differentiation of European subsp. mycoides SC (small colony) isolates. | 2001-02-26 |
|
| Comparative hemolytic activity of undiluted organic water-miscible solvents for intravenous and intra-arterial injection. | 2001-02-24 |
|
| Upregulation of uncoupling protein homologues in skeletal muscle but not adipose tissue in posttraumatic insulin resistance. | 2001-02-23 |
|
| Chronic ingestion of ethanol stimulates lipogenic response in rat hepatocytes. | 2001-02-02 |
|
| RNA-dependent RNA polymerase activity associated with endogenous double-stranded RNA in rice. | 2001-02 |
|
| Potential of freezing in wastewater treatment: soluble pollutant applications. | 2001-02 |
|
| Characterization of northern pintail (Anas acuta) ejaculate and the effect of sperm preservation on fertility. | 2001-02 |
|
| Effects of the perfusion of beta-, beta2-, or beta3-adrenergic agonists or epinephrine on in situ adipose tissue lipolysis measured by microdialysis in underfed ewes. | 2001-02 |
|
| Isolation and characterization of mitochondrial F(1)-ATPase from crayfish (Orconectes virilis) gills. | 2001-02 |
|
| Increase in hydration and protective function of horny layer by glycerol and a W/O emulsion: are these effects maintained during long-term use? | 2001-02 |
|
| Vascular endothelial growth factor in peritoneal dialysis: a longitudinal follow-up. | 2001-02 |
|
| Intracellular contents and assembly states of all 12 subunits of the RNA polymerase II in the fission yeast Schizosaccharomyces pombe. | 2001-02 |
|
| Probing the relative timing of hydrogen abstraction steps in the flavocytochrome b2 reaction with primary and solvent deuterium isotope effects and mutant enzymes. | 2001-01-30 |
|
| Modification of the lyotropic liquid crystalline microstructure of amphiphilic block copolymers in the presence of cosolvents. | 2001-01-29 |
|
| Aquaporin 3, a glycerol and water transporter, is regulated by p73 of the p53 family. | 2001-01-26 |
|
| Evidence against a major role of plasmalogens in the resistance of astrocytes in lactic acid-induced oxidative stress in vitro. | 2001-01 |
|
| Biochemical characterization of Mycoplasma bovirhinis, Mycoplasma dispar and recent bovine isolates of Mycoplasma canis. | 2001-01 |
|
| A technique for preserving pigmentation in some capsalid monogeneans for taxonomic purposes. | 2001-01 |
|
| Azospirillum doebereinerae sp. nov., a nitrogen-fixing bacterium associated with the C4-grass Miscanthus. | 2001-01 |
|
| Avoid unnecessary drug-related carbohydrates for patients consuming the ketogenic diet. | 2001-01 |
|
| Distinct long-term regulation of glycerol and non-esterified fatty acid release by insulin and TNF-alpha in 3T3-L1 adipocytes. | 2001-01 |
|
| Lipid-dependent control of hepatic glycogen stores in healthy humans. | 2001-01 |
|
| Effects of L-carnitine on nitrogen retention and blood metabolites of growing steers and performance of finishing steers. | 2001-01 |
|
| L-glutamate efflux with Corynebacterium glutamicum: why is penicillin treatment or Tween addition doing the same? | 2001-01 |
|
| Determination of Cremophor EL in plasma after sample preparation with solid phase extraction and plasma protein precipitation. | 2001-01 |
|
| Modeling the growth boundary of Staphylococcus aureus for risk assessment purposes. | 2001-01 |
|
| [Life style-related disease]. | 2001-01 |
|
| Spontaneous otoacoustic emissions in humans with endolymphatic hydrops. | 2001-01 |
|
| Distortion-product otoacoustic emissions and glycerol testing in endolymphatic hydrops. | 2001-01 |
|
| The innervation of the triangular fibrocartilage complex: nitric acid maceration rediscovered. | 2001-01 |
|
| The thermic effect is greater for structured medium- and long-chain triacylglycerols versus long-chain triacylglycerols in healthy young women. | 2001-01 |
|
| Partially carboxymethylated feather keratins. 2. Thermal and mechanical properties of films. | 2001-01 |
|
| Identification of amino acids in wines by one- and two-dimensional nuclear magnetic resonance spectroscopy. | 2001-01 |
|
| Nod factor-induced phosphatidic acid and diacylglycerol pyrophosphate formation: a role for phospholipase C and D in root hair deformation. | 2001-01 |
|
| Inhibition of carcinogen induced c-Ha-ras and c-fos proto-oncogenes expression by dietary curcumin. | 2001 |
|
| Capillary electrophoresis with glycerol as an additive. | 2001 |
|
| Protein microarrays for highly parallel detection and quantitation of specific proteins and antibodies in complex solutions. | 2001 |
|
| Isolation and characterization of rheumatoid arthritis synovial fibroblasts from primary culture--primary culture cells markedly differ from fourth-passage cells. | 2001 |
|
| Induced cytoskeletal changes in bovine pulmonary artery endothelial cells by resveratrol and the accompanying modified responses to arterial shear stress. | 2001 |
|
| Postexercise ketosis in night-migrating passerine birds. | 2000-09-05 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 17:35:08 GMT 2025
by
admin
on
Mon Mar 31 17:35:08 GMT 2025
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| Record UNII |
PDC6A3C0OX
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| Record Status |
Validated (UNII)
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| Record Version |
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| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
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LOINC |
54283-7
Created by
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FDA ORPHAN DRUG |
28188
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JECFA EVALUATION |
GLYCEROL
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JECFA EVALUATION |
INS-422
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CODEX ALIMENTARIUS (GSFA) |
INS-422
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LOINC |
45300-1
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WHO-VATC |
QA16QA03
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LOINC |
54285-2
Created by
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LOINC |
2388-7
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LOINC |
2387-9
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DSLD |
1110 (Number of products:309)
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WHO-ATC |
A06AG04
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CFR |
21 CFR 349.12
Created by
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WHO-ATC |
A06AX01
Created by
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LOINC |
54284-5
Created by
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NCI_THESAURUS |
C29697
Created by
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WHO-VATC |
QA06AG04
Created by
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NDF-RT |
N0000185370
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EPA PESTICIDE CODE |
63507
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WHO-VATC |
QA06AX01
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CFR |
21 CFR 347.10
Created by
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LOINC |
47632-5
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| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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DTXSID9020663
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PRIMARY | |||
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DB09462
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PRIMARY | |||
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N0000006566
Created by
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PRIMARY | Glycerol [Chemical/Ingredient] | ||
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GLYCEROL
Created by
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PRIMARY | |||
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SUB07948MIG
Created by
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PRIMARY | |||
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SUB13992MIG
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PRIMARY | |||
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N0000171131
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PRIMARY | Allergens [Chemical/Ingredient] | ||
|
753
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PRIMARY | |||
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GLYCERIN
Created by
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PRIMARY | Description: A clear, colourless or almost colourless, syrupy liquid; odourless. Miscibility: Miscible with water and ethanol (~750 g/l) TS; slightly miscible with acetone R; practically immiscible with ether R. Category: Solvent; humectant.Storage: Glycerol should be kept in a tightly closed container. Additional information: Glycerol is hygroscopic. Requirement: Glycerol contains not less than 95.0% and not more than the equivalent of 101.0% of C3H8O3, calculated with reference to theanhydrous substance. | ||
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PDC6A3C0OX
Created by
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PRIMARY | |||
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56-81-5
Created by
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PRIMARY | |||
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CHEMBL692
Created by
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PRIMARY | |||
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C29077
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PRIMARY | |||
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N0000184306
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PRIMARY | Cell-mediated Immunity [PE] | ||
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200-289-5
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PRIMARY | |||
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PDC6A3C0OX
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PRIMARY | |||
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1316
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PRIMARY | |||
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m5790
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PRIMARY | Merck Index | ||
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444
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PRIMARY | |||
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N0000175629
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PRIMARY | Increased Histamine Release [PE] | ||
|
1295607
Created by
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PRIMARY | |||
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9230
Created by
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PRIMARY | |||
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4910
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PRIMARY | RxNorm | ||
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D005990
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PRIMARY | |||
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N0000185001
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PRIMARY | Increased IgG Production [PE] | ||
|
492
Created by
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PRIMARY | |||
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17754
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PRIMARY | |||
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100000092821
Created by
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PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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SALT/SOLVATE -> PARENT |
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SALT/SOLVATE -> PARENT |
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PARENT -> CONSTITUENT ALWAYS PRESENT |
Glycerol (mg/cigarette)
Canadian = 13.2 SD(1.3)
Imported = 13.5 SD(0.0)
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SALT/SOLVATE -> PARENT |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (GC)
USP
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IMPURITY -> PARENT |
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (GC)
USP
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PARENT -> IMPURITY |
CHROMATOGRAPHIC PURITY (GC)
USP
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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ACTIVE MOIETY |
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