Nickel

Details

Stereochemistry	ACHIRAL
Molecular Formula	Ni
Molecular Weight	58.6934
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Ni]

InChI

InChIKey=PXHVJJICTQNCMI-UHFFFAOYSA-N

InChI=1S/Ni

HIDE SMILES / InChI

Molecular Formula	Ni
Molecular Weight	58.6934
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
In vitro evaluation of the toxicity induced by nickel soluble and particulate forms in human airway epithelial cells.	2011-03	21111804
Gene expression changes in peripheral blood mononuclear cells in occupational exposure to nickel.	2011-02	21054559
Reactive oxygen species and oxidative DNA damage mediate the cytotoxicity of tungsten-nickel-cobalt alloys in vitro.	2011-01-01	20934443
Exposure to inhaled nickel nanoparticles causes a reduction in number and function of bone marrow endothelial progenitor cells.	2010-12	20936915
Hypoxia and nickel inhibit histone demethylase JMJD1A and repress Spry2 expression in human bronchial epithelial BEAS-2B cells.	2010-12	20881000
From GC-rich DNA binding to the repression of survivin gene for quercetin nickel (II) complex: implications for cancer therapy.	2010-12	20577783
Nickel induces oxidative burst, NF-κB activation and interleukin-8 production in human neutrophils.	2010-11	20632048
Diverse neurotoxicants converge on gene expression for neuropeptides and their receptors in an in vitro model of neurodifferentiation: effects of chlorpyrifos, diazinon, dieldrin and divalent nickel in PC12 cells.	2010-09-24	20682304
Transcriptional profiles for glutamate transporters reveal differences between organophosphates but similarities with unrelated neurotoxicants.	2010-08-30	20600679
Soluble ions more than particulate cobalt-alloy implant debris induce monocyte costimulatory molecule expression and release of proinflammatory cytokines critical to metal-induced lymphocyte reactivity.	2010-06-15	19844976
Involvement of prostaglandins and histamine in nickel wire-induced acute inflammation in mice.	2010-06-15	19839048
Nickel sensitisation in mice: a critical appraisal.	2010-06	20456924
Comparative in situ topoproteome analysis reveals differences in patch test-induced eczema: cytotoxicity-dominated nickel versus pleiotrope pollen reaction.	2010-06	19758337
IL-17 amplifies human contact hypersensitivity by licensing hapten nonspecific Th1 cells to kill autologous keratinocytes.	2010-05-01	20357258
Genome-wide pathways analysis of nickel ion-induced differential genes expression in fibroblasts.	2010-03	20053437
Oxidative damage effects in the copepod Tigriopus japonicus Mori experimentally exposed to nickel.	2010-02	19821026
Nickel induces intracellular calcium mobilization and pathophysiological responses in human cultured airway epithelial cells.	2010-01-05	19781536
Expression and functional characterization of four aquaporin water channels from the European eel (Anguilla anguilla).	2009-09-01	19684221
Signal transducer and activator of transcription 1 (STAT1) is essential for chromium silencing of gene induction in human airway epithelial cells.	2009-07	19403854
Nickel mobilizes intracellular zinc to induce metallothionein in human airway epithelial cells.	2009-07	19097988
Effect of short-time exposures to nickel and lead on brain monoamine oxidase from Danio rerio and Poecilia reticulata.	2009-06	18767136
Patch-test results of the North American Contact Dermatitis Group 2005-2006.	2009-05-28	19470301
Oxidative and excitatory mechanisms of developmental neurotoxicity: transcriptional profiles for chlorpyrifos, diazinon, dieldrin, and divalent nickel in PC12 cells.	2009-04	19440498
Transcriptional profiles reveal similarities and differences in the effects of developmental neurotoxicants on differentiation into neurotransmitter phenotypes in PC12 cells.	2009-03-16	18812211
HMOX1 and NQO1 genes are upregulated in response to contact sensitizers in dendritic cells and THP-1 cell line: role of the Keap1/Nrf2 pathway.	2009-02	19033392
Comparison of gene expression profiles in HepG2 cells exposed to arsenic, cadmium, nickel, and three model carcinogens for investigating the mechanisms of metal carcinogenesis.	2009-01	19031421
Mechanisms of cytotoxicity of nickel ions based on gene expression profiles.	2009-01	18922574
Developmental neurotoxicants target neurodifferentiation into the serotonin phenotype: Chlorpyrifos, diazinon, dieldrin and divalent nickel.	2008-12-01	18835401
Unrelated developmental neurotoxicants elicit similar transcriptional profiles for effects on neurotrophic factors and their receptors in an in vitro model.	2008-07-03	19130878
Release of nickel from coins and deposition onto skin from coin handling--comparing euro coins and SEK.	2008-07	18537991
Deposition of nickel, chromium, and cobalt on the skin in some occupations - assessment by acid wipe sampling.	2008-06	18503684
Efficacy of caffeic acid in preventing nickel induced oxidative damage in liver of rats.	2008-05-28	18405891
Gene expression time course in the human skin during elicitation of allergic contact dermatitis.	2007-11	17597826
Characterization and distribution of the selected metals in the scalp hair of cancer patients in comparison with normal donors.	2007-09	17916923
Chemokine responses distinguish chemical-induced allergic from irritant skin inflammation: memory T cells make the difference.	2007-06	17337293
The contact allergen nickel triggers a unique inflammatory and proangiogenic gene expression pattern via activation of NF-kappaB and hypoxia-inducible factor-1alpha.	2007-03-01	17312168
Allergic contact dermatitis to nickel: modified in vitro test protocols for better detection of allergen-specific response.	2007-02	17244072
Ni K-edge XAS suggests that coordination of Ni(II) to the unstructured amyloidogenic region of the human prion protein produces a Ni(2) bis-mu-hydroxo dimer.	2007-02	17126907
T-type Ca2+ channels mediate propagation of odor-induced Ca2+ transients in rat olfactory receptor neurons.	2007-01-19	17110049
Antigen-driven HIV expansion in allergen-specific T cells.	2007-01	17263646
Activation of MAP kinases by hexavalent chromium, manganese and nickel in human lung epithelial cells.	2006-12-01	17045426
Cytogenetic effects of a mixture of selected metals following subchronic exposure through drinking water in male rats.	2006-12	17176674
Nickel, cobalt, chromium, palladium and gold induce a mixed Th1- and Th2-type cytokine response in vitro in subjects with contact allergy to the respective metals.	2006-12	17100760
Effect of metal ions on HIF-1alpha and Fe homeostasis in human A549 cells.	2006-11-07	16877034
Ni(II) affects ubiquitination of core histones H2B and H2A.	2006-10-15	16870173
LH release by Cu and Ni salts and metal-GnRH complexes, in vitro.	2006-08	16892001
Oxidative stress due to nickel toxicity in the liver of protein-deficient rats.	2005	20021064
Use of an optimized in vitro lymphocyte blastogenesis assay to detect contact sensitivity to nickel sulfate in mice.	1990-06-01	1694310
Attempts to identify the causative allergen in cases of allergic contact dermatitis using an in vitro lymphocyte transformation test.	1990	20702182
An optimized lymphocyte blastogenesis assay for detecting the response of contact sensitized or photosensitized lymphocytes to hapten or photohapten modified antigen presenting cells.	1990	20702180

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:33:18 GMT 2025` Edited by `admin` on `Mon Mar 31 18:33:18 GMT 2025`
Record UNII	7OV03QG267
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NICCOLUM METALLICUM

Preferred Name

English

Nickel

Systematic Name

English

RANEY NICKEL [MI]

Common Name

English

NICKEL [VANDF]

Common Name

English

NICKEL [MI]

Common Name

English

Nickel [WHO-DD]

Common Name

English

NICCOLUM METALLICUM [HPUS]

Common Name

English

NICKEL [FCC]

Common Name

English

NI

Common Name

English

NICKEL [HSDB]

Common Name

English

METALLIC NICKEL

Common Name

English

CARBONYL-NICKEL

Systematic Name

English

NICKEL, METALLIC AND ALLOYS [IARC]

Common Name

English

Classification Tree Code System Code

CFR

21 CFR 184.1537