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Details

Stereochemistry ACHIRAL
Molecular Formula NO3
Molecular Weight 62.0049
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge -1

SHOW SMILES / InChI
Structure of NITRATE ION

SMILES

[O-][N+]([O-])=O

InChI

InChIKey=NHNBFGGVMKEFGY-UHFFFAOYSA-N
InChI=1S/NO3/c2-1(3)4/q-1

HIDE SMILES / InChI
Molecular Formula NO3
Molecular Weight 62.0049
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Nitrate ion (NO3 −) is found naturally in the environment and is an important plant nutrient. It is present at varying concentrations in all plants and is a part of the nitrogen cycle. Nitrate probably has a role in protecting the gastrointestinal tract against a variety of gastrointestinal pathogens, as nitrous oxide and acidified nitrite have antibacterial properties. Significant bacterial reduction of nitrate to nitrite does not normally take place in the stomach, except in individuals with low gastric acidity or with gastrointestinal infections. These may include individuals using antacids, particularly those that block acid secretion. Potassium nitrate is used as mild local desensitizer in toothpastes.

Approval Year

1921
1467
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
Not Provided
504
MAXIMUM STRENGTH SENSITIVE TRUE MINT

Approved Use

builds increasing protection against painful sensitivity of the teeth to cold, heat, acids, sweets, or contact; helps protect against cavities.

Launch Date

2009
PubMed

PubMed

TitleDatePubMed
Proton translocation and the respiratory nitrate reductase of Escherichia coli.
1975 Dec
Calcium antagonists.
1985
Drug-induced torsade de pointes.
1985 Nov-Dec
Nitrates in acute myocardial infarction.
1987
[Drug treatment of myocardial ischemia].
1991
[Anti-angina therapy of coronary heart disease. Mono- or combination treatment].
1991 May
Transient reversal of blood flow in an internal thoracic artery to coronary artery graft during syncope.
1994 Aug
Dipyridamole enhances interleukin-1beta-stimulated nitric oxide production by cultured rat vascular smooth muscle cells.
1996 Feb 5
Therapy of angina pectoris with long-acting nitrates: which agent and when?
1996 May
Serum and tissue nitrate levels in murine visceral leishmaniasis correlate with parasite load but not with host protection.
1997 Jul-Aug
Prevention by morphine of apomorphine- and oxytocin-induced penile erection and yawning: involvement of nitric oxide.
1997 May
Atrial natriuretic peptide and oxytocin induce natriuresis by release of cGMP.
1999 Jan 5
[Nitrate contaminated drinking water from private wells has an impact on the size and functional state of the thyroid gland in schoolchildren].
2000 Nov
Diltiazem-mediated inhibition of sildenafil metabolism may promote nitrate-induced hypotension.
2000 Oct
[Upper gastrointestinal tract injury caused by ingestion of caustic substances].
2001 Apr
Respiratory tract responses to repeated inhalation of an oxidant and acid gas-particle air pollutant mixture.
2001 Jun
Municipal drinking water nitrate level and cancer risk in older women: the Iowa Women's Health Study.
2001 May
Gallium nitrate accelerates partial thickness wound repair and alters keratinocyte integrin expression to favor a motile phenotype.
2002 Apr
Assessing nitrate metabolism in the intestinal tract by measuring breath nitric oxide and nitrous oxide, and its clinical significance.
2002 May 7
Acute gastric perforation after acid ingestion.
2002 Sep
Raised nitrate concentration and low SOD activity in the CSF of sporadic ALS patients.
2003 May
Adrenomedullin contributes to vascular hyporeactivity in cirrhotic rats with ascites via a release of nitric oxide.
2004 Jul
Nitrification by plants that also fix nitrogen.
2004 Jul 1
Simultaneous determination of nitrate and nitrite in biological fluids by capillary electrophoresis and preliminary study on their determination by microchip capillary electrophoresis.
2004 Oct 8
Epidemiology of 377 patients with chemical burns in Guangdong province.
2004 Sep
Effects of various antioxidants on endotoxin-induced lung injury and gene expression: mRNA expressions of MnSOD, interleukin-1beta and iNOS.
2004 Sep 30
Rate and extent of percutaneous absorption of sertaconazole nitrate after topical administration.
2005
[Clinical observation on acupuncture combined with medication for intractable angina pectoris].
2005 Feb
Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate.
2005 Feb 1
Role of tumor necrosis factor-alpha in down-regulation of hepatic cytochrome P450 and P-glycoprotein by endotoxin.
2005 Jan 10
Nitric acid-induced bronchiolitis in rats mimics childhood Bronchiolitis obliterans.
2005 Nov-Dec
Cl- interference with the epithelial Na+ channel ENaC.
2005 Sep 9
Clinical diagnostic indicators of renal and bone damage in rats intramuscularly injected with depleted uranium.
2006
Blockade of endothelin ET(A)/ET(B) receptors favors a role for endothelin during acute Trypanosoma cruzi infection in rats.
2006 Jul
Immune cell infiltration and broncovascular remodeling after nitric acid nasal instillation in a mouse bronchiolitis obliterans model.
2006 Jul-Aug
Modifications of inflammatory pathways in rat intestine following chronic ingestion of depleted uranium.
2007 Aug
Oxidative and nitrosative stress in acute ischaemic stroke.
2007 Jan
Successful extracorporeal life support after potentially fatal pulmonary oedema caused by inhalation of nitric and hydrofluoric acid fumes.
2007 Oct
Serofendic acid, a substance extracted from fetal calf serum, as a novel drug for cardioprotection.
2007 Winter
Acute lung injury after inhalation of nitric acid.
2008 Dec
Reduced systemic vascular resistance in healthy volunteers with presyncopal symptoms during a nitrate-stimulated tilt-table test.
2011 Jan
Patents

Patents

03931177
6
03957791
6
03973039
6
03978092
6
03987186
7
03988268
6
03992446
6
03994968
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04005219
6
04010201
7
04021479
14
04036838
7
04038405
6
04049705
7
04053479
6
04055411
6
04066651
6
04066830
6
04067993
6
04071524
20
04093446
6
04096337
6
04107315
6
04118461
7
04120899
6
04126444
6
04136192
6
04141990
6
04154941
20
04159273
8
04166119
6
04174342
6
04174397
6
04177057
6
04178387
13
04180572
7
04180679
6
04196120
7
04199586
6
04200640
6
04279918
13
04415752
6
04555386
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04604267
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04652559
10
05292387
6
05300511
7
05616586
6
05633248
6
05739129
7
05965679
6
05972136
6
06531502
6
06972286
6
07029504
8
07495021
31
08106064
6
08394837
6
08629277
6
08735322
6
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:55:59 GMT 2023
Edited
by admin
on Fri Dec 15 16:55:59 GMT 2023
Record UNII
T93E9Y2844
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
NITRATE ION
Common Name English
NITRATE (NO3-)
Common Name English
NITRATE ANION
Common Name English
NITRIC ACID, ION(1-)
Common Name English
NITRATE
Systematic Name English
NITRATE(1-)
Common Name English
ISOSORBIDE MONONITRATE, DILUTED IMPURITY A [EP IMPURITY]
Common Name English
NITRATO
Common Name English
INORGANIC NITRATES
Common Name English
ISOSORBIDE DINITRATE, DILUTED IMPURITY A [EP IMPURITY]
Common Name English
NITRATE ION (NO3-)
Common Name English
Classification Tree Code System Code
DSLD 3333 (Number of products:10)
Created by admin on Fri Dec 15 16:55:59 GMT 2023 , Edited by admin on Fri Dec 15 16:55:59 GMT 2023
Code System Code Type Description
FDA UNII
T93E9Y2844
Created by admin on Fri Dec 15 16:55:59 GMT 2023 , Edited by admin on Fri Dec 15 16:55:59 GMT 2023
PRIMARY
EVMPD
SUB14657MIG
Created by admin on Fri Dec 15 16:55:59 GMT 2023 , Edited by admin on Fri Dec 15 16:55:59 GMT 2023
PRIMARY
DAILYMED
T93E9Y2844
Created by admin on Fri Dec 15 16:55:59 GMT 2023 , Edited by admin on Fri Dec 15 16:55:59 GMT 2023
PRIMARY
PUBCHEM
943
Created by admin on Fri Dec 15 16:55:59 GMT 2023 , Edited by admin on Fri Dec 15 16:55:59 GMT 2023
PRIMARY
CHEBI
51084
Created by admin on Fri Dec 15 16:55:59 GMT 2023 , Edited by admin on Fri Dec 15 16:55:59 GMT 2023
PRIMARY
EPA CompTox
DTXSID5024217
Created by admin on Fri Dec 15 16:55:59 GMT 2023 , Edited by admin on Fri Dec 15 16:55:59 GMT 2023
PRIMARY
RXCUI
1546271
Created by admin on Fri Dec 15 16:55:59 GMT 2023 , Edited by admin on Fri Dec 15 16:55:59 GMT 2023
PRIMARY RxNorm
DRUG BANK
DB14049
Created by admin on Fri Dec 15 16:55:59 GMT 2023 , Edited by admin on Fri Dec 15 16:55:59 GMT 2023
PRIMARY
WIKIPEDIA
Nitrate ion
Created by admin on Fri Dec 15 16:55:59 GMT 2023 , Edited by admin on Fri Dec 15 16:55:59 GMT 2023
PRIMARY
CAS
14797-55-8
Created by admin on Fri Dec 15 16:55:59 GMT 2023 , Edited by admin on Fri Dec 15 16:55:59 GMT 2023
PRIMARY
CHEBI
17632
Created by admin on Fri Dec 15 16:55:59 GMT 2023 , Edited by admin on Fri Dec 15 16:55:59 GMT 2023
PRIMARY
Related Record Type Details
TOBACCO LEAF
PARENT -> CONSTITUENT ALWAYS PRESENT
Nitrate (mg/cigarette) Canadian = 1.2 SD(0.6) Imported = 5.9 SD(2.0)
Related Record Type Details
Structure of ISOSORBIDE MONONITRATE
PARENT -> IMPURITY
calculated as potassium nitrate
CHROMATOGRAPHIC PURITY (TLC)
EP
Structure of ISOSORBIDE DINITRATE
PARENT -> IMPURITY
calculated as potassium nitrate
CHROMATOGRAPHIC PURITY (TLC)
EP
Related Record Type Details
Structure of NITRATE ION
ACTIVE MOIETY
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