PROPYLENE GLYCOL

US Approved OTC

First approved in 1961

Details

Stereochemistry	RACEMIC
Molecular Formula	C3H8O2
Molecular Weight	76.0944
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(O)CO

InChI

InChIKey=DNIAPMSPPWPWGF-UHFFFAOYSA-N

InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3

HIDE SMILES / InChI

Molecular Formula	C3H8O2
Molecular Weight	76.0944
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=15bc06ec-f3dc-3180-ca1a-106769a770ea&type=display | https://www.systane.com/products/eye-relief/systane-lubricant-eye-drops

PROPYLENE GLYCOL is a component of SYSTANE® Lubricant. It is used for the temporary relief of burning and irritation due to dryness of the eye.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Dryness of the eye 1 Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=15bc06ec-f3dc-3180-ca1a-106769a770ea	Palliative		Approved 8429	SYSTANE LUBRICANT Approved Use Uses: - For the temporary relief of burning and irritation due to dryness of the eye. Launch Date 2003

C_max

Value	Dose	Co-administered	Analyte	Population
0.8 mg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/4032274/	20.7 mg 3 times / day steady-state, oral dose: 20.7 mg route of administration: Oral experiment type: STEADY-STATE co-administered:		PROPYLENE GLYCOL plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

AUC

Value	Dose	Co-administered	Analyte	Population
3.23 mg × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/4032274/	20.7 mg 3 times / day steady-state, oral dose: 20.7 mg route of administration: Oral experiment type: STEADY-STATE co-administered:		PROPYLENE GLYCOL plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

T_1/2

Value	Dose	Co-administered	Analyte	Population
3.79 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/4032274/	20.7 mg 3 times / day steady-state, oral dose: 20.7 mg route of administration: Oral experiment type: STEADY-STATE co-administered:		PROPYLENE GLYCOL plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

Doses

Dose	Population	Adverse events
0.8 g/kg 1 times / day multiple, oral (mean) Dose: 0.8 g/kg, 1 times / day Route: oral Route: multiple Dose: 0.8 g/kg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/28331645	unhealthy, 13 years n = 1 Health Status: unhealthy Condition: refractory myoclonic status epilepticus Age Group: 13 years Sex: M Population Size: 1 Sources: https://pubmed.ncbi.nlm.nih.gov/28331645	Other AEs: Distributive shock, Acidosis metabolic... Other AEs: Distributive shock Acidosis metabolic Sources: https://pubmed.ncbi.nlm.nih.gov/28331645
20.7 g 3 times / day multiple, oral Dose: 20.7 g, 3 times / day Route: oral Route: multiple Dose: 20.7 g, 3 times / day Co-administed with:: sodium phenytoin(oral solution) Sources: https://pubmed.ncbi.nlm.nih.gov/4032274	unhealthy, 18 - 65 years n = 16 Health Status: unhealthy Age Group: 18 - 65 years Sex: M+F Population Size: 16 Sources: https://pubmed.ncbi.nlm.nih.gov/4032274	Other AEs: Mental disorder NOS... Other AEs: Mental disorder NOS (severe, 1 patient) Sources: https://pubmed.ncbi.nlm.nih.gov/4032274
41.4 g 2 times / day multiple, oral Dose: 41.4 g, 2 times / day Route: oral Route: multiple Dose: 41.4 g, 2 times / day Co-administed with:: sodium phenytoin(oral solution) Sources: https://pubmed.ncbi.nlm.nih.gov/4032274	unhealthy, 18 - 65 years n = 6 Health Status: unhealthy Age Group: 18 - 65 years Sex: M+F Population Size: 6 Sources: https://pubmed.ncbi.nlm.nih.gov/4032274	Other AEs: Mental disorder NOS... Other AEs: Mental disorder NOS (severe, 2 patients) Sources: https://pubmed.ncbi.nlm.nih.gov/4032274
8.64 g single, rectal Dose: 8.64 g Route: rectal Route: single Dose: 8.64 g Sources: https://pubmed.ncbi.nlm.nih.gov/8826536	healthy, adult n = 10 Health Status: healthy Age Group: adult Population Size: 10 Sources: https://pubmed.ncbi.nlm.nih.gov/8826536	Sources: https://pubmed.ncbi.nlm.nih.gov/8826536
173 mg/kg single, rectal Dose: 173 mg/kg Route: rectal Route: single Dose: 173 mg/kg Sources: https://pubmed.ncbi.nlm.nih.gov/8826536	healthy, children n = 4 Health Status: healthy Age Group: children Population Size: 4 Sources: https://pubmed.ncbi.nlm.nih.gov/8826536	Sources: https://pubmed.ncbi.nlm.nih.gov/8826536

AEs

AE	Significance	Dose	Population
Acidosis metabolic		0.8 g/kg 1 times / day multiple, oral (mean) Dose: 0.8 g/kg, 1 times / day Route: oral Route: multiple Dose: 0.8 g/kg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/28331645	unhealthy, 13 years n = 1 Health Status: unhealthy Condition: refractory myoclonic status epilepticus Age Group: 13 years Sex: M Population Size: 1 Sources: https://pubmed.ncbi.nlm.nih.gov/28331645
Distributive shock		0.8 g/kg 1 times / day multiple, oral (mean) Dose: 0.8 g/kg, 1 times / day Route: oral Route: multiple Dose: 0.8 g/kg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/28331645	unhealthy, 13 years n = 1 Health Status: unhealthy Condition: refractory myoclonic status epilepticus Age Group: 13 years Sex: M Population Size: 1 Sources: https://pubmed.ncbi.nlm.nih.gov/28331645
Mental disorder NOS	severe, 1 patient	20.7 g 3 times / day multiple, oral Dose: 20.7 g, 3 times / day Route: oral Route: multiple Dose: 20.7 g, 3 times / day Co-administed with:: sodium phenytoin(oral solution) Sources: https://pubmed.ncbi.nlm.nih.gov/4032274	unhealthy, 18 - 65 years n = 16 Health Status: unhealthy Age Group: 18 - 65 years Sex: M+F Population Size: 16 Sources: https://pubmed.ncbi.nlm.nih.gov/4032274
Mental disorder NOS	severe, 2 patients	41.4 g 2 times / day multiple, oral Dose: 41.4 g, 2 times / day Route: oral Route: multiple Dose: 41.4 g, 2 times / day Co-administed with:: sodium phenytoin(oral solution) Sources: https://pubmed.ncbi.nlm.nih.gov/4032274	unhealthy, 18 - 65 years n = 6 Health Status: unhealthy Age Group: 18 - 65 years Sex: M+F Population Size: 6 Sources: https://pubmed.ncbi.nlm.nih.gov/4032274

Overview

CYP3A4	CYP2C9	CYP2D6	hERG

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
CYP2E1 882 CYP1A2 1524

Drug as perpetrator

Target	Modality	Activity	Metabolite	Clinical evidence
CYP2E1 970	inhibitor 3277 Sources: https://pubmed.ncbi.nlm.nih.gov/8004132/;https://pubmed.ncbi.nlm.nih.gov/7479582/	likely		yes (co-administration study) Comment: Can't find IC50/Ki values;Propylene glycol inhibited the activity of CYP2El as indicated by 84% reduction in the clearance of 3 mg/kg dose of chlorzoxazone Sources: https://pubmed.ncbi.nlm.nih.gov/8004132/;https://pubmed.ncbi.nlm.nih.gov/7479582/
CYP1A2 1692	inhibitor 3277 Sources: https://pubmed.ncbi.nlm.nih.gov/7479582/ Page: 4.0	no

Sourcing

Vendor/Aggregator	ID	URL
001 Chemical	DY20330	https://www.001chemical.com/chem/4254-14-2
001 Chemical	DY554323	https://www.001chemical.com/chem/4254-15-3
001 Chemical	DY561043	https://www.001chemical.com/chem/57-55-6
3B Scientific (Wuhan) Corp	3B4-0065	http://www.3bsc.com/index/pro_info.php?id=17913
3B Scientific (Wuhan) Corp	3B4-0066	http://www.3bsc.com/index/pro_info.php?id=17914
3B Scientific (Wuhan) Corp	3B4-0067	http://www.3bsc.com/index/pro_info.php?id=17915
3B Scientific (Wuhan) Corp	3B4-0068	http://www.3bsc.com/index/pro_info.php?id=17916
3B Scientific (Wuhan) Corp	3B4-2726	http://www.3bsc.com/index/pro_info.php?id=77360
AA Blocks	AA0032I6	http://www.aablocks.com/goods/Goods/detail?id=AA0032I6
AK Scientific, Inc. (AKSCI)	67773	http://www.aksci.com/item_detail.php?cat=67773
AK Scientific, Inc. (AKSCI)	69522	http://www.aksci.com/item_detail.php?cat=69522
Aaron Chemicals	AR00339Y	http://www.aaronchem.com/57-55-6
Acadechem	ACDX-012553	http://acadechemical.com/product/87277
Acadechem	ACDS-021184	http://www.acadechemical.com/product/95883
Accela ChemBio Inc	SY003769	http://www.accelachem.com/cn/search.html?keyword=SY003769&attname=GoodsCode
Accela ChemBio Inc	SY003770	http://www.accelachem.com/cn/search.html?keyword=SY003770&attname=GoodsCode
Achemica	ACMC-209jq5	http://www.achemica.com/prodinfo/?id=127691
Achemica	ACMC-1AMKJ	http://www.achemica.com/prodinfo/?id=12896
Achemica	ACMC-209jq6	http://www.achemica.com/prodinfo/?id=20300
Achemtek	0104-007743	http://www.achemtek.com/57-55-6
Acros Organics	AC220870010	https://www.fishersci.com/shop/products/1-2-propanediol-99-analysis-acros-organics-1/AC220870010
Acros Organics	AC220870025	https://www.fishersci.com/shop/products/1-2-propanediol-99-analysis-acros-organics-1/AC220870025
Acros Organics	AC158720010	https://www.fishersci.com/shop/products/1-2-propanediol-99-extra-pure-acros-organics/AC158720010
Acros Organics	AC158720025	https://www.fishersci.com/shop/products/1-2-propanediol-99-extra-pure-acros-organics/AC158720025
Acros Organics	AC158720250	https://www.fishersci.com/shop/products/1-2-propanediol-99-extra-pure-acros-organics/AC158720250
Alfa Aesar	30948	https://www.alfa.com/en/catalog/030948/
Alfa Aesar	A18406	https://www.alfa.com/en/catalog/A18406/
Alfa Chemistry	AP57556	https://reagents.alfa-chemistry.com/product/propylene-glycol-cas-57-55-6-13384.html
Alfa Chemistry	123120-98-9	https://www.alfa-chemistry.com/cas_123120-98-9.htm
Alfa Chemistry	57-55-6	https://www.alfa-chemistry.com/propylene-glycol-cas-57-55-6-item-292736.htm
Alichem	490018556	http://www.alichem.com/en/products/57-55-6.html
Anward	ANW-49390	http://www.anward.com/pro_result/35841
Ark Pharm	AK158454	http://www.arkpharminc.com/products/4254-14-2.html
Ark Pharm	AK111153	http://www.arkpharminc.com/products/4254-15-3.html
Ark Pharm	AK-46689	http://www.arkpharminc.com/products/57-55-6.html
Avantor Inc	101183-798	https://us.vwr.com/store/catalog/product.jsp?catalog_number=101183-798
Avantor Inc	101223-542	https://us.vwr.com/store/catalog/product.jsp?catalog_number=101223-542
Avantor Inc	101225-304	https://us.vwr.com/store/catalog/product.jsp?catalog_number=101225-304
Avantor Inc	101226-554	https://us.vwr.com/store/catalog/product.jsp?catalog_number=101226-554
Avantor Inc	200001-396	https://us.vwr.com/store/product/7515827/1-2-propanediol-99-extra-pure
BLD Pharm	BD01089935	http://www.bldpharm.com/products/25322-69-4.html
BLD Pharm	BD01094278	http://www.bldpharm.com/products/25322-69-4.html
BLD Pharm	BD01108102	http://www.bldpharm.com/products/25322-69-4.html
BLD Pharm	BD148603	http://www.bldpharm.com/products/25322-69-4.html
BLD Pharm	BD149321	http://www.bldpharm.com/products/57-55-6.html
BioChemPartner	BCP23677	http://www.biochempartner.com/57-55-6-BCP23677
BioSynth	J-502273	https://www.biosynth.com/en/products/all-products/products/J-502273.html
BroadPharm	BP-21014	http://www.broadpharm.com/web/product.php?catalog=BP-21014
CSNpharm	CSN23611	https://www.csnpharm.com/products/1,2-propanediol.html
Chem Scene	CS-0015917	http://www.chemscene.com/57-55-6.html
ChemMol	49425895	http://www.chemmol.com/chemmol/49425895.html
ChemMol	99111243	http://www.chemmol.com/chemmol/99111243.html
ChemMol	99184080	http://www.chemmol.com/chemmol/99184080.html
Chemenu	CM115918	http://www.chemenu.com/products/CM115918
Chemspace	CSSB00000214687	https://chem-space.com/CSSB00000214687
China MainChem Co., Ltd	57-55-6	https://www.mainchem.com/product/china-propylene-glycol-cas-57-55-6-supplier/
Clearsynth	CS-EB-01807	https://www.clearsynth.com/en/CSEB01807.html
Clearsynth	CS-ER-01799	https://www.clearsynth.com/en/CSER01799.html
Debye Scientific	DB-013280	http://www.debyesci.com/cas_4254-14-2.html
Enamine	Z1939437503	https://www.enaminestore.com/catalog/Z1939437503
Finetech	FT-0605030	http://www.finetechnology-ind.com/prod/detail/pub/4254-14-2.html
Finetech	FT-0605236	http://www.finetechnology-ind.com/prod/detail/pub/4254-15-3.html
Finetech	FT-0606483	http://www.finetechnology-ind.com/prod/detail/pub/57-55-6.html
Fisher Chemical	P3551	https://www.fishersci.com/shop/products/propylene-glycol-usp-fcc-fisher-chemical-7/p-187807
Fisher Chemical	P35520	https://www.fishersci.com/shop/products/propylene-glycol-usp-fcc-fisher-chemical-7/p-187807
Fisher Chemical	P355200	https://www.fishersci.com/shop/products/propylene-glycol-usp-fcc-fisher-chemical-7/p-187807
Fisher Chemical	P3554	https://www.fishersci.com/shop/products/propylene-glycol-usp-fcc-fisher-chemical-7/p-187807
Glentham Life Sciences	GK2653	http://www.glentham.com/products/product/GK2653/
Hairui	HR134690	http://www.hairuichem.com/en/product/57-55-6.html
LGC Standards	DRE-A16405200AL-100	https://www.lgcstandards.com/US/en/p/DRE-A16405200AL-100
LGC Standards	DRE-C16405200	https://www.lgcstandards.com/US/en/p/DRE-C16405200
LGC Standards	MM1481.00	https://www.lgcstandards.com/US/en/p/MM1481.00
Lab Network	LN00194149	https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN00194149
Matrix Scientific	203032	https://www.matrixscientific.com/203032.html
MedChem Express	HY-Y0921	https://www.medchemexpress.com/__plusmn__-1,2-Propanediol.html
Molcore	MC20330	https://www.molcore.com/product/4254-14-2
Molcore	MC554323	https://www.molcore.com/product/4254-15-3
Molcore	MC561043	https://www.molcore.com/product/57-55-6
MuseChem	M017837	https://www.musechem.com/product/M017837.html
MuseChem	R022211	https://www.musechem.com/product/R022211.html
Oakwood	492646	http://www.oakwoodchemical.com/ProductsList.aspx?CategoryID=-2&txtSearch=164783&ExtHyperLink=1
Parchem	17032	http://www.parchem.com/chemical-supplier-distributor/JEFFCOOL-P150-007032.aspx
Parchem	16853	http://www.parchem.com/chemical-supplier-distributor/Propylene-Glycol-50-50-006853.aspx
Parchem	13008	http://www.parchem.com/chemical-supplier-distributor/Propylene-Glycol-Industrial-Grade-003008.aspx
Parchem	17805	http://www.parchem.com/chemical-supplier-distributor/Propylene-Glycol-Reagent-Grade-007805.aspx
Parchem	10450	http://www.parchem.com/chemical-supplier-distributor/Propylene-Glycol-USP-000450.aspx
Renno Tech	RP18353	http://www.rennotech.com/product_show.asp?id=24159
Sigma-Aldrich	24-6170_SAJ	https://www.sigmaaldrich.com/catalog/product/saj/246170?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	12279_SIAL	https://www.sigmaaldrich.com/catalog/product/sial/12279?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	134368_SIAL	https://www.sigmaaldrich.com/catalog/product/sial/134368?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	16033_SIAL	https://www.sigmaaldrich.com/catalog/product/sial/16033?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	1576708_USP	https://www.sigmaaldrich.com/catalog/product/usp/1576708?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sinfoo Biotech	S005527	http://www.sinfoobiotech.com/product/1008925
Smolecule	S597487	https://www.smolecule.com/products/s597487
TCI (Tokyo Chemical Industry)	P0485	http://www.tcichemicals.com/eshop/en/us/commodity/P0485/index.html
THE BioTek	bt-315133	https://www.thebiotek.com/product/others/bt-315133
VladaChem	VL144020	https://www.vladachem.com/product.php?products=57-55-6
VladaChem	VL160667	https://www.vladachem.com/product.php?products=57-55-6
VladaChem	VL280485-1L	https://www.vladachem.com/product.php?products=57-55-6
VladaChem	VL281092-100ML	https://www.vladachem.com/product.php?products=57-55-6
abcr GmbH	AB120921	http://www.abcr.com/shop/en/AB120921
abcr GmbH	AB207089	http://www.abcr.com/shop/en/AB207089
iChemical	EBD2202702	http://www.ichemical.com/products/57-55-6.html?utm_source=PubChem&utm_medium=website&utm_campaign=product%20catalogs
mcule	MCULE-5574440784	https://mcule.com/MCULE-5574440784/

PubMed

Title	Date	PubMed
Practical production of (S)-1,2-propanediol and its derivative through baker's yeast-mediated reduction.	2001	16233034
Enantiomeric separation of N-protected amino acids by non-aqueous capillary electrophoresis with dimeric forms of quinine and quinidine derivatives serving as chiral selectors.	2002 Mar 1	12831205
Stereoselective oxidation of aliphatic diols and reduction of hydroxy-ketones with galactitol dehydrogenase from Rhodobacter sphaeroides D.	2003	15296184
Freezing monolayers of cells without gap junctions.	2003 Apr	12686210
Vitrification of ECV304 cell suspensions using solutions containing propane-1,2-diol and trehalose.	2003 Apr	12686203
A practical and scaleable synthesis of A-224817.0, a novel nonsteroidal ligand for the glucocorticoid receptor.	2003 Apr 18	12688796
[Study on the toxicological effect of chloropropanols on rats].	2003 Jul	14535099
Alternative liquid chromatographic method for determination of the methoxyl and 2-hydroxypropoxyl content in cellulose ether derivatives.	2003 Jul-Aug	14509426
Cryopreservation of cornea: a low cooling rate improves functional survival of endothelium after freezing and thawing.	2003 Jun	12818218
Structural rationalization for the lack of stereospecificity in coenzyme B12-dependent diol dehydratase.	2003 Jun 20	12684496
The epimeric 9-oxobicyclo[3.3.1]nonane-3-carboxylic acids: hydrogen-bonding patterns of the endo acid and the lactol of the exo acid.	2003 Mar	12711798
Determination of the dermal penetration of esterom components using microdialysis sampling.	2003 Nov	14661928
Enantiospecific synthesis of the phospholipase A2 inhibitors (-)-cinatrin C1 and (+)-cinatrin C3.	2003 Oct 21	14599020
Protein content of polyhedral organelles involved in coenzyme B12-dependent degradation of 1,2-propanediol in Salmonella enterica serovar Typhimurium LT2.	2003 Sep	12923081
Conversion of 2-deoxy-D-ribose into 2-amino-5-(2-deoxy-beta-D-ribofuranosyl)pyridine, 2'-deoxypseudouridine, and other C-(2'-deoxyribonucleosides).	2003 Sep 21	14527147
Effect of chronic ritonavir administration on pregnant rats and their fetuses.	2004	15491071
Aglacins I-K, three highly methoxylated lignans from Aglaia cordata.	2004 Apr	15104504
Highly stereoselective intermolecular oxy-michael addition reaction to alpha,beta-unsaturated malonate esters.	2004 Apr 29	15101741
Impaired endothelial function in young women with premature ovarian failure: normalization with hormone therapy.	2004 Aug	15292326
Sevoflurane promotes endothelium-dependent smooth muscle relaxation in isolated human omental arteries and veins.	2004 Aug	15271717
Chiral ligand exchange capillary electrophoresis using borate anion as a central ion.	2004 Dec	15565225
Vitrification of pronuclear-stage mouse embryos on solid surface (SSV) versus in cryotube: comparison of the effect of equilibration time and different sugars in the vitrification solution.	2004 Feb	14694434
Scintigraphic sign of functional biliary obstruction is pathognomic for sphincter of Oddi dysfunction.	2004 Jan-Feb	15011834
Simultaneous XRD-DSC measurements of water-2-propanol at sub-zero temperatures.	2004 Jul	15293406
In vitro-in vivo characterization of release modifying agents for parenteral sustained-release ketorolac formulation.	2004 Jul	15285335
Synthesis of optically pure (+)-puraquinonic acid and assignment of absolute configuration to natural (-)-puraquinonic acid. Use of radical cyclization for asymmetric generation of a quaternary center.	2004 Jun 11	15176837
Expression of connexins in human preimplantation embryos in vitro.	2004 Jun 2	15175102
Close association of endothelial dysfunction with insulin resistance and carotid wall thickening in hypertension.	2004 Mar	15001196
Fermentative production of chemicals that can be used for polymer synthesis.	2004 Mar 15	15468205
Structure-activity relationships of a novel class of endothelin receptor selective antagonists; 6-carboxy-2-isopropylamino-5,7-diarylcyclopenteno[1,2-b]pyridines.	2004 Mar 22	15006391
Glycosidase-inhibiting pyrrolidines and pyrrolizidines with a long side chain in Scilla peruviana.	2004 May	15165148
Unprovoked and glyceryl trinitrate-provoked head-up tilt table test is safe in older people: a review of 10 years' experience.	2004 Nov	15507071
Endothelial nitric oxide synthase and methylenetetrahydrofolate reductase gene polymorphisms are associated with endothelial dysfunction in young, healthy men.	2004 Oct	15494775
Highly stereoselective oxy-Michael additions to alpha,beta-disubstituted nitro olefins: asymmetric synthesis of pseudo-norephedrine derivatives and THP* protected alpha-hydroxy ketones.	2004 Oct 21	15480457
Effects of cyclooxygenase inhibition on endothelial function in hypertensive patients treated with angiotensin-converting enzyme inhibitors.	2004 Sep	15471166
Pregnancies and births after oocyte cryopreservation.	2004 Sep	15374702
Metabolites in ventricular cerebrospinal fluid detected by proton magnetic resonance spectroscopic imaging.	2004 Sep	15332258
Design of oligolactone-based scaffolds for bone tissue engineering.	2005	15623932
Two (+)-alpha,4-dimethyl-2-oxocyclohexaneacetic acids: hydrogen bonding in a terpenoid gamma-keto acid and in a diastereomeric lactol.	2005 Apr	15805642
Design of low-toxic and temperature-sensitive anionic microemulsions using short propyleneglycol alkyl ethers as cosurfactants.	2005 Aug 30	16114914
Pentane-1,5-diol as a percutaneous absorption enhancer.	2005 Dec	16215760
Identification of the 1,2-propanediol-1-yl radical as an intermediate in adenosylcobalamin-dependent diol dehydratase reaction.	2005 Feb 15	15697237
A chemoenzymatic total synthesis of the undecenolide (-)-cladospolide B via a mid-stage ring-closing metathesis and a late-stage photo-rearrangement of the E-isomer.	2005 Mar 21	15750652
Novel approach for classifying chemicals according to skin sensitizing potency by non-radioisotopic modification of the local lymph node assay.	2005 Mar-Apr	15744759
Are all aciclovir cream formulations bioequivalent?	2005 Nov 4	16139970
Patch testing with patients' own cosmetics and toiletries--results of the IVDK*, 1998-2002.	2005 Oct	16191021
The diazo route to diazonamide A: studies on the tyrosine-derived fragment.	2005 Oct 21	16211117
Virucidal activity of a new hand disinfectant with reduced ethanol content: comparison with other alcohol-based formulations.	2006 Jan	16307826
Bifunctional compounds eliciting anti-inflammatory and anti-cholinesterase activity as potential treatment of nerve and blister chemical agents poisoning.	2006 Jan-Feb	16167317
Modulation of the rheological and mucoadhesive properties of thermosensitive poloxamer-based hydrogels intended for the rectal administration of quinine.	2006 Mar	16356700

Patents

Sample Use Guides

In Vivo Use Guide

Instill 1 or 2 drops in the affected eye(s) as needed.

Route of Administration: Topical

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:20:47 GMT 2023` Edited by `admin` on `Fri Dec 15 15:20:47 GMT 2023`
Record UNII	6DC9Q167V3
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PROPYLENE GLYCOL

Official Name

English

ISOPROPYLENE GLYCOL

Common Name

English

PROPYLENE GLYCOL [FCC]

Common Name

English

1,2-PROPANEDIOL

Systematic Name

English

PROPYLENE GLYCOL [INCI]

Common Name

English

PROPYLENE GLYCOL [MI]

Common Name

English

PROPYLENE GLYCOL [USP MONOGRAPH]

Common Name

English

PROPYLENE GLYCOL [VANDF]

Common Name

English

KOLLISOLV PG

Brand Name

English

GLYCEROL IMPURITY C [EP IMPURITY]

Common Name

English

INS-1520

Common Name

English

NSC-69860

Code

English

PROPYLENE GLYCOL [HSDB]

Common Name

English

PROPYLENE GLYCOL [MART.]

Common Name

English

(2RS)-PROPANE-1,2-DIOL

Systematic Name

English

PROPYLENE GLYCOL [FHFI]

Common Name

English

FEMA NO. 2940

Code

English

PROPYLENE GLYCOL (SOLVENT)

Common Name

English

PROPANEDIOL-

Systematic Name

English

MONOPROPYLENE GLYCOL

Systematic Name

English

PROPYLENE GLYCOL [USP-RS]

Common Name

English

PROPYLENE GLYCOL [WHO-IP]

Common Name

English

PROPYLENE GLYCOL [II]

Common Name

English

E-1520

Common Name

English

PROPYLENE GLYCOL (SOLVENT) [VANDF]

Common Name

English

(±)-1,2-PROPANEDIOL

Systematic Name

English

METHYL GLYCOL

Common Name

English

PROPYLENEGLYCOLUM [WHO-IP LATIN]

Common Name

English

1,2-PROPYLENE GLYCOL

Systematic Name

English

Propylene glycol [WHO-DD]

Common Name

English

KILFROST ABC-S

Brand Name

English

PROPYLENE GLYCEROL

Systematic Name

English

PROPYLENE GLYCOL [EP MONOGRAPH]

Common Name

English

PROPYLENE GLYCOL [JAN]

Common Name

English

PROPYLENE GLYCOL DL-FORM [MI]

Common Name

English

INS NO.1520

Common Name

English

Classification Tree Code System Code

CODEX ALIMENTARIUS (GSFA)

INS-1520