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Details

Stereochemistry ACHIRAL
Molecular Formula Cd
Molecular Weight 112.411
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CADMIUM

SMILES

[Cd]

InChI

InChIKey=BDOSMKKIYDKNTQ-UHFFFAOYSA-N
InChI=1S/Cd

HIDE SMILES / InChI

Molecular Formula Cd
Molecular Weight 112.411
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Cadmium is a chemical element with symbol Cd and atomic number 48. Its most common oxidation state is +2. Cadmium has no known biological function in higher organisms, but a cadmium-dependent carbonic anhydrase has been found in marine diatoms. In humans, the highest concentration of cadmium is absorbed by the kidneys and up to 30 mg of cadmium is commonly inhaled during childhood and adolescence. Cadmium is under preliminary research for its toxicity in humans, potentially contributing to risks of cancer, cardiovascular disease, and osteoporosis. The most risk of cadmium toxicity is from industrial exposure to inhalation of dust and fumes, or ingestion of soluble cadmium compounds.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
PubMed

PubMed

TitleDatePubMed
Cadmium induces conformational modifications of wild-type p53 and suppresses p53 response to DNA damage in cultured cells.
1999 Oct 29
Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene.
1999 Sep 10
Disruption of dioxin-inducible phase I and phase II gene expression patterns by cadmium, chromium, and arsenic.
2000 Aug
Cadmium blocks hypoxia-inducible factor (HIF)-1-mediated response to hypoxia by stimulating the proteasome-dependent degradation of HIF-1alpha.
2000 Jul
Cadmium mutagenicity and human nucleotide excision repair protein XPA: CD, EXAFS and (1)H/(15)N-NMR spectroscopic studies on the zinc(II)- and cadmium(II)-associated minimal DNA-binding domain (M98-F219).
2000 May
Coronary microvascular endothelial cells cosecrete angiotensin II and endothelin-1 via a regulated pathway.
2000 Sep
Cadmium-induced cell transformation and tumorigenesis are associated with transcriptional activation of c-fos, c-jun, and c-myc proto-oncogenes: role of cellular calcium and reactive oxygen species.
2001 Jun
Alteration of cadmium-induced mutational spectrum by catalase depletion in Chinese hamster ovary-K1 cells.
2001 Nov 15
Bisphenol A enhances cadmium toxicity through estrogen receptor.
2001 Sep
Cadmium exposure decreases androgen-dependent metabolism of acetohexamide in liver microsomes of male rats through its testicular toxicity.
2002 Feb
Attenuation of both apoptotic and necrotic actions of cadmium by Bcl-2.
2002 Jan
Role of a copper-specific metallothionein of the blue crab, Callinectes sapidus, in copper metabolism associated with degradation and synthesis of hemocyanin.
2002 Jan 15
N-acetylcysteine and celecoxib lessen cadmium cytotoxicity which is associated with cyclooxygenase-2 up-regulation in mouse neuronal cells.
2002 Jul 12
White-sided dolphin metallothioneins: purification, characterisation and potential role.
2002 Mar
Upregulation of stress response mRNAs in COS-7 cells exposed to cadmium.
2002 May 24
Protective influence of vitamin E on antioxidant defense system in the blood of rats treated with cadmium.
2003
Tissue-dependent induction of heme oxygenase-1 and metallothionein-1/2 by methyl methanesulfonate.
2003 Aug
Regulation of metallothionein and zinc transporter expression in human prostate cancer cells and tissues.
2003 Oct 28
Upregulation of heme oxygenase-1 and p21 confers resistance to apoptosis in human gastric cancer cells.
2004 Jan 15
Diversity of metallothioneins in the American oyster, Crassostrea virginica, revealed by transcriptomic and proteomic approaches.
2004 May
Patents

Sample Use Guides

Rats were intravenously administered doses of 1.34, 2.67, 4.01 mg/kg of Cadmium fluoride. The 24 hour LD50 was determined to be 3.29 mg/kg with severe hepatocellular injury and acute renal failure recorded at 2.67 mg/kg. At doses of 4.01 mg/ kg and higher, there was a marked increase in serum potassium and metabolic acidosis as well as AST and ALT activities greater the 1,500 IU/L.
Route of Administration: Intravenous
Human keratinocyte HACAT cells were cultured at 37 deg-C in a 5% CO2 atmosphere in RPMI1640 medium containing 10% FCS, 5000 U/mL penicillin and 2 mM L-glutamine. Cadmium chloride was prepared in distilled water and added to the culture medium to obtain final concentrations of 15, 50, and 100 micro-M. Cell cultures were then incubated for 24 hours then analyzed for apoptotic DNA fragmentation, Caspase-9 activity, Caspase-3 activity, p53 activation, cellular content, and other protein expression levels. Cadmium did not induce apoptotic cell death nor did it increase caspase-9 or caspase-3 activity in HaCaT cells. When HaCaT cells were also treated with 9 micro-g/mL of p553 activator and 100 micro-M Cadmium there was a significant reduction in cell viability from 54% to 28%.
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:33:31 UTC 2023
Edited
by admin
on Fri Dec 15 16:33:31 UTC 2023
Record UNII
00BH33GNGH
Record Status Validated (UNII)
Record Version
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Name Type Language
CADMIUM
HSDB   MART.   MI   WHO-DD  
Systematic Name English
CADMIUM, ELEMENTAL
Common Name English
ELEMENTAL CADMIUM
Common Name English
CADMIUM [MI]
Common Name English
CADMIUM METALLICUM
HPUS  
Common Name English
CI 77180
Common Name English
C.I. 77180
Common Name English
CADMIUM [HSDB]
Common Name English
CADMIUM AND CADMIUM COMPOUNDS [IARC]
Common Name English
Cadmium [WHO-DD]
Common Name English
CADMIUM [MART.]
Common Name English
CADMIUM METALLICUM [HPUS]
Common Name English
CD
Code English
CADMIUM METAL
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C637
Created by admin on Fri Dec 15 16:33:31 UTC 2023 , Edited by admin on Fri Dec 15 16:33:31 UTC 2023
DSLD 544 (Number of products:8)
Created by admin on Fri Dec 15 16:33:31 UTC 2023 , Edited by admin on Fri Dec 15 16:33:31 UTC 2023
NCI_THESAURUS C45383
Created by admin on Fri Dec 15 16:33:31 UTC 2023 , Edited by admin on Fri Dec 15 16:33:31 UTC 2023
WHO-ATC D11AC02
Created by admin on Fri Dec 15 16:33:31 UTC 2023 , Edited by admin on Fri Dec 15 16:33:31 UTC 2023
Code System Code Type Description
HSDB
282
Created by admin on Fri Dec 15 16:33:31 UTC 2023 , Edited by admin on Fri Dec 15 16:33:31 UTC 2023
PRIMARY
CAS
7440-43-9
Created by admin on Fri Dec 15 16:33:31 UTC 2023 , Edited by admin on Fri Dec 15 16:33:31 UTC 2023
PRIMARY
PUBCHEM
23973
Created by admin on Fri Dec 15 16:33:31 UTC 2023 , Edited by admin on Fri Dec 15 16:33:31 UTC 2023
PRIMARY
ECHA (EC/EINECS)
231-152-8
Created by admin on Fri Dec 15 16:33:31 UTC 2023 , Edited by admin on Fri Dec 15 16:33:31 UTC 2023
PRIMARY
MERCK INDEX
m2888
Created by admin on Fri Dec 15 16:33:31 UTC 2023 , Edited by admin on Fri Dec 15 16:33:31 UTC 2023
PRIMARY Merck Index
WIKIPEDIA
Cadmium
Created by admin on Fri Dec 15 16:33:31 UTC 2023 , Edited by admin on Fri Dec 15 16:33:31 UTC 2023
PRIMARY
RXCUI
1362694
Created by admin on Fri Dec 15 16:33:31 UTC 2023 , Edited by admin on Fri Dec 15 16:33:31 UTC 2023
PRIMARY RxNorm
DAILYMED
00BH33GNGH
Created by admin on Fri Dec 15 16:33:31 UTC 2023 , Edited by admin on Fri Dec 15 16:33:31 UTC 2023
PRIMARY
CHEBI
22977
Created by admin on Fri Dec 15 16:33:31 UTC 2023 , Edited by admin on Fri Dec 15 16:33:31 UTC 2023
PRIMARY
SMS_ID
300000008080
Created by admin on Fri Dec 15 16:33:31 UTC 2023 , Edited by admin on Fri Dec 15 16:33:31 UTC 2023
PRIMARY
NCI_THESAURUS
C44348
Created by admin on Fri Dec 15 16:33:31 UTC 2023 , Edited by admin on Fri Dec 15 16:33:31 UTC 2023
PRIMARY
DRUG BANK
DB14085
Created by admin on Fri Dec 15 16:33:31 UTC 2023 , Edited by admin on Fri Dec 15 16:33:31 UTC 2023
PRIMARY
MESH
D002104
Created by admin on Fri Dec 15 16:33:31 UTC 2023 , Edited by admin on Fri Dec 15 16:33:31 UTC 2023
PRIMARY
EPA CompTox
DTXSID1023940
Created by admin on Fri Dec 15 16:33:31 UTC 2023 , Edited by admin on Fri Dec 15 16:33:31 UTC 2023
PRIMARY
FDA UNII
00BH33GNGH
Created by admin on Fri Dec 15 16:33:31 UTC 2023 , Edited by admin on Fri Dec 15 16:33:31 UTC 2023
PRIMARY
Related Record Type Details
PARENT -> CONSTITUENT ALWAYS PRESENT
CADMIUM (ng/cigarette) Canadian = 929.7 SD(201.8) Imported = 765.8 SD(69.8)
Related Record Type Details
ACTIVE MOIETY