Octyldodecanol is a long chain fatty alcohol. It is a medium spreading emollient which is due to its chemical structure hydrolysis stable and therefore beneficially suitable for all formulations where a wide pH range is needed e.g. deo/antiperspirant and hair remover formulations. It is an emulsifier and opacifying agent, used primarily as a thickener in moisturizers because of its lubricating and emollient properties in the formulation of skin care products. Octyldodecanol is approved by ECOCERT for Natural and Organic Cosmetics.

Carminic acid is a natural compound extracted from cochineal insects, such as the cochineal, Armenian cochineal, and Polish cochineal. . The chromophore in this molecule is the conjugated pi system extending across the central anthraquinone ring system. Carminic acid can combine with various metals to form the pigment carmine.2 In industry, it is commonly complexed with aluminum to produce a purple/pink precipitate (with calcium as a counterion). Carmine’s color differs depending on the metal it is complexed to. For centuries, carminic acid and carmine have been used as dyes. The source material is cochineal, a blood-like fluid found within the cochineal insect. Currently, carminic acid and carmine have a multitude of applications in the modern world. They are used as nontoxic food additives and biological stains and are finding new uses as electrochemical modifiers and photosensitizers.

Betiatide (CAS 103725-47-9; aka S-benzoylmercapto¬acetyltriglycine or 2-[[2-[[2-[(2-benzoylsulfanylacetyl)¬amino]¬acetyl]¬amino]¬acetyl]¬amino] acetic acid) is the API in TechneScan MAG3™; a kit for the preparation of technetium Tc 99m mertiatide. It is used in the diagnosis of congenital and acquired abnormalities, renal failure, urinary tract obstruction and calculi. Furthermore it is used in providing renal function, split function, renal angiograms and renogram curves for whole kidney and renal cortex. Betiatide is light sensitive and must be protected as such.

Sorbitan Trioleate (Tween 85) is a triester of oleic acid and hexitol anhydrides derived from sorbitol. It functions as a surfactant and emulsifying agent. This product is a white to tan-colored solid. In cosmetics and personal care products, Sorbitan Esters are used in a variety of products including skin care products, skin cleansing products, moisturizers, eye makeup and other makeup.

Mebrofenin is a chelating component which, when attached to Technetium TC-99M, forms a diagnostic drug marketed under the name Choletec. Choletec is approved by FDA as a hepatobiliary imaging agent.

Dibutyl phthalate (DBP) is used to help make plastics soft and flexible. It is used in shower curtains, raincoats, food wraps, bowls, car interiors, vinyl fabrics, floor tiles, and other products. Animal studies have reported developmental and reproductive effects from oral exposure. Dibutyl phthalate (DBP) is classified as a substance toxic to reproduction. No information is available on the carcinogenic effects of dibutyl phthalate in humans or animals. Treatment with dibutyl phthalate enhanced Aryl Hydrocarbon Receptor mRNA expression, which was reflected by the increased AhR protein level. ERα, ERβ, and PPARγ antagonists stimulated DBP-induced caspase-3 and LDH activities. AhR is involved in DBP-induced apoptosis and neurotoxicity, while the ERs and PPARγ signaling pathways are impaired by the phthalate. In vitro test showed that DBP killed all Demodex mites within 1 hour. Dibutyl phthalate emulsion is promising to be developed as a safe, effective therapeutic medicament on demodicidosis.

1,4-Sorbitan is a sorbitol anhydration product. 1,4-Sorbitan is a precursor to environmentally benign surfactants. It is a component of Sorbitol-Sorbitan mixtures used as soft gel plasticizers. They enhance the soft gelatin capsule finish gloss for a premium appearance, help to prevent leakage, provide consistent pharmaceutical quality, and extend shelf life by maintaining a proper moisture balance within the capsule shell.

Sorbitan monopalmitate (Span 40) is a nonionic emulsifier, surfactant and food additive. The product of Croda Inc. Span 40 is used in skin care, hair care and decorative cosmetics. It is also used as an effector in compositions capable of facilitating penetration across a biological barrier. Inactive ingredient of some medications it improves transdermal delivery of drugs and is a potential carrier for topical drug delivery. In PLIAGLIS cream (lidocaine and tetracaine) sorbitan monopalmitate is used as an inactive ingredient. Sorbitan monopalmitate is a fatty acid sorbitan ester, yellowish brown wax, slightly soluble in isopropanol, xylene and liquid paraffin, insoluble in water, non-toxic.