SORBITAN MONOPALMITATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C22H42O6
Molecular Weight	402.5653
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]1(OC[C@H](O)[C@H]1O)[C@H](O)COC(=O)CCCCCCCCCCCCCCC

InChI

InChIKey=IYFATESGLOUGBX-YVNJGZBMSA-N

InChI=1S/C22H42O6/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-20(25)27-17-19(24)22-21(26)18(23)16-28-22/h18-19,21-24,26H,2-17H2,1H3/t18-,19+,21+,22+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C22H42O6
Molecular Weight	402.5653
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/cfrsearch.cfm?fr=178.3400
Curator's Comment: Description was created using several sources including: https://www.ulprospector.com/en/na/PersonalCare/Detail/134/37087/Span-40; http://www.irochemical.com/product/Surfactants/Span-40.htm; http://www.ervesa.com/index.php/home/83-products/123-e495-sorbitan-monopalmitat; http://www.ncbi.nlm.nih.gov/pubmed/15824032; http://www.rxlist.com/pliaglis-drug.htm; http://patft.uspto.gov/netacgi/nph-Parser?d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=8241670.PN.&OS=PN/8241670&RS=PN/8241670

Sorbitan monopalmitate (Span 40) is a nonionic emulsifier, surfactant and food additive. The product of Croda Inc. Span 40 is used in skin care, hair care and decorative cosmetics. It is also used as an effector in compositions capable of facilitating penetration across a biological barrier. Inactive ingredient of some medications it improves transdermal delivery of drugs and is a potential carrier for topical drug delivery. In PLIAGLIS cream (lidocaine and tetracaine) sorbitan monopalmitate is used as an inactive ingredient. Sorbitan monopalmitate is a fatty acid sorbitan ester, yellowish brown wax, slightly soluble in isopropanol, xylene and liquid paraffin, insoluble in water, non-toxic.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Pain 614 Sources: https://www.rxlist.com/pliaglis-drug/patient-images-side-effects.htm	Inactive ingredient		Approved 8429	PLIAGLIS Approved Use Pliaglis is indicated for use on intact skin in adults to provide topical local analgesia for superficial dermatological procedures such as dermal filler injection, pulsed dye laser therapy, facial laser resurfacing, and laser-assisted tattoo removal.

PubMed

Title	Date	PubMed
Crystallization kinetics of cocoa butter in the presence of sorbitan esters.	2017 Jan 1	27507503

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

10% sorbitan monopalmitate added to the ointment significantly increased percutaneous absorption of sodium salicylate determined from blood levels in New Zealand white rabbits at regular intervals for 8 hr following application of the ointment.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:00:52 GMT 2023` Edited by `admin` on `Fri Dec 15 15:00:52 GMT 2023`
Record UNII	77K6Z421KU
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SORBITAN MONOPALMITATE

Official Name

English

E-495

Code

English

SPAN 40

Brand Name

English

SORBITAN MONOPALMITATE [FCC]

Common Name

English

SORBITAN PALMITATE [EP MONOGRAPH]

Common Name

English

1,4-ANHYDRO-D-GLUCITOL, 6-HEXADECANOATE

Common Name

English

SORBITAN PALMITATE [INCI]

Common Name

English

ARLACEL 40

Brand Name

English

sorbitan palmitate [INN]

Common Name

English

SORBITAN PALMITATE

Official Name

English

SORBITAN, ESTERS, MONOHEXADECANOATE

Common Name

English

D-GLUCITOL, 1,4-ANHYDRO-, 6-HEXADECANOATE

Common Name

English

INS NO.495

Code

English

SORBITAN, MONOHEXADECANOATE

Common Name

English

SORBITAN MONOPALMITATE [II]

Common Name

English

SORBITAN MONOPALMITATE [USAN]

Common Name

English

INS-495

Code

English

SORBITAN PALMITATE [MART.]

Common Name

English

Classification Tree Code System Code

CODEX ALIMENTARIUS (GSFA)

INS-495