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Details

Stereochemistry ABSOLUTE
Molecular Formula C22H42O6
Molecular Weight 402.5653
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SORBITAN MONOPALMITATE

SMILES

[H][C@@]1(OC[C@H](O)[C@H]1O)[C@H](O)COC(=O)CCCCCCCCCCCCCCC

InChI

InChIKey=IYFATESGLOUGBX-YVNJGZBMSA-N
InChI=1S/C22H42O6/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-20(25)27-17-19(24)22-21(26)18(23)16-28-22/h18-19,21-24,26H,2-17H2,1H3/t18-,19+,21+,22+/m0/s1

HIDE SMILES / InChI

Molecular Formula C22H42O6
Molecular Weight 402.5653
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 4 / 4
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Sorbitan monopalmitate (Span 40) is a nonionic emulsifier, surfactant and food additive. The product of Croda Inc. Span 40 is used in skin care, hair care and decorative cosmetics. It is also used as an effector in compositions capable of facilitating penetration across a biological barrier. Inactive ingredient of some medications it improves transdermal delivery of drugs and is a potential carrier for topical drug delivery. In PLIAGLIS cream (lidocaine and tetracaine) sorbitan monopalmitate is used as an inactive ingredient. Sorbitan monopalmitate is a fatty acid sorbitan ester, yellowish brown wax, slightly soluble in isopropanol, xylene and liquid paraffin, insoluble in water, non-toxic.

Originator

Approval Year

Conditions

ConditionModalityTargetsHighest PhaseProduct
Inactive ingredient
PLIAGLIS

PubMed

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
10% sorbitan monopalmitate added to the ointment significantly increased percutaneous absorption of sodium salicylate determined from blood levels in New Zealand white rabbits at regular intervals for 8 hr following application of the ointment.
Substance Class Chemical
Record UNII
77K6Z421KU
Record Status Validated (UNII)
Record Version