MEBROFENIN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H19BrN2O5
Molecular Weight	387.226
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=CC(C)=C(Br)C(C)=C1NC(=O)CN(CC(O)=O)CC(O)=O

InChI

InChIKey=MHPZZZZLAQGTHT-UHFFFAOYSA-N

InChI=1S/C15H19BrN2O5/c1-8-4-9(2)15(10(3)14(8)16)17-11(19)5-18(6-12(20)21)7-13(22)23/h4H,5-7H2,1-3H3,(H,17,19)(H,20,21)(H,22,23)

HIDE SMILES / InChI

Description
Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=fd085485-998d-42a3-879a-b2d96cb8aed7
Curator's Comment: Description was created based on several sources, including: http://www.accessdata.fda.gov/drugsatfda_docs/label/2005/018124s013lbl.pdf

Mebrofenin is a chelating component which, when attached to Technetium TC-99M, forms a diagnostic drug marketed under the name Choletec. Choletec is approved by FDA as a hepatobiliary imaging agent.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Hepatobiliary disease 8 Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=fd085485-998d-42a3-879a-b2d96cb8aed7	Diagnostic		Approved 8429	CHOLETEC Approved Use Technetium Tc 99m Mebrofenin is indicated as a hepatobiliary imaging agent. Launch Date 1987

PubMed

Title	Date	PubMed
Quantification of hepatobiliary function as an integral part of imaging with technetium-99m-mebrofenin in health and disease.	1991 Jan	1988637
The role of IDA scintigraphy in the follow-up of liver disease in patients with cystic fibrosis.	2002 Jul	12089490

Patents

Sample Use Guides

In Vivo Use Guide

The dose range of Technetium Tc 99m Mebrofenin in the average patient (70 kg) is: 74-185 MBq (2-5mCi) for nonjaundiced patient and 111-370 MBq (3-10 mCi) for patients with serum bilirubin level greater than 1.5 mg/dL.

Route of Administration: Intravenous

In Vitro Use Guide

Human hepatocyte suspensions were preincubated in 16×100mm glass vials at 37C for 5min, then 0.1% DMSO or chemical inhibitor was added (1 min before), followed by 5uCi/ mL of Technetium Tc 99m Mebrofenin.

Name

Type

Language

MEBROFENIN

Official Name

English

MEBROFENIN [MI]

Common Name

English

mebrofenin [INN]

Common Name

English

SQ-26962

Code

English

SQ 26962

Code

English

GLYCINE, N-(2-((3-BROMO-2,4,6-TRIMETHYLPHENYL)AMINO)-2-OXOETHYL)-N-(CARBOXYMETHYL)-

Systematic Name

English

MEBROFENIN [USP-RS]

Common Name

English

[[[(3-Bromomesityl)carbamoyl]methyl]imino]diacetic acid

Systematic Name

English

MEBROFENIN [USP MONOGRAPH]

Common Name

English

MEBROFENIN [II]

Common Name

English

MEBROFENIN [USAN]

Common Name

English

Mebrofenin [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1937