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Details

Stereochemistry ACHIRAL
Molecular Formula C15H19BrN2O5
Molecular Weight 387.226
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MEBROFENIN

SMILES

CC1=CC(C)=C(Br)C(C)=C1NC(=O)CN(CC(O)=O)CC(O)=O

InChI

InChIKey=MHPZZZZLAQGTHT-UHFFFAOYSA-N
InChI=1S/C15H19BrN2O5/c1-8-4-9(2)15(10(3)14(8)16)17-11(19)5-18(6-12(20)21)7-13(22)23/h4H,5-7H2,1-3H3,(H,17,19)(H,20,21)(H,22,23)

HIDE SMILES / InChI

Molecular Formula C15H19BrN2O5
Molecular Weight 387.226
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Mebrofenin is a chelating component which, when attached to Technetium TC-99M, forms a diagnostic drug marketed under the name Choletec. Choletec is approved by FDA as a hepatobiliary imaging agent.

Originator

Approval Year

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
CHOLETEC

PubMed

Patents

Sample Use Guides

In Vivo Use Guide
The dose range of Technetium Tc 99m Mebrofenin in the average patient (70 kg) is: 74-185 MBq (2-5mCi) for nonjaundiced patient and 111-370 MBq (3-10 mCi) for patients with serum bilirubin level greater than 1.5 mg/dL.
Route of Administration: Intravenous
In Vitro Use Guide
Human hepatocyte suspensions were preincubated in 16×100mm glass vials at 37C for 5min, then 0.1% DMSO or chemical inhibitor was added (1 min before), followed by 5uCi/ mL of Technetium Tc 99m Mebrofenin.
Substance Class Chemical
Record UNII
7PV0B6ED98
Record Status Validated (UNII)
Record Version