MEBROFENIN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H19BrN2O5
Molecular Weight	387.226
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=CC(C)=C(NC(=O)CN(CC(O)=O)CC(O)=O)C(C)=C1Br

InChI

InChIKey=MHPZZZZLAQGTHT-UHFFFAOYSA-N

InChI=1S/C15H19BrN2O5/c1-8-4-9(2)15(10(3)14(8)16)17-11(19)5-18(6-12(20)21)7-13(22)23/h4H,5-7H2,1-3H3,(H,17,19)(H,20,21)(H,22,23)

HIDE SMILES / InChI

Molecular Formula	C15H19BrN2O5
Molecular Weight	387.226
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=fd085485-998d-42a3-879a-b2d96cb8aed7
Curator's Comment: Description was created based on several sources, including: http://www.accessdata.fda.gov/drugsatfda_docs/label/2005/018124s013lbl.pdf

Mebrofenin is a chelating component which, when attached to Technetium TC-99M, forms a diagnostic drug marketed under the name Choletec. Choletec is approved by FDA as a hepatobiliary imaging agent.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Hepatobiliary disease 8 Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=fd085485-998d-42a3-879a-b2d96cb8aed7	Diagnostic		Approved 8583	CHOLETEC Approved Use Technetium Tc 99m Mebrofenin is indicated as a hepatobiliary imaging agent. Launch Date 1987

PubMed

Title	Date	PubMed
The role of IDA scintigraphy in the follow-up of liver disease in patients with cystic fibrosis.	2002-07	12089490
Quantification of hepatobiliary function as an integral part of imaging with technetium-99m-mebrofenin in health and disease.	1991-01	1988637

Patents

Sample Use Guides

In Vivo Use Guide

The dose range of Technetium Tc 99m Mebrofenin in the average patient (70 kg) is: 74-185 MBq (2-5mCi) for nonjaundiced patient and 111-370 MBq (3-10 mCi) for patients with serum bilirubin level greater than 1.5 mg/dL.

Route of Administration: Intravenous

In Vitro Use Guide

Human hepatocyte suspensions were preincubated in 16×100mm glass vials at 37C for 5min, then 0.1% DMSO or chemical inhibitor was added (1 min before), followed by 5uCi/ mL of Technetium Tc 99m Mebrofenin.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:59:41 GMT 2025` Edited by `admin` on `Mon Mar 31 17:59:41 GMT 2025`
Record UNII	7PV0B6ED98
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SQ 26962

Preferred Name

English

MEBROFENIN

Official Name

English

MEBROFENIN [MI]

Common Name

English

mebrofenin [INN]

Common Name

English

SQ-26962

Code

English

GLYCINE, N-(2-((3-BROMO-2,4,6-TRIMETHYLPHENYL)AMINO)-2-OXOETHYL)-N-(CARBOXYMETHYL)-

Systematic Name

English

MEBROFENIN [USP-RS]

Common Name

English

[[[(3-Bromomesityl)carbamoyl]methyl]imino]diacetic acid

Systematic Name

English

MEBROFENIN [USP MONOGRAPH]

Common Name

English

MEBROFENIN [II]

Common Name

English

MEBROFENIN [USAN]

Common Name

English

Mebrofenin [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1937