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Details

Stereochemistry ABSOLUTE
Molecular Formula C6H12O5
Molecular Weight 164.1565
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of 1,4-SORBITAN

SMILES

[H][C@@]1(OC[C@H](O)[C@H]1O)[C@H](O)CO

InChI

InChIKey=JNYAEWCLZODPBN-JGWLITMVSA-N
InChI=1S/C6H12O5/c7-1-3(8)6-5(10)4(9)2-11-6/h3-10H,1-2H2/t3-,4+,5-,6-/m1/s1

HIDE SMILES / InChI
Molecular Formula C6H12O5
Molecular Weight 164.1565
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 4 / 4
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

1,4-Sorbitan is a sorbitol anhydration product. 1,4-Sorbitan is a precursor to environmentally benign surfactants. It is a component of Sorbitol-Sorbitan mixtures used as soft gel plasticizers. They enhance the soft gelatin capsule finish gloss for a premium appearance, help to prevent leakage, provide consistent pharmaceutical quality, and extend shelf life by maintaining a proper moisture balance within the capsule shell.

Originator

Approval Year

1986
103
PubMed

PubMed

TitleDatePubMed
Final report on the safety assessment of PEG-6, -8, and -20 sorbitan beeswax.
2001
Investigating the molecular heterogeneity of polysorbate emulsifiers by MALDI-TOF MS.
2001 Jul
Comparison of impact of the different hydrophilic carriers on the properties of piperazine-containing drug.
2001 May
Final report on the safety assessment of sorbitan caprylate, sorbitan cocoate, sorbitan diisostearate, sorbitan dioleate, sorbitan distearate, sorbitan isostearate, sorbitan olivate, sorbitan sesquiisostearate, sorbitan sesquistearate, and sorbitan triisostearate.
2002
A novel synthesis of D-galactofuranosyl, D-glucofuranosyl and D-mannofuranosyl 1-phosphates based on remote activation of new and free hexofuranosyl donors.
2002 Dec 16
Rheological properties of three component creams containing sorbitan monoesters as surfactants.
2002 Oct 24
[Simultaneous analysis of four kinds of emulsifiers in beverages by GC/MS].
2003 Feb
Development and physical characterization of sorbitan monoester niosomes for insulin oral delivery.
2003 Oct-Dec
Formation and characterization of three-component-sorbitan monoester surfactant, oil and water-creams.
2004 Jan 9
Coupling aggressive mass removal with microbial reductive dechlorination for remediation of DNAPL source zones: a review and assessment.
2005 Apr
General one-step synthesis of free hexofuranosyl 1-phosphates using unprotected 1-thioimidoyl hexofuranosides.
2005 Feb 4
Cationic niosomes as gene carriers: preparation and cellular uptake in vitro.
2005 Jun
Sorbitan monopalmitate-based proniosomes for transdermal delivery of chlorpheniramine maleate.
2005 Mar-Apr
Niosomes with sorbitan monoester as a carrier for vaginal delivery of insulin: studies in rats.
2005 Nov-Dec
Safety assessment on polyethylene glycols (PEGs) and their derivatives as used in cosmetic products.
2005 Oct 15
Formulation and evaluation of a vitamin C multiple emulsion.
2006
Emulsifier content and side effects of oil-based adjuvant vaccine in swine.
2006 Aug
Composition analysis of two batches of polysorbate 60 using MS and NMR techniques.
2006 Mar 18
Water mass transfer in W/O emulsions.
2006 May 15
Enzymatic synthesis of sorbitan methacrylate according to acyl donors.
2006 Spring
Optimization of lipase-catalyzed synthesis of sorbitan acrylate using response surface methodology.
2007 Apr
Evidence for vesicle formation from 1:1 nonionic surfactant span 60 and fatty alcohol mixtures in aqueous ethanol: potential delivery vehicle composition.
2007 Aug 1
Phase transition water-in-oil microemulsions as ocular drug delivery systems: in vitro and in vivo evaluation.
2007 Jan 2
Correlation between transcript profiles and fitness of deletion mutants in anaerobic chemostat cultures of Saccharomyces cerevisiae.
2007 Mar
The use of solvent relaxation technique to investigate headgroup hydration and protein binding of simple and mixed phosphatidylcholine/surfactant bilayer membranes.
2007 May
Bioremediation of diesel fuel contaminated soil: effect of non ionic surfactants and selected bacteria addition.
2007 Sep
Dermal delivery of selected hydrophilic drugs from elastic liposomes: effect of phospholipid formulation and surfactants.
2007 Sep
Selection of surfactants for enhancing diesel hydrocarbons-contaminated media bioremediation.
2008 Apr 15
Allergens in corticosteroid vehicles.
2008 Jan-Feb
Effect of water-in-oil microemulsions and lamellar liquid crystalline systems on the precorneal tear film of albino New Zealand rabbits.
2008 Mar
Some considerations about the hydrophilic-lipophilic balance system.
2008 May 22
Sorbitan sesquioleate, a common emulsifier in topical corticosteroids, is an important contact allergen.
2008 Nov-Dec
Formulation and in vitro assessment of minoxidil niosomes for enhanced skin delivery.
2009 Jul 30
Efficacy of niosomal formulation of diallyl sulfide against experimental candidiasis in Swiss albino mice.
2009 Oct
Structure of high internal phase aqueous-in-oil emulsions and related inverse micelle solutions. 3. Variation of surfactant.
2009 Sep 10
Between the devil and the deep blue sea: dispersants in the gulf of Mexico.
2010 Aug
Comparative study on the effects of some polyoxyethylene alkyl ether and sorbitan fatty acid ester surfactants on the performance of transdermal carvedilol proniosomal gel using experimental design.
2010 Dec
Niosome as a drug carrier for topical delivery of N-acetyl glucosamine.
2010 Jul
Application of liquid chromatography in polymer non-ionic antistatic additives analysis.
2010 Nov
Patents

Patents

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4
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:06:18 UTC 2023
Edited
by admin
on Fri Dec 15 16:06:18 UTC 2023
Record UNII
AV0YTZ4E6J
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
1,4-SORBITAN
USP-RS  
Common Name English
1,4-ANHYDRO-D-GLUCITOL
Common Name English
1,4-ANHYDROSORBITOL
Common Name English
1,4-SORBITAN [USP-RS]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C83486
Created by admin on Fri Dec 15 16:06:18 UTC 2023 , Edited by admin on Fri Dec 15 16:06:18 UTC 2023
Code System Code Type Description
NCI_THESAURUS
C83509
Created by admin on Fri Dec 15 16:06:18 UTC 2023 , Edited by admin on Fri Dec 15 16:06:18 UTC 2023
PRIMARY
CAS
27299-12-3
Created by admin on Fri Dec 15 16:06:18 UTC 2023 , Edited by admin on Fri Dec 15 16:06:18 UTC 2023
PRIMARY
DAILYMED
AV0YTZ4E6J
Created by admin on Fri Dec 15 16:06:18 UTC 2023 , Edited by admin on Fri Dec 15 16:06:18 UTC 2023
PRIMARY
EPA CompTox
DTXSID50893383
Created by admin on Fri Dec 15 16:06:18 UTC 2023 , Edited by admin on Fri Dec 15 16:06:18 UTC 2023
PRIMARY
ECHA (EC/EINECS)
248-391-9
Created by admin on Fri Dec 15 16:06:18 UTC 2023 , Edited by admin on Fri Dec 15 16:06:18 UTC 2023
PRIMARY
PUBCHEM
10953859
Created by admin on Fri Dec 15 16:06:18 UTC 2023 , Edited by admin on Fri Dec 15 16:06:18 UTC 2023
PRIMARY
FDA UNII
AV0YTZ4E6J
Created by admin on Fri Dec 15 16:06:18 UTC 2023 , Edited by admin on Fri Dec 15 16:06:18 UTC 2023
PRIMARY
RXCUI
1307571
Created by admin on Fri Dec 15 16:06:18 UTC 2023 , Edited by admin on Fri Dec 15 16:06:18 UTC 2023
PRIMARY RxNorm
SMS_ID
100000087532
Created by admin on Fri Dec 15 16:06:18 UTC 2023 , Edited by admin on Fri Dec 15 16:06:18 UTC 2023
PRIMARY
RS_ITEM_NUM
1616008
Created by admin on Fri Dec 15 16:06:18 UTC 2023 , Edited by admin on Fri Dec 15 16:06:18 UTC 2023
PRIMARY
EVMPD
SUB21060
Created by admin on Fri Dec 15 16:06:18 UTC 2023 , Edited by admin on Fri Dec 15 16:06:18 UTC 2023
PRIMARY
NIH
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