SORBITAN TRIOLEATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C60H108O8
Molecular Weight	957.4947
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	3
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC

InChI

InChIKey=PRXRUNOAOLTIEF-ADSICKODSA-N

InChI=1S/C60H108O8/c1-4-7-10-13-16-19-22-25-28-31-34-37-40-43-46-49-56(62)65-53-55(67-57(63)50-47-44-41-38-35-32-29-26-23-20-17-14-11-8-5-2)60-59(54(61)52-66-60)68-58(64)51-48-45-42-39-36-33-30-27-24-21-18-15-12-9-6-3/h25-30,54-55,59-61H,4-24,31-53H2,1-3H3/b28-25-,29-26-,30-27-/t54-,55+,59+,60+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C60H108O8
Molecular Weight	957.4947
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	3
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ulprospector.com/en/na/PersonalCare/Detail/4230/122885/Sorbitan-Trioleate-SPA85 | https://www.drugs.com/inactive/sorbitan-monooleate-461.html

Sorbitan Trioleate (Tween 85) is a triester of oleic acid and hexitol anhydrides derived from sorbitol. It functions as a surfactant and emulsifying agent. This product is a white to tan-colored solid. In cosmetics and personal care products, Sorbitan Esters are used in a variety of products including skin care products, skin cleansing products, moisturizers, eye makeup and other makeup.

Approval Year

PubMed

Title	Date	PubMed
Crystallization kinetics of cocoa butter in the presence of sorbitan esters.	2017-01-01	27507503
Microemulsion Using Polyoxyethylene Sorbitan Trioleate and its Usage for Skin Delivery of Resveratrol to Protect Skin against UV-Induced Damage.	2015	26329869
Final report on the safety assessment of sorbitan caprylate, sorbitan cocoate, sorbitan diisostearate, sorbitan dioleate, sorbitan distearate, sorbitan isostearate, sorbitan olivate, sorbitan sesquiisostearate, sorbitan sesquistearate, and sorbitan triisostearate.	2002	12042063
Study on subacute toxicity of intravenous sorbitan trioleate (STO) in Wistar rats.	1983-11	6663660

Sample Use Guides

In Vivo Use Guide

Subacute toxicity of sorbitan trioleate (STO) was carried out using Wistar rats. STO was administered intravenously at dose levels of 12.5, 50.0 and 200.0 mg/kg for 35 days. No influence on general symptom, body weight, food and water consumption and urinalysis were observed. In 200.0 mg/kg group, the hematological examination revealed anemia corresponding to the histological findings of the bone marrow. Biochemical analysis displayed the significant increase and/or decrease of enzyme values in 200.0 mg/kg group. The maximal no-effect level of the STO in Wistar rats was considered to be 50.0 mg/kg.

Route of Administration: Intravenous

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:34:39 GMT 2025` Edited by `admin` on `Mon Mar 31 17:34:39 GMT 2025`
Record UNII	QE6F49RPJ1
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SORBITAN TRIOLEATE

Official Name

English

ANHYDROSORBITOL TRIOLEATE

Preferred Name

English

ARLACEL 85

Brand Name

English

SPAN85

Common Name

English

SORBITAN, TRI-9-OCTADECENOATE

Common Name

English

SORBITAN TRIOLEATE [II]

Common Name

English

SORBITAN TRIOLEATE [MART.]

Common Name

English

SPAN-85

Common Name

English

MF59 COMPONENT SPAN85

Common Name

English

SORBITAN TRIOLEATE [USAN]

Common Name

English

SORBITAN TRIOLEATE [EP MONOGRAPH]

Common Name

English

SPAN 85

Brand Name

English

sorbitan trioleate [INN]

Common Name

English

SORBITAN TRIOLEATE [VANDF]

Common Name

English

SORBITAN, TRI-(9Z)-9-OCTADECENOATE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C83486