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Details

Stereochemistry ACHIRAL
Molecular Formula C16H22O4
Molecular Weight 278.3435
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DIBUTYL PHTHALATE

SMILES

CCCCOC(=O)C1=C(C=CC=C1)C(=O)OCCCC

InChI

InChIKey=DOIRQSBPFJWKBE-UHFFFAOYSA-N
InChI=1S/C16H22O4/c1-3-5-11-19-15(17)13-9-7-8-10-14(13)16(18)20-12-6-4-2/h7-10H,3-6,11-12H2,1-2H3

HIDE SMILES / InChI

Molecular Formula C16H22O4
Molecular Weight 278.3435
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Dibutyl phthalate (DBP) is used to help make plastics soft and flexible. It is used in shower curtains, raincoats, food wraps, bowls, car interiors, vinyl fabrics, floor tiles, and other products. Animal studies have reported developmental and reproductive effects from oral exposure. Dibutyl phthalate (DBP) is classified as a substance toxic to reproduction. No information is available on the carcinogenic effects of dibutyl phthalate in humans or animals. Treatment with dibutyl phthalate enhanced Aryl Hydrocarbon Receptor mRNA expression, which was reflected by the increased AhR protein level. ERα, ERβ, and PPARγ antagonists stimulated DBP-induced caspase-3 and LDH activities. AhR is involved in DBP-induced apoptosis and neurotoxicity, while the ERs and PPARγ signaling pathways are impaired by the phthalate. In vitro test showed that DBP killed all Demodex mites within 1 hour. Dibutyl phthalate emulsion is promising to be developed as a safe, effective therapeutic medicament on demodicidosis.

CNS Activity

Approval Year

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Unknown

PubMed

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
Substance Class Chemical
Record UNII
2286E5R2KE
Record Status Validated (UNII)
Record Version