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Details

Stereochemistry ABSOLUTE
Molecular Formula C6H12O5
Molecular Weight 164.1565
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of 1,4-SORBITAN

SMILES

OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O

InChI

InChIKey=JNYAEWCLZODPBN-JGWLITMVSA-N
InChI=1S/C6H12O5/c7-1-3(8)6-5(10)4(9)2-11-6/h3-10H,1-2H2/t3-,4+,5-,6-/m1/s1

HIDE SMILES / InChI

Description

1,4-Sorbitan is a sorbitol anhydration product. 1,4-Sorbitan is a precursor to environmentally benign surfactants. It is a component of Sorbitol-Sorbitan mixtures used as soft gel plasticizers. They enhance the soft gelatin capsule finish gloss for a premium appearance, help to prevent leakage, provide consistent pharmaceutical quality, and extend shelf life by maintaining a proper moisture balance within the capsule shell.

Originator

Approval Year

1986
107
PubMed

PubMed

TitleDatePubMed
Comparative study on the effects of some polyoxyethylene alkyl ether and sorbitan fatty acid ester surfactants on the performance of transdermal carvedilol proniosomal gel using experimental design.
2010-12
Application of liquid chromatography in polymer non-ionic antistatic additives analysis.
2010-11
Between the devil and the deep blue sea: dispersants in the gulf of Mexico.
2010-08
Niosome as a drug carrier for topical delivery of N-acetyl glucosamine.
2010-07
Efficacy of niosomal formulation of diallyl sulfide against experimental candidiasis in Swiss albino mice.
2009-10
Structure of high internal phase aqueous-in-oil emulsions and related inverse micelle solutions. 3. Variation of surfactant.
2009-09-10
Formulation and in vitro assessment of minoxidil niosomes for enhanced skin delivery.
2009-07-30
Sorbitan sesquioleate, a common emulsifier in topical corticosteroids, is an important contact allergen.
2009-01-13
Some considerations about the hydrophilic-lipophilic balance system.
2008-05-22
Selection of surfactants for enhancing diesel hydrocarbons-contaminated media bioremediation.
2008-04-15
Allergens in corticosteroid vehicles.
2008-03-19
Effect of water-in-oil microemulsions and lamellar liquid crystalline systems on the precorneal tear film of albino New Zealand rabbits.
2008-03
Bioremediation of diesel fuel contaminated soil: effect of non ionic surfactants and selected bacteria addition.
2007-09
Dermal delivery of selected hydrophilic drugs from elastic liposomes: effect of phospholipid formulation and surfactants.
2007-09
Evidence for vesicle formation from 1:1 nonionic surfactant span 60 and fatty alcohol mixtures in aqueous ethanol: potential delivery vehicle composition.
2007-08-01
The use of solvent relaxation technique to investigate headgroup hydration and protein binding of simple and mixed phosphatidylcholine/surfactant bilayer membranes.
2007-05
Optimization of lipase-catalyzed synthesis of sorbitan acrylate using response surface methodology.
2007-04
Correlation between transcript profiles and fitness of deletion mutants in anaerobic chemostat cultures of Saccharomyces cerevisiae.
2007-03
Phase transition water-in-oil microemulsions as ocular drug delivery systems: in vitro and in vivo evaluation.
2007-01-02
Emulsifier content and side effects of oil-based adjuvant vaccine in swine.
2006-08
Water mass transfer in W/O emulsions.
2006-05-15
Composition analysis of two batches of polysorbate 60 using MS and NMR techniques.
2006-03-18
Enzymatic synthesis of sorbitan methacrylate according to acyl donors.
2006
Formulation and evaluation of a vitamin C multiple emulsion.
2006
Niosomes with sorbitan monoester as a carrier for vaginal delivery of insulin: studies in rats.
2005-10-29
Safety assessment on polyethylene glycols (PEGs) and their derivatives as used in cosmetic products.
2005-10-15
Cationic niosomes as gene carriers: preparation and cellular uptake in vitro.
2005-06
Sorbitan monopalmitate-based proniosomes for transdermal delivery of chlorpheniramine maleate.
2005-04-13
Coupling aggressive mass removal with microbial reductive dechlorination for remediation of DNAPL source zones: a review and assessment.
2005-04
General one-step synthesis of free hexofuranosyl 1-phosphates using unprotected 1-thioimidoyl hexofuranosides.
2005-02-04
Formation and characterization of three-component-sorbitan monoester surfactant, oil and water-creams.
2004-01-09
Development and physical characterization of sorbitan monoester niosomes for insulin oral delivery.
2003-11-13
[Simultaneous analysis of four kinds of emulsifiers in beverages by GC/MS].
2003-02
A novel synthesis of D-galactofuranosyl, D-glucofuranosyl and D-mannofuranosyl 1-phosphates based on remote activation of new and free hexofuranosyl donors.
2002-12-16
Rheological properties of three component creams containing sorbitan monoesters as surfactants.
2002-10-24
Final report on the safety assessment of sorbitan caprylate, sorbitan cocoate, sorbitan diisostearate, sorbitan dioleate, sorbitan distearate, sorbitan isostearate, sorbitan olivate, sorbitan sesquiisostearate, sorbitan sesquistearate, and sorbitan triisostearate.
2002
Investigating the molecular heterogeneity of polysorbate emulsifiers by MALDI-TOF MS.
2001-07
Comparison of impact of the different hydrophilic carriers on the properties of piperazine-containing drug.
2001-05
Final report on the safety assessment of PEG-6, -8, and -20 sorbitan beeswax.
2001
Patents

Patents

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4
Name Type Language
1,4-ANHYDRO-D-GLUCITOL
Preferred Name English
1,4-SORBITAN
USP-RS  
Common Name English
1,4-ANHYDROSORBITOL
Common Name English
1,4-SORBITAN [USP-RS]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C83486
Created by admin on Mon Mar 31 18:19:09 GMT 2025 , Edited by admin on Mon Mar 31 18:19:09 GMT 2025
Code System Code Type Description
NCI_THESAURUS
C83509
Created by admin on Mon Mar 31 18:19:09 GMT 2025 , Edited by admin on Mon Mar 31 18:19:09 GMT 2025
PRIMARY
CAS
27299-12-3
Created by admin on Mon Mar 31 18:19:09 GMT 2025 , Edited by admin on Mon Mar 31 18:19:09 GMT 2025
PRIMARY
DAILYMED
AV0YTZ4E6J
Created by admin on Mon Mar 31 18:19:09 GMT 2025 , Edited by admin on Mon Mar 31 18:19:09 GMT 2025
PRIMARY
EPA CompTox
DTXSID50893383
Created by admin on Mon Mar 31 18:19:09 GMT 2025 , Edited by admin on Mon Mar 31 18:19:09 GMT 2025
PRIMARY
ECHA (EC/EINECS)
248-391-9
Created by admin on Mon Mar 31 18:19:09 GMT 2025 , Edited by admin on Mon Mar 31 18:19:09 GMT 2025
PRIMARY
PUBCHEM
10953859
Created by admin on Mon Mar 31 18:19:09 GMT 2025 , Edited by admin on Mon Mar 31 18:19:09 GMT 2025
PRIMARY
FDA UNII
AV0YTZ4E6J
Created by admin on Mon Mar 31 18:19:09 GMT 2025 , Edited by admin on Mon Mar 31 18:19:09 GMT 2025
PRIMARY
RXCUI
1307571
Created by admin on Mon Mar 31 18:19:09 GMT 2025 , Edited by admin on Mon Mar 31 18:19:09 GMT 2025
PRIMARY RxNorm
SMS_ID
100000087532
Created by admin on Mon Mar 31 18:19:09 GMT 2025 , Edited by admin on Mon Mar 31 18:19:09 GMT 2025
PRIMARY
RS_ITEM_NUM
1616008
Created by admin on Mon Mar 31 18:19:09 GMT 2025 , Edited by admin on Mon Mar 31 18:19:09 GMT 2025
PRIMARY
EVMPD
SUB21060
Created by admin on Mon Mar 31 18:19:09 GMT 2025 , Edited by admin on Mon Mar 31 18:19:09 GMT 2025
PRIMARY
SUBSTANCE RECORD
Structure of 1,4-SORBITAN
NIH
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