Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C22H42O6 |
Molecular Weight | 402.5653 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 4 / 4 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]1(OC[C@H](O)[C@H]1O)[C@H](O)COC(=O)CCCCCCCCCCCCCCC
InChI
InChIKey=IYFATESGLOUGBX-YVNJGZBMSA-N
InChI=1S/C22H42O6/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-20(25)27-17-19(24)22-21(26)18(23)16-28-22/h18-19,21-24,26H,2-17H2,1H3/t18-,19+,21+,22+/m0/s1
DescriptionCurator's Comment: Description was created using several sources including:
https://www.ulprospector.com/en/na/PersonalCare/Detail/134/37087/Span-40;
http://www.irochemical.com/product/Surfactants/Span-40.htm;
http://www.ervesa.com/index.php/home/83-products/123-e495-sorbitan-monopalmitat;
http://www.ncbi.nlm.nih.gov/pubmed/15824032;
http://www.rxlist.com/pliaglis-drug.htm;
http://patft.uspto.gov/netacgi/nph-Parser?d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=8241670.PN.&OS=PN/8241670&RS=PN/8241670
Curator's Comment: Description was created using several sources including:
https://www.ulprospector.com/en/na/PersonalCare/Detail/134/37087/Span-40;
http://www.irochemical.com/product/Surfactants/Span-40.htm;
http://www.ervesa.com/index.php/home/83-products/123-e495-sorbitan-monopalmitat;
http://www.ncbi.nlm.nih.gov/pubmed/15824032;
http://www.rxlist.com/pliaglis-drug.htm;
http://patft.uspto.gov/netacgi/nph-Parser?d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=8241670.PN.&OS=PN/8241670&RS=PN/8241670
Sorbitan monopalmitate (Span 40) is a nonionic emulsifier, surfactant and food additive. The product of Croda Inc. Span 40 is used in skin care, hair care and decorative cosmetics. It is also used as an effector in compositions capable of facilitating penetration across a biological barrier. Inactive ingredient of some medications it improves transdermal delivery of drugs and is a potential carrier for topical drug delivery. In PLIAGLIS cream (lidocaine and tetracaine) sorbitan monopalmitate is used as an inactive ingredient. Sorbitan monopalmitate is a fatty acid sorbitan ester, yellowish brown wax, slightly soluble in isopropanol, xylene and liquid paraffin, insoluble in water, non-toxic.
Approval Year
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Inactive ingredient | PLIAGLIS Approved UsePliaglis is indicated for use on intact skin in adults to provide topical local analgesia for superficial dermatological procedures such as dermal filler injection, pulsed dye laser therapy, facial laser resurfacing, and laser-assisted tattoo removal. |
Sample Use Guides
In Vitro Use Guide
Sources: http://www.ncbi.nlm.nih.gov/pubmed/1032661
10% sorbitan monopalmitate added to the ointment significantly increased percutaneous absorption of sodium salicylate determined from blood levels in New Zealand white rabbits at regular intervals for 8 hr following application of the ointment.
Name | Type | Language | ||
---|---|---|---|---|
|
Official Name | English | ||
|
Code | English | ||
|
Brand Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Brand Name | English | ||
|
Common Name | English | ||
|
Official Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Common Name | English |
Classification Tree | Code System | Code | ||
---|---|---|---|---|
|
CODEX ALIMENTARIUS (GSFA) |
INS-495
Created by
admin on Fri Dec 15 15:00:52 GMT 2023 , Edited by admin on Fri Dec 15 15:00:52 GMT 2023
|
||
|
JECFA EVALUATION |
INS-495
Created by
admin on Fri Dec 15 15:00:52 GMT 2023 , Edited by admin on Fri Dec 15 15:00:52 GMT 2023
|
||
|
NCI_THESAURUS |
C83486
Created by
admin on Fri Dec 15 15:00:52 GMT 2023 , Edited by admin on Fri Dec 15 15:00:52 GMT 2023
|
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
SUB10599MIG
Created by
admin on Fri Dec 15 15:00:52 GMT 2023 , Edited by admin on Fri Dec 15 15:00:52 GMT 2023
|
PRIMARY | |||
|
CHEMBL2107514
Created by
admin on Fri Dec 15 15:00:52 GMT 2023 , Edited by admin on Fri Dec 15 15:00:52 GMT 2023
|
PRIMARY | |||
|
C75655
Created by
admin on Fri Dec 15 15:00:52 GMT 2023 , Edited by admin on Fri Dec 15 15:00:52 GMT 2023
|
PRIMARY | |||
|
1363701
Created by
admin on Fri Dec 15 15:00:52 GMT 2023 , Edited by admin on Fri Dec 15 15:00:52 GMT 2023
|
PRIMARY | RxNorm | ||
|
1872
Created by
admin on Fri Dec 15 15:00:52 GMT 2023 , Edited by admin on Fri Dec 15 15:00:52 GMT 2023
|
PRIMARY | |||
|
DTXSID6029335
Created by
admin on Fri Dec 15 15:00:52 GMT 2023 , Edited by admin on Fri Dec 15 15:00:52 GMT 2023
|
PRIMARY | |||
|
247-568-8
Created by
admin on Fri Dec 15 15:00:52 GMT 2023 , Edited by admin on Fri Dec 15 15:00:52 GMT 2023
|
PRIMARY | |||
|
16212480
Created by
admin on Fri Dec 15 15:00:52 GMT 2023 , Edited by admin on Fri Dec 15 15:00:52 GMT 2023
|
PRIMARY | |||
|
77K6Z421KU
Created by
admin on Fri Dec 15 15:00:52 GMT 2023 , Edited by admin on Fri Dec 15 15:00:52 GMT 2023
|
PRIMARY | |||
|
Sorbitan monopalmitate
Created by
admin on Fri Dec 15 15:00:52 GMT 2023 , Edited by admin on Fri Dec 15 15:00:52 GMT 2023
|
PRIMARY | |||
|
100000083793
Created by
admin on Fri Dec 15 15:00:52 GMT 2023 , Edited by admin on Fri Dec 15 15:00:52 GMT 2023
|
PRIMARY | |||
|
26266-57-9
Created by
admin on Fri Dec 15 15:00:52 GMT 2023 , Edited by admin on Fri Dec 15 15:00:52 GMT 2023
|
PRIMARY | |||
|
77K6Z421KU
Created by
admin on Fri Dec 15 15:00:52 GMT 2023 , Edited by admin on Fri Dec 15 15:00:52 GMT 2023
|
PRIMARY |
ACTIVE MOIETY