U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
This repository is under review for potential modification in compliance with Administration directives.

Approval Year

Substance Class Protein
Created
by admin
on Tue Apr 01 16:56:39 GMT 2025
Edited
by admin
on Tue Apr 01 16:56:39 GMT 2025
Protein Sub Type
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
V23K99CV7G
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CHRM1
Preferred Name English
MUSCARINIC ACETYLCHOLINE RECEPTOR M1
Common Name English
acetylcholine receptor, muscarinic 1
Common Name English
M1
Common Name English
Code System Code Type Description
PHAROS
P11229
Created by admin on Tue Apr 01 16:56:39 GMT 2025 , Edited by admin on Tue Apr 01 16:56:39 GMT 2025
PRIMARY
FDA UNII
V23K99CV7G
Created by admin on Tue Apr 01 16:56:39 GMT 2025 , Edited by admin on Tue Apr 01 16:56:39 GMT 2025
PRIMARY
UNIPROT
P11229
Created by admin on Tue Apr 01 16:56:39 GMT 2025 , Edited by admin on Tue Apr 01 16:56:39 GMT 2025
PRIMARY
From To
1_98 1_178
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_2
N 1_12
Related Record Type Details
AGONIST -> TARGET
full agonist; pERK1/2
EC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
Ki
AGONIST -> TARGET
ACTIVATOR -> TARGET
Promising, novel CNS-permeable oxime ACHE reactivator.
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
Pirenzepine is a selective muscarinic M1 receptor antagonist
INHIBITOR -> TARGET
INHIBITOR -> TARGET
BINDING
IC50
RADIOLIGAND->TARGET
Kd
AGONIST -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
PARTIAL AGONIST->TARGET
AGONIST -> TARGET
INHIBITOR -> TARGET
INHIBITOR->OFF-TARGET
Radioligand binding assay
BINDING
IC50
INHIBITOR -> TARGET
Ki
INHIBITOR -> TARGET
Kd
INHIBITOR -> TARGET
THRX-195518 possesses activity at target muscarinic receptors that was slightly lower (approximately one-third to one-tenth) than revefenacin.
BINDING
Ki
INHIBITOR -> TARGET
Ki
POSITIVE ALLOSTERIC MODULATOR->TARGET
AGONIST -> TARGET
AGONIST -> TARGET
NON-INHIBITOR->OFF TARGET
NON-INHIBITOR
Ki
AGONIST -> TARGET
INHIBITOR -> TARGET
BINDING
Kd
AGONIST -> TARGET
INHIBITOR -> TARGET
INHIBITOR->OFF-TARGET
INHIBITOR -> TARGET
PARTIAL AGONIST->TARGET
INHIBITOR -> TARGET
NON-INHIBITOR->OFF TARGET
Ki
INHIBITOR -> TARGET
Ki
PARTIAL AGONIST->TARGET
AGONIST -> TARGET
AGONIST -> TARGET
INHIBITOR -> TARGET
BINDING
IC50
RADIOLIGAND->TARGET
Ki
MODULATOR->TARGET
INHIBITOR -> TARGET

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO ACID SUBSTITUTION [1_230] [1_428] [1_455] THREONINE PHOSPHATE 3L4WX7B1EI
AMINO ACID SUBSTITUTION [1_451] [1_457] DEXFOSFOSERINE VI4F0K069V
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT CHEMICAL