MILAMELINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C8H14N2O
Molecular Weight	154.2096
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CO\N=C\C1=CCCN(C)C1

InChI

InChIKey=YMMXHEYLRHNXAB-RMKNXTFCSA-N

InChI=1S/C8H14N2O/c1-10-5-3-4-8(7-10)6-9-11-2/h4,6H,3,5,7H2,1-2H3/b9-6+

HIDE SMILES / InChI

Molecular Formula	C8H14N2O
Molecular Weight	154.2096
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/10188788 | https://www.ncbi.nlm.nih.gov/pubmed/16958947 | https://adisinsight.springer.com/drugs/800001410

Milameline (previously known as RU 35926/CI-979), a partial muscarinic agonist that was developed as a cognition-enhancing agent for the treatment of patients with Alzheimer's disease. In spite of this drug has achieved phase III clinical trials, further studies were apparently discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed
Preclinical and phase 1 clinical characterization of CI-979/RU35926, a novel muscarinic agonist for the treatment of Alzheimer's disease.	1995	10188788
Combined cerebral blood flow effects of a cholinergic agonist (milameline) and a verbal recognition task in early Alzheimer's disease.	2006 Oct	16958947

Patents

Sample Use Guides

In Vivo Use Guide

CI-979/RU35926 (milameline) was well tolerated at doses of 0.002-1.0 mg with cholinergic symptoms such as hypersalivation and sweating, observed at 2-4 mg.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:37:37 GMT 2023` Edited by `admin` on `Fri Dec 15 18:37:37 GMT 2023`
Record UNII	R9X77R42FN
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MILAMELINE

Official Name

English

PD-129409

Code

English

3-PYRIDINECARBOXALDEHYDE, 1,2,5,6-TETRAHYDRO-1-METHYL-, O-METHYLOXIME, (E)

Common Name

English

PD-129,409

Code

English

milameline [INN]

Common Name

English

1,2,5,6-TETRAHYDRO-1-METHYLNICOTINALDEHYDE (E)-O-METHYLOXIME

Systematic Name

English

MILAMELINE [MART.]

Common Name

English

Milameline [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C47796