MUSCARINIC ACETYLCHOLINE RECEPTOR M2

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Sun Dec 18 08:08:19 UTC 2022` Edited by `admin` on `Sun Dec 18 08:08:19 UTC 2022`
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	U87RX375T5
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

MUSCARINIC ACETYLCHOLINE RECEPTOR M2

Common Name

English

Code System Code Type Description

FDA UNII

U87RX375T5

Created by admin on Sun Dec 18 08:08:21 UTC 2022 , Edited by admin on Sun Dec 18 08:08:21 UTC 2022

PRIMARY

From	To
1_96	1_176
1_413	1_416

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_2
N	1_3
N	1_6
N	1_9

Related Record Type Details


					K9P6MC7092

INHIBITOR -> TARGET


					WHE7A56U7K

INHIBITOR -> TARGET


					7C0697DR9I

ATROPINE

INHIBITOR -> TARGET

Amount:


					L6UH7ZF8HC

NON-INHIBITOR->OFF TARGET

Qualification:

Ki

Amount:


					WRE554RFEZ

INHIBITOR -> TARGET


					JJH94R3PWB

NERATINIB

INHIBITOR -> TARGET

Amount:


					G2AE2VE07O

INHIBITOR -> TARGET

Interaction Type:

BINDING

Qualification:

Kd

Amount:


					V92SO9WP2I

INHIBITOR -> TARGET

Qualification:

Ki

Amount:


					01MI4Q9DI3

AGONIST -> TARGET


					5BRQ29UUB7

INHIBITOR -> TARGET

Amount:


					8Y164V895Y

CARBACHOL

AGONIST -> TARGET


					JJH94R3PWB

NERATINIB

INHIBITOR->OFF-TARGET

Amount:


					838F01T721

NON-INHIBITOR->OFF TARGET

Interaction Type:

NON-INHIBITOR

Qualification:

Ki

Amount:


					GE2T1418SV

INHIBITOR -> TARGET


					K17VY42F6C

ANTAGONIST->TARGET

Qualification:

Ki

Amount:


					5ASJ6HUZ7D

DOXEPIN

INHIBITOR -> TARGET


					A6X64T4LZ4

INHIBITOR -> TARGET

Comments:

THRX-195518 possesses activity at target muscarinic receptors that was slightly lower (approximately one-third to one-tenth) than revefenacin.

Interaction Type:

BINDING

Qualification:

Ki

Amount:


					A8910SQJ1U

WEAK INHIBITOR->TARGET

Qualification:

Ki

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT	CHEMICAL