MUSCARINIC ACETYLCHOLINE RECEPTOR M2

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 11:38:28 UTC 2023` Edited by `admin` on `Sat Dec 16 11:38:28 UTC 2023`
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	U87RX375T5
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

MUSCARINIC ACETYLCHOLINE RECEPTOR M2

Common Name

English

acetylcholine receptor, muscarinic 2

Common Name

English

M2

Common Name

English

Code System Code Type Description

FDA UNII

U87RX375T5

Created by admin on Sat Dec 16 11:38:30 UTC 2023 , Edited by admin on Sat Dec 16 11:38:30 UTC 2023

PRIMARY

From	To
1_96	1_176
1_413	1_416

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_2
N	1_3
N	1_6
N	1_9

Related Record Type Details


					K9P6MC7092

INHIBITOR -> TARGET


					WHE7A56U7K

INHIBITOR -> TARGET


					NVJ76B897D

METHOCTRAMINE FREE BASE

INHIBITOR -> TARGET

Qualification:

IC50

Amount:


					R9X77R42FN

AGONIST -> TARGET

Amount:


					7C0697DR9I

ATROPINE

INHIBITOR -> TARGET

Qualification:

IC50

Amount:


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Qualification:

Ki

Amount:


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Qualification:

IC50

Amount:


					D42OWK5383

INHIBITOR -> TARGET

Amount:


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PARTIAL AGONIST->TARGET

Amount:


					WRE554RFEZ

INHIBITOR -> TARGET


					JJH94R3PWB

NERATINIB

INHIBITOR -> TARGET

Amount:


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Qualification:

Kd

Amount:


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INHIBITOR -> TARGET

Interaction Type:

BINDING

Qualification:

Kd

Amount:


					RLO2T99XT3

INHIBITOR -> TARGET

Comments:

methoctramine is a selective muscarinic M2 receptor antagonist

Amount:


					KFR8EX22KX

AF-DX-384

INHIBITOR -> TARGET

Qualification:

Kd

Amount:


					9ORI6L73CJ

AGONIST -> TARGET

Amount:


					V92SO9WP2I

INHIBITOR -> TARGET

Qualification:

Ki

Amount:


					T2C393VHB9

INHIBITOR -> TARGET

Interaction Type:

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Qualification:

IC50

Amount:


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AGONIST -> TARGET


					5BRQ29UUB7

INHIBITOR -> TARGET

Amount:


					8Y164V895Y

CARBACHOL

AGONIST -> TARGET

Amount:


					JJH94R3PWB

NERATINIB

INHIBITOR->OFF-TARGET

Amount:


					838F01T721

NON-INHIBITOR->OFF TARGET

Interaction Type:

NON-INHIBITOR

Qualification:

Ki

Amount:


					GE2T1418SV

INHIBITOR -> TARGET


					1IAT42T80T

INHIBITOR -> TARGET

Amount:


					K17VY42F6C

ANTAGONIST->TARGET

Qualification:

Ki

Amount:


					4XFD7B36M6

INHIBITOR -> TARGET

Amount:


					5ASJ6HUZ7D

DOXEPIN

INHIBITOR -> TARGET

Amount:


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AGONIST -> TARGET

Amount:


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INHIBITOR -> TARGET

Comments:

THRX-195518 possesses activity at target muscarinic receptors that was slightly lower (approximately one-third to one-tenth) than revefenacin.

Interaction Type:

BINDING

Qualification:

Ki

Amount:


					A8910SQJ1U

WEAK INHIBITOR->TARGET

Qualification:

Ki

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT	CHEMICAL