MUSCARINIC ACETYLCHOLINE RECEPTOR M3

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 11:39:49 UTC 2023` Edited by `admin` on `Sat Dec 16 11:39:49 UTC 2023`
Protein Type	RECEPTOR
Protein Sub Type	ACETYLCHOLINE RECEPTOR
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	W3JX5KZ4V2
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MUSCARINIC ACETYLCHOLINE RECEPTOR M3

Common Name

English

acetylcholine receptor, muscarinic 3

Common Name

English

M3 Human Acetylcholine (Muscarinic) Receptor

Common Name

English

CHRM3

Common Name

English

Common Name

English

Code System Code Type Description

FDA UNII

W3JX5KZ4V2

Created by admin on Sat Dec 16 11:39:52 UTC 2023 , Edited by admin on Sat Dec 16 11:39:52 UTC 2023

PRIMARY

UNIPROT

P20309

Created by admin on Sat Dec 16 11:39:52 UTC 2023 , Edited by admin on Sat Dec 16 11:39:52 UTC 2023

PRIMARY

PHAROS

P20309

Created by admin on Sat Dec 16 11:39:52 UTC 2023 , Edited by admin on Sat Dec 16 11:39:52 UTC 2023

PRIMARY

From	To
1_141	1_221
1_517	1_520

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_5
N	1_6
N	1_15
N	1_41
N	1_48

Related Record Type Details


					LDV98UN52Y

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					AC72FH2XG6

CHF-6366 muscarinic metabolite

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Qualification:

Amount:


					G2AE2VE07O

REVEFENACIN

INHIBITOR -> TARGET

Comments:

In the airways, it exhibits pharmacological effects through inhibition of M3 receptor at the smooth muscle leading to bronchodilation.

Interaction Type:

BINDING

Qualification:

Amount:


					K17VY42F6C

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					HFU99SBD7V

LAS-190792

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Binding assay

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IC50

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					838F01T721

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Interaction Type:

NON-INHIBITOR

Qualification:

Amount:


					05VP796JC6

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INHIBITOR -> TARGET

Comments:

S-ISOMER BINDS WITH LESS AVIDITY

Qualification:

IC50

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TALSACLIDINE

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GLYCOPYRROLATE

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Qualification:

Amount:


					GE2T1418SV

UMECLIDINIUM

INHIBITOR -> TARGET

Amount:


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CEVIMELINE

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Amount:


					3G0285N20N

PIRENZEPINE

INHIBITOR -> TARGET

Interaction Type:

BINDING

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IC50

Amount:


					98IW5HAV1N

VEDACLIDINE

INHIBITOR -> TARGET

Amount:


					00Y6A5AJU6

SOFPIRONIUM

INHIBITOR -> TARGET

Amount:


					U29GY32XJ4

NAVAFENTEROL

INHIBITOR -> TARGET

Amount:


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AF-DX-384

INHIBITOR -> TARGET

Qualification:

Amount:


					7C0697DR9I

ATROPINE

INHIBITOR -> TARGET

Interaction Type:

BINDING

Qualification:

IC50

Amount:


					X5ZU8S2UJA

4-DMAP H-3 CATION

RADIOLIGAND->TARGET

Qualification:

Amount:


					6ZE7T2VQ9F

CHF-6366

INHIBITOR -> TARGET

Qualification:

Amount:


					5ASJ6HUZ7D

DOXEPIN

INHIBITOR -> TARGET

Amount:


					R9X77R42FN

MILAMELINE

AGONIST -> TARGET

Amount:


					NVJ76B897D

METHOCTRAMINE FREE BASE

WEAK INHIBITOR->TARGET

Comments:

Membranes from transfected CHO cells

Interaction Type:

BINDING

Qualification:

IC50

Amount:


					3W7L15V40W

REVATROPATE

INHIBITOR -> TARGET

Amount:


					4XFD7B36M6

ALVAMELINE

INHIBITOR -> TARGET

Amount:


					YU871O78GR

DESFESOTERODINE

INHIBITOR -> TARGET

Amount:


					XJR8Y07LJO

IMIDAFENACIN

INHIBITOR -> TARGET

Amount:


					13MIU3750H

ESPATROPATE

INHIBITOR -> TARGET

Amount:


					A6X64T4LZ4

THRX-195518

INHIBITOR -> TARGET

Comments:

THRX-195518 possesses activity at target muscarinic receptors that was slightly lower (approximately one-third to one-tenth) than revefenacin.

Interaction Type:

BINDING

Qualification:

Amount:


					JJH94R3PWB

NERATINIB

INHIBITOR->OFF-TARGET

Comments:

Radioligand binding assay

Interaction Type:

BINDING

Qualification:

IC50

Amount:


					9ORI6L73CJ

XANOMELINE

AGONIST -> TARGET

Amount:


					L6UH7ZF8HC

RISPERIDONE

NON-INHIBITOR->OFF-TARGET

Amount:


					WHE7A56U7K

TOLTERODINE

INHIBITOR -> TARGET

Amount:


					O0RG3QM34H

PF-03635659

INHIBITOR -> TARGET

Amount:


					K9P6MC7092

Oxybutynin

INHIBITOR -> TARGET

Amount:


					A8910SQJ1U

SOLIFENACIN

INHIBITOR -> TARGET

Comments:

Appears to be more bladder-selective for the M3 receptor relative to salivary glands.eptor

Qualification:

Amount:


					T2C393VHB9

4-DAMP cation

INHIBITOR -> TARGET

Qualification:

IC50

Amount:


					01MI4Q9DI3

Pilocarpine

AGONIST -> TARGET

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT	CHEMICAL
Molecular Formula	CHEMICAL