Aroxybutynin

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C22H31NO3
Molecular Weight	357.4864
Optical Activity	( - )
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCN(CC)CC#CCOC(=O)[C@@](O)(C1CCCCC1)C2=CC=CC=C2

InChI

InChIKey=XIQVNETUBQGFHX-QFIPXVFZSA-N

InChI=1S/C22H31NO3/c1-3-23(4-2)17-11-12-18-26-21(24)22(25,19-13-7-5-8-14-19)20-15-9-6-10-16-20/h5,7-8,13-14,20,25H,3-4,6,9-10,15-18H2,1-2H3/t22-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C22H31NO3
Molecular Weight	357.4864
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

PubMed

Title	Date	PubMed
Tolterodine: a review of its use in the treatment of overactive bladder.	2001	11341475
Effect of OROS controlled-release delivery on the pharmacokinetics and pharmacodynamics of oxybutynin chloride.	2001 Oct	11678784
[Non-coordinated micturition syndrome mimicking posterior urethral valves in a male neonate].	2003 Jul	14565094
Oxybutynin transdermal (Oxytrol) for overactive bladder.	2003 May 12	12736598
[Prevalence of urinary incontinence and linked factors in men and women over 65].	2003 Oct 15	14572396
Drug approval highlights for 2003.	2004 Feb	14872168
Oxybutynin for treatment of urge urinary incontinence and overactive bladder: an updated review.	2004 Nov	15500382
Effect of controlled-release delivery on the pharmacokinetics of oxybutynin at different dosages: severity-dependent treatment of the overactive bladder.	2004 Oct	15476516
Prediction of genotoxicity of chemical compounds by statistical learning methods.	2005 Jun	15962942
Naftopidil monotherapy vs naftopidil and an anticholinergic agent combined therapy for storage symptoms associated with benign prostatic hyperplasia: A prospective randomized controlled study.	2006 Oct	17010005
Bladder dysfunction and vesicoureteral reflux.	2008	19009037
Patient perspectives in the management of overactive bladder, focus on transdermal oxybutynin.	2008 Feb 2	19920982
Treatment of urinary incontinence after stroke in adults.	2008 Jan 23	18254050
The neurogenic bladder: medical treatment.	2008 May	18095004
Locked-in Syndrome in a Nigerian male with Multiple Sclerosis: a case report and literature review.	2008 Oct 30	21532893
Behavioral intervention versus pharmacotherapy or their combinations in the management of overactive bladder dysfunction.	2009	20029638
Trospium chloride and oxybutynin hydrochloride in a german study of adults with urinary urge incontinence: results of a 12-week, multicenter, randomized, double-blind, parallel-group, flexible-dose noninferiority trial.	2009 Nov	20109997
Oxybutynin extended release for the management of overactive bladder: a clinical review.	2009 Sep 21	19920931
Application of oxybutynin selective sensors for monitoring the dissolution profile and assay of pharmaceutical dosage forms.	2010	20410565
Parasympathetic functions in children with sensory processing disorder.	2010	20300470
Medical management of overactive bladder.	2010 Apr	20877608
Liquid Chromatographic Determination of Flavoxate HCl in Pharmaceutical Formulation.	2010 Jul	21042486
Quantitative determination of oxybutynin hydrochloride by spectrophotometry, chemometry and HPTLC in presence of its degradation product and additives in different pharmaceutical dosage forms.	2010 Mar 15	20152446
[Isolated primary nocturnal enuresis: international evidence based management. Consensus recommendations by French expert group].	2010 May	20471578
Current practices in treatment of female genital fistula: a cross sectional study.	2010 Nov 10	21067606
Urological manifestations of Chikungunya fever: A single centre experience.	2010 Sep	20981198
Dose escalation improves therapeutic outcome: post hoc analysis of data from a 12-week, multicentre, double-blind, parallel-group trial of trospium chloride in patients with urinary urge incontinence.	2010 Sep 14	20840754

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 19:33:23 GMT 2023` Edited by `admin` on `Sat Dec 16 19:33:23 GMT 2023`
Record UNII	5BRQ29UUB7
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Aroxybutynin

Official Name

English

(-)-OXYBUTYNIN

Common Name

English

OXYBUTYNIN, (-)-

Common Name

English

4-(diethylamino)but-2-yn-1-yl (R)-cyclohexyl(hydroxy)(phenyl)acetate

Systematic Name

English

(R)-OXYBUTYNIN

Common Name

English

Benzeneacetic acid, α-cyclohexyl-α-hydroxy-, 4-(diethylamino)-2-butyn-1-yl ester, (αR)-

Systematic Name

English

aroxybutynin [INN]

Common Name

English

R-OXYBUTYNIN

Common Name

English

OXYBUTYNIN, (R)-

Common Name

English

Code System Code Type Description

FDA UNII

5BRQ29UUB7