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Details

Stereochemistry ABSOLUTE
Molecular Formula C22H31NO3
Molecular Weight 357.4864
Optical Activity ( - )
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of Aroxybutynin

SMILES

CCN(CC)CC#CCOC(=O)[C@@](O)(C1CCCCC1)C2=CC=CC=C2

InChI

InChIKey=XIQVNETUBQGFHX-QFIPXVFZSA-N
InChI=1S/C22H31NO3/c1-3-23(4-2)17-11-12-18-26-21(24)22(25,19-13-7-5-8-14-19)20-15-9-6-10-16-20/h5,7-8,13-14,20,25H,3-4,6,9-10,15-18H2,1-2H3/t22-/m0/s1

HIDE SMILES / InChI

Molecular Formula C22H31NO3
Molecular Weight 357.4864
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Approval Year

PubMed

PubMed

TitleDatePubMed
Oxytrol approved for overactive bladder.
2003 Aug
[Non-coordinated micturition syndrome mimicking posterior urethral valves in a male neonate].
2003 Jul
Pharmacokinetics, metabolism, and saliva output during transdermal and extended-release oral oxybutynin administration in healthy subjects.
2003 Jun
[Prevalence of urinary incontinence and linked factors in men and women over 65].
2003 Oct 15
Rapid and selective UV spectrophotometric and RP-HPLC methods for dissolution studies of oxybutynin immediate-release and controlled-release formulations.
2004 Nov 15
Effect of controlled-release delivery on the pharmacokinetics of oxybutynin at different dosages: severity-dependent treatment of the overactive bladder.
2004 Oct
Prediction of genotoxicity of chemical compounds by statistical learning methods.
2005 Jun
New transdermal bioadhesive film containing oxybutynin: In vitro permeation across rabbit ear skin.
2006 Nov 15
Improved efficacy of extended release oxybutynin in children with persistent daytime urinary incontinence converted from regular oxybutynin.
2006 Oct
Naftopidil monotherapy vs naftopidil and an anticholinergic agent combined therapy for storage symptoms associated with benign prostatic hyperplasia: A prospective randomized controlled study.
2006 Oct
Bladder augmentation: Review of the literature and recent advances.
2007 Oct
Effects of the M3 receptor selective muscarinic antagonist darifenacin on bladder afferent activity of the rat pelvic nerve.
2007 Sep
Locked-in Syndrome in a Nigerian male with Multiple Sclerosis: a case report and literature review.
2008 Oct 30
Reversible bilateral optic neuritis after Infliximab discontinuation in a patient with Crohn's disease.
2009 Sep
Posterior urethral valves: Morphological normalization of posterior urethra after fulguration is a significant factor in prognosis.
2010 Jul
[Isolated primary nocturnal enuresis: international evidence based management. Consensus recommendations by French expert group].
2010 May
Anesthetic management of the emergency laparotomy for a patient with multiple sclerosis -A case report-.
2010 Nov
Dose escalation improves therapeutic outcome: post hoc analysis of data from a 12-week, multicentre, double-blind, parallel-group trial of trospium chloride in patients with urinary urge incontinence.
2010 Sep 14
Patents
Substance Class Chemical
Created
by admin
on Mon Dec 19 00:53:22 UTC 2022
Edited
by admin
on Mon Dec 19 00:53:22 UTC 2022
Record UNII
5BRQ29UUB7
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Aroxybutynin
INN  
Official Name English
(-)-OXYBUTYNIN
Common Name English
OXYBUTYNIN, (-)-
Common Name English
4-(diethylamino)but-2-yn-1-yl (R)-cyclohexyl(hydroxy)(phenyl)acetate
Systematic Name English
(R)-OXYBUTYNIN
Common Name English
Benzeneacetic acid, ?-cyclohexyl-?-hydroxy-, 4-(diethylamino)-2-butyn-1-yl ester, (?R)-
Systematic Name English
aroxybutynin [INN]
Common Name English
R-OXYBUTYNIN
Common Name English
OXYBUTYNIN, (R)-
Common Name English
Code System Code Type Description
FDA UNII
5BRQ29UUB7
Created by admin on Mon Dec 19 00:53:25 UTC 2022 , Edited by admin on Mon Dec 19 00:53:25 UTC 2022
PRIMARY
CAS
119618-21-2
Created by admin on Mon Dec 19 00:53:25 UTC 2022 , Edited by admin on Mon Dec 19 00:53:25 UTC 2022
PRIMARY
INN
12152
Created by admin on Mon Dec 19 00:53:25 UTC 2022 , Edited by admin on Mon Dec 19 00:53:25 UTC 2022
PRIMARY
PUBCHEM
6098167
Created by admin on Mon Dec 19 00:53:25 UTC 2022 , Edited by admin on Mon Dec 19 00:53:25 UTC 2022
PRIMARY
NCI_THESAURUS
C190351
Created by admin on Mon Dec 19 00:53:25 UTC 2022 , Edited by admin on Mon Dec 19 00:53:25 UTC 2022
PRIMARY
Related Record Type Details
TARGET -> INHIBITOR
RACEMATE -> ACTIVE ENANTIOMER
TARGET -> INHIBITOR
TARGET -> INHIBITOR
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ACTIVE MOIETY