Aroxybutynin

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C22H31NO3
Molecular Weight	357.4864
Optical Activity	( - )
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCN(CC)CC#CCOC(=O)[C@@](O)(C1CCCCC1)C2=CC=CC=C2

InChI

InChIKey=XIQVNETUBQGFHX-QFIPXVFZSA-N

InChI=1S/C22H31NO3/c1-3-23(4-2)17-11-12-18-26-21(24)22(25,19-13-7-5-8-14-19)20-15-9-6-10-16-20/h5,7-8,13-14,20,25H,3-4,6,9-10,15-18H2,1-2H3/t22-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C22H31NO3
Molecular Weight	357.4864
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

PubMed

Title	Date	PubMed
Preformulation studies on the S-isomer of oxybutynin hydrochloride, an Improved Chemical Entity (ICE).	2001 Apr	11411899
Oxytrol approved for overactive bladder.	2003 Aug	12902940
Oxybutynin for treatment of urge urinary incontinence and overactive bladder: an updated review.	2004 Nov	15500382
Rapid and selective UV spectrophotometric and RP-HPLC methods for dissolution studies of oxybutynin immediate-release and controlled-release formulations.	2004 Nov 15	15522548
A peripheric neuromodulation technique for curing detrusor overactivity: Stoller afferent neurostimulation.	2005	16118096
Prediction of genotoxicity of chemical compounds by statistical learning methods.	2005 Jun	15962942
New transdermal bioadhesive film containing oxybutynin: In vitro permeation across rabbit ear skin.	2006 Nov 15	16860952
Analysis of pharmacological effects of drugs used for treatment of urinary disturbance based on anticholinergic and smooth muscle-relaxing effects.	2007 Jul	17603170
A review of urodynamic evaluation in children and its role in the management of boys with posterior urethral valves.	2007 Oct	19718301
Primary monosymptomatic nocturnal enuresis in children and adolescents.	2007 Sep	17727574
The neurogenic bladder: medical treatment.	2008 May	18095004
Polymeric matrix membrane sensors for stability-indicating potentiometric determination of oxybutynin hydrochloride and flavoxate hydrochloride urogenital system drugs.	2008 Nov-Dec	19202792
Locked-in Syndrome in a Nigerian male with Multiple Sclerosis: a case report and literature review.	2008 Oct 30	21532893
Behavioral intervention versus pharmacotherapy or their combinations in the management of overactive bladder dysfunction.	2009	20029638
Posterior urethral valves: Morphological normalization of posterior urethra after fulguration is a significant factor in prognosis.	2010 Jul	21124660

Patents

Substance Class	Chemical Created by `admin` on `Fri Jul 07 00:49:47 UTC 2023` Edited by `admin` on `Fri Jul 07 00:49:47 UTC 2023`
Record UNII	5BRQ29UUB7
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Aroxybutynin

Official Name

English

(-)-OXYBUTYNIN

Common Name

English

OXYBUTYNIN, (-)-

Common Name

English

4-(diethylamino)but-2-yn-1-yl (R)-cyclohexyl(hydroxy)(phenyl)acetate

Systematic Name

English

(R)-OXYBUTYNIN

Common Name

English

Benzeneacetic acid, α-cyclohexyl-α-hydroxy-, 4-(diethylamino)-2-butyn-1-yl ester, (αR)-

Systematic Name

English

aroxybutynin [INN]

Common Name

English

R-OXYBUTYNIN

Common Name

English

OXYBUTYNIN, (R)-

Common Name

English

Code System Code Type Description

FDA UNII

5BRQ29UUB7