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Details

Stereochemistry ACHIRAL
Molecular Formula C20H21N3O
Molecular Weight 319.4002
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of IMIDAFENACIN

SMILES

CC1=NC=CN1CCC(C(N)=O)(C2=CC=CC=C2)C3=CC=CC=C3

InChI

InChIKey=SQKXYSGRELMAAU-UHFFFAOYSA-N
InChI=1S/C20H21N3O/c1-16-22-13-15-23(16)14-12-20(19(21)24,17-8-4-2-5-9-17)18-10-6-3-7-11-18/h2-11,13,15H,12,14H2,1H3,(H2,21,24)

HIDE SMILES / InChI
Molecular Formula C20H21N3O
Molecular Weight 319.4002
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: Description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/25636812

Imidafenacin (KRP-197/ONO-8025) is the latest antimuscarinic (AM) developed for the treatment of overactive bladder syndrome (OAB) and, at the moment, it is marketed only in Japan. It has high affinities for the M3 and M1 muscarinic receptor subtypes, a low affinity for M2 receptors, and a potent inhibitory activity against rhythmic bladder contractions. Imidafenacin has excellent efficacy, tolerability, and safety. It is indicated for patients with nocturia, nocturnal polyuria, and benign prostatic hyperplasia.

CNS Activity

CNS Penetrant
2554
Curator's Comment: Imidafenacin showed little binding to brain muscarinic receptors.

Originator

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8297
 6.8 nM [IC50]
Antagonist
2778
 7.55 nM [Ki]
Antagonist
2778
 1.42 nM [Ki]
Inhibitor
8297
 0.747 nM [IC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
Uritos

Approved Use

For the treatment of Overactive bladder

Launch Date

2007
PubMed

PubMed

TitleDatePubMed
Effects of imidafenacin (KRP-197/ONO-8025), a new anti-cholinergic agent, on muscarinic acetylcholine receptors. High affinities for M3 and M1 receptor subtypes and selectivity for urinary bladder over salivary gland.
2007
Absolute bioavailability of imidafenacin after oral administration to healthy subjects.
2008 Feb
Response to "Suspected differential interactions of digoxin with imidafenacin and propantheline; some thoughts for introspection".
2009
Patents

Patents

07868183
1
JP2003201281A
1
JP2010013485A
1

Sample Use Guides

In Vivo Use Guide
Usually, for adults, a single dose of 0.1mg as imidafenacin is orally administered, twice daily, after each meal in the morning and evening. If the desired efficacy is not observed a single dose can be increased up to 0.2mg (0.4mg daily).
Route of Administration: Oral
In Vitro Use Guide
10(–8) to 10(–7) M Imidafenacin (KRP-197) significantly decreased electrical field stimulation-induced acetylcholine release and the contractile responses in a concentration-dependent manner.
Substance Class Chemical
Created
by admin
on Fri Dec 15 17:10:16 GMT 2023
Edited
by admin
on Fri Dec 15 17:10:16 GMT 2023
Record UNII
XJR8Y07LJO
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
IMIDAFENACIN
INN   JAN   MART.   WHO-DD  
INN  
Official Name English
URITOS
Brand Name English
STAYBLA
Brand Name English
IMIDAFENACIN [JAN]
Common Name English
KRP-197
Code English
IMIDAFENACIN [MART.]
Common Name English
ONO-8025
Code English
Imidafenacin [WHO-DD]
Common Name English
imidafenacin [INN]
Common Name English
IMIDAFENACIN [MI]
Common Name English
4-(2-METHYL-1H-IMIDAZOL-1-YL)-2,2-DIPHENYLBUTANAMIDE
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C29704
Created by admin on Fri Dec 15 17:10:16 GMT 2023 , Edited by admin on Fri Dec 15 17:10:16 GMT 2023
Code System Code Type Description
DRUG CENTRAL
4902
Created by admin on Fri Dec 15 17:10:16 GMT 2023 , Edited by admin on Fri Dec 15 17:10:16 GMT 2023
PRIMARY
MERCK INDEX
m11873
Created by admin on Fri Dec 15 17:10:16 GMT 2023 , Edited by admin on Fri Dec 15 17:10:16 GMT 2023
PRIMARY
MESH
C120953
Created by admin on Fri Dec 15 17:10:16 GMT 2023 , Edited by admin on Fri Dec 15 17:10:16 GMT 2023
PRIMARY
DRUG BANK
DB09262
Created by admin on Fri Dec 15 17:10:16 GMT 2023 , Edited by admin on Fri Dec 15 17:10:16 GMT 2023
PRIMARY
EPA CompTox
DTXSID00870104
Created by admin on Fri Dec 15 17:10:16 GMT 2023 , Edited by admin on Fri Dec 15 17:10:16 GMT 2023
PRIMARY
FDA UNII
XJR8Y07LJO
Created by admin on Fri Dec 15 17:10:16 GMT 2023 , Edited by admin on Fri Dec 15 17:10:16 GMT 2023
PRIMARY
NCI_THESAURUS
C83789
Created by admin on Fri Dec 15 17:10:16 GMT 2023 , Edited by admin on Fri Dec 15 17:10:16 GMT 2023
PRIMARY
PUBCHEM
6433090
Created by admin on Fri Dec 15 17:10:16 GMT 2023 , Edited by admin on Fri Dec 15 17:10:16 GMT 2023
PRIMARY
CAS
170105-16-5
Created by admin on Fri Dec 15 17:10:16 GMT 2023 , Edited by admin on Fri Dec 15 17:10:16 GMT 2023
PRIMARY
WIKIPEDIA
IMIDAFENACIN
Created by admin on Fri Dec 15 17:10:16 GMT 2023 , Edited by admin on Fri Dec 15 17:10:16 GMT 2023
PRIMARY
INN
8402
Created by admin on Fri Dec 15 17:10:16 GMT 2023 , Edited by admin on Fri Dec 15 17:10:16 GMT 2023
PRIMARY
SMS_ID
100000124434
Created by admin on Fri Dec 15 17:10:16 GMT 2023 , Edited by admin on Fri Dec 15 17:10:16 GMT 2023
PRIMARY
ChEMBL
CHEMBL53366
Created by admin on Fri Dec 15 17:10:16 GMT 2023 , Edited by admin on Fri Dec 15 17:10:16 GMT 2023
PRIMARY
EVMPD
SUB32180
Created by admin on Fri Dec 15 17:10:16 GMT 2023 , Edited by admin on Fri Dec 15 17:10:16 GMT 2023
PRIMARY
Related Record Type Details
MUSCARINIC ACETYLCHOLINE RECEPTOR M1
TARGET -> INHIBITOR
CYTOCHROME P450 3A4
METABOLIC ENZYME -> SUBSTRATE
Structure of IMIDAFENACIN
EXCRETED UNCHANGED
URINE
MUSCARINIC ACETYLCHOLINE RECEPTOR M3
TARGET -> INHIBITOR
URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A4
METABOLIC ENZYME -> SUBSTRATE
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Structure of 4-(2-METHYL-4,5-DIOXOIMIDAZOLIDIN-1-YL)-2,2-DIPHENYLBUTANAMIDE
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2h plasma
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Structure of 4-((ACETIMIDOYL)AMINO)-2,2-DIPHENYLBUTANAMIDE
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2h plasma
PLASMA
Structure of 2-ACETYLAMINO-N-(3-CARBAMOYL-3,3-DIPHENYLPROPYL)ACETAMIDE
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Structure of 3,3-DIPHENYL-2-PYRROLIDINONE
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Structure of 4-(2-METHYLIMIDAZOL-1-YL)-2,2-DIPHENYL-BUTANAMIDE N-OXIDE
METABOLITE -> PARENT
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Structure of N-(3-CARBAMOYL-3-(4-HYDROXYPHENYL)-3-PHENYLPROPYL)OXAMIDE
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Structure of 2-((4-AMINO-4-OXO-3,3-DIPHENYLBUTYL)AMINO)-2-OXOACETIC ACID
METABOLITE -> PARENT
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Structure of (2S,3S,4S,5R,6R)-6-(3-(4-AMINO-4-OXO-3,3-DIPHENYL-BUTYL)-2-METHYL-IMIDAZOL-1-YL)-3,4,5-TRIHYDROXY-TETRAHYDROPYRAN-2-CARBOXYLIC ACID
METABOLITE -> PARENT
2h plasma
PLASMA
Related Record Type Details
Structure of IMIDAFENACIN
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Tmax PHARMACOKINETIC
Biological Half-life PHARMACOKINETIC
NIH
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