REVATROPATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C19H27NO4S
Molecular Weight	365.487
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[S@@+]([O-])CC[C@](CO)(C(=O)O[C@H]1CN2CCC1CC2)C3=CC=CC=C3

InChI

InChIKey=VGXACJMXDYPFDB-SXMMONRFSA-N

InChI=1S/C19H27NO4S/c1-25(23)12-9-19(14-21,16-5-3-2-4-6-16)18(22)24-17-13-20-10-7-15(17)8-11-20/h2-6,15,17,21H,7-14H2,1H3/t17-,19+,25+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C19H27NO4S
Molecular Weight	365.487
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/22850354 | https://www.ncbi.nlm.nih.gov/pubmed/9121347 | https://adisinsight.springer.com/drugs/800009111 |

Revatropate is a muscarinic antagonist with selectivity for M1 and M3 receptor subtypes. Significant improvement in airway function was shown in horses with heaves after inhalation of revatropate, and it was found to be a safe and effective bronchodilator. Early clinical studies in chronic obstructive airway disease (COAD) patients also showed that inhaled revatropate was an effective bronchodilator, and well tolerated.

Originator

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:32:11 GMT 2023` Edited by `admin` on `Sat Dec 16 16:32:11 GMT 2023`
Record UNII	3W7L15V40W
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

REVATROPATE

Official Name

English

UK-112,166

Code

English

BENZENEACETIC ACID, .ALPHA.-(HYDROXYMETHYL)-.ALPHA.-(2-(METHYLSULFINYL)ETHYL)-, 1-AZABICYCLO(2.2.2)OCT-3-YL ESTER, (3R-(3R*(S*(R*))))-

Systematic Name

English

UK-112166

Code

English

BENZENEACETIC ACID, .ALPHA.-(HYDROXYMETHYL)-.ALPHA.-(2-((R)-METHYLSULFINYL)ETHYL)-, (3R)-1-AZABICYCLO(2.2.2)OCT-3-YL ESTER, (.ALPHA.S)-

Systematic Name

English

revatropate [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29704