MILAMELINE HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C8H14N2O.ClH
Molecular Weight	190.671
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CO\N=C\C1=CCCN(C)C1

InChI

InChIKey=WEBMRZODPLSRKR-MLBSPLJJSA-N

InChI=1S/C8H14N2O.ClH/c1-10-5-3-4-8(7-10)6-9-11-2;/h4,6H,3,5,7H2,1-2H3;1H/b9-6+;

HIDE SMILES / InChI

Molecular Formula	C8H14N2O
Molecular Weight	154.2096
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/10188788 | https://www.ncbi.nlm.nih.gov/pubmed/16958947 | https://adisinsight.springer.com/drugs/800001410

Milameline (previously known as RU 35926/CI-979), a partial muscarinic agonist that was developed as a cognition-enhancing agent for the treatment of patients with Alzheimer's disease. In spite of this drug has achieved phase III clinical trials, further studies were apparently discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed
Preclinical and phase 1 clinical characterization of CI-979/RU35926, a novel muscarinic agonist for the treatment of Alzheimer's disease.	1995	10188788

Patents

Sample Use Guides

In Vivo Use Guide

CI-979/RU35926 (milameline) was well tolerated at doses of 0.002-1.0 mg with cholinergic symptoms such as hypersalivation and sweating, observed at 2-4 mg.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Sat Dec 16 05:09:16 UTC 2023` Edited by `admin` on `Sat Dec 16 05:09:16 UTC 2023`
Record UNII	W867E71LPD
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MILAMELINE HYDROCHLORIDE

Official Name

English

MILAMELINE HCL

Common Name

English

Milameline hydrochloride [WHO-DD]

Common Name

English

RU35926

Code

English

MILAMELINE HYDROCHLORIDE [USAN]

Common Name

English

CI-979

Code

English

RU-35926

Code

English

3-PYRIDINECARBOXALDEHYDE, 1,2,5,6-TETRAHYDRO-1-METHYL-, O-METHYLOXIME, MONOHYDROCHLORIDE, (E)

Common Name

English

1,2,5,6-Tetrahydro-1-methylnicotinaldehyde (E)-O-methyloxime monohydrochloride

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C47796