U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Sat Dec 16 11:39:00 GMT 2023
Edited
by admin
on Sat Dec 16 11:39:00 GMT 2023
Protein Sub Type
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
8HOL4T03PN
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MUSCARINIC ACETYLCHOLINE RECEPTOR M4
Common Name English
CHRM4
Common Name English
m4
Common Name English
Code System Code Type Description
UNIPROT
P08173
Created by admin on Sat Dec 16 11:39:01 GMT 2023 , Edited by admin on Sat Dec 16 11:39:01 GMT 2023
PRIMARY
FDA UNII
8HOL4T03PN
Created by admin on Sat Dec 16 11:39:01 GMT 2023 , Edited by admin on Sat Dec 16 11:39:01 GMT 2023
PRIMARY
From To
1_105 1_185
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_8
N 1_13
Related Record Type Details
INHIBITOR -> TARGET
Binding Assay
IC50
INHIBITOR -> TARGET
Kd
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
BINDING
Ki
INHIBITOR -> TARGET
RADIOLIGAND->TARGET
Ki
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
THRX-195518 possesses activity at target muscarinic receptors that was slightly lower (approximately one-third to one-tenth) than revefenacin.
BINDING
Ki
INHIBITOR -> TARGET
Binding Assay
IC50
AGONIST -> TARGET
AGONIST -> TARGET
INHIBITOR -> TARGET
NON-AGONIST->OFF-TARGET
Ki
INHIBITOR -> TARGET
Membranes from transfected CHO cells
BINDING
IC50
LIGAND->TARGET
Binding Assay
Kd
INHIBITOR -> TARGET
Ki
AGONIST -> TARGET
INHIBITOR -> TARGET
BINDING
Kd
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
Shown to be a PAM of ACh function in a cell-based Ca2+mobilization assay. In this assay, increasing concentrations of MK-6884 potentiated the ability of a fixed concentration of ACh (EC20) to mobilize intracellular Ca2+
ALLOSTERIC ACTIVATOR
EC50
NON-INHIBITOR->OFF TARGET
NON-INHIBITOR
Ki
INHIBITOR -> TARGET
ANTAGONIST
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT CHEMICAL