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Details

Stereochemistry ACHIRAL
Molecular Formula C25H25N5O
Molecular Weight 411.4989
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MK-6884

SMILES

CN1CC2=CC=C(C=C2C1=O)C3=C(C=CC(=N3)C#N)C4=CN(CC5(C)CCCC5)N=C4

InChI

InChIKey=PREPVVXBTJBVOZ-UHFFFAOYSA-N
InChI=1S/C25H25N5O/c1-25(9-3-4-10-25)16-30-15-19(13-27-30)21-8-7-20(12-26)28-23(21)17-5-6-18-14-29(2)24(31)22(18)11-17/h5-8,11,13,15H,3-4,9-10,14,16H2,1-2H3

HIDE SMILES / InChI

Molecular Formula C25H25N5O
Molecular Weight 411.4989
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Substance Class Chemical
Created
by admin
on Sat Dec 16 14:46:15 GMT 2023
Edited
by admin
on Sat Dec 16 14:46:15 GMT 2023
Record UNII
LP9S42UN97
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MK-6884
Code English
2-Pyridinecarbonitrile, 6-(2,3-dihydro-2-methyl-3-oxo-1H-isoindol-5-yl)-5-[1-[(1-methylcyclopentyl)methyl]-1H-pyrazol-4-yl]-
Systematic Name English
Code System Code Type Description
PUBCHEM
129285824
Created by admin on Sat Dec 16 14:46:16 GMT 2023 , Edited by admin on Sat Dec 16 14:46:16 GMT 2023
PRIMARY
FDA UNII
LP9S42UN97
Created by admin on Sat Dec 16 14:46:16 GMT 2023 , Edited by admin on Sat Dec 16 14:46:16 GMT 2023
PRIMARY
CAS
2102194-04-5
Created by admin on Sat Dec 16 14:46:16 GMT 2023 , Edited by admin on Sat Dec 16 14:46:16 GMT 2023
PRIMARY
Related Record Type Details
TARGET->POSITIVE ALLOSTERIC MODULATOR (PAM)
Shown to be a PAM of ACh function in a cell-based Ca2+mobilization assay. In this assay, increasing concentrations of MK-6884 potentiated the ability of a fixed concentration of ACh (EC20) to mobilize intracellular Ca2+
ALLOSTERIC ACTIVATOR
EC50
LABELED -> NON-LABELED
TARGET->POSITIVE ALLOSTERIC MODULATOR (PAM)
BINDING
Ki
Related Record Type Details
ACTIVE MOIETY