MK-6884

Details

Stereochemistry	ACHIRAL
Molecular Formula	C25H25N5O
Molecular Weight	411.4989
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1CC2=CC=C(C=C2C1=O)C3=C(C=CC(=N3)C#N)C4=CN(CC5(C)CCCC5)N=C4

InChI

InChIKey=PREPVVXBTJBVOZ-UHFFFAOYSA-N

InChI=1S/C25H25N5O/c1-25(9-3-4-10-25)16-30-15-19(13-27-30)21-8-7-20(12-26)28-23(21)17-5-6-18-14-29(2)24(31)22(18)11-17/h5-8,11,13,15H,3-4,9-10,14,16H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C25H25N5O
Molecular Weight	411.4989
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 14:46:15 GMT 2023` Edited by `admin` on `Sat Dec 16 14:46:15 GMT 2023`
Record UNII	LP9S42UN97
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MK-6884

Code

English

2-Pyridinecarbonitrile, 6-(2,3-dihydro-2-methyl-3-oxo-1H-isoindol-5-yl)-5-[1-[(1-methylcyclopentyl)methyl]-1H-pyrazol-4-yl]-

Systematic Name

English

Code System Code Type Description

PUBCHEM

129285824

Created by admin on Sat Dec 16 14:46:16 GMT 2023 , Edited by admin on Sat Dec 16 14:46:16 GMT 2023

PRIMARY

FDA UNII

LP9S42UN97

Created by admin on Sat Dec 16 14:46:16 GMT 2023 , Edited by admin on Sat Dec 16 14:46:16 GMT 2023

PRIMARY

CAS

2102194-04-5

Created by admin on Sat Dec 16 14:46:16 GMT 2023 , Edited by admin on Sat Dec 16 14:46:16 GMT 2023

PRIMARY

Related Record Type Details


					8HOL4T03PN

MUSCARINIC ACETYLCHOLINE RECEPTOR M4

TARGET->POSITIVE ALLOSTERIC MODULATOR (PAM)

Comments:

Shown to be a PAM of ACh function in a cell-based Ca2+mobilization assay. In this assay, increasing concentrations of MK-6884 potentiated the ability of a fixed concentration of ACh (EC20) to mobilize intracellular Ca2+

Interaction Type:

ALLOSTERIC ACTIVATOR

Qualification:

EC50

Amount: