TRIHEXYPHENIDYL

Details

Stereochemistry	RACEMIC
Molecular Formula	C20H31NO
Molecular Weight	301.4662
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(CCN1CCCCC1)(C2CCCCC2)C3=CC=CC=C3

InChI

InChIKey=HWHLPVGTWGOCJO-UHFFFAOYSA-N

InChI=1S/C20H31NO/c22-20(18-10-4-1-5-11-18,19-12-6-2-7-13-19)14-17-21-15-8-3-9-16-21/h1,4-5,10-11,19,22H,2-3,6-9,12-17H2

HIDE SMILES / InChI

Molecular Formula	C20H31NO
Molecular Weight	301.4662
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: http://www.drugbank.ca/drugs/DB00376
Curator's Comment: Description was created based on several sources, including http://www.accessdata.fda.gov/drugsatfda_docs/nda/2003/006773_s036_artane.pdf

Trihexyphenidyl (Artane, Apo-Trihex, Parkin, Pacitane), also known as benzhexol and trihex has been in clinical usage for decades.It is an anticholinergic used in the symptomatic treatment of all etiologic groups of parkinsonism and drug induced extrapyramidal reactions (except tardive dyskinesia). Trihexyphenidyl possesses both anticholinergic and antihistaminic effects, although only the former has been established as therapeutically significant in the management of parkinsonism. Trihexyphenidyl is a selective M1 muscarinic acetylcholine receptor antagonist. It is able to discriminate between the M1 (cortical or neuronal) and the peripheral muscarinic subtypes (cardiac and glandular). Trihexyphenidyl partially blocks cholinergic activity in the CNS, which is responsible for the symptoms of Parkinson's disease. It is also thought to increase the availability of dopamine, a brain chemical that is critical in the initiation and smooth control of voluntary muscle movement. Trihexyphenidyl is indicated for the treatment of parkinson's disease and extrapyramidal reactions caused by drugs.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Potency
Muscarinic acetylcholine receptor M1 169 Target ID: CHEMBL216 Sources: http://www.drugbank.ca/drugs/DB00376	Antagonist 2778	1.3 nM [IC50]
Muscarinic acetylcholine receptor M4 86 Target ID: CHEMBL1821 Sources: http://www.drugbank.ca/drugs/DB00376 \| http://www.genome.jp/dbget-bin/www_bget?D00787	Antagonist 2778	6.7 nM [IC50]
Muscarinic acetylcholine receptor M5 62 Target ID: CHEMBL2035 Sources: http://www.drugbank.ca/drugs/DB00376 \| http://www.genome.jp/dbget-bin/www_bget?D00787	Antagonist 2778	10.3 nM [IC50]
Muscarinic acetylcholine receptor M3 159 Target ID: CHEMBL245 Sources: http://www.drugbank.ca/drugs/DB00376 \| http://www.genome.jp/dbget-bin/www_bget?D00787	Antagonist 2778	26.3 nM [IC50]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Parkinson's disease 226 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/nda/2003/006773_s036_artane.pdf	Primary		Approved 8429	Trihexyphenidyl hydrochloride Approved Use Trihexyphenidyl HCl tablets are indicated as an adjunct in the treatment of all forms of parkinsonism (postencephalitic, arteriosclerotic, and idiopathic). It is often useful as adjuvant therapy when treating these forms of parkinsonism with levodopa. Additionally, it is indicated for the control of extrapyramidal disorders caused by central nervous system drugs such as the dibenzoxazepines, phenothiazines, thioxanthenes, and butyrophenones. Launch Date 1949
Extrapyramidal disorders caused by central nervous system drugs 2 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/nda/2003/006773_s036_artane.pdf	Secondary		Approved 8429	Trihexyphenidyl hydrochloride Approved Use Trihexyphenidyl HCl tablets are indicated as an adjunct in the treatment of all forms of parkinsonism (postencephalitic, arteriosclerotic, and idiopathic). It is often useful as adjuvant therapy when treating these forms of parkinsonism with levodopa. Additionally, it is indicated for the control of extrapyramidal disorders caused by central nervous system drugs such as the dibenzoxazepines, phenothiazines, thioxanthenes, and butyrophenones. Launch Date 1949

C_max

Value	Dose	Co-administered	Analyte	Population
14.9 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/3225767/	5 mg single, oral dose: 5 mg route of administration: Oral experiment type: SINGLE co-administered:		TRIHEXYPHENIDYL serum	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED
24.4 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/3225767/	5 mg 2 times / day multiple, oral dose: 5 mg route of administration: Oral experiment type: MULTIPLE co-administered:		TRIHEXYPHENIDYL serum	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED

AUC

Value	Dose	Co-administered	Analyte	Population
294 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/3225767/	5 mg single, oral dose: 5 mg route of administration: Oral experiment type: SINGLE co-administered:		TRIHEXYPHENIDYL serum	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED
334 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/3225767/	5 mg 2 times / day multiple, oral dose: 5 mg route of administration: Oral experiment type: MULTIPLE co-administered:		TRIHEXYPHENIDYL serum	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED

T_1/2

Value	Dose	Co-administered	Analyte	Population
10.1 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/3225767/	5 mg single, oral dose: 5 mg route of administration: Oral experiment type: SINGLE co-administered:		TRIHEXYPHENIDYL serum	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED
8.67 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/3225767/	5 mg 2 times / day multiple, oral dose: 5 mg route of administration: Oral experiment type: MULTIPLE co-administered:		TRIHEXYPHENIDYL serum	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED

Doses

Dose	Population	Adverse events
0.55 mg/kg 1 times / day multiple, oral (mean) Highest studied dose Dose: 0.55 mg/kg, 1 times / day Route: oral Route: multiple Dose: 0.55 mg/kg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/21310336/	unhealthy, 1-18 years n = 101 Health Status: unhealthy Condition: cerebral palsy with dystonia or/and sialorrhea Age Group: 1-18 years Sex: M+F Population Size: 101 Sources: https://pubmed.ncbi.nlm.nih.gov/21310336/	Disc. AE: Constipation, Gastrointestinal disorders... AEs leading to discontinuation/dose reduction: Constipation (2 patients) Gastrointestinal disorders (4 patients) Behaviour disorder (2 patients) Movements involuntary (1 patient) Drowsiness (1 patient) Skin rash (1 patient) Sources: https://pubmed.ncbi.nlm.nih.gov/21310336/
40 mg multiple, oral Higher than recommended Dose: 40 mg Route: oral Route: multiple Dose: 40 mg Sources: https://pubmed.ncbi.nlm.nih.gov/6741602/	unhealthy, 25 years n = 1 Health Status: unhealthy Condition: drug and alcohol dependence Age Group: 25 years Sex: M Population Size: 1 Sources: https://pubmed.ncbi.nlm.nih.gov/6741602/	Other AEs: Dependence... Other AEs: Dependence (1 patient) Sources: https://pubmed.ncbi.nlm.nih.gov/6741602/
5 mg 28 times / day multiple, oral Higher than recommended Dose: 5 mg, 28 times / day Route: oral Route: multiple Dose: 5 mg, 28 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/6741602/	unhealthy, 35 years n = 1 Health Status: unhealthy Condition: schizophrenic Age Group: 35 years Sex: F Population Size: 1 Sources: https://pubmed.ncbi.nlm.nih.gov/6741602/	Other AEs: Dependence... Other AEs: Dependence (1 patient) Sources: https://pubmed.ncbi.nlm.nih.gov/6741602/
0.75 mg/kg 1 times / day multiple, oral (mean) Highest studied dose Dose: 0.75 mg/kg, 1 times / day Route: oral Route: multiple Dose: 0.75 mg/kg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/17690057/	unhealthy, 4-15 years n = 26 Health Status: unhealthy Condition: cerebral palsy Age Group: 4-15 years Sex: M+F Population Size: 26 Sources: https://pubmed.ncbi.nlm.nih.gov/17690057/	Disc. AE: Chorea, Rash... AEs leading to discontinuation/dose reduction: Chorea (1 patient) Rash (1 patient) Hyperactivity (1 patient) Sources: https://pubmed.ncbi.nlm.nih.gov/17690057/
24 mg 1 times / day multiple, oral (mean) Highest studied dose Dose: 24 mg, 1 times / day Route: oral Route: multiple Dose: 24 mg, 1 times / day Co-administed with:: ethopropazine(350 mg) Sources: https://pubmed.ncbi.nlm.nih.gov/6136938/	unhealthy, adult n = 52 Health Status: unhealthy Condition: torsion dystonia Age Group: adult Sex: unknown Population Size: 52 Sources: https://pubmed.ncbi.nlm.nih.gov/6136938/	Sources: https://pubmed.ncbi.nlm.nih.gov/6136938/
41 mg 1 times / day multiple, oral (mean) Highest studied dose Dose: 41 mg, 1 times / day Route: oral Route: multiple Dose: 41 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/6136938/	unhealthy, children n = 23 Health Status: unhealthy Condition: torsion dystonia Age Group: children Sex: unknown Population Size: 23 Sources: https://pubmed.ncbi.nlm.nih.gov/6136938/	Sources: https://pubmed.ncbi.nlm.nih.gov/6136938/
8 mg 1 times / day multiple, oral (mean) Recommended Dose: 8 mg, 1 times / day Route: oral Route: multiple Dose: 8 mg, 1 times / day Co-administed with:: neuroleptic Sources: https://pubmed.ncbi.nlm.nih.gov/3984771/	unhealthy, mean 49.7 years n = 22 Health Status: unhealthy Condition: schizophrenia or mental retardation Age Group: mean 49.7 years Sex: M+F Population Size: 22 Sources: https://pubmed.ncbi.nlm.nih.gov/3984771/	Other AEs: Extrapyramidal symptoms... Other AEs: Extrapyramidal symptoms (77%) Sources: https://pubmed.ncbi.nlm.nih.gov/3984771/

AEs

AE	Significance	Dose	Population
Drowsiness	1 patient Disc. AE	0.55 mg/kg 1 times / day multiple, oral (mean) Highest studied dose Dose: 0.55 mg/kg, 1 times / day Route: oral Route: multiple Dose: 0.55 mg/kg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/21310336/	unhealthy, 1-18 years n = 101 Health Status: unhealthy Condition: cerebral palsy with dystonia or/and sialorrhea Age Group: 1-18 years Sex: M+F Population Size: 101 Sources: https://pubmed.ncbi.nlm.nih.gov/21310336/
Movements involuntary	1 patient Disc. AE	0.55 mg/kg 1 times / day multiple, oral (mean) Highest studied dose Dose: 0.55 mg/kg, 1 times / day Route: oral Route: multiple Dose: 0.55 mg/kg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/21310336/	unhealthy, 1-18 years n = 101 Health Status: unhealthy Condition: cerebral palsy with dystonia or/and sialorrhea Age Group: 1-18 years Sex: M+F Population Size: 101 Sources: https://pubmed.ncbi.nlm.nih.gov/21310336/
Skin rash	1 patient Disc. AE	0.55 mg/kg 1 times / day multiple, oral (mean) Highest studied dose Dose: 0.55 mg/kg, 1 times / day Route: oral Route: multiple Dose: 0.55 mg/kg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/21310336/	unhealthy, 1-18 years n = 101 Health Status: unhealthy Condition: cerebral palsy with dystonia or/and sialorrhea Age Group: 1-18 years Sex: M+F Population Size: 101 Sources: https://pubmed.ncbi.nlm.nih.gov/21310336/
Behaviour disorder	2 patients Disc. AE	0.55 mg/kg 1 times / day multiple, oral (mean) Highest studied dose Dose: 0.55 mg/kg, 1 times / day Route: oral Route: multiple Dose: 0.55 mg/kg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/21310336/	unhealthy, 1-18 years n = 101 Health Status: unhealthy Condition: cerebral palsy with dystonia or/and sialorrhea Age Group: 1-18 years Sex: M+F Population Size: 101 Sources: https://pubmed.ncbi.nlm.nih.gov/21310336/
Constipation	2 patients Disc. AE	0.55 mg/kg 1 times / day multiple, oral (mean) Highest studied dose Dose: 0.55 mg/kg, 1 times / day Route: oral Route: multiple Dose: 0.55 mg/kg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/21310336/	unhealthy, 1-18 years n = 101 Health Status: unhealthy Condition: cerebral palsy with dystonia or/and sialorrhea Age Group: 1-18 years Sex: M+F Population Size: 101 Sources: https://pubmed.ncbi.nlm.nih.gov/21310336/
Gastrointestinal disorders	4 patients Disc. AE	0.55 mg/kg 1 times / day multiple, oral (mean) Highest studied dose Dose: 0.55 mg/kg, 1 times / day Route: oral Route: multiple Dose: 0.55 mg/kg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/21310336/	unhealthy, 1-18 years n = 101 Health Status: unhealthy Condition: cerebral palsy with dystonia or/and sialorrhea Age Group: 1-18 years Sex: M+F Population Size: 101 Sources: https://pubmed.ncbi.nlm.nih.gov/21310336/
Dependence	1 patient	40 mg multiple, oral Higher than recommended Dose: 40 mg Route: oral Route: multiple Dose: 40 mg Sources: https://pubmed.ncbi.nlm.nih.gov/6741602/	unhealthy, 25 years n = 1 Health Status: unhealthy Condition: drug and alcohol dependence Age Group: 25 years Sex: M Population Size: 1 Sources: https://pubmed.ncbi.nlm.nih.gov/6741602/
Dependence	1 patient	5 mg 28 times / day multiple, oral Higher than recommended Dose: 5 mg, 28 times / day Route: oral Route: multiple Dose: 5 mg, 28 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/6741602/	unhealthy, 35 years n = 1 Health Status: unhealthy Condition: schizophrenic Age Group: 35 years Sex: F Population Size: 1 Sources: https://pubmed.ncbi.nlm.nih.gov/6741602/
Chorea	1 patient Disc. AE	0.75 mg/kg 1 times / day multiple, oral (mean) Highest studied dose Dose: 0.75 mg/kg, 1 times / day Route: oral Route: multiple Dose: 0.75 mg/kg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/17690057/	unhealthy, 4-15 years n = 26 Health Status: unhealthy Condition: cerebral palsy Age Group: 4-15 years Sex: M+F Population Size: 26 Sources: https://pubmed.ncbi.nlm.nih.gov/17690057/
Hyperactivity	1 patient Disc. AE	0.75 mg/kg 1 times / day multiple, oral (mean) Highest studied dose Dose: 0.75 mg/kg, 1 times / day Route: oral Route: multiple Dose: 0.75 mg/kg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/17690057/	unhealthy, 4-15 years n = 26 Health Status: unhealthy Condition: cerebral palsy Age Group: 4-15 years Sex: M+F Population Size: 26 Sources: https://pubmed.ncbi.nlm.nih.gov/17690057/
Rash	1 patient Disc. AE	0.75 mg/kg 1 times / day multiple, oral (mean) Highest studied dose Dose: 0.75 mg/kg, 1 times / day Route: oral Route: multiple Dose: 0.75 mg/kg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/17690057/	unhealthy, 4-15 years n = 26 Health Status: unhealthy Condition: cerebral palsy Age Group: 4-15 years Sex: M+F Population Size: 26 Sources: https://pubmed.ncbi.nlm.nih.gov/17690057/
Extrapyramidal symptoms	77%	8 mg 1 times / day multiple, oral (mean) Recommended Dose: 8 mg, 1 times / day Route: oral Route: multiple Dose: 8 mg, 1 times / day Co-administed with:: neuroleptic Sources: https://pubmed.ncbi.nlm.nih.gov/3984771/	unhealthy, mean 49.7 years n = 22 Health Status: unhealthy Condition: schizophrenia or mental retardation Age Group: mean 49.7 years Sex: M+F Population Size: 22 Sources: https://pubmed.ncbi.nlm.nih.gov/3984771/

Sourcing

Vendor/Aggregator	ID	URL
001 Chemical	DY523868	https://www.001chemical.com/chem/144-11-6
3B Scientific (Wuhan) Corp	3B3-065679	http://www.3bsc.com/index/pro_info.php?id=104940
Aurora Fine Chemicals LLC	A12.862.769	http://online.aurorafinechemicals.com/info?ID=A12.862.769
Aurum Pharmatech LLC	H2264	http://www.Aurumpharmatech.com/Product/ProductDetails/H2264
BLD Pharm	BD41291	http://www.bldpharm.com/products/144-11-6.html
ChemMol	49416053	http://www.chemmol.com/chemmol/49416053.html
Chemspace	CSSS00020675549	https://chem-space.com/CSSS00020675549
Hairui	HR141293	http://www.hairuichem.com/en/product/144-11-6.html
MolPort	MolPort-001-783-510	https://www.molport.com/shop/molecule-link/MolPort-001-783-510
Molcore	MC523868	https://www.molcore.com/product/144-11-6
OChem	12132	http://www.ocheminc.com/index.php?act=psearch&pid=144T116
Parchem	30212	http://www.parchem.com/chemical-supplier-distributor/Trihexyphenidyl-020212.aspx
Smolecule	S520860	http://www.smolecule.com/products/s520860
THE BioTek	bt-261968	https://www.thebiotek.com/product/inhibitors/bt-261968
Vitas-M Laboratory	BBL024959	http://www.request.vitasmlab.biz/index.php?option=com_search_stk&Itemid=22&stk=BBL024959&?utm_source=pubchem&utm_medium=p_search_link&utm_campaign=pubchem_search&utm_content=pubchem_slink
eNovation Chemicals	D674824	https://www.enovationchem.com/ProductDetails.asp?ProductID=D674824
mcule	MCULE-6065307656	https://mcule.com/MCULE-6065307656/

PubMed

Title	Date	PubMed
Toxic psychosis induced by benzhexol hydrochloride.	1970 Oct 10	5506119
Benzhexol and side effects with long-acting fluphenazine therapy.	1972 Jan 29	4550377
Toxic liver injuries.	1973 Aug	4800729
Depot phenothiazine treatment in acute psychosis: a sequential comparative clinical study.	1973 Jan	4566388
Neuroleptics and neurologic reactions.	1973 Mar	4144147
Abnormal involuntary movements induced by anticholinergic therapy.	1974	4155220
Comparative trial of benzhexol, amantadine, and levodopa in the treatment of Parkinson's disease.	1974 Apr	4838913
Fluphenazine enanthate induced decompensations.	1975	1178807
[Effects of diazepam on six drug-induced locomotor hyperactivities in mice (author's transl)].	1975 Dec 31	129788
Amodiaquine-induced involuntary movements.	1976 Jul 24	974497
Anticholinergic exacerbation of phenothiazine-induced extrapyramidal syndrome.	1976 Sep	961932
Mood elevating effect of trihexyphenidyl and biperiden in individuals taking antipsychotic medication.	1977 May	852367
Choreiform movements induced by anticholinergic therapy.	1979 May 19	470689
Catalepsy produced by long-acting neuroleptics, fluphenazine enanthate and fluphenazine decanoate, in mice.	1982	7200248
Sexual dysfunction in women using major tranquilizers.	1982 Sep	7146292
Trihexyphenidyl dependence.	1984 Jun	6741602
Withdrawal of trihexyphenidyl.	1985 Mar	3984771
Binding and functional profiles of the selective M1 muscarinic receptor antagonists trihexyphenidyl and dicyclomine.	1986 Sep	2432979
Lithium-induced akathisia.	1987 Feb	3100511
Schizophrenic psychosis associated with benzhexol (artane) therapy.	1989 Sep	2795088
[A case of choreoathetoid movements induced by anticholinergic drugs, trihexyphenidyl HCl and dosulepin HCl].	1992 Sep	1434066
[A 75-year-old man with parkinsonism and delirium].	1994 Jan	8192765
Positron emission tomography of reversible intellectual impairment induced by long-term anticholinergic therapy.	1995 Sep	8523038
Trihexyphenidyl as a possible therapeutic option in clozapine-induced nocturnal enuresis.	1996 Mar	8732317
Anticholinergic overdose induced torsade de pointes successfully treated with verapamil.	1996 Nov	9057687
Antiparkinsonian drugs causing inappropriate antidiuretic hormone secretion.	1998 Jan	9452348
Chronic haloperidol produces a time- and dose-related slowing of lick rhythm in rats: implications for rodent models of tardive dyskinesia and neuroleptic-induced parkinsonism.	1998 May	9631956
Anti-nicotinic properties of anticholinergic antiparkinson drugs.	1998 Nov	9877318
Risperidone-induced rabbit syndrome.	1998 Sep	9926106
Electromyography in cervical dystonia: changes after botulinum and trihexyphenidyl.	1998 Sep	9748032
Medication-induced hallucination and cerebral blood flow in Parkinson's disease.	1999 May	10399867
Effects of selected anticholinergics on acoustic startle response in rats.	2001 Dec	11920928
A systematic review for evidence of efficacy of anticholinergic drugs to treat drooling.	2003 Oct	14500313
Discriminative stimulus properties of 1.25 and 5.0 mg/kg doses of clozapine in rats: examination of the role of dopamine, serotonin, and muscarinic receptor mechanisms.	2004 Feb	14751446
Increased anticholinergic challenge-induced memory impairment associated with the APOE-epsilon4 allele in the elderly: a controlled pilot study.	2004 Feb	14735126
[A case of Parkinsonian syndrome, cognitive impairment and hyperammonemia induced by divalproate sodium prescribed for bipolar disorder].	2005 Jan-Feb	15971646
[Two cases of tardive Tourette syndrome].	2006	16869393
Aripiprazole-induced acute dystonia.	2006 Jun	16741220
Acute dystonic reaction to metoclopramide in patients carrying homozygous cytochrome P450 2D6 genetic polymorphisms.	2006 May	16702617
Sustained improvement of motor function in hemiparkinsonian rats chronically treated with low doses of caffeine or trihexyphenidyl.	2007 Jan	17250882
Decreased prepulse inhibition and increased sensitivity to muscarinic, but not dopaminergic drugs in M5 muscarinic acetylcholine receptor knockout mice.	2007 May	17310388
Sclerosing mesenteritis: an ergot-related complication of pergolide therapy in Parkinson's disease?	2008 Apr 30	18361473
Therapeutic and cosmeceutical potential of ethosomes: An overview.	2010 Jul	22247858
Bipolar affective disorder associated with thenar hypoplasia: is lithium safe?	2010 Jul-Aug	19829091
Simultaneous spectrophotometric estimation of haloperidol and trihexyphenidyl in tablets.	2010 Mar	20838539
Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.	2011 Jul 14	21599003

Patents

Sample Use Guides

In Vivo Use Guide

Usual Adult Dose for Extrapyramidal Reaction 4 to 10 mg orally each day. The total daily dose is best tolerated when administered in 2 or three equally separated doses. Usual Adult Dose for Parkinson's Disease Initial: 1 mg/day; increase by 2 mg increments at intervals of 3 to 5 days Usual dose: 6 to 10 mg/day in 3 to 4 divided doses; doses of 12 to 15 mg/day may be required Drug-induced extrapyramidal symptoms: Initial: 1 mg/day; increase as necessary to usual range of 5 to 15 mg/day in 3 to 4 divided doses Use in combination with levodopa: Usual range: 3 to 6 mg/day in divided doses

Route of Administration: Oral

In Vitro Use Guide

Trihexyphenidyl 10, 50, and 100 umol/L depressed the maximal upstroke velocity (Vmax) and the action potential amplitude (APA) of SAP in guinea pig papillary muscles.

Substance Class	Chemical Created by `admin` on `Sat Dec 16 15:54:27 GMT 2023` Edited by `admin` on `Sat Dec 16 15:54:27 GMT 2023`
Record UNII	6RC5V8B7PO
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TRIHEXYPHENIDYL

Official Name

English

NSC-12268

Code

English

APO-TRIHEX

Brand Name

English

Trihexyphenidyl [WHO-DD]

Common Name

English

TRIHEXYPHENIDYL [VANDF]

Common Name

English

TRIHEXYPHENIDYL [HSDB]

Common Name

English

1-CYCLOHEXYL-1-PHENYL-3-(1-PIPERIDYL)PROPAN-1-OL

Systematic Name

English

trihexyphenidyl [INN]

Common Name

English

BENZHEXOL

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C38149