U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry RACEMIC
Molecular Formula C20H31NO.ClH
Molecular Weight 337.927
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TRIHEXYPHENIDYL HYDROCHLORIDE

SMILES

Cl.OC(CCN1CCCCC1)(C2CCCCC2)C3=CC=CC=C3

InChI

InChIKey=QDWJJTJNXAKQKD-UHFFFAOYSA-N
InChI=1S/C20H31NO.ClH/c22-20(18-10-4-1-5-11-18,19-12-6-2-7-13-19)14-17-21-15-8-3-9-16-21;/h1,4-5,10-11,19,22H,2-3,6-9,12-17H2;1H

HIDE SMILES / InChI
Molecular Formula C20H31NO
Molecular Weight 301.4662
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: Description was created based on several sources, including http://www.accessdata.fda.gov/drugsatfda_docs/nda/2003/006773_s036_artane.pdf

Trihexyphenidyl (Artane, Apo-Trihex, Parkin, Pacitane), also known as benzhexol and trihex has been in clinical usage for decades.It is an anticholinergic used in the symptomatic treatment of all etiologic groups of parkinsonism and drug induced extrapyramidal reactions (except tardive dyskinesia). Trihexyphenidyl possesses both anticholinergic and antihistaminic effects, although only the former has been established as therapeutically significant in the management of parkinsonism. Trihexyphenidyl is a selective M1 muscarinic acetylcholine receptor antagonist. It is able to discriminate between the M1 (cortical or neuronal) and the peripheral muscarinic subtypes (cardiac and glandular). Trihexyphenidyl partially blocks cholinergic activity in the CNS, which is responsible for the symptoms of Parkinson's disease. It is also thought to increase the availability of dopamine, a brain chemical that is critical in the initiation and smooth control of voluntary muscle movement. Trihexyphenidyl is indicated for the treatment of parkinson's disease and extrapyramidal reactions caused by drugs.

CNS Activity

Originator

Approval Year

1949
70
Targets

Targets

Primary TargetPharmacologyConditionPotency
Antagonist
2778
 1.3 nM [IC50]
Antagonist
2778
 6.7 nM [IC50]
Antagonist
2778
 10.3 nM [IC50]
Antagonist
2778
 26.3 nM [IC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
Trihexyphenidyl hydrochloride

Approved Use

Trihexyphenidyl HCl tablets are indicated as an adjunct in the treatment of all forms of parkinsonism (postencephalitic, arteriosclerotic, and idiopathic). It is often useful as adjuvant therapy when treating these forms of parkinsonism with levodopa. Additionally, it is indicated for the control of extrapyramidal disorders caused by central nervous system drugs such as the dibenzoxazepines, phenothiazines, thioxanthenes, and butyrophenones.

Launch Date

-6.5136958E11
Secondary
Approved
8429
Trihexyphenidyl hydrochloride

Approved Use

Trihexyphenidyl HCl tablets are indicated as an adjunct in the treatment of all forms of parkinsonism (postencephalitic, arteriosclerotic, and idiopathic). It is often useful as adjuvant therapy when treating these forms of parkinsonism with levodopa. Additionally, it is indicated for the control of extrapyramidal disorders caused by central nervous system drugs such as the dibenzoxazepines, phenothiazines, thioxanthenes, and butyrophenones.

Launch Date

-6.5136958E11
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
14.9 ng/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/3225767/
5 mg single, oral
dose: 5 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
TRIHEXYPHENIDYL serum
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
24.4 ng/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/3225767/
5 mg 2 times / day multiple, oral
dose: 5 mg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
TRIHEXYPHENIDYL serum
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
294 ng × h/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/3225767/
5 mg single, oral
dose: 5 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
TRIHEXYPHENIDYL serum
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
334 ng × h/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/3225767/
5 mg 2 times / day multiple, oral
dose: 5 mg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
TRIHEXYPHENIDYL serum
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
10.1 h
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/3225767/
5 mg single, oral
dose: 5 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
TRIHEXYPHENIDYL serum
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
8.67 h
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/3225767/
5 mg 2 times / day multiple, oral
dose: 5 mg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
TRIHEXYPHENIDYL serum
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
Doses

Doses

DosePopulationAdverse events​
0.55 mg/kg 1 times / day multiple, oral (mean)
Highest studied dose
Dose: 0.55 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 0.55 mg/kg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/21310336/
unhealthy, 1-18 years
n = 101
Health Status: unhealthy
Condition: cerebral palsy with dystonia or/and sialorrhea
Age Group: 1-18 years
Sex: M+F
Population Size: 101
Sources:
https://pubmed.ncbi.nlm.nih.gov/21310336/
Disc. AE: Constipation, Gastrointestinal disorders...
AEs leading to
discontinuation/dose reduction:
Constipation (2 patients)
Gastrointestinal disorders (4 patients)
Behaviour disorder (2 patients)
Movements involuntary (1 patient)
Drowsiness (1 patient)
Skin rash (1 patient)
Sources:
https://pubmed.ncbi.nlm.nih.gov/21310336/
40 mg multiple, oral
Higher than recommended
Dose: 40 mg
Route: oral
Route: multiple
Dose: 40 mg
Sources:
https://pubmed.ncbi.nlm.nih.gov/6741602/
unhealthy, 25 years
n = 1
Health Status: unhealthy
Condition: drug and alcohol dependence
Age Group: 25 years
Sex: M
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/6741602/
Other AEs: Dependence...
Other AEs:
Dependence (1 patient)
Sources:
https://pubmed.ncbi.nlm.nih.gov/6741602/
5 mg 28 times / day multiple, oral
Higher than recommended
Dose: 5 mg, 28 times / day
Route: oral
Route: multiple
Dose: 5 mg, 28 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/6741602/
unhealthy, 35 years
n = 1
Health Status: unhealthy
Condition: schizophrenic
Age Group: 35 years
Sex: F
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/6741602/
Other AEs: Dependence...
Other AEs:
Dependence (1 patient)
Sources:
https://pubmed.ncbi.nlm.nih.gov/6741602/
0.75 mg/kg 1 times / day multiple, oral (mean)
Highest studied dose
Dose: 0.75 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 0.75 mg/kg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/17690057/
unhealthy, 4-15 years
n = 26
Health Status: unhealthy
Condition: cerebral palsy
Age Group: 4-15 years
Sex: M+F
Population Size: 26
Sources:
https://pubmed.ncbi.nlm.nih.gov/17690057/
Disc. AE: Chorea, Rash...
AEs leading to
discontinuation/dose reduction:
Chorea (1 patient)
Rash (1 patient)
Hyperactivity (1 patient)
Sources:
https://pubmed.ncbi.nlm.nih.gov/17690057/
24 mg 1 times / day multiple, oral (mean)
Highest studied dose
Dose: 24 mg, 1 times / day
Route: oral
Route: multiple
Dose: 24 mg, 1 times / day
Co-administed with::
ethopropazine(350 mg)
Sources:
https://pubmed.ncbi.nlm.nih.gov/6136938/
unhealthy, adult
n = 52
Health Status: unhealthy
Condition: torsion dystonia
Age Group: adult
Sex: unknown
Population Size: 52
Sources:
https://pubmed.ncbi.nlm.nih.gov/6136938/
Sources:
https://pubmed.ncbi.nlm.nih.gov/6136938/
41 mg 1 times / day multiple, oral (mean)
Highest studied dose
Dose: 41 mg, 1 times / day
Route: oral
Route: multiple
Dose: 41 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/6136938/
unhealthy, children
n = 23
Health Status: unhealthy
Condition: torsion dystonia
Age Group: children
Sex: unknown
Population Size: 23
Sources:
https://pubmed.ncbi.nlm.nih.gov/6136938/
Sources:
https://pubmed.ncbi.nlm.nih.gov/6136938/
8 mg 1 times / day multiple, oral (mean)
Recommended
Dose: 8 mg, 1 times / day
Route: oral
Route: multiple
Dose: 8 mg, 1 times / day
Co-administed with::
neuroleptic
Sources:
https://pubmed.ncbi.nlm.nih.gov/3984771/
unhealthy, mean 49.7 years
n = 22
Health Status: unhealthy
Condition: schizophrenia or mental retardation
Age Group: mean 49.7 years
Sex: M+F
Population Size: 22
Sources:
https://pubmed.ncbi.nlm.nih.gov/3984771/
Other AEs: Extrapyramidal symptoms...
Other AEs:
Extrapyramidal symptoms (77%)
Sources:
https://pubmed.ncbi.nlm.nih.gov/3984771/
AEs

AEs

AESignificanceDosePopulation
Drowsiness 1 patient
Disc. AE
0.55 mg/kg 1 times / day multiple, oral (mean)
Highest studied dose
Dose: 0.55 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 0.55 mg/kg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/21310336/
unhealthy, 1-18 years
n = 101
Health Status: unhealthy
Condition: cerebral palsy with dystonia or/and sialorrhea
Age Group: 1-18 years
Sex: M+F
Population Size: 101
Sources:
https://pubmed.ncbi.nlm.nih.gov/21310336/
Movements involuntary 1 patient
Disc. AE
0.55 mg/kg 1 times / day multiple, oral (mean)
Highest studied dose
Dose: 0.55 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 0.55 mg/kg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/21310336/
unhealthy, 1-18 years
n = 101
Health Status: unhealthy
Condition: cerebral palsy with dystonia or/and sialorrhea
Age Group: 1-18 years
Sex: M+F
Population Size: 101
Sources:
https://pubmed.ncbi.nlm.nih.gov/21310336/
Skin rash 1 patient
Disc. AE
0.55 mg/kg 1 times / day multiple, oral (mean)
Highest studied dose
Dose: 0.55 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 0.55 mg/kg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/21310336/
unhealthy, 1-18 years
n = 101
Health Status: unhealthy
Condition: cerebral palsy with dystonia or/and sialorrhea
Age Group: 1-18 years
Sex: M+F
Population Size: 101
Sources:
https://pubmed.ncbi.nlm.nih.gov/21310336/
Behaviour disorder 2 patients
Disc. AE
0.55 mg/kg 1 times / day multiple, oral (mean)
Highest studied dose
Dose: 0.55 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 0.55 mg/kg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/21310336/
unhealthy, 1-18 years
n = 101
Health Status: unhealthy
Condition: cerebral palsy with dystonia or/and sialorrhea
Age Group: 1-18 years
Sex: M+F
Population Size: 101
Sources:
https://pubmed.ncbi.nlm.nih.gov/21310336/
Constipation 2 patients
Disc. AE
0.55 mg/kg 1 times / day multiple, oral (mean)
Highest studied dose
Dose: 0.55 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 0.55 mg/kg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/21310336/
unhealthy, 1-18 years
n = 101
Health Status: unhealthy
Condition: cerebral palsy with dystonia or/and sialorrhea
Age Group: 1-18 years
Sex: M+F
Population Size: 101
Sources:
https://pubmed.ncbi.nlm.nih.gov/21310336/
Gastrointestinal disorders 4 patients
Disc. AE
0.55 mg/kg 1 times / day multiple, oral (mean)
Highest studied dose
Dose: 0.55 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 0.55 mg/kg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/21310336/
unhealthy, 1-18 years
n = 101
Health Status: unhealthy
Condition: cerebral palsy with dystonia or/and sialorrhea
Age Group: 1-18 years
Sex: M+F
Population Size: 101
Sources:
https://pubmed.ncbi.nlm.nih.gov/21310336/
Dependence 1 patient
40 mg multiple, oral
Higher than recommended
Dose: 40 mg
Route: oral
Route: multiple
Dose: 40 mg
Sources:
https://pubmed.ncbi.nlm.nih.gov/6741602/
unhealthy, 25 years
n = 1
Health Status: unhealthy
Condition: drug and alcohol dependence
Age Group: 25 years
Sex: M
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/6741602/
Dependence 1 patient
5 mg 28 times / day multiple, oral
Higher than recommended
Dose: 5 mg, 28 times / day
Route: oral
Route: multiple
Dose: 5 mg, 28 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/6741602/
unhealthy, 35 years
n = 1
Health Status: unhealthy
Condition: schizophrenic
Age Group: 35 years
Sex: F
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/6741602/
Chorea 1 patient
Disc. AE
0.75 mg/kg 1 times / day multiple, oral (mean)
Highest studied dose
Dose: 0.75 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 0.75 mg/kg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/17690057/
unhealthy, 4-15 years
n = 26
Health Status: unhealthy
Condition: cerebral palsy
Age Group: 4-15 years
Sex: M+F
Population Size: 26
Sources:
https://pubmed.ncbi.nlm.nih.gov/17690057/
Hyperactivity 1 patient
Disc. AE
0.75 mg/kg 1 times / day multiple, oral (mean)
Highest studied dose
Dose: 0.75 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 0.75 mg/kg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/17690057/
unhealthy, 4-15 years
n = 26
Health Status: unhealthy
Condition: cerebral palsy
Age Group: 4-15 years
Sex: M+F
Population Size: 26
Sources:
https://pubmed.ncbi.nlm.nih.gov/17690057/
Rash 1 patient
Disc. AE
0.75 mg/kg 1 times / day multiple, oral (mean)
Highest studied dose
Dose: 0.75 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 0.75 mg/kg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/17690057/
unhealthy, 4-15 years
n = 26
Health Status: unhealthy
Condition: cerebral palsy
Age Group: 4-15 years
Sex: M+F
Population Size: 26
Sources:
https://pubmed.ncbi.nlm.nih.gov/17690057/
Extrapyramidal symptoms 77%
8 mg 1 times / day multiple, oral (mean)
Recommended
Dose: 8 mg, 1 times / day
Route: oral
Route: multiple
Dose: 8 mg, 1 times / day
Co-administed with::
neuroleptic
Sources:
https://pubmed.ncbi.nlm.nih.gov/3984771/
unhealthy, mean 49.7 years
n = 22
Health Status: unhealthy
Condition: schizophrenia or mental retardation
Age Group: mean 49.7 years
Sex: M+F
Population Size: 22
Sources:
https://pubmed.ncbi.nlm.nih.gov/3984771/
Sourcing

Sourcing

Vendor/AggregatorIDURL
001 Chemical
DY523868
https://www.001chemical.com/chem/144-11-6
3B Scientific (Wuhan) Corp
3B3-065679
http://www.3bsc.com/index/pro_info.php?id=104940
Aurora Fine Chemicals LLC
A12.862.769
http://online.aurorafinechemicals.com/info?ID=A12.862.769
Aurum Pharmatech LLC
H2264
http://www.Aurumpharmatech.com/Product/ProductDetails/H2264
BLD Pharm
BD41291
http://www.bldpharm.com/products/144-11-6.html
ChemMol
49416053
http://www.chemmol.com/chemmol/49416053.html
Chemspace
CSSS00020675549
https://chem-space.com/CSSS00020675549
Hairui
HR141293
http://www.hairuichem.com/en/product/144-11-6.html
MolPort
MolPort-001-783-510
https://www.molport.com/shop/molecule-link/MolPort-001-783-510
Molcore
MC523868
https://www.molcore.com/product/144-11-6
OChem
12132
http://www.ocheminc.com/index.php?act=psearch&pid=144T116
Parchem
30212
http://www.parchem.com/chemical-supplier-distributor/Trihexyphenidyl-020212.aspx
Smolecule
S520860
http://www.smolecule.com/products/s520860
THE BioTek
bt-261968
https://www.thebiotek.com/product/inhibitors/bt-261968
Vitas-M Laboratory
BBL024959
http://www.request.vitasmlab.biz/index.php?option=com_search_stk&Itemid=22&stk=BBL024959&?utm_source=pubchem&utm_medium=p_search_link&utm_campaign=pubchem_search&utm_content=pubchem_slink
eNovation Chemicals
D674824
https://www.enovationchem.com/ProductDetails.asp?ProductID=D674824
mcule
MCULE-6065307656
https://mcule.com/MCULE-6065307656/
PubMed

PubMed

TitleDatePubMed
Phenothiazines in early labour.
1967 Feb 11
Drug-induced extrapyramidal symptoms: their incidence and treatment.
1967 Jan
Toxic psychosis induced by benzhexol hydrochloride.
1970 Oct 10
Benzhexol-induced blindness in Parkinson's disease.
1972 Mar 4
Abnormal involuntary movements induced by anticholinergic therapy.
1974
[Effects of diazepam on six drug-induced locomotor hyperactivities in mice (author's transl)].
1975 Dec 31
Amodiaquine-induced involuntary movements.
1976 Jul 24
Anticholinergic exacerbation of phenothiazine-induced extrapyramidal syndrome.
1976 Sep
Death attributed to ventricular arrhythmia induced by thioridazine in combination with a single Contac C capsule.
1978 Oct 7
Choreiform movements induced by anticholinergic therapy.
1979 May 19
Neuroleptic malignant syndrome.
1980 Jul
Withdrawal of trihexyphenidyl.
1985 Mar
Successful treatment of levodopa-induced myoclonus and levodopa withdrawal-induced neuroleptic malignant syndrome. A case report.
1988 Jun
[A 75-year-old man with parkinsonism and delirium].
1994 Jan
Trihexyphenidyl withdrawal encephalopathy.
1997 Jan
Anti-nicotinic properties of anticholinergic antiparkinson drugs.
1998 Nov
Risperidone-induced rabbit syndrome.
1998 Sep
Electromyography in cervical dystonia: changes after botulinum and trihexyphenidyl.
1998 Sep
Effects of selected anticholinergics on acoustic startle response in rats.
2001 Dec
Discriminative stimulus properties of 1.25 and 5.0 mg/kg doses of clozapine in rats: examination of the role of dopamine, serotonin, and muscarinic receptor mechanisms.
2004 Feb
Increased anticholinergic challenge-induced memory impairment associated with the APOE-epsilon4 allele in the elderly: a controlled pilot study.
2004 Feb
Acute dystonic reaction to metoclopramide in patients carrying homozygous cytochrome P450 2D6 genetic polymorphisms.
2006 May
Sclerosing mesenteritis: an ergot-related complication of pergolide therapy in Parkinson's disease?
2008 Apr 30
Flow injection determination of benzhexol based on its sensitizing effect on the chemiluminescent reaction of Ce(IV)-sulfite.
2010 Jul-Aug
A randomised, double-blind, placebo-controlled trial of tropisetron in patients with schizophrenia.
2010 Jun 24
Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.
2011 Jul 14
Patents

Patents

CN102030723B
2
US2016068510
2
US2016068514
2

Sample Use Guides

In Vivo Use Guide
Usual Adult Dose for Extrapyramidal Reaction 4 to 10 mg orally each day. The total daily dose is best tolerated when administered in 2 or three equally separated doses. Usual Adult Dose for Parkinson's Disease Initial: 1 mg/day; increase by 2 mg increments at intervals of 3 to 5 days Usual dose: 6 to 10 mg/day in 3 to 4 divided doses; doses of 12 to 15 mg/day may be required Drug-induced extrapyramidal symptoms: Initial: 1 mg/day; increase as necessary to usual range of 5 to 15 mg/day in 3 to 4 divided doses Use in combination with levodopa: Usual range: 3 to 6 mg/day in divided doses
Route of Administration: Oral
In Vitro Use Guide
Trihexyphenidyl 10, 50, and 100 umol/L depressed the maximal upstroke velocity (Vmax) and the action potential amplitude (APA) of SAP in guinea pig papillary muscles.
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:13:31 UTC 2023
Edited
by admin
on Fri Dec 15 16:13:31 UTC 2023
Record UNII
AO61G82577
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TRIHEXYPHENIDYL HYDROCHLORIDE
EP   MART.   MI   ORANGE BOOK   USP   USP-RS   VANDF   WHO-DD   WHO-IP  
Common Name English
ARTANE
Brand Name English
TRIHEXYPHENIDYL HYDROCHLORIDE [ORANGE BOOK]
Common Name English
BENZHEXOL HYDROCHLORIDE [WHO-IP]
Common Name English
PARCOPANE
Common Name English
TRIHEXYPHENIDYL HCL
Common Name English
ROMPARKIN
Common Name English
1-PIPERIDINEPROPANOL, .ALPHA.-CYCLOHEXYL-.ALPHA.-PHENYL-, HYDROCHLORIDE, (±)-
Systematic Name English
TRIHEXYPHENIDYL HYDROCHLORIDE [VANDF]
Common Name English
TRIHEXYPHENIDYL HYDROCHLORIDE [JAN]
Common Name English
TREMIN
Brand Name English
TRIHEXYPHENIDYL HYDROCHLORIDE [MART.]
Common Name English
CYCLODOL
Common Name English
Trihexyphenidyl hydrochloride [WHO-DD]
Common Name English
TRIHEXYPHENIDYL HYDROCHLORIDE [USP-RS]
Common Name English
CYCLODOLUM [WHO-IP]
Common Name English
(±)-.ALPHA.-CYCLOHEXYL-.ALPHA.-PHENYL-1-PIPERIDINEPROPANOL HYDROCHLORIDE
Systematic Name English
TRIPHEDINON
Common Name English
APARKANE
Common Name English
BENZHEXOL HYDROCHLORIDE
WHO-IP  
Common Name English
TRIHEXYPHENIDYL HYDROCHLORIDE [EP MONOGRAPH]
Common Name English
NSC-757357
Code English
TRIHEXYPHENIDYL HYDROCHLORIDE [WHO-IP]
Common Name English
TRIHEXYPHENIDYLI HYDROCHLORIDUM [WHO-IP LATIN]
Common Name English
TRIHEXYPHENIDYL HYDROCHLORIDE [MI]
Common Name English
TRIHEXYPHENIDYL HYDROCHLORIDE [USP MONOGRAPH]
Common Name English
SEDRINA
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C38149
Created by admin on Fri Dec 15 16:13:31 UTC 2023 , Edited by admin on Fri Dec 15 16:13:31 UTC 2023
NCI_THESAURUS C29704
Created by admin on Fri Dec 15 16:13:31 UTC 2023 , Edited by admin on Fri Dec 15 16:13:31 UTC 2023
Code System Code Type Description
ECHA (EC/EINECS)
200-142-5
Created by admin on Fri Dec 15 16:13:31 UTC 2023 , Edited by admin on Fri Dec 15 16:13:31 UTC 2023
PRIMARY
EVMPD
SUB04961MIG
Created by admin on Fri Dec 15 16:13:31 UTC 2023 , Edited by admin on Fri Dec 15 16:13:31 UTC 2023
PRIMARY
DAILYMED
AO61G82577
Created by admin on Fri Dec 15 16:13:31 UTC 2023 , Edited by admin on Fri Dec 15 16:13:31 UTC 2023
PRIMARY
SMS_ID
100000092344
Created by admin on Fri Dec 15 16:13:31 UTC 2023 , Edited by admin on Fri Dec 15 16:13:31 UTC 2023
PRIMARY
EPA CompTox
DTXSID8045802
Created by admin on Fri Dec 15 16:13:31 UTC 2023 , Edited by admin on Fri Dec 15 16:13:31 UTC 2023
PRIMARY
PUBCHEM
66007
Created by admin on Fri Dec 15 16:13:31 UTC 2023 , Edited by admin on Fri Dec 15 16:13:31 UTC 2023
PRIMARY
ChEMBL
CHEMBL1490
Created by admin on Fri Dec 15 16:13:31 UTC 2023 , Edited by admin on Fri Dec 15 16:13:31 UTC 2023
PRIMARY
FDA UNII
AO61G82577
Created by admin on Fri Dec 15 16:13:31 UTC 2023 , Edited by admin on Fri Dec 15 16:13:31 UTC 2023
PRIMARY
CAS
52-49-3
Created by admin on Fri Dec 15 16:13:31 UTC 2023 , Edited by admin on Fri Dec 15 16:13:31 UTC 2023
PRIMARY
NCI_THESAURUS
C47771
Created by admin on Fri Dec 15 16:13:31 UTC 2023 , Edited by admin on Fri Dec 15 16:13:31 UTC 2023
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WHO INTERNATIONAL PHARMACOPEIA
TRIHEXYPHENIDYL HYDROCHLORIDE
Created by admin on Fri Dec 15 16:13:31 UTC 2023 , Edited by admin on Fri Dec 15 16:13:31 UTC 2023
PRIMARY Description: A white or off-white, crystalline powder; odourless or almost odourless. Solubility: Slightly soluble in water; soluble in ethanol (~750 g/l) TS and methanol R. Category: Anticholinergic; antiparkinsonism drug. Storage: Trihexyphenidyl hydrochloride should be kept in a tightly closed container. Definition: Trihexyphenidyl hydrochloride contains not less than 98.0% and not more than 101.0% of C20H31NO,HCl, calculated with reference to the dried substance.
DRUG BANK
DBSALT000448
Created by admin on Fri Dec 15 16:13:31 UTC 2023 , Edited by admin on Fri Dec 15 16:13:31 UTC 2023
PRIMARY
RXCUI
1115
Created by admin on Fri Dec 15 16:13:31 UTC 2023 , Edited by admin on Fri Dec 15 16:13:31 UTC 2023
PRIMARY RxNorm
NSC
757357
Created by admin on Fri Dec 15 16:13:31 UTC 2023 , Edited by admin on Fri Dec 15 16:13:31 UTC 2023
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MERCK INDEX
m11134
Created by admin on Fri Dec 15 16:13:31 UTC 2023 , Edited by admin on Fri Dec 15 16:13:31 UTC 2023
PRIMARY Merck Index
RS_ITEM_NUM
1687006
Created by admin on Fri Dec 15 16:13:31 UTC 2023 , Edited by admin on Fri Dec 15 16:13:31 UTC 2023
PRIMARY
Related Record Type Details
Structure of TRIHEXYPHENIDYL
PARENT -> SALT/SOLVATE
Structure of TRIHEXYPHENIDYL HYDROCHLORIDE
BASIS OF STRENGTH->SUBSTANCE
ASSAY (TITRATION)
EP
Structure of TRIHEXYPHENIDYL HYDROCHLORIDE
BASIS OF STRENGTH->SUBSTANCE
ASSAY (HPLC)
USP
Related Record Type Details
Structure of 3-PIPERIDINOPROPIOPHENONE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of (1-PHENYL-3-(PIPERIDIN-1-YL)PROPAN-1-ONE HYDROCHLORIDE)
IMPURITY -> PARENT
Related Record Type Details
Structure of TRIHEXYPHENIDYL
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