Approval Year
Substance Class |
Protein
Created
by
admin
on
Edited
Sat Dec 16 11:28:53 GMT 2023
by
admin
on
Sat Dec 16 11:28:53 GMT 2023
|
Protein Sub Type | |
Sequence Type | COMPLETE |
Record UNII |
FZW85LW99M
|
Record Status |
Validated (UNII)
|
Record Version |
|
-
Download
Name | Type | Language | ||
---|---|---|---|---|
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
P04150
Created by
admin on Sat Dec 16 11:28:57 GMT 2023 , Edited by admin on Sat Dec 16 11:28:57 GMT 2023
|
PRIMARY | |||
|
P04150
Created by
admin on Sat Dec 16 11:28:57 GMT 2023 , Edited by admin on Sat Dec 16 11:28:57 GMT 2023
|
PRIMARY | |||
|
FZW85LW99M
Created by
admin on Sat Dec 16 11:28:57 GMT 2023 , Edited by admin on Sat Dec 16 11:28:57 GMT 2023
|
PRIMARY |
Linkage Type | Residue Index | |||
---|---|---|---|---|
COORDINATION COMPOUND | 1_421 | 1_424 | 1_438 | 1_441 |
COORDINATION COMPOUND | 1_457 | 1_463 | 1_473 | 1_476 |
Related Record | Type | Details | ||
---|---|---|---|---|
|
INHIBITOR -> TARGET | |||
|
AGONIST -> TARGET | |||
|
INHIBITOR -> TARGET |
|
||
|
AGONIST -> TARGET |
enhanced-affinity glucocorticoid
AGONIST
|
||
|
AGONIST -> TARGET |
|
||
|
AGONIST -> TARGET |
EC50
|
||
|
AGONIST -> TARGET |
Selective Nonsteroidal Glucocorticoid Receptor Modulator
|
||
|
AGONIST -> TARGET | |||
|
AGONIST -> TARGET |
|
||
|
AGONIST -> TARGET | |||
|
AGONIST -> TARGET | |||
|
AGONIST -> TARGET |
|
||
|
AGONIST -> TARGET | |||
|
INHIBITOR -> TARGET | |||
|
AGONIST -> TARGET |
BINDING
|
||
|
AGONIST -> TARGET | |||
|
AGONIST -> TARGET |
|
||
|
INHIBITOR -> TARGET |
IC50
|
||
|
AGONIST -> TARGET | |||
|
AGONIST -> TARGET |
BINDING
IC50
|
||
|
MODULATOR->TARGET |
|
||
|
AGONIST -> TARGET | |||
|
AGONIST -> TARGET |
|
||
|
AGONIST -> TARGET |
LPS-induced TNF-α release in peripheral blood mononuclear cells. Efficacy, maximum response relative to Dexamethasone (100%)=75%
|
||
|
PARTIAL AGONIST->TARGET |
|
||
|
AGONIST -> TARGET | |||
|
AGONIST -> TARGET |
|
||
|
AGONIST -> TARGET |
BINDING
IC50
|
||
|
AGONIST -> TARGET | |||
|
AGONIST -> TARGET |
Luciferase transactivation assay in CV-1 (African green monkey kidney) cells transfected with hGR.alpha. expression vectors
AGONIST
EC50
|
||
|
INHIBITOR -> TARGET |
BINDING
IC50
|
||
|
AGONIST -> TARGET | |||
|
INHIBITOR -> TARGET |
Ki
|
||
|
PARTIAL AGONIST->TARGET | |||
|
AGONIST -> TARGET |
|
||
|
AGONIST -> TARGET | |||
|
AGONIST -> TARGET |
|
||
|
AGONIST -> TARGET |
BINDING
Ki
|
||
|
RADIOLIGAND->TARGET |
Kd
|
||
|
AGONIST -> TARGET | |||
|
INHIBITOR -> TARGET |
|
||
|
INHIBITOR -> TARGET |
|
||
|
AGONIST -> TARGET |
|
||
|
INHIBITOR -> TARGET | |||
|
INHIBITOR -> TARGET | |||
|
AGONIST -> TARGET |
|
||
|
INHIBITOR -> TARGET |
|
||
|
INHIBITOR -> TARGET |
6β-OH-21-desDFZ exhibited minimal binding to the human glucocorticoid receptor (<15%) at concentration up to 1 μM.
MINOR
Ki
|
||
|
INHIBITOR -> TARGET |
|
||
|
INHIBITOR -> TARGET |
BINDING
IC50
|
Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
---|---|---|---|---|---|---|
MOL_WEIGHT | CHEMICAL |
|