GLUCOCORTICOID RECEPTOR

Approval Year

Substance Class	Protein
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	FZW85LW99M
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

GLUCOCORTICOID RECEPTOR

Common Name

English

NUCLEAR RECEPTOR SUBFAMILY 3 GROUP C MEMBER 1

Common Name

English

GRL

Common Name

English

Common Name

English

Showing 1 to 4 of 4 entries

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Code System

Code

Type

Description

PHAROS

P04150

PRIMARY

UNIPROT

P04150

PRIMARY

FDA UNII

FZW85LW99M

PRIMARY

Showing 1 to 3 of 3 entries

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Subunit 0

Linkage Type	Residue Index
COORDINATION COMPOUND	1_421	1_424	1_438	1_441
COORDINATION COMPOUND	1_457	1_463	1_473	1_476

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					311Y5GV21M

MIRICORILANT

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BMS-791826

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Nenocorilant

INHIBITOR -> TARGET

Amount:


					JS86977WNV

FLUTICASONE FUROATE

AGONIST -> TARGET

Comments:

enhanced-affinity glucocorticoid

Interaction Type:

AGONIST

Amount:


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DEXBUDESONIDE

AGONIST -> TARGET

Amount:


					9AMX4Q13CC

SEGESTERONE ACETATE

AGONIST -> TARGET

Qualification:

EC50

Amount:

4.68 NANOMOLAR (average)


					641H0Q518W

AZD-5423

AGONIST -> TARGET

Comments:

Selective Nonsteroidal Glucocorticoid Receptor Modulator

Amount:


					91A0K1TY3Z

HALOBETASOL PROPIONATE

AGONIST -> TARGET


					S59502J185

CICLESONIDE

AGONIST -> TARGET

Amount:


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FLUOCINOLONE ACETONIDE

AGONIST -> TARGET


					VFC6ZX3584

PARAMETHASONE

AGONIST -> TARGET


					SN8JN2RU5L

AZD-2906

AGONIST -> TARGET

Amount:


					8EUL29XUQT

FLURANDRENOLIDE

AGONIST -> TARGET


					GTB859B7K8

EXICORILANT

INHIBITOR -> TARGET


					7S5I7G3JQL

DEXAMETHASONE

AGONIST -> TARGET

Interaction Type:

BINDING


					136H45TB7B

ALCLOMETASONE

AGONIST -> TARGET


					YEH1EZ96K6

LOTEPREDNOL ETABONATE

AGONIST -> TARGET

Amount:


					56J566JLR6

CYMIPRISTONE

INHIBITOR -> TARGET

Qualification:

IC50

Amount:

0.45 NANOMOLAR [0.38 to 0.52] (average)


					P789X65VWC

SUN-597

AGONIST -> TARGET


					4G7DS2Q64Y

Progesterone

AGONIST -> TARGET

Interaction Type:

BINDING

Qualification:

IC50

Amount:

69 NANOMOLAR (average)


					FWC6IWT3EH

Adalimumab Fosimdesonide

MODULATOR->TARGET

Amount:


					WI4X0X7BPJ

HYDROCORTISONE

AGONIST -> TARGET


					5B307S63B2

BECLOMETHASONE DIPROPIONATE

AGONIST -> TARGET

Amount:


					P30N0911C2

VELSECORAT

AGONIST -> TARGET

Comments:

LPS-induced TNF-α release in peripheral blood mononuclear cells. Efficacy, maximum response relative to Dexamethasone (100%)=75%

Amount:


					OPM23UN90U

DAGROCORAT

PARTIAL AGONIST->TARGET

Amount:


					O7M2E4264D

RIMEXOLONE

AGONIST -> TARGET


					145V79YBVP

MAPRACORAT

AGONIST -> TARGET

Amount:


					1ZK20VI6TY

TRIAMCINOLONE

AGONIST -> TARGET

Interaction Type:

BINDING

Qualification:

IC50

Amount:

1.8 NANOMOLAR (average)


					QK4DYS664X

FLUNISOLIDE

AGONIST -> TARGET


					T1LWN33J2P

21-DESACETYLDEFLAZACORT

AGONIST -> TARGET

Comments:

Luciferase transactivation assay in CV-1 (African green monkey kidney) cells transfected with hGR.alpha. expression vectors

Interaction Type:

AGONIST

Qualification:

EC50

Amount:

4.37 NANOMOLAR (average)
Emax = 1.28


					7S5I7G3JQL

DEXAMETHASONE

INHIBITOR -> TARGET

Interaction Type:

BINDING

Qualification:

IC50

Amount:

3 NANOMOLAR (average)


					D2UFC189XF

MEDRYSONE

AGONIST -> TARGET


					A17W0640NB

CORT-108297

INHIBITOR -> TARGET

Qualification:

Amount:

0.9 NANOMOLAR (average)


					8WW8T70RDC

MK-5932

PARTIAL AGONIST->TARGET


					J05S86ZS6R

TOMICORAT

AGONIST -> TARGET

Amount:


					O891A2A3ZU

GW-870086

AGONIST -> TARGET


					9PHQ9Y1OLM

PREDNISOLONE

AGONIST -> TARGET

Amount:


					T1LWN33J2P

21-DESACETYLDEFLAZACORT

AGONIST -> TARGET

Interaction Type:

BINDING

Qualification:

Amount:

10 NANOMOLAR (average)


					5LQB9UHQ45

Dexamethasone H-3

RADIOLIGAND->TARGET

Qualification:

Amount:

1.5 NANOMOLAR (average)


					SV0CSG527L

FLUOROMETHOLONE

AGONIST -> TARGET


					VI6E2D3CYP

ORIC-101

INHIBITOR -> TARGET

Amount:


					HR4RD5RBJ6

Dazucorilant

INHIBITOR -> TARGET

Amount:


					GGK40O1O85

Mizacorat

AGONIST -> TARGET

Amount:


					KR5YZ6AE4B

DEFLAZACORT

INHIBITOR -> TARGET


					6J5J15Q2X8

ULIPRISTAL

INHIBITOR -> TARGET


					O2GMZ0LF5W

FLUTICASONE PROPIONATE

AGONIST -> TARGET

Amount:

2158753C7E

RELACORILANT

INHIBITOR -> TARGET

Amount:


					L93L6AWV7W

6BETA-HYDROXY-21-DESACETYL DEFLAZACORT

INHIBITOR -> TARGET

Comments:

6β-OH-21-desDFZ exhibited minimal binding to the human glucocorticoid receptor (<15%) at concentration up to 1 μM.

Interaction Type:

MINOR

Qualification:

Amount:

[>1] MICROMOLAR (average)


					74XPH8W9F6

ZAVACORILANT

INHIBITOR -> TARGET

Amount:


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ESTRADIOL

INHIBITOR -> TARGET

Interaction Type:

BINDING

Qualification:

IC50

Amount:

1.736 MICROMOLAR (average)

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT	CHEMICAL