CORT-108297

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C26H25F4N3O3S
Molecular Weight	535.554
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCOC[C@@]12CN(CCC1=CC3=C(C2)C=NN3C4=CC=C(F)C=C4)S(=O)(=O)C5=CC=C(C=C5)C(F)(F)F

InChI

InChIKey=SLKURXRZHJOZOD-RUZDIDTESA-N

InChI=1S/C26H25F4N3O3S/c1-2-36-17-25-14-18-15-31-33(22-7-5-21(27)6-8-22)24(18)13-20(25)11-12-32(16-25)37(34,35)23-9-3-19(4-10-23)26(28,29)30/h3-10,13,15H,2,11-12,14,16-17H2,1H3/t25-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C26H25F4N3O3S
Molecular Weight	535.554
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Glucocorticoid receptor 172 Target ID: CHEMBL2034 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18226897	Antagonist 2778		0.9 nM [Ki]

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 19:50:24 GMT 2023` Edited by `admin` on `Fri Dec 15 19:50:24 GMT 2023`
Record UNII	A17W0640NB
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

CORT-108297

Code

English

ADS-108297

Code

English

CORT 108297

Code

English

4A-(ETHOXYMETHYL)-1-(4-FLUOROPHENYL)-6-((4-(TRIFLUOROMETHYL)PHENYL)SULFONYL)-4,4A,5,6,7,8-HEXAHYDRO-1H-PYRAZOLO(3,4-G)ISOQUINOLINE, (R)-

Common Name

English

1H-PYRAZOLO(3,4-G)ISOQUINOLINE, 4A-(ETHOXYMETHYL)-1-(4-FLUOROPHENYL)-4,4A,5,6,7,8-HEXAHYDRO-6-((4-(TRIFLUOROMETHYL)PHENYL)SULFONYL)-, (4AR)-

Common Name

English

(R)-4A-(ETHOXYMETHYL)-1-(4-FLUOROPHENYL)-6-((4-(TRIFLUOROMETHYL)PHENYL)SULFONYL)-4,4A,5,6,7,8-HEXAHYDRO-1H-PYRAZOLO(3,4-G)ISOQUINOLINE

Common Name

English

Code System Code Type Description

EPA CompTox

DTXSID70144304