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Details

Stereochemistry ABSOLUTE
Molecular Formula C26H25F4N3O3S
Molecular Weight 535.5557
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CORT-108297

SMILES

CCOC[C@@]12Cc3cnn(-c4ccc(cc4)F)c3C=C2CCN(C1)S(=O)(=O)c5ccc(cc5)C(F)(F)F

InChI

InChIKey=SLKURXRZHJOZOD-RUZDIDTESA-N
InChI=1S/C26H25F4N3O3S/c1-2-36-17-25-14-18-15-31-33(22-7-5-21(27)6-8-22)24(18)13-20(25)11-12-32(16-25)37(34,35)23-9-3-19(4-10-23)26(28,29)30/h3-10,13,15H,2,11-12,14,16-17H2,1H3/t25-/m1/s1

HIDE SMILES / InChI

Molecular Formula C26H25F4N3O3S
Molecular Weight 535.5557
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
0.9 nM [Ki]
Substance Class Chemical
Created
by admin
on Sat Jun 26 03:19:37 UTC 2021
Edited
by admin
on Sat Jun 26 03:19:37 UTC 2021
Record UNII
A17W0640NB
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CORT-108297
Code English
ADS-108297
Code English
CORT 108297
Code English
4A-(ETHOXYMETHYL)-1-(4-FLUOROPHENYL)-6-((4-(TRIFLUOROMETHYL)PHENYL)SULFONYL)-4,4A,5,6,7,8-HEXAHYDRO-1H-PYRAZOLO(3,4-G)ISOQUINOLINE, (R)-
Common Name English
1H-PYRAZOLO(3,4-G)ISOQUINOLINE, 4A-(ETHOXYMETHYL)-1-(4-FLUOROPHENYL)-4,4A,5,6,7,8-HEXAHYDRO-6-((4-(TRIFLUOROMETHYL)PHENYL)SULFONYL)-, (4AR)-
Common Name English
(R)-4A-(ETHOXYMETHYL)-1-(4-FLUOROPHENYL)-6-((4-(TRIFLUOROMETHYL)PHENYL)SULFONYL)-4,4A,5,6,7,8-HEXAHYDRO-1H-PYRAZOLO(3,4-G)ISOQUINOLINE
Common Name English
Code System Code Type Description
EPA CompTox
1018679-79-2
Created by admin on Sat Jun 26 03:19:37 UTC 2021 , Edited by admin on Sat Jun 26 03:19:37 UTC 2021
PRIMARY
CAS
1018679-79-2
Created by admin on Sat Jun 26 03:19:37 UTC 2021 , Edited by admin on Sat Jun 26 03:19:37 UTC 2021
PRIMARY
FDA UNII
A17W0640NB
Created by admin on Sat Jun 26 03:19:37 UTC 2021 , Edited by admin on Sat Jun 26 03:19:37 UTC 2021
PRIMARY
ChEMBL
CHEMBL271220
Created by admin on Sat Jun 26 03:19:37 UTC 2021 , Edited by admin on Sat Jun 26 03:19:37 UTC 2021
PRIMARY
PUBCHEM
44454750
Created by admin on Sat Jun 26 03:19:37 UTC 2021 , Edited by admin on Sat Jun 26 03:19:37 UTC 2021
PRIMARY
Related Record Type Details
TARGET -> INHIBITOR
Ki
Related Record Type Details
ACTIVE MOIETY