U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C21H30O2
Molecular Weight 314.4617
Optical Activity UNSPECIFIED
Defined Stereocenters 6 / 6
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of Progesterone

SMILES

[H][C@@]12CC[C@H](C(C)=O)[C@@]1(C)CC[C@@]3([H])[C@@]2([H])CCC4=CC(=O)CC[C@]34C

InChI

InChIKey=RJKFOVLPORLFTN-LEKSSAKUSA-N
InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1

HIDE SMILES / InChI

Molecular Formula C21H30O2
Molecular Weight 314.4617
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 6 / 6
E/Z Centers 0
Optical Activity UNSPECIFIED

Description
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/8282004 http://www.rxlist.com/endometrin-drug/clinical-pharmacology.htm

Progesterone is indicated in amenorrhea and abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology, such as submucous fibroids of uterine cancer. Progesterone, converted from pregnenolone, also serves as an intermediate in the biosynthesis of gonadal steroid hormones and adrenal corticosteroids. Progesterone is a naturally occurring steroid that is secreted by the ovary, placenta, and adrenal gland. In the presence of adequate estrogen, progesterone transforms a proliferative endometrium into a secretory endometrium. Progesterone is necessary to increase endometrial receptivity for implantation of an embryo. Once an embryo is implanted, progesterone acts to maintain a pregnancy. Progesterone shares the pharmacological actions of the progestins. Progesterone binds to the progesterone and estrogen receptors. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progesterone will slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH (luteinizing hormone) surge. In women who have adequate endogenous estrogen, progesterone transforms a proliferative endometrium into a secretory one. Progesterone is metabolized primarily by the liver largely to pregnanediols and pregnanolones. Pregnanediols and pregnanolones are conjugated in the liver to glucuronide and sulfate metabolites. Progesterone metabolites that are excreted in the bile may be deconjugated and may be further metabolized in the gut via reduction, dehydroxylation, and epimerization. Common progesterone side effects may include: drowsiness, dizziness; breast pain; mood changes; headache; constipation, diarrhea, heartburn; bloating, swelling in your hands or feet; joint pain; hot flashes; or vaginal discharge.

CNS Activity

Curator's Comment: Progesterone readily cross the blood brain barrier (BBB) reducing oedema to barely measurable levels.

Originator

Sources: DOI:10.1159/000301641
Curator's Comment: Using a test based upon Fraenkel and Ancel/ Bouin, Corner and W.M. Allen isolated the hormone progesterone (1929) and first maintained pregnancy with corpus luteum extracts after early ablation of the ovaries rabbit, 1930).

Approval Year

Targets

Targets

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
PROGESTERONE

Approved Use

Is indicated in amenorrhea and abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology, such as submucous fibroids of uterine cancer.

Launch Date

2007
Primary
PROGESTERONE

Approved Use

Is indicated in amenorrhea and abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology, such as submucous fibroids of uterine cancer.

Launch Date

2007
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
60.6 ng/mL
300 mg 1 times / day multiple, oral
dose: 300 mg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
PROGESTERONE plasma
Homo sapiens
population: UNKNOWN
age: ADULT
sex: FEMALE
food status: UNKNOWN
14.87 ng/mL
90 mg single, vaginal
dose: 90 mg
route of administration: Vaginal
experiment type: SINGLE
co-administered:
PROGESTERONE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE
food status: UNKNOWN
15.97 ng/mL
90 mg 1 times / day steady-state, vaginal
dose: 90 mg
route of administration: Vaginal
experiment type: STEADY-STATE
co-administered:
PROGESTERONE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
175.7 ng × h/mL
300 mg 1 times / day multiple, oral
dose: 300 mg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
PROGESTERONE plasma
Homo sapiens
population: UNKNOWN
age: ADULT
sex: FEMALE
food status: UNKNOWN
296.78 ng × h/mL
90 mg single, vaginal
dose: 90 mg
route of administration: Vaginal
experiment type: SINGLE
co-administered:
PROGESTERONE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE
food status: UNKNOWN
391.98 ng × h/mL
90 mg 1 times / day steady-state, vaginal
dose: 90 mg
route of administration: Vaginal
experiment type: STEADY-STATE
co-administered:
PROGESTERONE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
34.8 h
90 mg single, vaginal
dose: 90 mg
route of administration: Vaginal
experiment type: SINGLE
co-administered:
PROGESTERONE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE
food status: UNKNOWN
45 h
90 mg 1 times / day steady-state, vaginal
dose: 90 mg
route of administration: Vaginal
experiment type: STEADY-STATE
co-administered:
PROGESTERONE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
400 mg single, vaginal
Dose: 400 mg
Route: vaginal
Route: single
Dose: 400 mg
Sources:
healthy, 32.6 ± 7.3 years
n = 10
Health Status: healthy
Age Group: 32.6 ± 7.3 years
Sex: F
Population Size: 10
Sources:
Other AEs: Drowsiness, Tiredness...
Other AEs:
Drowsiness (1 patient)
Tiredness (1 patient)
Headaches (1 patient)
Faint (1 patient)
Urinary frequency (1 patient)
Sources:
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Co-administed with::
estrogen
Sources:
unhealthy, 50-79 years
Health Status: unhealthy
Age Group: 50-79 years
Sex: F
Sources:
Other AEs: Deep vein thrombosis, Pulmonary embolism...
Other AEs:
Deep vein thrombosis
Pulmonary embolism
Stroke
Myocardial infarction
Dementia
Breast cancer
Sources:
400 mg 1 times / day multiple, oral
Highest studied dose
Dose: 400 mg, 1 times / day
Route: oral
Route: multiple
Dose: 400 mg, 1 times / day
Sources:
unhealthy, adult
n = 25
Other AEs: Fatigue, Headache...
Other AEs:
Fatigue (8%)
Headache (16%)
Dizziness (24%)
Diarrhea (8%)
Nausea (8%)
Back pain (8%)
Musculoskeletal pain (12%)
Irritability (8%)
Breast pain (16%)
Coughing (8%)
Sources:
AEs

AEs

AESignificanceDosePopulation
Drowsiness 1 patient
400 mg single, vaginal
Dose: 400 mg
Route: vaginal
Route: single
Dose: 400 mg
Sources:
healthy, 32.6 ± 7.3 years
n = 10
Health Status: healthy
Age Group: 32.6 ± 7.3 years
Sex: F
Population Size: 10
Sources:
Faint 1 patient
400 mg single, vaginal
Dose: 400 mg
Route: vaginal
Route: single
Dose: 400 mg
Sources:
healthy, 32.6 ± 7.3 years
n = 10
Health Status: healthy
Age Group: 32.6 ± 7.3 years
Sex: F
Population Size: 10
Sources:
Headaches 1 patient
400 mg single, vaginal
Dose: 400 mg
Route: vaginal
Route: single
Dose: 400 mg
Sources:
healthy, 32.6 ± 7.3 years
n = 10
Health Status: healthy
Age Group: 32.6 ± 7.3 years
Sex: F
Population Size: 10
Sources:
Tiredness 1 patient
400 mg single, vaginal
Dose: 400 mg
Route: vaginal
Route: single
Dose: 400 mg
Sources:
healthy, 32.6 ± 7.3 years
n = 10
Health Status: healthy
Age Group: 32.6 ± 7.3 years
Sex: F
Population Size: 10
Sources:
Urinary frequency 1 patient
400 mg single, vaginal
Dose: 400 mg
Route: vaginal
Route: single
Dose: 400 mg
Sources:
healthy, 32.6 ± 7.3 years
n = 10
Health Status: healthy
Age Group: 32.6 ± 7.3 years
Sex: F
Population Size: 10
Sources:
Breast cancer
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Co-administed with::
estrogen
Sources:
unhealthy, 50-79 years
Health Status: unhealthy
Age Group: 50-79 years
Sex: F
Sources:
Deep vein thrombosis
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Co-administed with::
estrogen
Sources:
unhealthy, 50-79 years
Health Status: unhealthy
Age Group: 50-79 years
Sex: F
Sources:
Dementia
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Co-administed with::
estrogen
Sources:
unhealthy, 50-79 years
Health Status: unhealthy
Age Group: 50-79 years
Sex: F
Sources:
Myocardial infarction
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Co-administed with::
estrogen
Sources:
unhealthy, 50-79 years
Health Status: unhealthy
Age Group: 50-79 years
Sex: F
Sources:
Pulmonary embolism
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Co-administed with::
estrogen
Sources:
unhealthy, 50-79 years
Health Status: unhealthy
Age Group: 50-79 years
Sex: F
Sources:
Stroke
200 mg 1 times / day multiple, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Co-administed with::
estrogen
Sources:
unhealthy, 50-79 years
Health Status: unhealthy
Age Group: 50-79 years
Sex: F
Sources:
Musculoskeletal pain 12%
400 mg 1 times / day multiple, oral
Highest studied dose
Dose: 400 mg, 1 times / day
Route: oral
Route: multiple
Dose: 400 mg, 1 times / day
Sources:
unhealthy, adult
n = 25
Breast pain 16%
400 mg 1 times / day multiple, oral
Highest studied dose
Dose: 400 mg, 1 times / day
Route: oral
Route: multiple
Dose: 400 mg, 1 times / day
Sources:
unhealthy, adult
n = 25
Headache 16%
400 mg 1 times / day multiple, oral
Highest studied dose
Dose: 400 mg, 1 times / day
Route: oral
Route: multiple
Dose: 400 mg, 1 times / day
Sources:
unhealthy, adult
n = 25
Dizziness 24%
400 mg 1 times / day multiple, oral
Highest studied dose
Dose: 400 mg, 1 times / day
Route: oral
Route: multiple
Dose: 400 mg, 1 times / day
Sources:
unhealthy, adult
n = 25
Back pain 8%
400 mg 1 times / day multiple, oral
Highest studied dose
Dose: 400 mg, 1 times / day
Route: oral
Route: multiple
Dose: 400 mg, 1 times / day
Sources:
unhealthy, adult
n = 25
Coughing 8%
400 mg 1 times / day multiple, oral
Highest studied dose
Dose: 400 mg, 1 times / day
Route: oral
Route: multiple
Dose: 400 mg, 1 times / day
Sources:
unhealthy, adult
n = 25
Diarrhea 8%
400 mg 1 times / day multiple, oral
Highest studied dose
Dose: 400 mg, 1 times / day
Route: oral
Route: multiple
Dose: 400 mg, 1 times / day
Sources:
unhealthy, adult
n = 25
Fatigue 8%
400 mg 1 times / day multiple, oral
Highest studied dose
Dose: 400 mg, 1 times / day
Route: oral
Route: multiple
Dose: 400 mg, 1 times / day
Sources:
unhealthy, adult
n = 25
Irritability 8%
400 mg 1 times / day multiple, oral
Highest studied dose
Dose: 400 mg, 1 times / day
Route: oral
Route: multiple
Dose: 400 mg, 1 times / day
Sources:
unhealthy, adult
n = 25
Nausea 8%
400 mg 1 times / day multiple, oral
Highest studied dose
Dose: 400 mg, 1 times / day
Route: oral
Route: multiple
Dose: 400 mg, 1 times / day
Sources:
unhealthy, adult
n = 25
OverviewDrug as perpetrator​Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
yes
yes
yes
yes
yes
likely (co-administration study)
Comment: Ketoconazole is a known inhibitor of cytochrome P450 3A4, hence these data suggest that ketoconazole or other known inhibitors of this enzyme may increase the bioavailability of progesterone
Tox targets

Tox targets

TargetModalityActivityMetaboliteClinical evidence
PubMed

PubMed

TitleDatePubMed
Estrogen and progesterone distinctively modulate methamphetamine-induced dopamine and serotonin depletions in C57BL/6J mice.
2000
Thrombospondin-1 and -2 in node-negative breast cancer: correlation with angiogenic factors, p53, cathepsin D, hormone receptors and prognosis.
2001
The rate-determining step in P450 C21-catalyzing reactions in a membrane-reconstituted system.
2001 Apr 6
Dexamethasone up-regulates type II IL-1 receptor in mouse primary activated astrocytes.
2001 Feb
Human types 1 and 3 3 alpha-hydroxysteroid dehydrogenases: differential lability and tissue distribution.
2001 Feb
Endothelins enhance prostaglandin (PGE(2) and PGF(2alpha)) biosynthesis and release by human luteal cells: evidence of a new paracrine/autocrine regulation of luteal function.
2001 Feb
Action of chicken II GnRH on the human placenta.
2001 Feb
Adenosine triphosphate-evoked cytosolic calcium oscillations in human granulosa-luteal cells: role of protein kinase C.
2001 Feb
Short-term administration of antivascular endothelial growth factor antibody in the late follicular phase delays follicular development in the rhesus monkey.
2001 Feb
Follow-up examination at the age of 15 months of extremely preterm infants after postnatal estradiol and progesterone replacement.
2001 Feb
Prognostic and predictive significance of ErbB-2 breast tumor levels measured by enzyme immunoassay.
2001 Feb 1
Re: Randomized trial of fenretinide to prevent second breast malignancy in women with early breast cancer.
2001 Feb 7
Lp(a) lipoprotein--an independent risk factor for coronary heart disease after menopause.
2001 Jan
Reliability of ovulation tests in infertile women.
2001 Jan
Serum allopregnanolone in women with postpartum "blues".
2001 Jan
Sex steroids and bone.
2001 Jan
The APC is dispensable for first meiotic anaphase in Xenopus oocytes.
2001 Jan
Targeted disruption of luteinizing hormone/human chorionic gonadotropin receptor gene.
2001 Jan
Mutations at the boundary of the hinge and ligand binding domain of the androgen receptor confer increased transactivation function.
2001 Jan
Estrogen receptor beta regulates sexually dimorphic neural responses to estradiol.
2001 Jan
Establishment and characterization of a steroidogenic human granulosa-like tumor cell line, KGN, that expresses functional follicle-stimulating hormone receptor.
2001 Jan
Glucocorticoids regulate plasma membrane potential during rat thymocyte apoptosis in vivo and in vitro.
2001 Jan
Assessment of mechanisms of thyroid hormone action in mouse Leydig cells: regulation of the steroidogenic acute regulatory protein, steroidogenesis, and luteinizing hormone receptor function.
2001 Jan
Biphasic action of prolactin in the regulation of murine Leydig tumor cell functions.
2001 Jan
Differential regulation of two forms of gonadotropin-releasing hormone messenger ribonucleic acid in human granulosa-luteal cells.
2001 Jan
Molecular cytogenetic comparison of apocrine hyperplasia and apocrine carcinoma of the breast.
2001 Jan
Prostaglandin receptors and role of G protein-activated pathways on corpora lutea of pseudopregnant rabbit in vitro.
2001 Jan
In vitro regulation of local secretion and contraction of the bovine oviduct: stimulation by luteinizing hormone, endothelin-1 and prostaglandins, and inhibition by oxytocin.
2001 Jan
Granulosa-luteal cell function in vitro and ovarian stimulation protocols.
2001 Jan
Charcoal treatment and risk of escape ovulation in oral contraceptive users.
2001 Jan
Reproductive hormones and blood pressure during pregnancy.
2001 Jan
Hormones and the brain: more studies.
2001 Jan
Effect of endogenous estrogen on blood flow through carotid arteries.
2001 Jan
Feed restriction and insulin treatment affect subsequent luteal function in the immediate postovulatory period in pigs: progesterone production in vitro and messenger ribonucleic acid expression for key steroidogenic enzymes.
2001 Jan
Female steroid hormones modulate receptors for nerve growth factor in rat dorsal root ganglia.
2001 Jan
Increased expression of a novel heat shock protein transcript in the mouse uterus during decidualization and in response to progesterone.
2001 Jan
Follicle selection in cattle: role of luteinizing hormone.
2001 Jan
Changes in plasma inhibin A levels during sexual maturation in the female chicken and the effects of active immunization against inhibin alpha-subunit on reproductive hormone profiles and ovarian function.
2001 Jan
Dexamethasone inhibits luteinizing hormone-induced synthesis of steroidogenic acute regulatory protein in cultured rat preovulatory follicles.
2001 Jan
Lysyl oxidase and MMP-2 expression in dehydroepiandrosterone-induced polycystic ovary in rats.
2001 Jan
Changes in follicle-stimulating hormone and follicle populations during the ovarian cycle of the common marmoset.
2001 Jan
Follicle-stimulating hormone regulation of inhibin alpha- and beta(B)-subunit and follistatin messenger ribonucleic acid in cultured avian granulosa cells.
2001 Jan
Oestrogen and progesterone increase the levels of apoptosis induced by the human papillomavirus type 16 E2 and E7 proteins.
2001 Jan
Metabolism of estradiol, ethynylestradiol, and moxestrol in rat uterus, vagina, and aorta: influence of sex steroid treatment.
2001 Jan
The influence of menstrual cycle phase on skeletal muscle contractile characteristics in humans.
2001 Jan 1
Tumor variants by hormone receptor expression in white patients with node-negative breast cancer from the surveillance, epidemiology, and end results database.
2001 Jan 1
Prolactin, growth hormone, and epidermal growth factor activate Stat5 in different compartments of mammary tissue and exert different and overlapping developmental effects.
2001 Jan 1
Effect of medroxyprogesterone acetate plus estradiol on endothelium-dependent vasodilation in postmenopausal women.
2001 Jan 15
Estrogen, selective estrogen receptor modulation, and coronary heart disease: something or nothing.
2001 Jan 3
Effects of low-frequency magnetic fields on implantation in rats.
2001 Jan-Feb
Patents

Sample Use Guides

5 to 10 mg during 8 consecutive days
Route of Administration: Intramuscular
In Vitro Use Guide
Curator's Comment: As a resule 34% reduction in cell proliferation was observed in the MB468 cells with treatment of P4, as compared with the cells with treatment of vehicle alone. As expected, P4 had no effects on cell proliferation of the parental MB231. However, the treatment of the mPRα stably-expressing MB231 cells with P4 induced a significant reduction of cell proliferation (28.1%). These data suggest that mPRα is also involved in regulating cell proliferation of BPBC cells.
To test whether the female sex hormone controls cell proliferation of MB468 (basal phenotype breast cancers) cells, cell were incubated the with progesterone (P4) (30 ng/ml) for 24 hours.
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:16:58 GMT 2023
Edited
by admin
on Fri Dec 15 15:16:58 GMT 2023
Record UNII
4G7DS2Q64Y
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Progesterone
EP   GREEN BOOK   HSDB   INCI   INN   MART.   MI   ORANGE BOOK   USP   USP-RS   VANDF   WHO-DD   WHO-IP  
INCI   INN  
Official Name English
PREGN-4-ENE-3,20-DIONE
Systematic Name English
PROGESTERONE [EP MONOGRAPH]
Common Name English
PROGESTERONE [JAN]
Common Name English
U 3672
Code English
PROGESTERONE [MI]
Common Name English
PROGESTERONE [HSDB]
Common Name English
PROGESTERONE [GREEN BOOK]
Common Name English
PROGESTERONE [VANDF]
Common Name English
Progesterone [WHO-DD]
Common Name English
PROGESTERONE [WHO-IP]
Common Name English
PROGESTERONE [ORANGE BOOK]
Common Name English
NSC-9704
Code English
CRINONE
Brand Name English
BIJUVA COMPONENT PROGESTERONE
Common Name English
PROGESTERONUM [WHO-IP LATIN]
Common Name English
UTROGESTAN
Brand Name English
ENDOMETRIN
Brand Name English
PROGESTERONE, MICRONIZED
Common Name English
MILPROSA
Brand Name English
PROGESTERONE [USP-RS]
Common Name English
PROMETRIUM
Brand Name English
PROGESTERONE [USP MONOGRAPH]
Common Name English
NSC-64377
Code English
PROGESTERONE COMPONENT OF BIJUVA
Common Name English
PROGESTERONE [MART.]
Common Name English
PROGESTASERT
Brand Name English
PROGESTERONE [INCI]
Common Name English
progesterone [INN]
Common Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 664818
Created by admin on Fri Dec 15 15:16:58 GMT 2023 , Edited by admin on Fri Dec 15 15:16:58 GMT 2023
WHO-VATC QG03FA04
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NDF-RT N0000005934
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LIVERTOX 803
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LOINC 83109-9
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FDA ORPHAN DRUG 82694
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CFR 21 CFR 556.540
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LOINC 83110-7
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DSLD 4218 (Number of products:3)
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LOINC 12820-7
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LOINC 44729-2
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CFR 21 CFR 522.1940
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LOINC 24109-1
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CFR 21 CFR 862.1430
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WHO-ATC G03FA04
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LOINC 14890-8
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EU-Orphan Drug EU/3/13/1101
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LOINC 17483-9
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WHO-VATC QG03DA04
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CFR 21 CFR 310.530
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NDF-RT N0000005934
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LOINC 44730-0
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LOINC 35223-7
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CFR 21 CFR 862.1620
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NCI_THESAURUS C2296
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NDF-RT N0000175601
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NDF-RT N0000005934
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LOINC 2838-1
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LOINC 2839-9
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WHO-ATC G03DA04
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FDA ORPHAN DRUG 284809
Created by admin on Fri Dec 15 15:16:58 GMT 2023 , Edited by admin on Fri Dec 15 15:16:58 GMT 2023
Code System Code Type Description
IUPHAR
2377
Created by admin on Fri Dec 15 15:16:58 GMT 2023 , Edited by admin on Fri Dec 15 15:16:58 GMT 2023
PRIMARY
CHEBI
17026
Created by admin on Fri Dec 15 15:16:58 GMT 2023 , Edited by admin on Fri Dec 15 15:16:58 GMT 2023
PRIMARY
RS_ITEM_NUM
1568007
Created by admin on Fri Dec 15 15:16:58 GMT 2023 , Edited by admin on Fri Dec 15 15:16:58 GMT 2023
PRIMARY
NSC
64377
Created by admin on Fri Dec 15 15:16:58 GMT 2023 , Edited by admin on Fri Dec 15 15:16:58 GMT 2023
PRIMARY
WIKIPEDIA
PROGESTERONE
Created by admin on Fri Dec 15 15:16:58 GMT 2023 , Edited by admin on Fri Dec 15 15:16:58 GMT 2023
PRIMARY
CAS
57-83-0
Created by admin on Fri Dec 15 15:16:58 GMT 2023 , Edited by admin on Fri Dec 15 15:16:58 GMT 2023
PRIMARY
ChEMBL
CHEMBL103
Created by admin on Fri Dec 15 15:16:58 GMT 2023 , Edited by admin on Fri Dec 15 15:16:58 GMT 2023
PRIMARY
EPA CompTox
DTXSID3022370
Created by admin on Fri Dec 15 15:16:58 GMT 2023 , Edited by admin on Fri Dec 15 15:16:58 GMT 2023
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FDA UNII
4G7DS2Q64Y
Created by admin on Fri Dec 15 15:16:58 GMT 2023 , Edited by admin on Fri Dec 15 15:16:58 GMT 2023
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PUBCHEM
5994
Created by admin on Fri Dec 15 15:16:58 GMT 2023 , Edited by admin on Fri Dec 15 15:16:58 GMT 2023
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DRUG BANK
DB00396
Created by admin on Fri Dec 15 15:16:58 GMT 2023 , Edited by admin on Fri Dec 15 15:16:58 GMT 2023
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MESH
D011374
Created by admin on Fri Dec 15 15:16:58 GMT 2023 , Edited by admin on Fri Dec 15 15:16:58 GMT 2023
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SMS_ID
100000090354
Created by admin on Fri Dec 15 15:16:58 GMT 2023 , Edited by admin on Fri Dec 15 15:16:58 GMT 2023
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WHO INTERNATIONAL PHARMACOPEIA
PROGESTERONE
Created by admin on Fri Dec 15 15:16:58 GMT 2023 , Edited by admin on Fri Dec 15 15:16:58 GMT 2023
PRIMARY Description: Colourless crystals or a white to slightly yellowish white, crystalline powder; odourless. Solubility: Practically insoluble in water; soluble in 8 parts of ethanol (~750 g/l) TS. Category: Progestational steroid. Storage: Progesterone should be kept in a well-closed container, protected from light. Additional information: Progesterone may exist in 2 polymorphic forms, one of which melts at about 130?C, the other at about 121?C. Definition: Progesterone contains not less than 97.0% and not more than 102.0% of C21H30O2, calculated with reference to the dried substance.
MERCK INDEX
m9159
Created by admin on Fri Dec 15 15:16:58 GMT 2023 , Edited by admin on Fri Dec 15 15:16:58 GMT 2023
PRIMARY Merck Index
EVMPD
SUB10076MIG
Created by admin on Fri Dec 15 15:16:58 GMT 2023 , Edited by admin on Fri Dec 15 15:16:58 GMT 2023
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DRUG CENTRAL
2279
Created by admin on Fri Dec 15 15:16:58 GMT 2023 , Edited by admin on Fri Dec 15 15:16:58 GMT 2023
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ECHA (EC/EINECS)
200-350-6
Created by admin on Fri Dec 15 15:16:58 GMT 2023 , Edited by admin on Fri Dec 15 15:16:58 GMT 2023
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LACTMED
Progesterone
Created by admin on Fri Dec 15 15:16:58 GMT 2023 , Edited by admin on Fri Dec 15 15:16:58 GMT 2023
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NCI_THESAURUS
C777
Created by admin on Fri Dec 15 15:16:58 GMT 2023 , Edited by admin on Fri Dec 15 15:16:58 GMT 2023
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DAILYMED
4G7DS2Q64Y
Created by admin on Fri Dec 15 15:16:58 GMT 2023 , Edited by admin on Fri Dec 15 15:16:58 GMT 2023
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INN
417
Created by admin on Fri Dec 15 15:16:58 GMT 2023 , Edited by admin on Fri Dec 15 15:16:58 GMT 2023
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HSDB
3389
Created by admin on Fri Dec 15 15:16:58 GMT 2023 , Edited by admin on Fri Dec 15 15:16:58 GMT 2023
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NSC
9704
Created by admin on Fri Dec 15 15:16:58 GMT 2023 , Edited by admin on Fri Dec 15 15:16:58 GMT 2023
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RXCUI
8727
Created by admin on Fri Dec 15 15:16:58 GMT 2023 , Edited by admin on Fri Dec 15 15:16:58 GMT 2023
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MESH
C400424
Created by admin on Fri Dec 15 15:16:58 GMT 2023 , Edited by admin on Fri Dec 15 15:16:58 GMT 2023
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RXCUI
259409
Created by admin on Fri Dec 15 15:16:58 GMT 2023 , Edited by admin on Fri Dec 15 15:16:58 GMT 2023
ALTERNATIVE
WIKIPEDIA
Progesterone (medication)
Created by admin on Fri Dec 15 15:16:58 GMT 2023 , Edited by admin on Fri Dec 15 15:16:58 GMT 2023
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