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Approval Year

Substance Class Protein
Created
by admin
on Sat Dec 16 12:14:09 GMT 2023
Edited
by admin
on Sat Dec 16 12:14:09 GMT 2023
Protein Sub Type
Sequence Type COMPLETE
Record UNII
EJC4C3UYXH
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ANDROGEN RECEPTOR
Common Name English
AR
Common Name English
DHTR
Common Name English
NR3C4
Common Name English
NUCLEAR RECEPTOR SUBFAMILY 3 GROUP C MEMBER 4
Common Name English
DIHYDROTESTOSTERONE RECEPTOR
Common Name English
Classification Tree Code System Code
DRUG TARGET ONTOLOGY DTO_00117516
Created by admin on Sat Dec 16 12:14:12 GMT 2023 , Edited by admin on Sat Dec 16 12:14:12 GMT 2023
Code System Code Type Description
UNIPROT
P10275
Created by admin on Sat Dec 16 12:14:12 GMT 2023 , Edited by admin on Sat Dec 16 12:14:12 GMT 2023
PRIMARY
FDA UNII
EJC4C3UYXH
Created by admin on Sat Dec 16 12:14:12 GMT 2023 , Edited by admin on Sat Dec 16 12:14:12 GMT 2023
PRIMARY
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ANTAGONIST
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INHIBITOR -> TARGET
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INHIBITOR -> TARGET
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ANTAGONIST
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AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
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INHIBITOR -> TARGET
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an androgen-receptor (AR) antagonist with IC50 of 36 nM in LNCaP cells.
ANTAGONIST
IC50
AGONIST -> TARGET
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ANTAGONIST
IC50
AGONIST -> TARGET
MODULATOR->TARGET
AGONIST -> TARGET
AGONIST -> TARGET
DEGRADER, SELECTIVE->TARGET
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DEGRADER, SELECTIVE->TARGET
In VCaP cells
DC50
AGONIST -> TARGET
BINDING
IC50
AGONIST -> TARGET
INHIBITOR -> TARGET
ANTAGONIST
PARTIAL ANTAGONIST->TARGET
BINDING
IC50
AGONIST -> TARGET
AGONIST -> TARGET
RADIOLIGAND->TARGET
Kd
INHIBITOR -> TARGET
INHIBITOR -> TARGET
Bicalutamide Bicalutamide is an androgen receptor (AR) antagonist with IC50 of 0.16 μM in LNCaP/AR(cs)cell line
ANTAGONIST
IC50
AGONIST -> TARGET
INHIBITOR -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
INHIBITOR -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
INHIBITOR -> TARGET
Flutamide is an antiandrogen drug, with its active metablolite binding at androgen receptor with Ki values of 55 nM, and primarily used to treat prostate cancer
ANTAGONIST
IC50
AGONIST -> TARGET
INHIBITOR -> TARGET
Ki
INHIBITOR -> TARGET
INHIBITOR -> TARGET
BINDING
Ki
AGONIST -> TARGET
MK-2866 (GTx-024) is a selective androgen receptor modulator (SARM) with Ki of 3.8 nM, and is tissue-selective for anabolic organs. Phase 3.
ANTAGONIST
IC50
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BINDING
IC50
INHIBITOR -> TARGET
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ANTAGONIST
IC50
AGONIST -> TARGET
INHIBITOR -> TARGET
AGONIST -> TARGET
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ANTAGONIST
IC50
AGONIST -> TARGET
AGONIST -> TARGET
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ANTAGONIST
IC50
AGONIST -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
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INHIBITOR -> TARGET
INHIBITOR OF EXPRESSION->TARGET
AGONIST -> TARGET
INHIBITOR -> TARGET
IN-VIVO
INHIBITOR -> TARGET
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT CHEMICAL
Molecular Formula CHEMICAL