RALANITEN

CC(C)(C1=CC=C(OC[C@H](O)CO)C=C1)C2=CC=C(OC[C@H](O)CCl)C=C2

InChIKey=HDTYUHNZRYZEEB-QZTJIDSGSA-N

InChI=1S/C21H27ClO5/c1-21(2,15-3-7-19(8-4-15)26-13-17(24)11-22)16-5-9-20(10-6-16)27-14-18(25)12-23/h3-10,17-18,23-25H,11-14H2,1-2H3/t17-,18-/m1/s1

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Targets

Primary Target	Pharmacology	Condition	Potency
Androgen Receptor 167 Target ID: CHEMBL1871 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20541699 \|	Antagonist 2778		6.0 µM [IC50]

PubMed

Title	Date	PubMed
Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptor.	2010 Jun 15	20541699
EPI-001 is a selective peroxisome proliferator-activated receptor-gamma modulator with inhibitory effects on androgen receptor expression and activity in prostate cancer.	2015 Feb 28	25669987
EPI-001, A Compound Active against Castration-Resistant Prostate Cancer, Targets Transactivation Unit 5 of the Androgen Receptor.	2016 Sep 16	27356095

Substance Class	Chemical Created by `admin` on `Sat Dec 16 09:17:20 GMT 2023` Edited by `admin` on `Sat Dec 16 09:17:20 GMT 2023`
Record UNII	WC830G6O4X
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

RALANITEN

Official Name

English

1,2-PROPANEDIOL, 3-(4-(1-(4-((2S)-3-CHLORO-2-HYDROXYPROPOXY)PHENYL)-1-METHYLETHYL)PHENOXY)-, (2R)-

Systematic Name

English

RALANITEN [USAN]

Common Name

English

ralaniten [INN]

Common Name

English

EPI-002

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C242