ANDARINE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C19H18F3N3O6
Molecular Weight	441.3579
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(=O)NC1=CC=C(OC[C@](C)(O)C(=O)NC2=CC=C(C(=C2)C(F)(F)F)[N+]([O-])=O)C=C1

InChI

InChIKey=YVXVTLGIDOACBJ-SFHVURJKSA-N

InChI=1S/C19H18F3N3O6/c1-11(26)23-12-3-6-14(7-4-12)31-10-18(2,28)17(27)24-13-5-8-16(25(29)30)15(9-13)19(20,21)22/h3-9,28H,10H2,1-2H3,(H,23,26)(H,24,27)/t18-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C19H18F3N3O6
Molecular Weight	441.3579
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/12604714
Curator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/15308613 http://adisinsight.springer.com/drugs/800019485

Andarine is an investigational selective androgen receptor modulator (SARM) developed by GTX, Inc for treatment of conditions such as muscle wasting, osteoporosis and benign prostatic hypertrophy. Andarine is a selective non-steroidal androgen receptor (AR) agonist with Ki of 4 nM, tissue-selective for anabolic organs. Andarine had been in phase I clinical trials by GTx for the treatment of cancer-related cachexia and osteoporosis. However, this research has been discontinued.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Androgen Receptor 167 Target ID: CHEMBL1871 Sources: https://www.ncbi.nlm.nih.gov/pubmed/12604714 \| https://www.ncbi.nlm.nih.gov/pubmed/19432422	Modulator 828		4.0 nM [Ki]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Cachexia 8 Sources: http://adisinsight.springer.com/drugs/800019485	Primary		Phase I 428	Unknown Approved Use Unknown

Sourcing

Vendor/Aggregator	ID	URL
1PlusChem LLC	1P00C6UX	https://www.1pchem.com/search?query=1P00C6UX
A2B Chem	AF67961	http://a2bchem.com/prod/AF67961
AK Scientific	Y1119	https://aksci.com/item_detail.php?cat=Y1119
Ambeed	A466355	http://www.ambeed.com/search/Search.html?keyword=A466355
ApexBio Technology	A2150	https://www.apexbt.com/catalogsearch/result/?q=A2150
AstaTech	40703	http://astatechinc.com/CPSResult.php?CRNO=40703
BOC Sciences	401900-40-1	http://www.bocsci.com/description.asp?cas=401900-40-1
Cayman Chemical	18772	http://www.caymanchem.com/app/template/Product.vm/catalog/18772
Chem Scene	CS-0160	http://www.chemscene.com/goproductList/searchProductList?productObj=CS-0160
ChemShuttle	141352	https://www.chemshuttle.com/catalogsearch/result/?q=141352
Excenen	EX-A724	http://www.excenen.com/searchresultlist.php?id=EX-A724
Hairui	HR106354	http://www.hairuichem.com/en/product/search.do?q=HR106354
Hairui	HR111759	http://www.hairuichem.com/en/product/search.do?q=HR111759
KeyOrganics	AS-19581	http://www.keyorganicsinc.com/bionet/catalogsearch/result?q=AS-19581
Matrix Scientific	147195	http://www.matrixscientific.com/147195.html
MedChem Express	HY-12023	https://www.medchemexpress.com/search.html?q=HY-12023&ft=&fa=&fp=
Molnova	M14376	https://www.molnova.com/en/serch-list.html?keywords=M14376
MuseChem	I003460	https://www.musechem.com/product/I003460.html
Ryan Scientific	A66	https://ryansci.com/products?q=A66&list_q=&search_type=exact
ShangHai Biochempartner	BCP000134	http://www.biochempartner.com/search_BCP000134
ShangHai Biochempartner	BCP01832	http://www.biochempartner.com/search_BCP01832
TargetMol	T2108	https://www.targetmol.com/search?keyword=T2108
Tetrahedron	TS70347	http://www.thsci.com/search.do?q=TS70347
Toronto Research Chemicals	A637470	https://www.trc-canada.com/product-detail/?CatNum=A637470
Toronto Research Chemicals	N457015	https://www.trc-canada.com/product-detail/?CatNum=N457015
Wonderchem	WD06WH3	http://www.wonder-chem.com/search.html?text=WD06WH3
eMolecules	300734098	https://orderbb.emolecules.com/search/#?query=300734098
eMolecules	313124301	https://orderbb.emolecules.com/search/#?query=313124301
eMolecules	44457512	https://orderbb.emolecules.com/search/#?query=44457512
eMolecules	48859556	https://orderbb.emolecules.com/search/#?query=48859556
mcule	MCULE-3708503060	https://mcule.com/MCULE-3708503060/
mcule	MCULE-4199486425	https://mcule.com/MCULE-4199486425/

PubMed

Title	Date	PubMed
Nonsteroidal selective androgen receptor modulators (SARMs): dissociating the anabolic and androgenic activities of the androgen receptor for therapeutic benefit.	2009 Jun 25	19432422

Patents

Sample Use Guides

In Vivo Use Guide

Dogs: An intravenous (i.v.) bolus dose of 10 or 3 mg/kg, an oral(p.o.) solution dose of 10 mg/kg, or an oral capsule dose of 10 mg/kgadministered in a packed gelatin capsule

Route of Administration: Other

In Vitro Use Guide

Andarine stimulates AR-mediated transcription to 93% of that observed for 1 nM DHT at a concentration of 10 nM.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:42:25 GMT 2023` Edited by `admin` on `Fri Dec 15 15:42:25 GMT 2023`
Record UNII	7UT2HAH49H
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

ANDARINE

Common Name

English

GTX-007

Code

English

PROPANAMIDE, 3-(4-(ACETYLAMINO)PHENOXY)-2-HYDROXY-2-METHYL-N-(4-NITRO-3-(TRIFLUOROMETHYL)PHENYL)-, (2S)-

Systematic Name

English

Classification Tree Code System Code

WIKIPEDIA

Designer-drugs-Andarine