EPI-001

CC(C)(C1=CC=C(OCC(O)CO)C=C1)C2=CC=C(OCC(O)CCl)C=C2

InChIKey=HDTYUHNZRYZEEB-UHFFFAOYSA-N

InChI=1S/C21H27ClO5/c1-21(2,15-3-7-19(8-4-15)26-13-17(24)11-22)16-5-9-20(10-6-16)27-14-18(25)12-23/h3-10,17-18,23-25H,11-14H2,1-2H3

Stereochemistry	MIXED
Additional Stereochemistry	No
Defined Stereocenters	0 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Targets

Primary Target	Pharmacology	Condition	Potency
Androgen Receptor 167 Target ID: CHEMBL1871 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20541699 \|	Antagonist 2778		6.0 µM [IC50]

PubMed

Title	Date	PubMed
Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptor.	2010 Jun 15	20541699
EPI-001 is a selective peroxisome proliferator-activated receptor-gamma modulator with inhibitory effects on androgen receptor expression and activity in prostate cancer.	2015 Feb 28	25669987
EPI-001, A Compound Active against Castration-Resistant Prostate Cancer, Targets Transactivation Unit 5 of the Androgen Receptor.	2016 Sep 16	27356095

Substance Class	Chemical Created by `admin` on `Sat Dec 16 18:05:57 GMT 2023` Edited by `admin` on `Sat Dec 16 18:05:57 GMT 2023`
Record UNII	A9PRH4DC8H
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

EPI-001

Code

English

1,2-Propanediol, 3-[4-[1-[4-(3-chloro-2-hydroxypropoxy)phenyl]-1-methylethyl]phenoxy]-

Systematic Name

English

3-(4-(1-(4-(3-CHLORO-2-HYDROXYPROPOXY)PHENYL)-1-METHYLETHYL)PHENOXY)-1,2-PROPANEDIOL

Systematic Name

English

EPI001

Code

English

Code System Code Type Description

FDA UNII

A9PRH4DC8H