U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Tue Apr 01 18:49:40 GMT 2025
Edited
by admin
on Tue Apr 01 18:49:40 GMT 2025
Protein Sub Type
Sequence Type COMPLETE
Record UNII
DXN1OSB4IB
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
NR3C3
Preferred Name English
PROGESTERONE RECEPTOR
Common Name English
NUCLEAR RECEPTOR SUBFAMILY 3 GROUP C MEMBER 3
Common Name English
PGR
Common Name English
Code System Code Type Description
UNIPROT
P06401
Created by admin on Tue Apr 01 18:49:40 GMT 2025 , Edited by admin on Tue Apr 01 18:49:40 GMT 2025
PRIMARY
FDA UNII
DXN1OSB4IB
Created by admin on Tue Apr 01 18:49:40 GMT 2025 , Edited by admin on Tue Apr 01 18:49:40 GMT 2025
PRIMARY
Related Record Type Details
Structure of LONAPRISAN
INHIBITOR -> TARGET
Structure of SEGESTERONE
AGONIST -> TARGET
Structure of CHLORMADINONE ACETATE
AGONIST -> TARGET
Twenty times as potent as progesterone as far as its progestational action is concerned
Structure of Progesterone
AGONIST -> TARGET
IC50
Structure of PROMEGESTONE
INHIBITOR -> TARGET
Binding Assay
IC50
Structure of FLUOROFURANYLNORPROGESTERONE F-18
RADIOLIGAND->TARGET
Relative binding affinity (RBA)=190
Structure of TANAPROGET
AGONIST -> TARGET
EC50
Structure of TORIPRISTONE
INHIBITOR -> TARGET
Structure of Tanaproget C-11
RADIOLIGAND->TARGET
Structure of ONAPRISTONE
INHIBITOR -> TARGET
Structure of TRESTOLONE
AGONIST -> TARGET
Structure of SEGESTERONE ACETATE
AGONIST -> TARGET
EC50
Structure of DIMETHYLTRIENOLONE
AGONIST -> TARGET
Structure of NOMEGESTROL ACETATE
AGONIST -> TARGET
Ki
Structure of DANAZOL
AGONIST -> TARGET
Structure of TELAPRISTONE
INHIBITOR -> TARGET
Structure of ULIPRISTAL
AGONIST -> TARGET
Ulipristal acetate is an orally-active progesterone agonist/antagonist with antagonistic and partial agonistic effects at the progesterone receptor.
BINDING
Structure of BAY-1007626
AGONIST -> TARGET
Structure of VILAPRISAN
MODULATOR->TARGET
Structure of ASOPRISNIL
MODULATOR->TARGET
Structure of DIENOGEST
AGONIST -> TARGET
Structure of CRIDANIMOD
ACTIVATOR OF EXPRESSION->TARGET
Structure of ALLYLESTRENOL
AGONIST -> TARGET
Structure of DIMETHANDROLONE UNDECANOATE
AGONIST -> TARGET
Structure of N-Desmethyl ulipristal acetate
AGONIST -> TARGET
BINDING
Structure of ULIPRISTAL ACETATE
AGONIST -> TARGET
Structure of CYMIPRISTONE
INHIBITOR -> TARGET
IC50

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO ACID SUBSTITUTION [1_20] [1_81] [1_102] [1_130] [1_162] [1_190] [1_213] [1_676] DEXFOSFOSERINE VI4F0K069V
AMINO_ACID_SUBSTITUTION [1_567] [1_570] [1_584] [1_587] SITE_SPECIFIC C4-TYPE ZINC FINGER C56TF4V7OP
AMINO ACID SUBSTITUTION [1_294] DEXFOSFOSERINE VI4F0K069V
AMINO ACID SUBSTITUTION [1_345] DEXFOSFOSERINE VI4F0K069V
AMINO_ACID_SUBSTITUTION [1_603] [1_609] [1_619] [1_622] SITE_SPECIFIC C4-TYPE ZINC FINGER C56TF4V7OP
AMINO ACID SUBSTITUTION [1_400] DEXFOSFOSERINE VI4F0K069V
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT CHEMICAL
NIH
NCATS
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