U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C24H31ClO7
Molecular Weight 466.952
Optical Activity UNSPECIFIED
Defined Stereocenters 7 / 7
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of LOTEPREDNOL ETABONATE

SMILES

[H][C@@]12CC[C@](OC(=O)OCC)(C(=O)OCCl)[C@@]1(C)C[C@H](O)[C@@]3([H])[C@@]2([H])CCC4=CC(=O)C=C[C@]34C

InChI

InChIKey=DMKSVUSAATWOCU-HROMYWEYSA-N
InChI=1S/C24H31ClO7/c1-4-30-21(29)32-24(20(28)31-13-25)10-8-17-16-6-5-14-11-15(26)7-9-22(14,2)19(16)18(27)12-23(17,24)3/h7,9,11,16-19,27H,4-6,8,10,12-13H2,1-3H3/t16-,17-,18-,19+,22-,23-,24-/m0/s1

HIDE SMILES / InChI

Molecular Formula C24H31ClO7
Molecular Weight 466.952
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 7 / 7
E/Z Centers 0
Optical Activity UNSPECIFIED

Approval Year

Cmax

ValueDoseCo-administeredAnalytePopulation
621 ng/mL
0.5 μg single, intraocular
LOTEPREDNOL cornea
Oryctolagus cuniculus

AUC

ValueDoseCo-administeredAnalytePopulation
1130 ng × h/mL
0.5 μg single, intraocular
LOTEPREDNOL cornea
Oryctolagus cuniculus

T1/2

ValueDoseCo-administeredAnalytePopulation
3.75 h
0.5 μg single, intraocular
LOTEPREDNOL cornea
Oryctolagus cuniculus

Funbound

ValueDoseCo-administeredAnalytePopulation
2%
LOTEPREDNOL plasma
Homo sapiens

Doses

AEs

Substance Class Chemical
Record UNII
YEH1EZ96K6
Record Status Validated (UNII)
Record Version