BECLOMETHASONE DIPROPIONATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C28H37ClO7
Molecular Weight	521.042
Optical Activity	UNSPECIFIED
Defined Stereocenters	8 / 8
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of BECLOMETHASONE DIPROPIONATE

SMILES

[H][C@@]12C[C@H](C)[C@](OC(=O)CC)(C(=O)COC(=O)CC)[C@@]1(C)C[C@H](O)[C@@]3(Cl)[C@@]2([H])CCC4=CC(=O)C=C[C@]34C

InChI

InChIKey=KUVIULQEHSCUHY-XYWKZLDCSA-N

InChI=1S/C28H37ClO7/c1-6-23(33)35-15-22(32)28(36-24(34)7-2)16(3)12-20-19-9-8-17-13-18(30)10-11-25(17,4)27(19,29)21(31)14-26(20,28)5/h10-11,13,16,19-21,31H,6-9,12,14-15H2,1-5H3/t16-,19-,20-,21-,25-,26-,27-,28-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C28H37ClO7
Molecular Weight	521.042
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	8 / 8
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

C_max

Value	Dose	Co-administered	Analyte	Population
1.419 ng/mL	100 μg 4 times / day multiple, respiratory		BECLOMETHASONE 17-MONOPROPIONATE plasma	Homo sapiens

AUC

Value	Dose	Co-administered	Analyte	Population
4.985 ng × h/mL	100 μg 4 times / day multiple, respiratory		BECLOMETHASONE 17-MONOPROPIONATE plasma	Homo sapiens

T_1/2

Value	Dose	Co-administered	Analyte	Population
2.8 h	100 μg 4 times / day multiple, respiratory		BECLOMETHASONE 17-MONOPROPIONATE plasma	Homo sapiens

Doses

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Dose	Population	Adverse events
320 ug 1 times / day steady, intranasal Recommended	unhealthy, 12-74 years n = 414	Disc. AE: Epistaxis, Increased intraocular pressure...
320 ug 1 times / day steady, intranasal Recommended	unhealthy, 12-82 years n = 935	Disc. AE: Sinusitis, Nasopharyngitis...

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AEs

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AE	Significance	Dose	Population
Headache	1 patient Disc. AE	320 ug 1 times / day steady, intranasal Recommended	unhealthy, 12-74 years n = 414
Increased intraocular pressure	1 patient Disc. AE	320 ug 1 times / day steady, intranasal Recommended	unhealthy, 12-74 years n = 414
Nasal congestion	1 patient Disc. AE	320 ug 1 times / day steady, intranasal Recommended	unhealthy, 12-74 years n = 414
Nasal mucosal disorder	1 patient Disc. AE	320 ug 1 times / day steady, intranasal Recommended	unhealthy, 12-74 years n = 414
Colon cancer	2 patients Disc. AE	320 ug 1 times / day steady, intranasal Recommended	unhealthy, 12-74 years n = 414

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Sourcing

Sourcing

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Vendor/Aggregator	ID	URL
3B Scientific (Wuhan) Corp	3B3-032489	http://www.3bsc.com/index/pro_info.php?id=53753
AHH Chemical co.,ltd	MT-27153	http://www.ahhchemical.com/product/MT-27153.html
Chem Scene	CS-0120927	http://www.chemscene.com/5534-18-9.html
Chemspace	CSSB00020661129	https://chem-space.com/CSSB00020661129
LGC Standards	LGCFOR0199.01	https://www.lgcstandards.com/US/en/p/LGCFOR0199.01

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PubMed

Title	Date	PubMed
No data available in table

Patents

Substance Class	Chemical
Record UNII	5B307S63B2
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BECLOMETHASONE DIPROPIONATE

Official Name

English

TOPSTER

Brand Name

English

PROPADERM FORTE

Common Name

English

NSC-755901

Code

English

SCH 8020W

Code

English

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Classification Tree

Code System

Code

Designated

FDA ORPHAN DRUG

356311

Designated

FDA ORPHAN DRUG

111198

Therapeutic Corticosteroid

NCI_THESAURUS

C521

Designated

FDA ORPHAN DRUG

146501

Designated

FDA ORPHAN DRUG

144201

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Code System

Code

Type

Description

SMS_ID

100000091556

PRIMARY

CHEBI

3002

PRIMARY

RS_ITEM_NUM

1048506

PRIMARY

FDA UNII

5B307S63B2

PRIMARY

DRUG CENTRAL

294

PRIMARY

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Related Record

Type

Details


					FZW85LW99M

GLUCOCORTICOID RECEPTOR

TARGET -> AGONIST

Amount:


					BM9HZ2D59F

BECLOMETHASONE DIPROPIONATE, CYCLO-3'-.BETA.-

DEGRADENT -> PARENT

Amount:


					4H7L9AI22I

BECLOMETHASONE DIPROPIONATE MONOHYDRATE

SOLVATE->ANHYDROUS


					FZW85LW99M

GLUCOCORTICOID RECEPTOR

TARGET -> AGONIST

Comments:

Binds to the glucocorticoid receptor with about half the affinity of the potent glucocorticoid dexamethasone (Dexa), B was found to be 0·75 times less active than Dexa.

Amount: