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Details

Stereochemistry ABSOLUTE
Molecular Formula C25H21F4N3O3
Molecular Weight 487.4462
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of AZD-5423

SMILES

COC1=CC(=CC=C1)[C@@H](OC2=CC3=C(C=C2)N(N=C3)C4=CC=C(F)C=C4)[C@H](C)NC(=O)C(F)(F)F

InChI

InChIKey=FCNQMDSJHADDFT-WNSKOXEYSA-N
InChI=1S/C25H21F4N3O3/c1-15(31-24(33)25(27,28)29)23(16-4-3-5-20(12-16)34-2)35-21-10-11-22-17(13-21)14-30-32(22)19-8-6-18(26)7-9-19/h3-15,23H,1-2H3,(H,31,33)/t15-,23-/m0/s1

HIDE SMILES / InChI
Molecular Formula C25H21F4N3O3
Molecular Weight 487.4462
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

AZD5423, a non-steroidal glucocorticoid receptor agonist, was participated in clinical trials phase II for treatment of Asthma, and Chronic Obstructive Pulmonary Disease. However, the development of the product was discontinued.

Originator

AstraZeneca
131

Approval Year

Unknown
149,124

PubMed

Patents

07728030
10
08143290
4
20080214641
1

Sample Use Guides

In Vivo Use Guide
AZD5423 75ug Suspension for nebulisation once daily 7 days
Route of Administration: Other
Substance Class Chemical
Record UNII
641H0Q518W
Record Status Validated (UNII)
Record Version
NIH
NCATS
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