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Details

Stereochemistry ABSOLUTE
Molecular Formula C25H21F4N3O3
Molecular Weight 487.4462
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of AZD-5423

SMILES

COC1=CC(=CC=C1)[C@@H](OC2=CC3=C(C=C2)N(N=C3)C4=CC=C(F)C=C4)[C@H](C)NC(=O)C(F)(F)F

InChI

InChIKey=FCNQMDSJHADDFT-WNSKOXEYSA-N
InChI=1S/C25H21F4N3O3/c1-15(31-24(33)25(27,28)29)23(16-4-3-5-20(12-16)34-2)35-21-10-11-22-17(13-21)14-30-32(22)19-8-6-18(26)7-9-19/h3-15,23H,1-2H3,(H,31,33)/t15-,23-/m0/s1

HIDE SMILES / InChI

Molecular Formula C25H21F4N3O3
Molecular Weight 487.4462
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

AZD5423, a non-steroidal glucocorticoid receptor agonist, was participated in clinical trials phase II for treatment of Asthma, and Chronic Obstructive Pulmonary Disease. However, the development of the product was discontinued.

Approval Year

PubMed

PubMed

TitleDatePubMed
Patents

Sample Use Guides

AZD5423 75ug Suspension for nebulisation once daily 7 days
Route of Administration: Other
Substance Class Chemical
Created
by admin
on Thu Jul 06 11:02:20 UTC 2023
Edited
by admin
on Thu Jul 06 11:02:20 UTC 2023
Record UNII
641H0Q518W
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
AZD-5423
Common Name English
AZD 5423 [WHO-DD]
Common Name English
AZD5423
Code English
2,2,2-TRIFLUORO-N-((1R,2S)-1-(1-(4-FLUOROPHENYL)INDAZOL-5-YL)OXY-1-(3-METHOXYPHENYL)PROPAN-2-YL)ACETAMIDE
Systematic Name English
Code System Code Type Description
DRUG BANK
DB12280
Created by admin on Thu Jul 06 11:02:20 UTC 2023 , Edited by admin on Thu Jul 06 11:02:20 UTC 2023
PRIMARY
WIKIPEDIA
AZD-5423
Created by admin on Thu Jul 06 11:02:20 UTC 2023 , Edited by admin on Thu Jul 06 11:02:20 UTC 2023
PRIMARY
EPA CompTox
DTXSID40145823
Created by admin on Thu Jul 06 11:02:20 UTC 2023 , Edited by admin on Thu Jul 06 11:02:20 UTC 2023
PRIMARY
SMS_ID
100000175507
Created by admin on Thu Jul 06 11:02:20 UTC 2023 , Edited by admin on Thu Jul 06 11:02:20 UTC 2023
PRIMARY
FDA UNII
641H0Q518W
Created by admin on Thu Jul 06 11:02:20 UTC 2023 , Edited by admin on Thu Jul 06 11:02:20 UTC 2023
PRIMARY
CAS
1034148-04-3
Created by admin on Thu Jul 06 11:02:20 UTC 2023 , Edited by admin on Thu Jul 06 11:02:20 UTC 2023
PRIMARY
PUBCHEM
24825740
Created by admin on Thu Jul 06 11:02:20 UTC 2023 , Edited by admin on Thu Jul 06 11:02:20 UTC 2023
PRIMARY
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