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Details

Stereochemistry ABSOLUTE
Molecular Formula C22H29ClO5
Molecular Weight 408.9164
Optical Activity UNSPECIFIED
Defined Stereocenters 9 / 9
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ALCLOMETASONE

SMILES

C[C@]1([H])C[C@@]2([H])[C@]3([H])[C@@]([H])(CC4=CC(=O)C=C[C@]4(C)[C@@]3([H])[C@]([H])(C[C@]2(C)[C@]1(C(=O)CO)O)O)Cl

InChI

InChIKey=FJXOGVLKCZQRDN-PHCHRAKRSA-N
InChI=1S/C22H29ClO5/c1-11-6-14-18-15(23)8-12-7-13(25)4-5-20(12,2)19(18)16(26)9-21(14,3)22(11,28)17(27)10-24/h4-5,7,11,14-16,18-19,24,26,28H,6,8-10H2,1-3H3/t11-,14+,15-,16+,18-,19+,20+,21+,22+/m1/s1

HIDE SMILES / InChI

Molecular Formula C22H29ClO5
Molecular Weight 408.9164
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 8 / 9
E/Z Centers 0
Optical Activity UNSPECIFIED

Alclometasone is synthetic glucocorticoid steroid for topical use. Alclometasone dipropionate cream USP and alclometasone dipropionate ointment USP are indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. It may be used in pediatric patients 1 year of age or older, although the safety and efficacy of drug use for longer than 3 weeks have not been established. Like other topical corticosteroids, alclometasone dipropionate has anti-inflammatory, antipruritic, and vasoconstrictive properties. The mechanism of the anti-inflammatory activity of the topical steroids, in general, is unclear. However, corticosteroids are thought to act by the induction of phospholipase A2inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2. Alclometasone initially binds the corticosteroid receptor. This complex migrates to the nucleus where it binds to different glucocorticoid response elements on the DNA. This in turn enhances and represses various genes, especially those involved in inflammatory pathways.

CNS Activity

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
ALCLOMETASONE DIPROPIONATE

Approved Use

Alclometasone dipropionate cream USP and alclometasone dipropionate ointment USP are low to medium potency corticosteroids indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Alclometasone dipropionate cream USP and alclometasone dipropionate ointment USP may be used in pediatric patients 1 year of age or older, although the safety and efficacy of drug use for longer than 3 weeks have not been established

Launch Date

1.09105919E12
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
7708 ng × h/mL/m²
4 mg/m² single, topical
dose: 4 mg/m²
route of administration: Topical
experiment type: SINGLE
co-administered:
ALCLOMETASONE unknown
Homo sapiens
population: UNKNOWN
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
PubMed

PubMed

TitleDatePubMed
Subacute cutaneous lupus erythematosus presenting in a child.
2002 Feb
Three times weekly tacrolimus ointment reduces relapse in stabilized atopic dermatitis: a new paradigm for use.
2008 Dec

Sample Use Guides

Apply a thin film of alclometasone dipropionate cream USP or alclometasone dipropionate ointment USP to the affected skin areas 2 or 3 times daily
Route of Administration: Topical
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Sat Jun 26 13:29:34 UTC 2021
Edited
by admin
on Sat Jun 26 13:29:34 UTC 2021
Record UNII
136H45TB7B
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ALCLOMETASONE
INN   MI   VANDF   WHO-DD  
INN  
Official Name English
ALCLOMETASONE [MI]
Common Name English
ALCLOMETASONE [VANDF]
Common Name English
(7.ALPHA.,11.BETA.,16.ALPHA.)-7-CHLORO-11,17,21-TRIHYDROXY-16-METHYLPREGNA-1,4-DIENE-3,20-DIONE
Systematic Name English
PREGNA-1,4-DIENE-3,20-DIONE, 7-CHLORO-11,17,21-TRIHYDROXY-16-METHYL-, (7.ALPHA.,11.BETA.,16.ALPHA.)-
Systematic Name English
ALCLOMETASONE [WHO-DD]
Common Name English
ALCLOMETASONE [INN]
Common Name English
Classification Tree Code System Code
WHO-VATC QD07AB10
Created by admin on Sat Jun 26 13:29:34 UTC 2021 , Edited by admin on Sat Jun 26 13:29:34 UTC 2021
NDF-RT N0000175450
Created by admin on Sat Jun 26 13:29:34 UTC 2021 , Edited by admin on Sat Jun 26 13:29:34 UTC 2021
NDF-RT N0000175576
Created by admin on Sat Jun 26 13:29:34 UTC 2021 , Edited by admin on Sat Jun 26 13:29:34 UTC 2021
NCI_THESAURUS C521
Created by admin on Sat Jun 26 13:29:34 UTC 2021 , Edited by admin on Sat Jun 26 13:29:34 UTC 2021
WHO-VATC QS01BA10
Created by admin on Sat Jun 26 13:29:34 UTC 2021 , Edited by admin on Sat Jun 26 13:29:34 UTC 2021
WHO-ATC S01BA10
Created by admin on Sat Jun 26 13:29:34 UTC 2021 , Edited by admin on Sat Jun 26 13:29:34 UTC 2021
WHO-ATC D07AB10
Created by admin on Sat Jun 26 13:29:34 UTC 2021 , Edited by admin on Sat Jun 26 13:29:34 UTC 2021
Code System Code Type Description
INN
4616
Created by admin on Sat Jun 26 13:29:34 UTC 2021 , Edited by admin on Sat Jun 26 13:29:34 UTC 2021
PRIMARY
RXCUI
108088
Created by admin on Sat Jun 26 13:29:34 UTC 2021 , Edited by admin on Sat Jun 26 13:29:34 UTC 2021
PRIMARY RxNorm
CAS
67452-97-5
Created by admin on Sat Jun 26 13:29:34 UTC 2021 , Edited by admin on Sat Jun 26 13:29:34 UTC 2021
PRIMARY
EVMPD
SUB05300MIG
Created by admin on Sat Jun 26 13:29:34 UTC 2021 , Edited by admin on Sat Jun 26 13:29:34 UTC 2021
PRIMARY
NCI_THESAURUS
C65219
Created by admin on Sat Jun 26 13:29:34 UTC 2021 , Edited by admin on Sat Jun 26 13:29:34 UTC 2021
PRIMARY
WIKIPEDIA
ALCLOMETASONE
Created by admin on Sat Jun 26 13:29:34 UTC 2021 , Edited by admin on Sat Jun 26 13:29:34 UTC 2021
PRIMARY
PUBCHEM
5311000
Created by admin on Sat Jun 26 13:29:34 UTC 2021 , Edited by admin on Sat Jun 26 13:29:34 UTC 2021
PRIMARY
FDA UNII
136H45TB7B
Created by admin on Sat Jun 26 13:29:34 UTC 2021 , Edited by admin on Sat Jun 26 13:29:34 UTC 2021
PRIMARY
ChEMBL
CHEMBL1200989
Created by admin on Sat Jun 26 13:29:34 UTC 2021 , Edited by admin on Sat Jun 26 13:29:34 UTC 2021
PRIMARY
DRUG BANK
DB00240
Created by admin on Sat Jun 26 13:29:34 UTC 2021 , Edited by admin on Sat Jun 26 13:29:34 UTC 2021
PRIMARY
LACTMED
Alclometasone
Created by admin on Sat Jun 26 13:29:34 UTC 2021 , Edited by admin on Sat Jun 26 13:29:34 UTC 2021
PRIMARY
MERCK INDEX
M1483
Created by admin on Sat Jun 26 13:29:34 UTC 2021 , Edited by admin on Sat Jun 26 13:29:34 UTC 2021
PRIMARY Merck Index
Related Record Type Details
TARGET -> AGONIST
Related Record Type Details
ACTIVE MOIETY