U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C22H29FO5
Molecular Weight 392.4611
Optical Activity UNSPECIFIED
Defined Stereocenters 9 / 9
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PARAMETHASONE

SMILES

[H][C@@]12C[C@@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]3([H])[C@@]2([H])C[C@H](F)C4=CC(=O)C=C[C@]34C

InChI

InChIKey=MKPDWECBUAZOHP-AFYJWTTESA-N
InChI=1S/C22H29FO5/c1-11-6-14-13-8-16(23)15-7-12(25)4-5-20(15,2)19(13)17(26)9-21(14,3)22(11,28)18(27)10-24/h4-5,7,11,13-14,16-17,19,24,26,28H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19-,20+,21+,22+/m1/s1

HIDE SMILES / InChI

Molecular Formula C22H29FO5
Molecular Weight 392.4611
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 8 / 9
E/Z Centers 0
Optical Activity UNSPECIFIED

Paramethasone is a glucocorticoid. It exerts anti-inflammatory and immunosuppressant actions. Paramethasone stimulates the synthesis of enzymes needed to decrease anti-inflammatory response. It suppresses the immune system by reducing activity and volume of the lymphatic system, thus producing lymphocytopenia decreasing passage of immune complexes and possibly by depressing reactivity of tissue to antigen-antibody interactions.

Approval Year

PubMed

PubMed

TitleDatePubMed
Two cases of specific adverse reactions to systemic corticosteroids.
1996 Sep-Oct
[Hiccups crisis following paramethasone intraarticular injection].
2005 Jun 25
Substance Class Chemical
Created
by admin
on Wed Jul 05 22:58:20 UTC 2023
Edited
by admin
on Wed Jul 05 22:58:20 UTC 2023
Record UNII
VFC6ZX3584
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PARAMETHASONE
HSDB   INN   MI   VANDF   WHO-DD  
INN  
Official Name English
PARAMETHASONE [VANDF]
Common Name English
PARAMETHASONE [MI]
Common Name English
(6.ALPHA.,11.BETA.,16.ALPHA.)-6-FLUORO-11,17,21-TRIHYDROXY-16-METHYLPREGNA-1,4-DIENE-3,20-DIONE
Systematic Name English
PARAMETHASONE [HSDB]
Common Name English
DILLAR
Brand Name English
Paramethasone [WHO-DD]
Common Name English
PREGNA-1,4-DIENE-3,20-DIONE, 6-FLUORO-11,17,21-TRIHYDROXY-16-METHYL-, (6.ALPHA.,11.BETA.,16.ALPHA.)-
Systematic Name English
paramethasone [INN]
Common Name English
Classification Tree Code System Code
WHO-VATC QH02AB05
Created by admin on Wed Jul 05 22:58:20 UTC 2023 , Edited by admin on Wed Jul 05 22:58:20 UTC 2023
NCI_THESAURUS C521
Created by admin on Wed Jul 05 22:58:20 UTC 2023 , Edited by admin on Wed Jul 05 22:58:20 UTC 2023
WHO-ATC H02AB05
Created by admin on Wed Jul 05 22:58:20 UTC 2023 , Edited by admin on Wed Jul 05 22:58:20 UTC 2023
Code System Code Type Description
NCI_THESAURUS
C66309
Created by admin on Wed Jul 05 22:58:20 UTC 2023 , Edited by admin on Wed Jul 05 22:58:20 UTC 2023
PRIMARY
MERCK INDEX
M8403
Created by admin on Wed Jul 05 22:58:20 UTC 2023 , Edited by admin on Wed Jul 05 22:58:20 UTC 2023
PRIMARY Merck Index
DRUG BANK
DB01384
Created by admin on Wed Jul 05 22:58:20 UTC 2023 , Edited by admin on Wed Jul 05 22:58:20 UTC 2023
PRIMARY
SMS_ID
100000082771
Created by admin on Wed Jul 05 22:58:20 UTC 2023 , Edited by admin on Wed Jul 05 22:58:20 UTC 2023
PRIMARY
FDA UNII
VFC6ZX3584
Created by admin on Wed Jul 05 22:58:20 UTC 2023 , Edited by admin on Wed Jul 05 22:58:20 UTC 2023
PRIMARY
EVMPD
SUB09614MIG
Created by admin on Wed Jul 05 22:58:20 UTC 2023 , Edited by admin on Wed Jul 05 22:58:20 UTC 2023
PRIMARY
MESH
D010248
Created by admin on Wed Jul 05 22:58:20 UTC 2023 , Edited by admin on Wed Jul 05 22:58:20 UTC 2023
PRIMARY
WIKIPEDIA
PARAMETHASONE
Created by admin on Wed Jul 05 22:58:20 UTC 2023 , Edited by admin on Wed Jul 05 22:58:20 UTC 2023
PRIMARY
PUBCHEM
5875
Created by admin on Wed Jul 05 22:58:20 UTC 2023 , Edited by admin on Wed Jul 05 22:58:20 UTC 2023
PRIMARY
ChEMBL
CHEMBL1200342
Created by admin on Wed Jul 05 22:58:20 UTC 2023 , Edited by admin on Wed Jul 05 22:58:20 UTC 2023
PRIMARY
EPA CompTox
DTXSID3023421
Created by admin on Wed Jul 05 22:58:20 UTC 2023 , Edited by admin on Wed Jul 05 22:58:20 UTC 2023
PRIMARY
RXCUI
7910
Created by admin on Wed Jul 05 22:58:20 UTC 2023 , Edited by admin on Wed Jul 05 22:58:20 UTC 2023
PRIMARY RxNorm
ECHA (EC/EINECS)
200-169-2
Created by admin on Wed Jul 05 22:58:20 UTC 2023 , Edited by admin on Wed Jul 05 22:58:20 UTC 2023
PRIMARY
HSDB
3376
Created by admin on Wed Jul 05 22:58:20 UTC 2023 , Edited by admin on Wed Jul 05 22:58:20 UTC 2023
PRIMARY
INN
1096
Created by admin on Wed Jul 05 22:58:20 UTC 2023 , Edited by admin on Wed Jul 05 22:58:20 UTC 2023
PRIMARY
CAS
53-33-8
Created by admin on Wed Jul 05 22:58:20 UTC 2023 , Edited by admin on Wed Jul 05 22:58:20 UTC 2023
PRIMARY
Related Record Type Details
TARGET -> AGONIST
Related Record Type Details
ACTIVE MOIETY