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Details

Stereochemistry ABSOLUTE
Molecular Formula C22H29FO5
Molecular Weight 392.4619
Optical Activity UNSPECIFIED
Defined Stereocenters 9 / 9
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PARAMETHASONE

SMILES

C[C@]1([H])C[C@@]2([H])[C@]3([H])C[C@@]([H])(C4=CC(=O)C=C[C@]4(C)[C@@]3([H])[C@]([H])(C[C@]2(C)[C@]1(C(=O)CO)O)O)F

InChI

InChIKey=MKPDWECBUAZOHP-AFYJWTTESA-N
InChI=1S/C22H29FO5/c1-11-6-14-13-8-16(23)15-7-12(25)4-5-20(15,2)19(13)17(26)9-21(14,3)22(11,28)18(27)10-24/h4-5,7,11,13-14,16-17,19,24,26,28H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19-,20+,21+,22+/m1/s1

HIDE SMILES / InChI

Molecular Formula C22H29FO5
Molecular Weight 392.4619
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 8 / 9
E/Z Centers 0
Optical Activity UNSPECIFIED

Paramethasone is a glucocorticoid. It exerts anti-inflammatory and immunosuppressant actions. Paramethasone stimulates the synthesis of enzymes needed to decrease anti-inflammatory response. It suppresses the immune system by reducing activity and volume of the lymphatic system, thus producing lymphocytopenia decreasing passage of immune complexes and possibly by depressing reactivity of tissue to antigen-antibody interactions.

Approval Year

PubMed

PubMed

TitleDatePubMed
Pseudo-allergic reactions to corticosteroids: diagnosis and alternatives.
1995 May-Jun
Two cases of specific adverse reactions to systemic corticosteroids.
1996 Sep-Oct
[Chronic adhesive arachnoiditis following epidural paramethasone].
1997 Dec
Surgical decompression versus local steroid injection in carpal tunnel syndrome: a one-year, prospective, randomized, open, controlled clinical trial.
2005 Feb
Tachon's syndrome (suracute back and/or thoracic pain following local injections of corticosteroids). A report of 318 French cases.
2005 Jan
[Hiccups crisis following paramethasone intraarticular injection].
2005 Jun 25
Epidural dextran-40 and paramethasone injection for treatment of spontaneous intracranial hypotension.
2006 Jun
Adalimumab for the treatment of fistulas in patients with Crohn's disease.
2009 Jul
Substance Class Chemical
Created
by admin
on Sat Jun 26 08:08:15 UTC 2021
Edited
by admin
on Sat Jun 26 08:08:15 UTC 2021
Record UNII
VFC6ZX3584
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PARAMETHASONE
HSDB   INN   MI   VANDF   WHO-DD  
INN  
Official Name English
PARAMETHASONE [VANDF]
Common Name English
PARAMETHASONE [MI]
Common Name English
(6.ALPHA.,11.BETA.,16.ALPHA.)-6-FLUORO-11,17,21-TRIHYDROXY-16-METHYLPREGNA-1,4-DIENE-3,20-DIONE
Systematic Name English
PARAMETHASONE [HSDB]
Common Name English
DILLAR
Brand Name English
PARAMETHASONE [WHO-DD]
Common Name English
PREGNA-1,4-DIENE-3,20-DIONE, 6-FLUORO-11,17,21-TRIHYDROXY-16-METHYL-, (6.ALPHA.,11.BETA.,16.ALPHA.)-
Systematic Name English
PARAMETHASONE [INN]
Common Name English
Classification Tree Code System Code
WHO-VATC QH02AB05
Created by admin on Sat Jun 26 08:08:15 UTC 2021 , Edited by admin on Sat Jun 26 08:08:15 UTC 2021
NCI_THESAURUS C521
Created by admin on Sat Jun 26 08:08:15 UTC 2021 , Edited by admin on Sat Jun 26 08:08:15 UTC 2021
WHO-ATC H02AB05
Created by admin on Sat Jun 26 08:08:15 UTC 2021 , Edited by admin on Sat Jun 26 08:08:15 UTC 2021
Code System Code Type Description
NCI_THESAURUS
C66309
Created by admin on Sat Jun 26 08:08:15 UTC 2021 , Edited by admin on Sat Jun 26 08:08:15 UTC 2021
PRIMARY
MERCK INDEX
M8403
Created by admin on Sat Jun 26 08:08:15 UTC 2021 , Edited by admin on Sat Jun 26 08:08:15 UTC 2021
PRIMARY Merck Index
DRUG BANK
DB01384
Created by admin on Sat Jun 26 08:08:15 UTC 2021 , Edited by admin on Sat Jun 26 08:08:15 UTC 2021
PRIMARY
FDA UNII
VFC6ZX3584
Created by admin on Sat Jun 26 08:08:15 UTC 2021 , Edited by admin on Sat Jun 26 08:08:15 UTC 2021
PRIMARY
EVMPD
SUB09614MIG
Created by admin on Sat Jun 26 08:08:15 UTC 2021 , Edited by admin on Sat Jun 26 08:08:15 UTC 2021
PRIMARY
MESH
D010248
Created by admin on Sat Jun 26 08:08:15 UTC 2021 , Edited by admin on Sat Jun 26 08:08:15 UTC 2021
PRIMARY
WIKIPEDIA
PARAMETHASONE
Created by admin on Sat Jun 26 08:08:15 UTC 2021 , Edited by admin on Sat Jun 26 08:08:15 UTC 2021
PRIMARY
PUBCHEM
5875
Created by admin on Sat Jun 26 08:08:15 UTC 2021 , Edited by admin on Sat Jun 26 08:08:15 UTC 2021
PRIMARY
ChEMBL
CHEMBL1200342
Created by admin on Sat Jun 26 08:08:15 UTC 2021 , Edited by admin on Sat Jun 26 08:08:15 UTC 2021
PRIMARY
EPA CompTox
53-33-8
Created by admin on Sat Jun 26 08:08:15 UTC 2021 , Edited by admin on Sat Jun 26 08:08:15 UTC 2021
PRIMARY
RXCUI
7910
Created by admin on Sat Jun 26 08:08:15 UTC 2021 , Edited by admin on Sat Jun 26 08:08:15 UTC 2021
PRIMARY RxNorm
ECHA (EC/EINECS)
200-169-2
Created by admin on Sat Jun 26 08:08:15 UTC 2021 , Edited by admin on Sat Jun 26 08:08:15 UTC 2021
PRIMARY
HSDB
3376
Created by admin on Sat Jun 26 08:08:15 UTC 2021 , Edited by admin on Sat Jun 26 08:08:15 UTC 2021
PRIMARY
INN
1096
Created by admin on Sat Jun 26 08:08:15 UTC 2021 , Edited by admin on Sat Jun 26 08:08:15 UTC 2021
PRIMARY
CAS
53-33-8
Created by admin on Sat Jun 26 08:08:15 UTC 2021 , Edited by admin on Sat Jun 26 08:08:15 UTC 2021
PRIMARY
Related Record Type Details
TARGET -> AGONIST
Related Record Type Details
ACTIVE MOIETY