PARAMETHASONE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C22H29FO5
Molecular Weight	392.4611
Optical Activity	UNSPECIFIED
Defined Stereocenters	9 / 9
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12C[C@@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]3([H])[C@@]2([H])C[C@H](F)C4=CC(=O)C=C[C@]34C

InChI

InChIKey=MKPDWECBUAZOHP-AFYJWTTESA-N

InChI=1S/C22H29FO5/c1-11-6-14-13-8-16(23)15-7-12(25)4-5-20(15,2)19(13)17(26)9-21(14,3)22(11,28)18(27)10-24/h4-5,7,11,13-14,16-17,19,24,26,28H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19-,20+,21+,22+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C22H29FO5
Molecular Weight	392.4611
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	8 / 9
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.drugs.com/international/paramethasone.html | https://www.ncbi.nlm.nih.gov/pubmed/839089 | https://books.google.ru/books?id=ihxyHbnj3qYC&printsec=frontcover&hl=ru#v=onepage&q&f=false

Paramethasone is a glucocorticoid. It exerts anti-inflammatory and immunosuppressant actions. Paramethasone stimulates the synthesis of enzymes needed to decrease anti-inflammatory response. It suppresses the immune system by reducing activity and volume of the lymphatic system, thus producing lymphocytopenia decreasing passage of immune complexes and possibly by depressing reactivity of tissue to antigen-antibody interactions.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
inflammatory response 47 Target ID: GO:0006954 Sources: Ebadi, M. (2007) Desk Reference of Clinical Pharmacology, page 543, retrieved from: https://books.google.ru/books?id=ihxyHbnj3qYC	Modulator 828

PubMed

Title	Date	PubMed
Pseudo-allergic reactions to corticosteroids: diagnosis and alternatives.	1995 May-Jun	7582165
Two cases of specific adverse reactions to systemic corticosteroids.	1996 Sep-Oct	8959545

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:28:27 GMT 2023` Edited by `admin` on `Fri Dec 15 15:28:27 GMT 2023`
Record UNII	VFC6ZX3584
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PARAMETHASONE

Official Name

English

PARAMETHASONE [VANDF]

Common Name

English

PARAMETHASONE [MI]

Common Name

English

(6.ALPHA.,11.BETA.,16.ALPHA.)-6-FLUORO-11,17,21-TRIHYDROXY-16-METHYLPREGNA-1,4-DIENE-3,20-DIONE

Systematic Name

English

PARAMETHASONE [HSDB]

Common Name

English

DILLAR

Brand Name

English

Paramethasone [WHO-DD]

Common Name

English

PREGNA-1,4-DIENE-3,20-DIONE, 6-FLUORO-11,17,21-TRIHYDROXY-16-METHYL-, (6.ALPHA.,11.BETA.,16.ALPHA.)-

Systematic Name

English

paramethasone [INN]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QH02AB05