Antihistamine agent

Moxaverine, a derivative of papaverine, is a phosphodiesterase inhibitor. Moxaverine has been studied in phase III of a clinical trial for the treatment of ocular blood flow in patients with age- related macular degeneration and primary open angle glaucoma. In addition, it has been studied in phase II of the clinical trial for the treatment of ischemia. This compound is prohibited by FEI (International Federation of equine).

There is not much information about benzylhydrochlorothiazide. This compound in combination with another drugs is used to decrease blood pressure and as a diuretic.

Etofamide is a luminal amoebicide acting principally on the bowel lumen with actions and uses similar to diloxanide furoate. Adverse drug reactions might include flatulence, vomiting, urticaria, pruritis. 100 patients suffering chronic intestinal amebiasis were treated with Etofamide, in a dose of 1,0 g per day, for three consecutive days. The tolerance of this antiamebic drug was excellent in all patients, and the parasitological cure rate obtained was 92%.

Amogastrin [INN, JAN] is a pseudopeptide which acts as a Cholecystokinin receptor agonist(CCKs or. 'gastrin receptor'), and a gastric acid secretion stimulant. Is used as a diagnostic agent.

Itopride is a dopamine D2 receptor antagonist and inhibitor of acetylcholinesterase. It is indicated in the for the treatment of gastrointestinal symptoms caused by reduced gastrointestinal motility, such as functional non-ulcer dyspepsia (chronic gastritis), gastric fullness, rapid satiation, pain or discomfort in the upper abdomen, anorexia, heartburn, nausea, and vomiting. The drug is not approved in the USA or UK but is available in Japan and Western European countries.

Dexetimide is a potent central and peripheral anticholinergic agent. It has a high affinity for all subtypes of muscarinic receptor and a long duration action. It forms very stable complex with mAChR. Dexetimide was used for many years in Europe for the treatment of extrapyramidal disorders. Neuroleptic-induced parkinsonian symptoms are effectively controlled by dexetimide. It is a safe, potent, and long-acting antiparkinsonian agent.

Norfenefrine or meta-octopamine, also known as 3,β-dihydroxyphenethylamine, is an adrenergic agent used as a sympathomimetic drug which is marketed in Europe, Japan, and Mexico. Along with its structural isomer p-octopamine and the tyramines, norfenefrine is a naturally occurring, endogenous trace amine and plays a role as a minor neurotransmitter in the brain. Norfenefrine controls blood pressure in acute hypotensive states eg pheochromocytomectomy, sympathectomy, poliomyelitis, spinal anesth, MI, septicemia, blood transfusion and drug reactions. Adjunct in treatment of cardiac arrest and hypotension.

Clebopride is a dopamine antagonist drug. It is used to treat functional gastrointestinal disorder such as nausea or vomiting. Unchanged parent drug was the most abundant compound in human urine. Major metabolites included the hydroxylation at benzyl group to yield carbinolamine and its further N-dealkylation product, and the piperidine ring hydroxylation/oxidation metabolite (a lactam).

Benexate is an active ingredient of benexate.CD or benexate hydrochloride betadex, a beta-cyclodextrin complex. Benexate was approved for the treatment of Gastric Ulcer in Japan. The terapeuthic effect of benexate is associated with promotion of prostaglandin synthesis, inhibition of acid secretion and increase in mucosal blood flow.