AMOGASTRIN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C35H46N6O8S
Molecular Weight	710.84
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCC(C)(C)OC(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC3=CC=CC=C3)C(N)=O

InChI

InChIKey=CAVZBWFUMSXZFB-LJWNLINESA-N

InChI=1S/C35H46N6O8S/c1-5-35(2,3)49-34(48)41-27(18-22-20-37-24-14-10-9-13-23(22)24)32(46)38-25(15-16-50-4)31(45)40-28(19-29(42)43)33(47)39-26(30(36)44)17-21-11-7-6-8-12-21/h6-14,20,25-28,37H,5,15-19H2,1-4H3,(H2,36,44)(H,38,46)(H,39,47)(H,40,45)(H,41,48)(H,42,43)/t25-,26-,27-,28-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C35H46N6O8S
Molecular Weight	710.84
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: http://www.ncbi.nlm.nih.gov/pubmed/2733241

Amogastrin [INN, JAN] is a pseudopeptide which acts as a Cholecystokinin receptor agonist(CCKs or. 'gastrin receptor'), and a gastric acid secretion stimulant. Is used as a diagnostic agent.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Cholecystokinin receptor 1 Target ID: CHEMBL2095185 Sources: link.springer.com/content/pdf/10.1007%2F978-94-011-4439-1.pdf	Agonist 2678

Conditions

Condition	Modality	Targets	Highest Phase	Product
Gastric diseases 1 Sources: http://www.ncbi.nlm.nih.gov/pubmed/6285422	Diagnostic		Basic research	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Amogastrin for the 99mTc-pertechnetate imaging of the gastric mucosa.	1982 Mar	6285422
Effect of amogastrin on the release of various prostaglandins into gastric lumen in man.	1989 Mar-Apr	2733241

Patents

Sample Use Guides

In Vivo Use Guide

bolus injection of 4 ug/kg

Route of Administration: Other

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:10:33 UTC 2023` Edited by `admin` on `Fri Dec 15 16:10:33 UTC 2023`
Record UNII	8T3Q0X4G5G
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

AMOGASTRIN

Official Name

English

AMOGASTRIN [JAN]

Common Name

English

amogastrin [INN]

Common Name

English

L-PHENYLALANINAMIDE, N-((1,1-DIMETHYLPROPOXY)CARBONYL)-L-TRYPTOPHYL-L-METHIONYL-L-.ALPHA.-ASPARTYL

Common Name

English

Amogastrin [WHO-DD]

Common Name

English

(3S)-4-(((1S)-2-AMINO-1-BENZYL-2-OXO-ETHYL)AMINO)-3-((2S)-2-(((2S)-2-(1,1-DIMETHYLPROPOXYCARBONYLAMINO)-3-(1H-INDOL-3-YL)PROPANOYL)AMINO)-4-METHYLSULFANYL-BUTANOYL)AMINO)-4-OXO-BUTANOIC ACID

Common Name

English

N-((1,1-DIMETHYLPROPOXY)CARBONYL)-L-TRYPTOPHYL-L-METHIONYL-L-.ALPHA.-ASPARTYL-L-PHENYLALANINAMIDE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1937