BENEXATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C23H27N3O4
Molecular Weight	409.4782
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC(=N)NC[C@H]1CC[C@@H](CC1)C(=O)OC2=C(C=CC=C2)C(=O)OCC3=CC=CC=C3

InChI

InChIKey=IAXUQWSLRKIRFR-SAABIXHNSA-N

InChI=1S/C23H27N3O4/c24-23(25)26-14-16-10-12-18(13-11-16)21(27)30-20-9-5-4-8-19(20)22(28)29-15-17-6-2-1-3-7-17/h1-9,16,18H,10-15H2,(H4,24,25,26)/t16-,18-

HIDE SMILES / InChI

Description
Sources: http://www.e-ce.org/upload/pdf/29400520.pdf
Curator's Comment: description was created based on several sources, including, http://www.ncbi.nlm.nih.gov/pubmed/27446246

Benexate is an active ingredient of benexate.CD or benexate hydrochloride betadex, a beta-cyclodextrin complex. Benexate was approved for the treatment of Gastric Ulcer in Japan. The terapeuthic effect of benexate is associated with promotion of prostaglandin synthesis, inhibition of acid secretion and increase in mucosal blood flow.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
prostaglandin biosynthetic process 23 Target ID: GO:0001516 Sources: http://www.ncbi.nlm.nih.gov/pubmed/27446246	Activator 1430
gastric acid secretion 6 Target ID: GO:0001696 Sources: http://www.ncbi.nlm.nih.gov/pubmed/27446246	Inhibitor 8297
gastric mucosal blood circulation 6 Target ID: GO:1990768 Sources: http://www.ncbi.nlm.nih.gov/pubmed/27446246	Activator 1430

Conditions

Condition	Modality	Targets	Highest Phase	Product
Gastric ulcer 67 Sources: http://backoffice.phillipcapital.in/Backoffice/Researchfiles/PC_-_Lupin_Co_Udpate_-_Aug_2016_20160802190017.pdf	Primary		Approved 8429	ULGUT Approved Use Unknown
Gastritis 45 Sources: http://backoffice.phillipcapital.in/Backoffice/Researchfiles/PC_-_Lupin_Co_Udpate_-_Aug_2016_20160802190017.pdf	Primary		Approved 8429	ULGUT Approved Use Unknown

PubMed

Title	Date	PubMed
Syntheses and inhibitory effects on gastric lesions of trans-guanidinomethylcyclohexane carboxylic acid arylamides.	1993 Mar	8477502
In-vitro and in-vivo antibacterial activity of plaunotol, a cytoprotective antiulcer agent, against Helicobacter pylori.	1996 May	8737142
Differential effect of benexate hydrochloride betadex on prostaglandin levels in stomach and inflammatory site in rats.	1996 Oct	8912919
Benexate hydrochloride betadex modulates nitric oxide synthesis and cytokine expression in gastric ulcers.	2016 Aug	27446246

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Oral

In Vitro Use Guide

Unknown

Name

Type

Language

BENEXATE

Official Name

English

BENZYL SALICYLATE, TRANS-4-(GUANIDINOMETHYL)CYCLOHEXANECARBOXYLATE

Systematic Name

English

benexate [INN]

Common Name

English

Benexate [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29698