ETOFAMIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H20Cl2N2O5
Molecular Weight	427.279
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCOCCN(CC1=CC=C(OC2=CC=C(C=C2)[N+]([O-])=O)C=C1)C(=O)C(Cl)Cl

InChI

InChIKey=QTRALMGDQMIVFF-UHFFFAOYSA-N

InChI=1S/C19H20Cl2N2O5/c1-2-27-12-11-22(19(24)18(20)21)13-14-3-7-16(8-4-14)28-17-9-5-15(6-10-17)23(25)26/h3-10,18H,2,11-13H2,1H3

HIDE SMILES / InChI

Molecular Formula	C19H20Cl2N2O5
Molecular Weight	427.279
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.mims.com/philippines/drug/info/etofamide?mtype=generic | https://www.drugs.com/international/etofamide.html | https://www.ncbi.nlm.nih.gov/pubmed/9363264 | http://apps.who.int/medicinedocs/documents/h5779e/h5779e.pdf | https://www.ncbi.nlm.nih.gov/pubmed/6778767

Etofamide is a luminal amoebicide acting principally on the bowel lumen with actions and uses similar to diloxanide furoate. Adverse drug reactions might include flatulence, vomiting, urticaria, pruritis. 100 patients suffering chronic intestinal amebiasis were treated with Etofamide, in a dose of 1,0 g per day, for three consecutive days. The tolerance of this antiamebic drug was excellent in all patients, and the parasitological cure rate obtained was 92%.

Approval Year

PubMed

Title	Date	PubMed
Activity of quinfamide against natural infections of Entamoeba criceti in hamsters: a new potent agent for intestinal amoebiasis.	1980 Aug	6252530
In-vitro susceptibility of Giardia lamblia to albendazole, mebendazole and other chemotherapeutic agents.	1992 Sep	1518040
[Comparison of quinfamide vs etofamide in the Mexican population with intestinal amebiasis].	1996	9363264

Patents

Sample Use Guides

In Vivo Use Guide

Oral Intestinal amoebiasis Adult: 1000 mg daily in 2 divided doses for 3 consecutive days. Child: As 100 mg/5ml suspension: 10 ml tid for 3 days or 15-20 mg/kg/day for 3 consecutive days.

Route of Administration: Oral

In Vitro Use Guide

Etofamide inhibited G. lamblia with IC50 value of 5.98 mg/L

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:12:09 GMT 2023` Edited by `admin` on `Fri Dec 15 16:12:09 GMT 2023`
Record UNII	03F36JH21U
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ETOFAMIDE

Official Name

English

2,2-DICHLORO-N-(2-ETHOXYETHYL)-N-((P-NITROPHENOXY)BENZYL)-ACETAMIDE

Common Name

English

Etofamide [WHO-DD]

Common Name

English

etofamide [INN]

Common Name

English

ETOFAMIDE [MART.]

Common Name

English

KITNOS

Brand Name

English

Classification Tree Code System Code

WHO-ATC

P01AC03