BENZYLHYDROCHLOROTHIAZIDE

Details

Stereochemistry	UNKNOWN
Molecular Formula	C14H14ClN3O4S2
Molecular Weight	387.862
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NS(=O)(=O)C1=CC2=C(NC(CC3=CC=CC=C3)NS2(=O)=O)C=C1Cl

InChI

InChIKey=BWSSMIJUDVUASQ-UHFFFAOYSA-N

InChI=1S/C14H14ClN3O4S2/c15-10-7-11-13(8-12(10)23(16,19)20)24(21,22)18-14(17-11)6-9-4-2-1-3-5-9/h1-5,7-8,14,17-18H,6H2,(H2,16,19,20)

HIDE SMILES / InChI

Molecular Formula	C14H14ClN3O4S2
Molecular Weight	387.862
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: http://www.ndrugs.com/?s=benzylhydrochlorothiazide/enalapril&t=dosage

There is not much information about benzylhydrochlorothiazide. This compound in combination with another drugs is used to decrease blood pressure and as a diuretic.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Hypertension 567 Sources: http://www.ndrugs.com/?s=benzylhydrochlorothiazide/enalapril&t=dosage	Secondary		Not Provided 504	Unknown Approved Use Unknown
Congestive heart failure 54 Sources: http://www.ndrugs.com/?s=benzylhydrochlorothiazide/enalapril&t=dosage	Secondary		Not Provided 504	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Studies on the phototoxic effects of oral antidiabetics and diuretics.	1997 Jan	9037453

Patents

Sample Use Guides

In Vivo Use Guide

Adult Dose for Hypertension: In combination with diuretics: Initial dose: 2.5 mg orally once a day. If feasible, the diuretic should be discontinued 2 to 3 days prior to initiation of therapy with enalapril. If required, diuretic therapy may be gradually resumed. Parenteral: 1.25 to 5 mg IV over a 5 minute period every 6 hours

Route of Administration: Oral

In Vitro Use Guide

The NHIK 3025 cell line (Norsk Hydro Institutt for Kreftforskning), a human in situ carcinoma of the cervix cell line, was used to investigate the benzylhydrochlorothiazide for its potential phototoxic properties. Cell death following UVA irradiation and dependent on test substance concentration was observed in the presence of benzylhydrochlorothiazide. This compound was phototoxic at 0.25 mM and higher.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:15:17 GMT 2023` Edited by `admin` on `Fri Dec 15 16:15:17 GMT 2023`
Record UNII	176437APQH
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BENZYLHYDROCHLOROTHIAZIDE

Common Name

English

BENZYLHYDROCHLOROTHIAZIDE [JAN]

Common Name

English

BENZYLHYDROCHLORTHIAZIDE

Common Name

English

NSC-263220

Code

English

3-BENZYL-3,4-DIHYDRO-6-CHLOR-2H, 1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE

Common Name

English

Benzylhydrochlorothiazide [WHO-DD]

Common Name

English

BENZYLHYDROCHLOROTHIAZIDE [MART.]

Common Name

English

BENZYLHYDROCHLOROTHIAZIDE [MI]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C49185