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Details

Stereochemistry RACEMIC
Molecular Formula C8H11NO2
Molecular Weight 153.1784
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of NORFENEFRINE

SMILES

NCC(O)C1=CC(O)=CC=C1

InChI

InChIKey=LRCXRAABFLIVAI-UHFFFAOYSA-N
InChI=1S/C8H11NO2/c9-5-8(11)6-2-1-3-7(10)4-6/h1-4,8,10-11H,5,9H2

HIDE SMILES / InChI

Molecular Formula C8H11NO2
Molecular Weight 153.1784
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Description

Norfenefrine or meta-octopamine, also known as 3,β-dihydroxyphenethylamine, is an adrenergic agent used as a sympathomimetic drug which is marketed in Europe, Japan, and Mexico. Along with its structural isomer p-octopamine and the tyramines, norfenefrine is a naturally occurring, endogenous trace amine and plays a role as a minor neurotransmitter in the brain. Norfenefrine controls blood pressure in acute hypotensive states eg pheochromocytomectomy, sympathectomy, poliomyelitis, spinal anesth, MI, septicemia, blood transfusion and drug reactions. Adjunct in treatment of cardiac arrest and hypotension.

CNS Activity

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown
Primary
Nevadral Retard

PubMed

Sample Use Guides

In Vivo Use Guide
For the treatment of female stress incontinence 60 mg were given in slow-release tablets.
Route of Administration: Oral
In Vitro Use Guide
At 0.1 and 1 umol/l, norfenefrine caused contractions of the rabbit pulmonary artery strips
Substance Class Chemical
Record UNII
D2P3M6SRN5
Record Status Validated (UNII)
Record Version