Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C8H11NO2 |
| Molecular Weight | 153.1784 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
NCC(O)C1=CC(O)=CC=C1
InChI
InChIKey=LRCXRAABFLIVAI-UHFFFAOYSA-N
InChI=1S/C8H11NO2/c9-5-8(11)6-2-1-3-7(10)4-6/h1-4,8,10-11H,5,9H2
| Molecular Formula | C8H11NO2 |
| Molecular Weight | 153.1784 |
| Charge | 0 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
DescriptionCurator's Comment: Description was created based on several sources, including http://www.kegg.jp/entry/D08286 and http://www.ncbi.nlm.nih.gov/pubmed/6351455
Curator's Comment: Description was created based on several sources, including http://www.kegg.jp/entry/D08286 and http://www.ncbi.nlm.nih.gov/pubmed/6351455
Norfenefrine or meta-octopamine, also known as 3,β-dihydroxyphenethylamine, is an adrenergic agent used as a sympathomimetic drug which is marketed in Europe, Japan, and Mexico. Along with its structural isomer p-octopamine and the tyramines, norfenefrine is a naturally occurring, endogenous trace amine and plays a role as a minor neurotransmitter in the brain. Norfenefrine controls blood pressure in acute hypotensive states eg pheochromocytomectomy, sympathectomy, poliomyelitis, spinal anesth, MI, septicemia, blood transfusion and drug reactions. Adjunct in treatment of cardiac arrest and hypotension.
CNS Activity
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Midodrine. A review of its pharmacological properties and therapeutic use in orthostatic hypotension and secondary hypotensive disorders. | 1989 Nov |
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| Effects of norepinephrine on the oxidative pentose phosphate pathway in the rat heart. | 1992 Aug |
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| In vivo alpha(1)-adrenergic lipolytic activity in subcutaneous adipose tissue of obese subjects. | 2002 Apr |
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| Early multiple organ failure after recurrent endotoxemia in the presence of vasoconstrictor-masked hypovolemia. | 2003 Mar |
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| Sympathetic regulation of glucose uptake by the alpha1-adrenoceptor in human obesity. | 2004 Apr |
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| Heat shock protein 72 and apoptosis indicate cardiac decompensation during early multiple organ failure in sheep. | 2004 Jul |
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| Roles of MMP-2/-9 in cardiac dysfunction during early multiple organ failure in an ovine animal model. | 2005 |
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| [Efficacy and safety of a herbal drug containing hawthorn berries and D-camphor in hypotension and orthostatic circulatory disorders/results of a retrospective epidemiologic cohort study]. | 2005 |
|
| Chiral separations on multichannel microfluidic chips. | 2005 Dec |
|
| A new copper(I)-tetrahydrosalen-catalyzed asymmetric Henry reaction and its extension to the synthesis of (S)-norphenylephrine. | 2007 |
|
| A multichannel electrophoresis microchip platform for rapid chiral selector screening. | 2008 May |
Patents
Sample Use Guides
In Vivo Use Guide
Curator's Comment: Can also be administered inramuscularly
http://www.ncbi.nlm.nih.gov/pubmed/7197979
For the treatment of female stress incontinence 60 mg were given in slow-release tablets.
Route of Administration:
Oral
| Substance Class |
Chemical
Created
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on
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Fri Dec 15 16:04:45 UTC 2023
by
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| Record UNII |
D2P3M6SRN5
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| Record Status |
Validated (UNII)
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| Record Version |
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WHO-VATC |
QC01CA05
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WHO-ATC |
C01CA05
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NCI_THESAURUS |
C29709
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| Code System | Code | Type | Description | ||
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536-21-0
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CHEMBL358040
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100000083615
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m8058
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NORFENEFRINE
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4538
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31988
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DTXSID3048314
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D2P3M6SRN5
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SUB09364MIG
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C84022
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DB13378
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2140
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1966
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208-626-8
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C005310
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