DEXETIMIDE

Possibly Marketed Outside US

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C23H26N2O2
Molecular Weight	362.4647
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O=C1CC[C@@](C2CCN(CC3=CC=CC=C3)CC2)(C(=O)N1)C4=CC=CC=C4

InChI

InChIKey=LQQIVYSCPWCSSD-HSZRJFAPSA-N

InChI=1S/C23H26N2O2/c26-21-11-14-23(22(27)24-21,19-9-5-2-6-10-19)20-12-15-25(16-13-20)17-18-7-3-1-4-8-18/h1-10,20H,11-17H2,(H,24,26,27)/t23-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C23H26N2O2
Molecular Weight	362.4647
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4947805 | https://www.ncbi.nlm.nih.gov/pubmed/4581374 | https://www.ncbi.nlm.nih.gov/pubmed/1020682 | De Deyn (1997) A Textbook Of: SPECT in Neurology and Psychiatry, page 20, retrieved from: https://books.google.ru/books?id=OdNnFrWm9SsC

Dexetimide is a potent central and peripheral anticholinergic agent. It has a high affinity for all subtypes of muscarinic receptor and a long duration action. It forms very stable complex with mAChR. Dexetimide was used for many years in Europe for the treatment of extrapyramidal disorders. Neuroleptic-induced parkinsonian symptoms are effectively controlled by dexetimide. It is a safe, potent, and long-acting antiparkinsonian agent.

Approval Year

PubMed

Title	Date	PubMed
Pharmacological comparison of the cloned human and rat M2 muscarinic receptor genes expressed in the murine fibroblast (B82) cell line.	1998-02	9454790
Subclassification of muscarinic receptors in the heart, urinary bladder and sympathetic ganglia in the pithed rat. Selectivity of some classical agonists.	1985-12	4094621
Dexetimide (R 16470) in the control of neuroleptic-induced extrapyramidal side-effects. Its prophylactic value and duration of action.	1973-07-01	4581374
A quantitative study of neuroleptic-induced extrapyramidal symptoms and their response to dexetimide, a potent and long-acting antiparkinsonian agent.	1971	4947805

Sample Use Guides

In Vivo Use Guide

Dosages ranged from 0.5 to 1.5 mg daily

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:19:32 GMT 2025` Edited by `admin` on `Mon Mar 31 18:19:32 GMT 2025`
Record UNII	43477QYX3D
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

DEXETIMIDE

Official Name

English

R 16,470 FREE BASE

Preferred Name

English

(+)-2-(1-BENZYL-4-PIPERIDYL)-2-PHENYLGLUTARIMIDE

Systematic Name

English

BENZETIMIDE, (S)-

Common Name

English

dexetimide [INN]

Common Name

English

DEXETIMIDE [MI]

Common Name

English

DEXETIMIDE [MART.]

Common Name

English

R-16470 FREE BASE

Code

English

(3,4'-BIPIPERIDINE)-2,6-DIONE, 3-PHENYL-1'-(PHENYLMETHYL)-, (S)-

Systematic Name

English

Dexetimide [WHO-DD]

Common Name

English

DEXETIMIDE [USAN]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QN04AA08