DEXETIMIDE HYDROCHLORIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C23H26N2O2.ClH
Molecular Weight	398.926
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.O=C1CC[C@@](C2CCN(CC3=CC=CC=C3)CC2)(C(=O)N1)C4=CC=CC=C4

InChI

InChIKey=XSOOSXRNMDUWEM-GNAFDRTKSA-N

InChI=1S/C23H26N2O2.ClH/c26-21-11-14-23(22(27)24-21,19-9-5-2-6-10-19)20-12-15-25(16-13-20)17-18-7-3-1-4-8-18;/h1-10,20H,11-17H2,(H,24,26,27);1H/t23-;/m1./s1

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C23H26N2O2
Molecular Weight	362.4647
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4947805 | https://www.ncbi.nlm.nih.gov/pubmed/4581374 | https://www.ncbi.nlm.nih.gov/pubmed/1020682 | De Deyn (1997) A Textbook Of: SPECT in Neurology and Psychiatry, page 20, retrieved from: https://books.google.ru/books?id=OdNnFrWm9SsC

Dexetimide is a potent central and peripheral anticholinergic agent. It has a high affinity for all subtypes of muscarinic receptor and a long duration action. It forms very stable complex with mAChR. Dexetimide was used for many years in Europe for the treatment of extrapyramidal disorders. Neuroleptic-induced parkinsonian symptoms are effectively controlled by dexetimide. It is a safe, potent, and long-acting antiparkinsonian agent.

Approval Year

PubMed

Title	Date	PubMed
A quantitative study of neuroleptic-induced extrapyramidal symptoms and their response to dexetimide, a potent and long-acting antiparkinsonian agent.	1971	4947805
Dexetimide (R 16470) in the control of neuroleptic-induced extrapyramidal side-effects. Its prophylactic value and duration of action.	1973 Jul-Aug	4581374
Subclassification of muscarinic receptors in the heart, urinary bladder and sympathetic ganglia in the pithed rat. Selectivity of some classical agonists.	1985 Dec	4094621
Pharmacological comparison of the cloned human and rat M2 muscarinic receptor genes expressed in the murine fibroblast (B82) cell line.	1998 Feb	9454790

Sample Use Guides

In Vivo Use Guide

Dosages ranged from 0.5 to 1.5 mg daily

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:20:03 UTC 2023` Edited by `admin` on `Fri Dec 15 15:20:03 UTC 2023`
Record UNII	B987A3XX7D
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DEXETIMIDE HYDROCHLORIDE

Common Name

English

Dexetimide hydrochloride [WHO-DD]

Common Name

English

DEXETIMIDE HYDROCHLORIDE [MART.]

Common Name

English

TREMBLEX

Brand Name

English

R-16470

Code

English

DEXETIMIDE HCL

Common Name

English

R 16,470

Code

English

DEXETIMIDE HYDROCHLORIDE [MI]

Common Name

English

(S)-2-(1-BENZYL-4-PIPERIDYL)-2-PHENYLGLUTARIMIDE HYDROCHLORIDE

Systematic Name

English

BENZETIMIDE HYDROCHLORIDE, (S)-

Common Name

English

Code System Code Type Description

DRUG BANK

DBSALT002920